Computational modeling of adherent cell growth in a hollow-fiber membrane bioreactor for large-scale 3-D bone tissue engineering

Journal of Artificial Organs

Volumn 15, Issue 3, 2012, Pages 250-265

  Mohebbi Kalhori, Davod ^a,b   Behzadmehr, Amin ^a,b   Doillon, Charles J ^c   Hadjizadeh, Afra ^d,e  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITY OF SISTAN AND BALUCHESTAN   (Iran)

^c LAVAL UNIVERSITY   (Canada)

^d UNIVERSITÉ LAVAL   (Canada)

^e ÉCOLE POLYTECHNIQUE DE MONTRÉAL   (Canada)

Author keywords

3 D bone tissue; Adherent cells; Bone marrow derived cells; Hollow fiber bioreactor; Nutrient dependent cell growth

Indexed keywords

COLLAGEN GEL; TISSUE SCAFFOLD;

ADHERENT CELL; ARTICLE; BIOREACTOR DESIGN; BONE TISSUE; CELL GROWTH; FLUID FLOW; HOLLOW FIBER REACTOR; MATHEMATICAL MODEL; OSSIFICATION; POROSITY; PRIORITY JOURNAL; REACTOR OPERATION; TISSUE ENGINEERING;

BIOREACTORS; BONE MARROW CELLS; BONE TRANSPLANTATION; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; CELLS, CULTURED; COMPUTER SIMULATION; MODELS, THEORETICAL; OSTEOGENESIS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84868367533     PISSN: 14347229     EISSN: 16190904     Source Type: Journal    
DOI: 10.1007/s10047-012-0649-1     Document Type: Article

References (53)

1. Hadjizadeh A, Mohebbi-Kalhori D. Porous hollow membrane sheet for tissue engineering applications. J Biomed Mater Res A. 2010;93:1140-50.
2. Mohebbi-Kalhori D. A positron emission tomography approach to visualize flow perfusion in hollow-fiber membrane bioreactors. J Artif Organs. 2011;14:318-30.
3. Abdullah NS, Das DB, Ye H, Cui ZF. 3D bone tissue growth in hollow fibre membrane bioreactor: implications of various process parameters on tissue nutrition. Int J Artif Organs. 2006;29:841-51.
4. Liu G, Zhao L, Cui L, Liu W, Cao Y. Tissue-engineered bone formation using human bone marrow stromal cells and novel beta-tricalcium phosphate. Biomed Mater (Bristol, England). 2007;2:78-86.
5. Meinel L, Karageorgiou V, Fajardo R, Snyder B, Shinde-Patil V, Zichner L, Kaplan D, Langer R, Vunjak-Novakovic G. Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng. 2004;32:112-22.
6. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844-53.
7. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR. Multilineage potential of adult human mesenchymal stem cells. Science. 1999;284:143-7.
8. Ho AD, Wagner W, Franke W. Heterogeneity of mesenchymal stromal cell preparations. Cytotherapy. 2008;10:320-30.
9. Chien HH, Lin WL, Cho MI. Down-regulation of osteoblastic cell differentiation by epidermal growth factor receptor. Calcif Tissue Int. 2000;67:141-50.
10. Zhao F, Pathi P, GraysonW, Xing Q, Locke BR, Ma T. Effects of oxygen transport on 3-D human mesenchymal stem cell metabolic activity in perfusion and static cultures: experiments and mathematical model. Biotechnol Prog. 2005;21:1269-80.
11. Vunjak-Novakovic G, Meinel L, Altman G, Kaplan D. Bioreactor cultivation of osteochondral grafts. Orthod Craniofac Res. 2005;8:209-18.
12. Ellis MJ, Chaudhuri JB. Poly(lactic-co-glycolic acid) hollow fibre membranes for use as a tissue engineering scaffold. Biotechnol Bioeng. 2007;96:177-87.
13. Dunn JCY, Chan WY, Cristini V, Kim JS, Lowengrub J, Singh S, Wu BM. Analysis of cell growth in three-dimensional scaffolds. Tissue Eng. 2006;12:705-16.
14. Bettahalli NM, Vicente J, Moroni L, Higuera GA, van Blitterswijk CA, Wessling M, Stamatialis DF. Integration of hollow fiber membranes improves nutrient supply in three-dimensional tissue constructs. Acta Biomater. 2011;7:3312-24.
15. Cartmell SH, Porter BD, Garcia AJ, Guldberg RE. Effect of medium perfusion rate on cell-seeded three-dimensional bone construct in vitro. Tissue Eng. 2003;9:1197-203.
16. Kellner K, Liebsch G, Klimant I, Wolfbeis OS, Blunk T, Schulz MB, Gopferich A. Determination of oxygen gradients in engineered tissue using a fluorescent sensor. Biotechnol Bioeng. 2002;80:73-83.
17. Abdullah NS, Das DB. Modelling nutrient transport in hollow fibre membrane bioreactor for growing bone tissue with consideration of multi-component interactions. Chem Eng Sci. 2007;62:5821-39.
18. Pierre J, Oddou C. Engineered bone culture in a perfusion bioreactor: a 2D computational study of stationary mass and momentum transport. Comput Methods Biomech Biomed Eng. 2007;10:429-38.
19. Chesnick IE, Avallone FA, Leapman RD, Landis WJ, Eidelman N, Potter K. Evaluation of bioreactor-cultivated bone by magnetic resonance microscopy and FTIR microspectroscopy. Bone. 2007;40:904-12.
20. Ye H, Xia Z, Ferguson DJ, Triffitt JT, Cui Z. Studies on the use of hollow fibre membrane bioreactors for tissue generation by using rat bone marrow fibroblastic cells and a composite scaffold. J Mater Sci Mater Med. 2007;18:641-8.
21. Das DB. Multiscale simulation of nutrient transport in hollow fibre membrane bioreactor for growing bone tissue: sub-cellular scale and beyond. Chem Eng Sci. 2007;62:3627-39.
22. Sikavitsas VI, Bancroft GN, Mikos AG. Formation of threedimensional cell/polymer constructs for bone tissue engineering in a spinner flask and a rotating wall vessel bioreactor. J Biomed Mater Res. 2002;62:136-48.
23. Zhang N, Heather LN, Shila T, Wen X. Fabrication of nanocrystalline hydroxyapatite doped degradable composite hollow fiber for guided and biomimetic bone tissue engineering. Mater Sci Eng. 2007;27:599-606.
24. Ye H, Das DB, Triffitt JT, Cui Z. Modelling nutrient transport in hollow fibre membrane bioreactors for growing three-dimensional bone tissue. J Membr Sci. 2006;272:169-78.
25. Krogh A. The rate of diffusion of gases through animal tissues, with some remarks on the coefficient of invasion. J Physiol. 1919;52:391-408.
26. Labecki M, Piret JM, Bowen BD. Effect of free convection on three-dimensional protein transport in hollow-fiber bioreactors. AIChE J. 2004;50:1974-90.
27. Ding W, He L, Zhao G, Zhang H, Shu Z, Gao D. Double porous media model for mass transfer of hemodialyzers. Int J Heat Mass Transf. 2004;47:4849-55.
28. Chresand TJ, Gillies RJ, Dale BE. Optimum fiber spacing in a hollow fiber bioreactor. Biotechnol Bioeng. 1988;32:983-92.
29. Sengers BG, Taylor M, Please CP, Oreffo RO. Computational modeling of cell spreading and tissue regeneration in porous scaffolds. Biomaterials. 2007;28:1926-40.
30. Galban CJ, Locke BR. Analysis of cell growth kinetics and substrate diffusion in a polymer scaffold. Biotechnol Bioeng. 1999;65:121-32.
31. Mehta K, Linderman JJ. Model-based analysis and design of a microchannel reactor for tissue engineering. Biotechnol Bioeng. 2006;94:596-609.
32. Brotherton JD, Chau PC. Modeling of axial-flow hollow fiber cell culture bioreactors. Biotechnol Prog. 1996;12:575-90.
33. McClelland RE, MacDonald JM, Coger RN. Modeling O2 transport within engineered hepatic devices. Biotechnol Bioeng. 2003;82:12-27.
34. Zhang Q, Cussler EL. Microporous hollow fibre for gas absorption. Part II. Mass transfer across the membrane. J Membr Sci. 1985;23:332-45.
35. Boyd RF, Lopez M, Stephens CL, Velez GM, Ramirez CA, Zydney AL. Solute washout experiments for characterizing mass transport in hollow fiber immunoisolation membranes. Ann Biomed Eng. 1998;26:618-26.
36. Mota M, Yelshin A, Fidaleo M, Flickinger MC. Modelling diffusivity in porous polymeric membranes with an intermediate layer containing microbial cells. Biochem Eng J. 2007;37:285-93.
37. Chresand TJ, Dale BE, Hanson SL, Gillies RJ. A stirred bath technique for diffusivity measurement in cell matrices. Biotechnol Bioeng. 1988;32:1029-36.
38. Maxwell JC. A treatise on electricity and magnetism. New York: Clarendon Press; 1973.
39. Brown DA, MacLellan WR, Laks H, Dunn JC, Wu BM, Beygui RE. Analysis of oxygen transport in a diffusion-limited model of engineered heart tissue. Biotechnol Bioeng. 2007;97:962-75.
40. Westrin BA, Axelsson A. Diffusion in gels containing immobilized cells: a critical review. Biotechnol Bioeng. 1991;38:439-46.
41. Curcio S, Calabro V, Iorio G. A theoretical and experimental analysis of a membrane bioreactor performance in recycle configuration. J Membr Sci. 2006;273:129-42.
42. Chow DC, Wenning LA, Miller WM, Papoutsakis ET. Modeling pO(2) distributions in the bone marrow hematopoietic compartment. I. Krogh's model. Biophys J. 2001;81:675-84.
43. Pathi P, Ma T, Locke BR. Role of nutrient supply on cell growth in bioreactor design for tissue engineering of hematopoietic cells. Biotechnol Bioeng. 2005;89:743-58.
44. Janssen FW, Oostra J, Oorschot A, van Blitterswijk CA. A perfusion bioreactor system capable of producing clinically relevant volumes of tissue-engineered bone: in vivo bone formation showing proof of concept. Biomaterials. 2006;27:315-23.
45. Tjia JS, Moghe PV. Regulation of cell motility on polymer substrates via ''dynamic,'' cell internalizable, ligand microinterfaces. Tissue Eng. 2002;8:247-61.
46. Cho CH, Park J, Nagrath D, Tilles AW, Berthiaume F, Toner M, Yarmush ML. Oxygen uptake rates and liver-specific functions of hepatocyte and 3T3 fibroblast co-cultures. Biotechnol Bioeng. 2007;97:188-99.
47. Windhaber RA, Wilkins RJ, Meredith D. Functional characterisation of glucose transport in bovine articular chondrocytes. Pflugers Arch Eur J Phys. 2003;446:572-7.
48. Obradovic B, Carrier RL, Vunjak-Novakovic G, Freed LE. Gas exchange is essential for bioreactor cultivation of tissue engineered cartilage. Biotechnol Bioeng. 1999;63:197-205.
49. Kleinstreuer C, Agarwal SS. Analysis and simulation of hollowfiber bioreactor dynamics. Biotechnol Bioeng. 1986;28:1233-40.
50. Ramanujan S, Pluen A, McKee TD, Brown EB, Boucher Y, Jain RK. Diffusion and convection in collagen gels: implications for transport in the tumor interstitium. Biophys J. 2002;83:1650-60.
51. Korin N, Bransky A, Dinnar U, Levenberg S. A parametric study of human fibroblasts culture in a microchannel bioreactor. Lab Chip. 2007;7:611-7.
52. Sun S, Cho M. Human fibroblast migration in three-dimensional collagen gel in response to noninvasive electrical stimulus. II. Identification of electrocoupling molecular mechanisms. Tissue Eng. 2004;10:1558-65.
53. Burrows RC, Freeman D, Charlop AW, Wiseman W, Adamsen TCH, Krohn A, Spence AM. [18F]-2-fluoro-2-deoxyglucose transport kinetics as a function of extracellular glucose concentration in malignant glioma, fibroblast and macrophage cells in vitro. Nucl Med Biol. 2004;31:1-9.