GRK5 intronic (CA)n polymorphisms associated with type 2 diabetes in Chinese Hainan Island

PLoS ONE

Volumn 9, Issue 3, 2014, Pages

  Xia, Zhenfang ^a   Yang, Tubao ^a   Wang, Zhuansuo ^b   Dong, Jianping ^b   Liang, Chunyan ^c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c Outpatients Department Community Health Service Center of Xiuying   (China)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR KINASE 5; GENOMIC DNA; GLUCOSE; MESSENGER RNA;

ADULT; AGED; ARTICLE; BODY MASS; CHINA; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE LOCATION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC SUSCEPTIBILITY; GLUCOSE BLOOD LEVEL; GRK5 GENE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INTRON; MAJOR CLINICAL STUDY; MALE; MOLECULAR DYNAMICS; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEOTIDE SEQUENCE; PATIENT CODING; POLYMERASE CHAIN REACTION; RISK FACTOR; RNA SPLICING; SHORT TANDEM REPEAT; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

ASIAN CONTINENTAL ANCESTRY GROUP; BASE SEQUENCE; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; G-PROTEIN-COUPLED RECEPTOR KINASE 5; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INTRONS; MOLECULAR SEQUENCE DATA; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; SEQUENCE ANALYSIS, DNA;

EID: 84896970319     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0090597     Document Type: Article

References (27)

1. Ginter E, Simko V (2012) Type 2 diabetes mellitus, pandemic in 21st century. Adv Exp Med Biol 771: 42-50.
2. Lin Y, Sun Z (2010) Current views on type 2 diabetes. JEndocrinol 204:1-11.
3. Li H, Gan W, Lu L, Dong X, Han X, et al. (2013) A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes 62: 291-298.
4. Tariq K, Malik SB, Ali SH, Maqsood SE, Azam A, et al. (2013) Association of Pro12Ala polymorphism in peroxisome proliferator activated receptor gamma with proliferative diabetic retinopathy. Mol Vis 19:710-717.
5. Yilmaz AH, Kurnaz O, Kucukhuseyin O, Akadam TB, Kurt O, et al.(2013) Different effects of PPARA, PPARG and ApoE SNPs on serum lipids in patients with coronary heart disease based on the presence of diabetes. Gene: 523, 20-26.
6. Yin YW, Hu AM, Sun QQ, Zhang BB, Liu HL, et al. (2013) Association between interleukin 10 gene -1082 A/G polymorphism and the risk of type 2 diabetes mellitus: A meta-analysis of 4250 subjects. Cytokine 62:226-231.
7. Dou H, Ma E, Yin L, Jin Y, Wang H (2013) The association between gene polymorphism of TCF7L2 and type 2 diabetes in Chinese Han population: a meta-analysis. PLoS One 8: e59495.
8. Chen HY, Huang W, Leung VH, Fung SL, Ma SL (2013) Functional Interaction Between SNPs and Microsatellite in the Transcriptional Regulation of Insulin-Like Growth Factor 1. Hum Mutat (doi: 10.1002/humu.22363).
9. World Health Organization (2006) Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO consultation, Geneva.
10. Hui J, Stangl K, Lane WS, Bindereif A (2003) HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol 10:33-37. (Pubitemid 36034174)
11. Hamilton BJ, Wang XW, Collins J, Bloch D, Bergeron A (2008) Separate cistrans pathways post-transcriptionally regulate murine CD154 (CD40 ligand) expression: a novel function for CA repeats in the 3′-untranslated region. J Biol Chem 283:25606-25616.
12. Zhang W, He L, Liu W, Sun C, Ratain MJ (2009) Exploring the relationship between polymorphic (TG/CA)n repeats in intron 1 regions and gene expression. Hum Genomics 3:236-245.
13. Wang Y, Ma M, Xiao X, Wang Z (2012) Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules. Nat Struct Mol Biol 19:1044-1052.
14. Agrafioti I, Stumpf MP (2007) SNPSTR: a database of compound microsatellite-SNP markers. Nucleic Acids Res 35:D71-75. (Pubitemid 46056173)
15. Wang L, Shen M, Wang F, Ma L (2012) GRK5 ablation contributes to insulin resistance. Biochem Biophys Res Commun 429:99-104.
16. Millar DS, Horan M, Chuzhanova NA, Cooper DN (2010) Characterisation of a functional intronic polymorphism in the human growth hormone (GH1) gene. Hum Genomics 4:289-301.
17. Tautz D, Schlötterer C (1994) Simple sequence. Curr Opin Genet Dev 4:832-837.
18. Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E,et al. (2012) Systematic localization of common disease-associated variation in regulatory DNA. Science 337:1190-1195.
19. Varela MA, Amos W (2010) Heterogeneous distribution of SNPs in the human genome: microsatellites as predictors of nucleotide diversity and divergence. Genomics 95:151-159.
20. Zhang W, Zeng F, Liu Y, Zhao Y, Lv H, et al. (2013) Crystal Structures and RNA-binding Properties of the RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein L: INSIGHTS INTO ITS ROLES IN ALTERNATIVE SPLICING REGULATION. J Biol Chem 288:22636-22649.
21. Wang WC, Mihlbachler KA, Bleecker ER, Weiss ST, Liggett SB (2008) A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors. Pharmacogenet Genomics 18:729-732.
22. So CH, Michal AM, Mashayekhi R, Benovic JL(2012) G protein-coupled receptor kinase 5 phosphorylates nucleophosmin and regulates cell sensitivity to polo-like kinase 1 inhibition. J Biol Chem 287:17088-17099.
23. Venkatakrishnan AJ, Deupi X, Lebon G, Tate CG, Schertler GF, et al. (2013) Molecular signatures of G-protein-coupled receptors. Nature 494:185-194.
24. Kunapuli P, Benovic JL (1993) Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family. Proc Natl Acad Sci USA 90:5588-5592. (Pubitemid 23176206)
25. Freedman NJ, Ament AS, Oppermann M, Stoffel RH, Exum ST(1997) Phosphorylation and desensitization of human endothelin A and B receptors, Evidence for G protein-coupled receptor kinase specificity. Biol Chem:272, 17734-17743. (Pubitemid 27311212)
26. Couvineau A, Laburthe M (2012) The family B1 GPCR: structural aspects and interaction with accessory proteins. Curr Drug Targets 13:103-115.
27. Hollenstein K, Kean J, Bortolato A, Cheng RK, Doré AS, et al.(2013) Structure of class B GPCR corticotropin-releasing factor receptor 1. Nature 499:438-443.