-
1
-
-
79955487526
-
-
For early examples of multicomponent aryne reactions, see
-
For early examples of multicomponent aryne reactions, see
-
-
-
-
2
-
-
0344874499
-
-
G. Wittig, G. Pieper, G. Fuhrmann, Ber. Dtsch. Chem. Ges. 1940, 73, 1193-1197
-
(1940)
Ber. Dtsch. Chem. Ges.
, vol.73
, pp. 1193-1197
-
-
Wittig, G.1
Pieper, G.2
Fuhrmann, G.3
-
7
-
-
79955494814
-
-
For select examples of multicomponent aryne methodologies to generate 1,2-disubstituted arene scaffolds, see
-
For select examples of multicomponent aryne methodologies to generate 1,2-disubstituted arene scaffolds, see
-
-
-
-
9
-
-
8744281396
-
-
H. Yoshida, M. Watanabe, H. Fukushima, J. Ohshita, A. Kunai, Org. Lett. 2004, 6, 4049-4051
-
(2004)
Org. Lett.
, vol.6
, pp. 4049-4051
-
-
Yoshida, H.1
Watanabe, M.2
Fukushima, H.3
Ohshita, J.4
Kunai, A.5
-
10
-
-
33750435912
-
-
I. Larrosa, M. I. Da Silva, P. M. Gõmez, P. Hannen, E. Ko, S. R. Lenger, S. R. Linke, A. J. P. White, D. Wilton, A. G. M. Barrett, J. Am. Chem. Soc. 2006, 128, 14042-14043
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 14042-14043
-
-
Larrosa, I.1
Da Silva, M.I.2
Gõmez, P.M.3
Hannen, P.4
Ko, E.5
Lenger, S.R.6
Linke, S.R.7
White, A.J.P.8
Wilton, D.9
Barrett, A.G.M.10
-
11
-
-
33748053357
-
-
H. Yoshida, H. Fukushima, J. Ohshita, A. Kunai, J. Am. Chem. Soc. 2006, 128, 11040-11041
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 11040-11041
-
-
Yoshida, H.1
Fukushima, H.2
Ohshita, J.3
Kunai, A.4
-
14
-
-
34548187748
-
-
H. Yoshida, T. Morishita, H. Fukushima, J. Ohshita, A. Kunai, Org. Lett. 2007, 9, 3367-3370
-
(2007)
Org. Lett.
, vol.9
, pp. 3367-3370
-
-
Yoshida, H.1
Morishita, T.2
Fukushima, H.3
Ohshita, J.4
Kunai, A.5
-
15
-
-
48249147369
-
-
T. Morishita, H. Fukushima, H. Yoshida, J. Ohshita, A. Kunai, J. Org. Chem. 2008, 73, 5452-5457
-
(2008)
J. Org. Chem.
, vol.73
, pp. 5452-5457
-
-
Morishita, T.1
Fukushima, H.2
Yoshida, H.3
Ohshita, J.4
Kunai, A.5
-
16
-
-
55949128562
-
-
D. Soorukram, T. Qu, A. G. M. Barrett, Org. Lett. 2008, 10, 3833-3835
-
(2008)
Org. Lett.
, vol.10
, pp. 3833-3835
-
-
Soorukram, D.1
Qu, T.2
Barrett, A.G.M.3
-
18
-
-
61349134773
-
-
H. Yoshida, T. Morishita, J. Ohshita, Org. Lett. 2008, 10, 3845-3847
-
(2008)
Org. Lett.
, vol.10
, pp. 3845-3847
-
-
Yoshida, H.1
Morishita, T.2
Ohshita, J.3
-
21
-
-
70349783775
-
-
Angew. Chem. Int. Ed. 2009, 48, 3458-3461.
-
(2009)
Angew. Chem. Int. Ed.
, vol.48
, pp. 3458-3461
-
-
-
25
-
-
0038801722
-
-
T. Saegusa, N. Taka-ishi, H. Fujii, Tetrahedron 1968, 24, 3795-3798
-
(1968)
Tetrahedron
, vol.24
, pp. 3795-3798
-
-
Saegusa, T.1
Taka-Ishi, N.2
Fujii, H.3
-
26
-
-
0040344639
-
-
in (Ed.: Z. Rappoport), Wiley, New York, pp. .
-
P. Hoffmann, D. Marquarding, H. Kliimann, I. Ugi, in The Chemistry of the Cyano Group (Ed.:, Z. Rappoport,), Wiley, New York, 1970, pp. 853-883.
-
(1970)
The Chemistry of the Cyano Group
, pp. 853-883
-
-
Hoffmann, P.1
Marquarding, D.2
Kliimann, H.3
Ugi, I.4
-
31
-
-
0002490493
-
-
in (Ed.: A. Padwa), Wiley, New York, pp.
-
R. Huisgen, in 1,3-Dipolar Cycloaddition Chemistry, Vol. 1 (Ed.:, A. Padwa,), Wiley, New York, 1984, pp. 1-176
-
(1984)
1,3-Dipolar Cycloaddition Chemistry, Vol. 1
, pp. 1-176
-
-
Huisgen, R.1
-
33
-
-
0001134069
-
-
in (Ed.: A. Padwa), Wiley, New York, pp. .
-
H.-J. Hansen, H. Heimgartner, in 1,3-Dipolar Cycloaddition Chemistry, Vol. 1 (Ed.:, A. Padwa,), Wiley, New York, 1984, pp. 177-290.
-
(1984)
1,3-Dipolar Cycloaddition Chemistry, Vol. 1
, pp. 177-290
-
-
Hansen, H.-J.1
Heimgartner, H.2
-
34
-
-
33746797933
-
-
H. Yoshida, H. Fukushima, J. Ohshita, A. Kunai, Angew. Chem. 2004, 116, 4025-4028
-
(2004)
Angew. Chem.
, vol.116
, pp. 4025-4028
-
-
Yoshida, H.1
Fukushima, H.2
Ohshita, J.3
Kunai, A.4
-
35
-
-
4544320921
-
-
Angew. Chem. Int. Ed. 2004, 43, 3935-3938.
-
(2004)
Angew. Chem. Int. Ed.
, vol.43
, pp. 3935-3938
-
-
-
36
-
-
7044231369
-
-
H. Yoshida, H. Fukushima, J. Ohshita, A. Kunai, Tetrahedron Lett. 2004, 45, 8659-8662.
-
(2004)
Tetrahedron Lett.
, vol.45
, pp. 8659-8662
-
-
Yoshida, H.1
Fukushima, H.2
Ohshita, J.3
Kunai, A.4
-
37
-
-
34247272920
-
-
H. Yoshida, H. Fukushima, T. Morishita, J. Ohshita, A. Kunai, Tetrahedron 2007, 63, 4793-4805.
-
(2007)
Tetrahedron
, vol.63
, pp. 4793-4805
-
-
Yoshida, H.1
Fukushima, H.2
Morishita, T.3
Ohshita, J.4
Kunai, A.5
-
38
-
-
79955496750
-
-
The phenoxy iminoisobenzofuran framework was unambiguously confirmed by obtaining the X-ray crystal structure of phenoxy iminoisobenzofuran 14 r (Table 1). See Supporting Information for details.
-
The phenoxy iminoisobenzofuran framework was unambiguously confirmed by obtaining the X-ray crystal structure of phenoxy iminoisobenzofuran 14 r (Table 1). See Supporting Information for details.
-
-
-
-
39
-
-
79955503565
-
-
The closest related structures include an iminium perchlorate reported by Boyd and a series of cyclic imidates reported by Sato et al. However, these structures are shown to be unstable in the presence of water. See
-
The closest related structures include an iminium perchlorate reported by Boyd and a series of cyclic imidates reported by Sato et al. However, these structures are shown to be unstable in the presence of water. See
-
-
-
-
42
-
-
0242324932
-
-
R. Sato, M. Ohmori, F. Kaitani, A. Kurosawa, T. Senzaki, T. Goto, M. Saito, Bull. Chem. Soc. Jpn. 1988, 61, 2481-2485.
-
(1988)
Bull. Chem. Soc. Jpn.
, vol.61
, pp. 2481-2485
-
-
Sato, R.1
Ohmori, M.2
Kaitani, F.3
Kurosawa, A.4
Senzaki, T.5
Goto, T.6
Saito, M.7
-
43
-
-
34548528526
-
-
C. B. Gilley, M. J. Buller, Y. Kobayashi, Org. Lett. 2007, 9, 3631-3634.
-
(2007)
Org. Lett.
, vol.9
, pp. 3631-3634
-
-
Gilley, C.B.1
Buller, M.J.2
Kobayashi, Y.3
-
44
-
-
79955487359
-
-
For results highlighting regioselective additions to unsymmetrical arynes, see
-
For results highlighting regioselective additions to unsymmetrical arynes, see
-
-
-
-
45
-
-
0342294532
-
-
R. Huisgen, W. Mack, M. L. Möbius, Tetrahedron 1960, 9, 29-39
-
(1960)
Tetrahedron
, vol.9
, pp. 29-39
-
-
Huisgen, R.1
MacK, W.2
Möbius, M.L.3
-
47
-
-
0343778914
-
-
J. F. Bunnett, D. A. R. Happer, M. Patsch, C. Pyun, H. Takayama, J. Am. Chem. Soc. 1966, 88, 5250-5254
-
(1966)
J. Am. Chem. Soc.
, vol.88
, pp. 5250-5254
-
-
Bunnett, J.F.1
Happer, D.A.R.2
Patsch, M.3
Pyun, C.4
Takayama, H.5
-
48
-
-
0013323018
-
-
E. R. Biehl, E. Nieh, K. C. Hsu, J. Org. Chem. 1969, 34, 3595-3599
-
(1969)
J. Org. Chem.
, vol.34
, pp. 3595-3599
-
-
Biehl, E.R.1
Nieh, E.2
Hsu, K.C.3
-
51
-
-
0005662608
-
-
Y. X. Han, M. V. Jovanovic, E. R. Biehl, J. Org. Chem. 1985, 50, 1334-1337
-
(1985)
J. Org. Chem.
, vol.50
, pp. 1334-1337
-
-
Han, Y.X.1
Jovanovic, M.V.2
Biehl, E.R.3
-
52
-
-
0000043357
-
-
E. R. Biehl, A. Razzuk, M. V. Jovanovic, S. P. Khanapure, J. Org. Chem. 1986, 51, 5157-5160
-
(1986)
J. Org. Chem.
, vol.51
, pp. 5157-5160
-
-
Biehl, E.R.1
Razzuk, A.2
Jovanovic, M.V.3
Khanapure, S.P.4
-
53
-
-
0026481036
-
-
M. Tielemans, V. Areschka, J. Colomer, R. Promel, W. Langenaeker, P. Geerlings, Tetrahedron 1992, 48, 10575-10586
-
(1992)
Tetrahedron
, vol.48
, pp. 10575-10586
-
-
Tielemans, M.1
Areschka, V.2
Colomer, J.3
Promel, R.4
Langenaeker, W.5
Geerlings, P.6
-
54
-
-
77949851037
-
-
P. M. Tadross, C. D. Gilmore, P. Bugga, S. C. Virgil, B. M. Stoltz, Org. Lett. 2010, 12, 1224-1227.
-
(2010)
Org. Lett.
, vol.12
, pp. 1224-1227
-
-
Tadross, P.M.1
Gilmore, C.D.2
Bugga, P.3
Virgil, S.C.4
Stoltz, B.M.5
-
55
-
-
79955517749
-
-
For computational studies of aryne electronic properties, see
-
For computational studies of aryne electronic properties, see
-
-
-
-
57
-
-
0000028441
-
-
W. Langenaeker, F. De Proft, P. Geerlings, J. Phys. Chem. A 1998, 102, 5944-5950
-
(1998)
J. Phys. Chem. A
, vol.102
, pp. 5944-5950
-
-
Langenaeker, W.1
De Proft, F.2
Geerlings, P.3
-
60
-
-
77950339557
-
-
P. H.-Y. Cheong, R. S. Paton, S. M. Bronner, G.-Y. J. Im, N. K. Garg, K. N. Houk, J. Am. Chem. Soc. 2010, 132, 1267-1269.
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 1267-1269
-
-
Cheong, P.H.-Y.1
Paton, R.S.2
Bronner, S.M.3
Im, G.-Y.J.4
Garg, N.K.5
Houk, K.N.6
-
61
-
-
77950335636
-
-
M. Yamazaki, H. Fujimoto, Y. Ohta, Y. Iitaka, A. Itai, Heterocycles 1981, 15, 889-893
-
(1981)
Heterocycles
, vol.15
, pp. 889-893
-
-
Yamazaki, M.1
Fujimoto, H.2
Ohta, Y.3
Iitaka, Y.4
Itai, A.5
-
63
-
-
79955488437
-
-
Attempts were made to carry out similar transformations using methyl acrylate, methyl methacrylate, 2-cyclopentenone, and 2-cyclohexenone in place of methyl propiolate (19 a). However, each failed to generate the corresponding iminoindanone under the reaction conditions.
-
Attempts were made to carry out similar transformations using methyl acrylate, methyl methacrylate, 2-cyclopentenone, and 2-cyclohexenone in place of methyl propiolate (19 a). However, each failed to generate the corresponding iminoindanone under the reaction conditions.
-
-
-
-
64
-
-
79955494654
-
-
Efforts to employ additional alkynes lacking conjugate acceptors (e.g., cyclohexylacetylene, ethoxyacetylene, and diphenylacetylene) failed to generate the corresponding three-component adducts.
-
Efforts to employ additional alkynes lacking conjugate acceptors (e.g., cyclohexylacetylene, ethoxyacetylene, and diphenylacetylene) failed to generate the corresponding three-component adducts.
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