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Volumn 16, Issue 6, 2014, Pages 1728-1731

Practical synthesis of phthalimides and benzamides by a multicomponent reaction involving arynes, isocyanides, and CO2/H2O

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; BENZAMIDE DERIVATIVE; CARBON DIOXIDE; CYANIDE; PHTHALIMIDE DERIVATIVE; WATER;

EID: 84896978911     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/ol500403x     Document Type: Article
Times cited : (78)

References (62)
  • 23
  • 33
    • 84891006730 scopus 로고    scopus 로고
    • Arylation reactions involving the formation of arynes
    • Ackermann, L. Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany
    • Chen, Y.; Larock, R. C. Arylation reactions involving the formation of arynes. In Modern Arylation Methods; Ackermann, L., Ed.; Wiley-VCH Verlag GmbH & Co. KGaA: Weinheim, Germany, 2009; p 401.
    • (2009) Modern Arylation Methods , pp. 401
    • Chen, Y.1    Larock, R.C.2
  • 40
    • 0034697834 scopus 로고    scopus 로고
    • For the initial report on isocyanide triggered MCR using activated alkynes and aldehydes, see
    • For the initial report on isocyanide triggered MCR using activated alkynes and aldehydes, see: Nair, V.; Vinod, A. U. Chem. Commun. 2000, 1019
    • (2000) Chem. Commun. , pp. 1019
    • Nair, V.1    Vinod, A.U.2
  • 62
    • 84887078300 scopus 로고    scopus 로고
    • It may be mentioned that the reaction of aryne with isocyanide 2g and water did not afford the expected aryl amide derivative, but instead the reaction furnished the N -phenyl morpholine 10 in 56% yield. It is likely that the reaction took place by the insertion of a tertiary amine moiety into the aryne. For a related transition-metal-free N -arylation of aromatic tertiary amines using arynes, see
    • It may be mentioned that the reaction of aryne with isocyanide 2g and water did not afford the expected aryl amide derivative, but instead the reaction furnished the N -phenyl morpholine 10 in 56% yield. It is likely that the reaction took place by the insertion of a tertiary amine moiety into the aryne. For a related transition-metal-free N -arylation of aromatic tertiary amines using arynes, see: Bhojgude, S. S.; Kaicharla, T.; Biju, A. T. Org. Lett. 2013, 15, 5452
    • (2013) Org. Lett. , vol.15 , pp. 5452
    • Bhojgude, S.S.1    Kaicharla, T.2    Biju, A.T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.