The immature heart and anesthesia

Anesthesiology

Volumn 87, Issue 6, 1997, Pages 1529-1548

  Baum, Victor C ^a   Palmisano, Barbara W ^b  

^a UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHESIA COMPLICATION; ANIMAL TISSUE; ECHOCARDIOGRAPHY; FETUS HEART; HEART DEVELOPMENT; HEART FUNCTION; HEART HEMODYNAMICS; NEWBORN PERIOD; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANESTHETICS; ANIMALS; FETAL HEART; HEART; HUMANS; INFANT, NEWBORN; MYOCARDIUM;

EID: 0031440498     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199712000-00032     Document Type: Review

References (237)

1. Nakanishi T, Jarmakani JM: Developmental changes in myocardial mechanical function and subcellular organelles. Am J Physiol 1984; 246:H615-25
2. Maylie JG: Excitation-contraction coupling in neonatal and adult myocardium of cat. Am J Physiol 1982; 242:H834-43
3. Park IS, Michael LH, Driscoll DJ: Comparative response of the developing canine myocardium to inotropic agents. Am J Physiol 1982; 242:H13-8
4. Park MK, Sheridan PH, Morgan WW, Beck N: Comparative inotropic response of newborn and adult rabbit papillary muscles to isoproterenol and calcium. Dev Pharmacol Ther 1980; 1:70-82
5. Artman M: Developmental changes in myocardial contractile responses to inotropic agents. Cardiovasc Res 1992; 26:3-13
6. Artman M, Kithas PA, Wike JS, Strada SJ: Inotropic responses change during postnatal maturation in rabbit. Am J Physiol 1988; 255:H335-42
7. Friedman WF: The intrinsic physiologic properties of the developing heart. Prog Cardiovasc Dis 1972; 15:87-111
8. Jarmakani JM, Nakanishi T, George BL, Bers D: Effect of extracellular calcium on myocardial mechanical function in the neonatal rabbit. Dev Pharmacol Ther 1982; 5:1-13
9. Nishioka K, Nakanishi T, George BL, Jarmakani JM: The effect of calcium on the inotropy of catecholamine and paired electrical stimulation in the newborn and adult myocardium. J Mol Cell Cardiol 1981; 13:511-20
10. Chin TK, Friedman WF, Klitzner TS: Developmental changes in cardiac myocyte calcium regulation. Circ Res 1990; 67:574-9
11. Klitzner T, Friedman WF: Excitation-contraction coupling in developing mammalian myocardium: Evidence from voltage clamp studies. Pediatr Res 1988; 23:428-32
12. Nicodemus HF, Nassiri-Rahimi C, Bachman L, Smith TC: Median effective dose (ED50) of halothane in adults and children. ANESTHESIOLOGY 1969; 31:344-8
13. Cook DR, Brandom BW, Shiu G, Wolfson B: The inspired median effective dose, brain concentration at anesthesia, and cardiovascular index for halothane in young rats. Anesth Analg 1981; 60:182-5
14. Friesen RH, Lichtor JL: Cardiovascular depression during halothane anesthesia in infants: A study of three induction techniques. Anesth Analg 1982; 61:42-5
15. Nassar R, Malouf NN, Kelly MB, Oakeley AE, Anderson PA: Force-pCa relation and troponin T isoforms of rabbit myocardium. Circ Res 1991; 69:1470-5
16. Hoerter J, Mazet F, Vassort G: Perinatal growth of the rabbit cardiac cell: Possible implications for the mechanism of relaxation. J Mol Cell Cardiol 1981; 13:725-40
17. Olivetti G, Anversa P, Loud AV: Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. II. Tissue composition, capillary growth, and sarcoplasmic alterations. Circ Res 1980; 46:503-12
18. Legato MJ: Cellular mechanisms of normal growth in the mammalian heart. II. A quantitative and qualitative comparison between the right and left ventricular myocytes in the dog from birth to five months of age. Circ Res 1979; 44:263-79
19. Gilbert RD: Effects of afterload and baroreceptors on cardiac function in fetal sheep. J Dev Physiol 1982; 4:299-309
20. Smolich JJ, Walker AM, Campbell GR, Adamson TM: Left and right ventricular myocardial morphometry in fetal, neonatal, and adult sheep. Am J Physiol 1989; 257:H1-9
21. Hirakow R, Gotoh T: Quantitative studies on the ultrastructural differentiation and growth of mammalian cardiac muscle cells. II. The atria and ventricles of the guinea pig. Acta Anat 1980; 108:230-7
22. Lynch C III: Cellular electrophysiology of the heart, Clinical Cardiac Electrophysiology. Edited by Lynch CI. Philadelphia, JB Lippincott, 1994, pp 1-52
23. Lynch C III: The biochemical and cellular basis of myocardial contractility, Ventricular Function. Edited by Warltier DC. Baltimore, Williams & Wilkins, 1995, pp 1-67
24. Anderson PA, Glick KL, Manring A, Crenshaw C Jr. Developmental changes in cardiac contractility in fetal and postnatal sheep: In vitro and in vivo. Am J Physiol 1984; 247:H371-9
25. Davies P, Dewar J, Tynan M, Ward R: Post-natal developmental changes in the length-tension relationship of cat papillary muscles. J Physiol 1975; 253:95-102
26. St John Sutton MG, Raichlen JS, Reichek N, Huff DS: Quantitative assessment of right and left ventricular growth in the human fetal heart: A pathoanatomic study. Circulation 1984; 70:935-41
27. St John Sutton MG, Gewitz MH, Shah B, Cohen A, Reichek N, Gabbe S, Huff DS: Quantitative assessment of growth and function of the cardiac chambers in the normal human fetus: A prospective longitudinal echocardiographic study. Circulation 1984; 69:645-54
28. Thornburg KL, Morton MJ: Filling and arterial pressures as determinants of RV stroke volume in the sheep fetus. Am J Physiol 1983; 244:H656-63
29. Thornburg KL, Morton MJ: Filling and arterial pressures as determinants of left ventricular stroke volume in fetal lambs. Am J Physiol 1986; 251:H961-8
30. Gilbert RD: Control of fetal cardiac output during changes in blood volume. Am J Physiol 1980; 238:H80-6
31. Anderson PA, Glick KL, Killam AP, Mainwaring RD: The effect of heart rate on in utero left ventricular output in the fetal sheep. J Physiol 1986; 372:557-73
32. Anderson PA, Killam AP, Mainwaring RD, Oakeley AE: In utero right ventricular output in the fetal lamb: the effect of heart rate. J Physiol 1987; 387:297-316
33. Anderson PA, Manring A, Glick KL, Crenshaw CC Jr. Biophysics of the developing heart. III. A comparison of the left ventricular dynamics of the fetal and neonatal lamb heart. Am J Obstet Gynecol 1982; 143:195-203
34. Teitel DF, Sidi D, Chin T, Brett C, Heymann MA, Rudolph AM: Developmental changes in myocardial contractile reserve in the lamb. Pediatr Res 1985; 19:948-55
35. Reller MD, Morton MJ, Reid DL, Thornburg KL: Fetal lamb ventricles respond differently to filling and arterial pressures and to in utero ventilation. Pediatr Res 1987; 22:621-6
36. Romero T, Covell J, Friedman WF: A comparison of pressure-volume relations of the fetal, newborn, and adult heart. Am J Physiol 1972; 222:1285-90
37. Teitel DF, Klautz, R, Steendijk P, van der Velde ET, van Bel F, Baan J: The end-systolic pressure-volume relationship in the newborn lamb: Effects of loading and inotropic interventions. Pediatr Res 1991; 29:473-82
38. Klopfenstein HS, Rudolph AM: Postnatal changes in the circulation and responses to volume loading in sheep. Circ Res 1978; 42:839-45
39. Shaddy RE, Tyndall MR, Teitel DF, Li C, Rudolph AM: Regulation of cardiac output with controlled heart rate in newborn lambs. Pediatr Res 1988; 24:577-82
40. Rudolph AM: Congenital Diseases of the Heart. Chicago, Year Book, 1974, pp 12-3
41. Rudolph AM, Heymann MA: Fetal and neonatal circulation and respiration. Ann Rev Physiol 1974; 36:187-207
42. Baum VC, Klitzner TS: Excitation-contraction coupling in neonatal myocardium - Effects of halothane and isoflurane. Dev Pharmacol Ther 1991; 16:99-107
43. Kirkpatrick SE, Pitlick PT, Naliboff J, Friedman WF: Frank-Starling relationship as an important determinant of fetal cardiac output. Am J Physiol 1976; 231:495-500
44. Kenny J, Plappert T, Doubilet P, Salzman D, Sutton MG: Effects of heart rate on ventricular size, stroke volume, and output in the normal human fetus: A prospective Doppler echocardiographic study. Circulation 1987; 76:52-8
45. Van Hare GF, Hawkins JA, Schmidt KG, Rudolph AM: The effects of increasing mean arterial pressure on left ventricular output in newborn lambs. Circ Res 1990; 67:78-83
46. van Splunder P, Stijnen T, Wladimiroff JW: Fetal atrioventricular flow-velocity waveforms and their relation to arterial and venous flow-velocity waveforms at 8 to 20 weeks of gestation. Circulation 1996; 94:1372-8
47. Rasanen J, Wood DC, Weiner S, Ludomirski A, Huhta JC: Role of the pulmonary circulation in the distribution of human fetal cardiac output during the second half of pregnancy. Circulation 1996; 94:1068-73
48. Pagel PS, Grossman W, Haering JM, Warltier DG: Left ventricular diastolic function in the normal and diseased heart. Perspective for the anesthesiologist (first of two parts). ANESTHESIOLOGY 1993; 79:836-54
49. Pagel PS, Grossman W, Haering JM, Warltier DG: Left ventricular diastolic function in the normal and diseased heart. Perspective for the anesthesiologist (second of two parts). ANESTHESIOLOGY 1993; 79:1104-20
50. Kaufman TM, Horton JW, White DJ, Mahony L: Age-related changes in myocardial relaxation and sarcoplasmic reticulum function. Am J Physiol 1990; 259:H309-16
51. Palmisano BW, Mehner RW, Stowe DF, Bosnjak ZJ, Kampine JP: Direct myocardial effects of halothane and isoflurane: Comparison between adult and infant rabbits. ANESTHESIOLOGY 1994; 81:718-29
52. Gilbert JC, Glantz SA: Determinants of left ventricular filling and of the diastolic pressure-volume relation. Circ Res 1989; 64:827-52
53. Reed KL, Meijboom EJ, Sahn DJ, Scagnelli SA, Valdes-Cruz LM, Shenker L: Cardiac Doppler flow velocities in human fetuses. Circulation 1986; 73:41-6
54. Kenny JF, Plappert T, Doubilet P, Saltzman DH, Cartier M, Zollars L, Leatherman GF, St John Sutton MG: Changes in intracardiac blood flow velocities and right and left ventricular stroke volumes with gestational age in the normal human fetus: A prospective Doppler echocardiographic study. Circulation 1986; 74:1208-16
55. Grant DA, Walker AM: Pleural and pericardial pressures limit fetal right ventricular output. Circulation 1996; 94:555-61
56. Cannell MB: Contribution of sodium-calcium exchange to calcium regulation in cardiac muscle. Ann N Y Acad Sci 1991; 639:428-43
57. Teitel DF, Iwamoto HS, Rudolph AM: Effects of birth-related events on central blood flow patterns. Pediatr Res 1987; 22:557-66
58. Fisher DJ, Heymann MA, Rudolph AM: Myocardial consumption of oxygen and carbohydrates in newborn sheep. Pediatr Res 1981; 15:843-6
59. Fisher DJ, Heymann MA, Rudolph AM: Regional myocardial blood flow and oxygen delivery in fetal, newborn, and adult sheep. Am J Physiol 1982; 243:H729-31
60. Fisher DJ, Heymann MA, Rudolph AM: Myocardial oxygen and carbohydrate consumption in fetal lambs in utero and in adult sheep. Am J Physiol 1980; 238:H399-405
61. Toda N: Age-related changes in the transmembrane potential of isolated rabbit sino-atrial nodes and atria. Cardiovasc Res 1980; 14:58-63
62. Hewett KW, Rosen MR: Developmental changes in the rabbit sinus node action potential and its response to adrenergic agonists. J Pharmacol Exp Ther 1985; 235:308-12
63. Hewett KW, Gaymes CH, Noh CI, Ross BA, Thompson RP, Buckles DS, Gillette PC: Cellular electrophysiology of neonatal and adult rabbit atrioventricular node. Am J Physiol 1991; 260:H1674-84
64. McCormack J, Gelband H, Xu H, Villafane J, Stolfi A, Pickoff AS: Atrioventricular nodal function in the immature canine heart. Pediatr Res 1988; 23:99-103
65. Sheridan DJ, Cullen MJ, Tynan MJ: Qualitative and quantitative observations on ultrastructural changes during postnatal development in the cat myocardium. J Mol Cell Cardiol 1979; 11:1173-81
66. Anversa P, Olivetti G, Loud AV: Morphometric study of early postnatal development in the left and right ventricular myocardium of the rat. I: Hypertrophy, hyperplasia, and binucleation of myocytes. Circ Res 1980; 46:495-502
67. Fishman GI, Spray DC, Leinwand LA: Molecular characterization and functional expression of the human cardiac gap junction channel. J Cell Biol 1990; 111:589-98
68. Sachis PN, Armstrong DL, Becker LE, Bryan AC: Myelination of the human vagus nerve from 24 weeks postconceptual age to adolescence. J Neuropath Exp Neurol 1982; 41:466-72
69. Arai M, Otsu K, MacLennan DH, Periasamy M: Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development. Am J Physiol 1992; 262:C614-20
70. Nakanishi T, Okuda H, Kamata K, Abe K, Sekiguchi M, Takao A: Development of myocardial contractile system in the fetal rabbit. Pediatr Res 1987; 22:201-7
71. Gotoh T: Quantitative studies on the ultrastructural differentiation and growth of mammalian cardiac muscle cells. The atria and ventricles of the cat. Acta Anat 1983; 115:168-77
72. Barth E, Stammler G, Speiser B, Schaper J: Ultrastructural quantitation of mitochondria and myofilaments in cardiac muscle from 10 different animal species including man. J Mol Cell Cardiol 1992; 24:669-81
73. Thornell L, Price MT: Structure, composition and developmental aspects of the myocardial cystoskeleton, Development cardiology: Morphogenesis and function. Edited by Clark EB, Takao A. Mount Kisco, NY, Futura, 1990. pp 115-26
74. Wetzel GT, Chen F, Klitzner TS: L- and T-type calcium channels in acutely isolated neonatal and adult cardiac myocytes. Pediatr Res 1991; 30:89-94
75. 2+ channel kinetics in acutely isolated fetal, neonatal, and adult rabbit cardiac myocytes. Circ Res 1993; 72:1065-74
76. Osaka T, Joyner RW: Developmental changes in calcium currents of rabbit ventricular cells. Circ Res 1991; 68:788-96
77. Cohen NM, Lederer WJ: Changes in the calcium current of rat heart ventricular myocytes during development. J Physiol 1988; 406:115-46
78. Bailey BA, Gaughan JP, Houser SR: Different L-type calcium channel isoforms are present in neonatal and adult cardiac myocytes (Abstract). Circulation 1995; 92:I-372
79. Ding S, Chen F, Van Dop C, Klitzner TS, Wetzel GT: Regulation of L-type calcium channel beta subunit mRNA expression in developing heart (Abstract). Circulation 1996; 94:I-484
80. Fabiato A: Calcium-induced release of calcium from the cardiac sarcoplasmic reticulum. Am J Physiol 1983; 245:C1-14
81. Boucek RJ Jr, Shelton M, Artman M, Mushlin PS, Starnes VA, Olson RD: Comparative effects of verapamil, nifedipine, and diltiazem on contractile function in the isolated immature and adult rabbit heart. Pediatr Res 1984; 18:948-52
82. Artman M, Graham TP Jr, Boucek RJ Jr: Effects of postnatal maturation on myocardial contractile responses to calcium antagonists and changes in contraction frequency. J Cardiovasc Pharm 1985; 7:850-5
83. 2+ antagonists on mechanical function in the neonatal heart. Pediatr Res 1986; 20:838-42
84. Epstein ML, Kiel EA, Victorica BE: Cardiac decompensation following verapamil therapy in infants with supraventricular tachycardia. Pediatrics 1985; 75:737-40
85. Kirk CR, Gibbs JL, Thomas R, Radley-Smith R, Qureshi SA: Cardiovascular collapse after verapamil in supraventricular tachycardia. Arch Dis Child 1987; 62:1265-66
86. Bers DM, Hryshko LV, Harrison SM, Dawson DD: Citrate decreases contraction and Ca current in cardiac muscle independent of its buffering action. Am J Physiol 1991; 260:C900-9
87. Klitzner TS, Chen F, Raven RR, Wetzel GT, Friedman WF: Calcium current and tension generation in immature mammalian myocardium: Effects of diltiazem. J Mol Cell Cardiol 1991; 807-15
88. 2+ exchange and cell contraction in isolated neonatal and adult rabbit cardiac myocytes. Am J Physiol 1995; 268:H1723-33
89. Baum VC, Klitzner TS: Effect of calcium channel agonist (BAY K8644) on volatile anesthetic-mediated depression in neonatal rabbit papillary muscle. Dev Pharmacol Ther 1993; 20:1-8
90. + currents in fetal, neonatal, and adult rabbit ventricular myocytes. Circ Res 1992; 70:508-15
91. Wibo M, Bravo G, Godfraind T: Postnatal maturation of excitation-contraction coupling in rat ventricle in relation to the subcellular localization and surface density of 1,4-dihydropyridine and ryanodine receptors. Circ Res 1991; 68:662-73
92. 2+ channels during pre- and postnatal development of cardiac and skeletal muscles. Ann N Y Acad Sci 1989; 560:418-25
93. 2+ channels in rat ventricular muscles. Br J Pharmacol 1990; 99:334-9
94. 2+ stores in neonatal human atrial myocytes. Am J Physiol 1995; 268:H1195-201
95. Nakanishi T, Jarmakani JM: Effect of extracellular sodium on mechanical function in the newborn rabbit. Dev Pharmacol Ther 1981; 2:188-200
96. 2+ exchange activity and exchanger immunoreactivity in developing rabbit hearts. Am J Physiol 1992; 263:H1506-13
97. 2+ exchanger peak near birth in developing rabbit and rat hearts. Circ Res 1994; 74:354-9
98. 2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development. Am J Physiol 1995; 268:H1714-22
99. 2+ exchange protein in developing rabbit myocytes. Am J Physiol 1995; 268:C1126-32
100. Nakanishi T, Jarmakani JM: Effect of extracellular sodium on mechanical function in the newborn rabbit. Dev Pharmacol Ther 1981; 2:188-200
101. 2+ exchanger cDNA. Proc Natl Acad Sci 1992; 89:4769-73
102. 2+ in immature cardiac ventricular myocytes during contraction (Abstract). Circulation 1995; 92:1304
103. Charlemagne D, Mayoux E, Poyard M, Oliviero P, Geering K: Identification of two isoforms of the catalytic subunit of Na,K-ATPase in myocytes from adult rat heart. J Biolog Chem 1987; 262:8941-3
104. +)-stimulated ATPase in brain. Separation, and difference in affinity for strophanthidin. J Biolog Chem 1979; 254:6060-7
105. +-ATPase catalytic subunit. Proc Natl Acad Sci 1987; 84:4039-43
106. Lucchesi PA, Sweadner KJ: Postnatal changes in Na,K-ATPase isoform expression in rat cardiac ventricle. Conservation of biphasic ouabain affinity. J Biolog Chem 1991; 266:9327-31
107. Orlowski J, Lingrel JB: Tissue-specific and developmental regulation of rat Na,K-ATPase catalytic alpha isoform and beta subunit mRNAs. J Biolog Chem 1988; 263:10436-42
108. Berman W Jr, Musselman J, Shortencarrier R: The physiologic effects of digoxin under steady-state drug conditions in newborn and adult sheep. Circulation 1980; 62:1165-71
109. Khatter JC: Mechanisms of age-related differences in the cardiotoxic action of digitalis. J Cardiovasc Pharmacol 1985; 7:258-61
110. 2+ exchange in newborn rabbit. Am J Physiol 1981; 241:H637-45
111. Nakanishi T, Shimizu T, Uemura S, Jarmakani JM: Ouabain effect on myocardial mechanical function and sodium pump in the fetus. Am J Physiol 1984; 246:H213-21
112. +-H+ exchange. J Mol Cell Cardiol 1989; 21:1179-85
113. Haworth RM, Yasutake M, Brooks G, Avkiran M: Cardiac Na/ H exchanger expression and activity during post-natal development (Abstract). Circulation 1996; 94:I-483
114. 2+ currents and contraction in rabbit hearts. J Mol Cell Cardiol 1996; 28:635-42
115. Nakanishi T, Seguchi M, Tsuchiya T, Yasukouchi S, Takao A: Effect of acidosis on intracellular pH and calcium concentration in the newborn and adult rabbit myocardium. Circ Res 1990; 67:111-23
116. Downing SE, Talner NS, Gardner TH: Influences of arterial oxygen tension and pH on cardiac function in the newborn lamb. Am J Physiol 1966; 211:1203-8
117. Page E, Buecker JL: Development of dyadic junctional complexes between sarcoplasmic reticulum and plasmalemma in rabbit left ventricular myocardial cells. Morphometric analysis. Circ Res 1981; 48:519-22
118. Arai M, Otsu K, MacLennan SH, Periasamy M: Regulation of sarcoplasmic reticulum gene expression during cardiac and skeletal muscle development. Am J Physiol 1992; 262:C614-20
119. Mahony L, Jones LR: Developmental changes in cardiac sarcoplasmic reticulum in sheep. J Biolog Chem 1986; 261:15257-65
120. Pegg W, Michalak M: Differentiation of sarcoplasmic reticulum during cardiac myogenesis. Am J Physiol 1987; 252:H22-31
121. Mahony L: Maturation of calcium transport in cardiac sarcoplasmic reticulum. Pediatr Res 1988; 24:639-43
122. Tanaka H, Shigenobu K: Effect of ryanodine on neonatal and adult rat heart: Developmental increase in sarcoplasmic reticulum function. J Mol Cell Cardiol 1989; 21:1305-13
123. Klitzner TS, Friedman WF: A diminished role for the sarcoplasmic reticulum in newborn myocardial contraction: effects of ryanodine. Pediatr Res 1989; 26:98-101
124. Ganim JR, Luo W, Ponniah S, Grupp I, Kim HW, Ferguson DG, Kadambi V, Neumann JC, Doetschman T, Kranias EG: Mouse phospholamban gene expression during development in vivo and in vitro. Circ Res 1992; 71:1021-30
125. Kim HW, Steenaart NA, Ferguson DG, Kranias EG: Functional reconstitution of the cardiac sarcoplasmic reticulum Ca2(+)-ATPase with phospholamban in phospholipid vesicles. J Biolog Chem 1990; 265:1702-9
126. Rybin VO, Buttrick PM, Steinberg SF: Developmental regulation of protein kinase C (PKC) isoform mRNAs; The identity of the atypical PKC (aPKC) isoform in neonatal myocytes (Abstract). Circulation 1996; 94:I-165
127. Wegener AD, Simmerman HK, Lindermann JP, Jones LR: Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation. J Biolog Chem 1989; 264:11468-74
128. Fabiato A: Calcium release in skinned cardiac cells: variations with species, tissues, and development. Fed Proc 1982; 41:2238-44
129. Lompre AM, Mercadier JJ, Wisnewsky C, Bouveret P, Pantaloni C, d'Albis A, Schwartz K: Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals. Dev Biol 1981; 84:286-90
130. Baum VC, Clark WA, Pelligrino DA: Cardiac myosin isoenzyme shifts in non-insulin treated spontaneously diabetic rats. Diabetes Res 1989; 10:187-90
131. Barany M: ATPase activity of myosin correlated with speed of muscle shortening. J Gen Physiol 1967; 50:Suppl:197-218
132. Hoh JF, McGrath PA, Hale PT: Electrophoretic analysis of multiple forms of rat cardiac myosin: Effects of hypophysectomy and thyroxine replacement. J Mol Cell Cardiol 1978; 10:1053-76
133. Mahdavi V, Izumo S, Nadal-Ginard B: Developmental and hormonal regulation of sarcomeric myosin heavy chain gene family. Circ Res 1987; 60:804-14
134. Cummins P, Price KM, Littler WA: Foetal myosin light chain in human ventricle. J Muscle Res Cell Mot 1980; 357-66
135. Cummins P, Lambert SJ: Myosin transitions in the bovine and human heart. A developmental and anatomical study of heavy and light chain subunits in the atrium and ventricle. Circ Res 1986; 58:846-58
136. Bouvagnet P, Neveu S, Montoya M, Leger JJ: Development changes in the human cardiac isomyosin distribution: An immunohistochemical study using monoclonal antibodies. Circ Res 1987; 61:329-36
137. Lompre AM, Nadal-Ginard B, Mahdavi V: Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated. J Biolog Chem 1984; 259:6437-46
138. Lompre AM, Schwartz K, d'Albis A, Lacombe G, Van Thiem N, Swynghedauw B: Myosin isoenzyme redistribution in chronic heart overload. Nature 1979; 282:105-7
139. Mercadier JJ, Bouveret P, Gorza L, Schiaffino S, Clark WA, Zak R, Swynghedauw B, Schwartz K: Myosin isoenzymes in normal and hypertrophied human ventricular myocardium. Circ Res 1983; 53:52-62
140. Price KM, Littler WA, Cummins P: Human atrial and ventricular myosin light-chains subunits in the adult and during development. Biochem J 1980; 191:571-80
141. Boheler KR, Carrier L, de la Bastie D, Allen PD, Komajda M, Mercadier JJ, Schwartz K: Skeletal actin mRNA increases in the human heart during ontogenic development and is the major isoform of control and failing adult hearts. J Clin Invest 1991; 88:323-30
142. Leger J, Bouveret P, Schwartz K, Swynghedauw B: A comparative study of skeletal and cardiac tropomyosins: subunits, thiol group content and biological activities. Pflug Arch Eur J Physiol 1976; 362:271-7
143. Humphreys JE, Cummins P: Regulatory proteins of the myocardium. Atrial and ventricular tropomyosin and troponin-I in the developing and adult bovine and human heart. J Mol Cell Cardiol 1984; 16:643-57
144. Anderson PA, Oakeley AE: Immunological identification of five troponin T isoforms reveals an elaborate maturational troponin T profile in rabbit myocardium. Circ Res 1989; 65:1087-93
145. Anderson PA, Malouf NN, Oakeley AE, Pagani ED, Allen PD: Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle. Circ Res 1991; 69:1226-33
146. Pan BS, Potter JD: Two genetically expressed troponin T fragments representing alpha and beta isoforms exhibit functional differences. J Biolog Chem 1992; 267:23052-6
147. 2+ binding associated with troponin T isoform switching in developing rabbit heart. Circ Res 1990; 66:1204-16
148. Martin AF, Ball K, Gao LZ, Kumar P, Solaro RJ: Identification and functional significance of troponin I isoforms in neonatal rat heart myofibrils. Circ Res 1991; 69:1244-52
149. Sasse S, Brand NJ, Kyprianou P, Dhoot GK, Wade R, Arai M, Periasamy M, Yacoub MH, Barton PJ: Troponin I gene expression during human cardiac development and in end-stage heart failure. Circ Res 1993; 72:932-8
150. Hunkeler NM, Kullman J, Murphy AM: Troponin I isoform expression in human heart. Circ Res 1991; 69:1409-14
151. Rybin VO, Aprigliano O, Buttrick PM, Robinson RB, Steinberg SF: The sympathetic innervation-dependent acceleration of the kinetics of the contraction in neonatal ventricular myocytes is associated with a switch from skeletal to cardiac troponin I (Abstract). Circulation 1996; 94:1-475
152. 2+-regulatory site of bovine cardiac troponin. J Biolog Chem 1982; 257:260-3
153. Solaro RJ, Kumar P, Blanchard EM, Martin AF: Differential effects of pH on calcium activation of myofilaments of adult and perinatal dog hearts. Evidence for developmental differences in thin filament regulation. Circ Res 1986; 58:721-9
154. Agata N, Tanaka H, Shigenobu K: Developmental changes in action potential properties of the guinea-pig myocardium. Acta Physiolog Scand 1993; 149:331-7
155. Osaka T, Ramza BM, Tan RC, Joyner RW: Developmental changes in the electrophysiologic properties of rabbit papillary muscles. Pediatr Res 1989; 26:543-7
156. Chen F, Wetzel GT, Friedman WF, Klitzner TS: Single-channel recording of inwardly rectifying potassium currents in developing myocardium. J Mol Cell Cardiol 1991; 23:259-67
157. Hewett K: Developmental cellular electrophysiology, Pediatrie Arrhythmias: Electrophysiology and Pacing. Edited by Gillete PC, Garson A. Philadelphia, WB Saunders, 1990, pp. 28-36
158. Xu YQ, Pickoff AS, Clarkson CW: Evidence for developmental changes in sodium channel inactivation gating and sodium channel block by phenytoin in rat cardiac myocytes. Circ Res 1991; 69:644-56
159. Osaka T, Ramza BM, Tan RC, Joyner RW: Developmental changes in the electrophysiologic properties of rabbit papillary muscles. Pediatr Res 1989; 26:543-7
160. Antzelevitch C, Sicouri S, Nesterenko V, Liu D, Di Diego J: Regional differences in the electrophysiology of ventricular cells: physiological and clinical implications, Cardiac Electrophysiology. Edited by Zipes D, Jalife J. Philadelphia, WB Saunders, 1995. pp. 228-43
161. Jeck CD, Boyden PA: Age-related appearance of outward currents may contribute to developmental differences in ventricular repolarization. Circ Res 1992; 71:1390-403
162. Chen F, Wetzel GT, Friedman WF, Klitzner TS: ATP-sensitive potassium channels in neonatal and adult rabbit ventricular myocytes. Pediatr Res 1992; 32:230-5
163. ATP channel. Circulation 1997; 95:1278-85
164. Papp JG: Autonomie responses and neurohumeral control in the early antenatal heart. Basic Res Cardiol 1988; 83:2-9
165. Padbury JF, Roberman B, Oddie TH, Hobel CJ, Fisher DA: Fetal catecholamine release in response to labor and delivery. Obstet Gynecol 1982; 60:607-11
166. Breall JA, Rudolph AM, Heymann MA: Role of thyroid hormone in postnatal circulatory and metabolic adjustments. J Clin Invest 1984; 73:1418-24
167. Das DK, Bandyopadhyay D, Bandyopadhyay S, Neogi A: Thyroid hormone regulation of beta-adrenergic receptors and catecholamine sensitive adenylate cyclase in foetal heart. Acta Endocrin 1984; 106:569-76
168. Whitsett JA, PollingerJ, Matz S: Beta-adrenergic receptors and catecholamine sensitive adenylate cyclase in developing rat ventricular myocardium: Effect of thyroid status. Pediatr Res 1982; 16:463-9
169. Feng ZP, Dryden WF, Gordon T: Postnatal development of adrenergic responsiveness in the rabbit heart. Can J Physiol Pharmacol 1989; 67:883-9
170. Tanaka H, Shigenobu K: Role of beta-adrenoceptor-adenylate cyclase system in the developmental decrease in sensitivity to isoprenaline in foetal and neonatal rat heart. Br J Pharmacol 1990; 100:138-42
171. Friedman WF, Pool PE, Jacobowitz D, Seagren SC, Braunwald E: Sympathetic innervation of the developing rabbit heart. Biochemical and histochemical comparisons of fetal, neonatal, and adult myocardium. Circ Res 1968; 23:25-32
172. Ursell PC, Ren CL, Danilo P Jr. Anatomic distribution of autonomic neural tissue in the developing dog heart: I. Sympathetic innervation. Anatom Record 1990; 226:71-80
173. Osaka T, Joyner RW: Developmental changes in the beta-adrenergic modulation of calcium currents in rabbit ventricular cells. Circ Res 1992; 70:104-15
174. Schumacher WA, Sheppard JR, Mirkin BL: Biological maturation and beta-adrenergic effectors: Pre- and postnatal development of the adenylate cyclase system in the rabbit heart. J Pharmacol Exp Ther 1982; 223:587-93
175. Okuda H, Nakanishi T, Nakazawa M, Takao A: Effect of isoproterenol on myocardial mechanical function and cyclic AMP content in the fetal rabbit. J Mol Cell Cardiol 1987; 19:151-7
176. Shigenobu K, Tanaka H, Kasuya Y: Changes in sensitivity of rat heart to norepinephrine and isoproterenol during pre- and postnatal development and its relation to sympathetic innervation. Dev Pharmacol Ther 1988; 11:226-36
177. Tanaka H, Kasuya Y, Saito H, Shigenobu K: Organ culture of rat heart: maintained high sensitivity of fetal atria before innervation to norepinephrine. Can J Physiol Pharmacol 1988; 66:901-6
178. Lau C, Slotkin TA: Maturation of sympathetic neurotransmission in the rat heart. VIII. Slowed development of noradrenergic synapses resulting from hypothyroidism. J Pharmacol Exp Ther 1982; 220:629-36
179. Baum VC, Wetzel GT, Klitzner TS: Effects of halothane and ketamine on activation and inactivation of myocardial calcium current. J Cardiovasc Pharmacol 1994; 23:799-805
180. Baum VC, Wetzel GT: Sodium-calcium exchange in neonatal myocardium: Reversible inhibition by halothane. Anesth Analg 1994; 78:1105-9
181. Izumo S, Nadal-Ginard B, Mahdavi V: Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci 1988; 85:339-43
182. Palmisano BW, Setlock MA, Brown MP, Siker D, Tripuraneni R: Dose-response for atropine and heart rate in infants and children anesthetized with halothane and nitrous oxide. ANESTHESIOLOGY 1991; 75:238-42
183. Bosnjak ZJ, Kampine JP: Effects of halothane, enflurane, and isoflurane on the SA node. ANESTHESIOLOGY 1983; 58:314-21
184. Hauswirth O, Schaer H: Effects of halothane on the sino-atrial node. J Pharmacol Exp Ther 1967; 158:36-9
185. Wu M, Su M, Sun SS: Age-related propofol effects on electrophysiologic properties of isolated hearts. Anesth Analg 1997; 84:964-71
186. Davis DA, Speziali U, Wagerle C, Heckman JL, Russo PA: Effects of halothane on the immature lamb heart. Ann Thorac Surg 1995; 59:695-8
187. Sahlman L, Henriksson B: Effects of halothane, enflurane, and isoflurane on coronary vascular tone, myocardial performance, and oxygen consumption during controlled changes in aortic and left atrial pressure. ANESTHESIOLOGY 1988; 69:1-10
188. Stowe DF, Marijic J, Bosnjak ZJ, Kampine JP: Direct comparative effects of halothane, enflurane, and isoflurane on oxygen supply and demand in isolated hearts. ANESTHESIOLOGY 1991; 74:1087-95
189. Marijic J, Bosnjak ZJ, Stowe DF, Kampine JP: Effects and interaction of verapamil and volatile anesthetics on the isolated perfused guinea pig heart. ANESTHESIOLOGY 1988; 69:914-22
190. Larach DR, Schuler HG: Direct vasodilation by sevoflurane, isoflurane, and halothane alters coronary flow reserve in the isolated rat heart. ANESTHESIOLOGY 1991; 75:268-78
191. Toma BS, Wangler RD, DeWitt DF, Sparks HV: Effect of development on coronary vasodilator reserve in the isolated guinea pig heart. Circ Res 1985; 57:538-44
192. Ascuitto RJ, Ross-Ascuitto NT, Ramage D, McDonough KH, Kadowitz PJ: Acetylcholine-induced coronary vasoconstriction and negative inotropy in the neonatal pig heart. Pediatr Res 1992; 32:236-42
193. Buss DD, Hennemann III WW, Posner P: Maturation of coronary responsiveness to exogeneous adenosine in the rabbit. Basic Res Cardiol 1987; 82:290-96
194. Downing SE, Chen V: Dissociation of adenosine from metabolic regulation of coronary flow in the lamb. Am J Physiol 1986; 251:H40-6
195. Hickey RF, Sybert PE, Verrier ED, Cason BA: Effects of halothane, enflurane, and isoflurane on coronary blood flow autoregulation and coronary vascular reserve in the canine heart. ANESTHESIOLOGY 1988; 68:21-30
196. Cameron CB, Gregory GA, Rudolph AM, Heymann M: The cardiovascular and metabolic effects of halothane in normoxic and hypoxic newborn lambs. ANESTHESIOLOGY 1985; 62:732-7
197. Brett CM, Teitel DF, Heymann MA, Rudolph AM: The young lamb can increase cardiovascular performance during isoflurane anesthesia. ANESTHESIOLOGY 1989; 71:751-6
198. Brett CM, Teitel DF, Heymann MA, Rudolph AM: The cardiovascular effects of isoflurane in lambs. ANESTHESIOLOGY 1987; 67:60-5
199. McAuliffe JJ, Hickey PR: The effect of halothane on the steady-state levels of high energy phosphates in the neonatal heart. ANESTHESIOLOGY 1987; 67:231-5
200. Murray DJ, Forbes RB, Mahoney LT: Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: An echocardiographic study. Anesth Analg 1992; 74:329-37
201. Barash PG, Glanz S, Katz JD, Taunt K, Talner NS: Ventricular function in children during halothane anesthesia. ANESTHESIOLOGY 1978; 49:79-85
202. Boudreaux JP, Schieber RA, Cook DR: Hemodynamic effects of halothane in the newborn piglet. Anesth Analg 1984; 63:731-7
203. Schieber RA, Nannoum A, Sugden A, Shiu GK, Orr RA, Cook DR: Hemodynamic effects of isoflurane in the newborn piglet: Comparison with halothane. Anesth Analg 1986; 65:633-8
204. 2+ mobilization in single rat ventricular myocytes. ANESTHESIOLOGY 1991; 75:1075-86
205. 2+ mobilization in isolated cardiac myocytes. ANESTHESIOLOGY 1993; 79:73-82
206. 2+ fluxes of isolated myocardial sarcoplasmic reticulum. ANESTHESIOLOGY 1992; 77:316-23
207. Nakao S, Hirata H, Kagawa Y: Effects of volatile anesthetics on cardiac calcium channels. Acta Anaesth Scand 1989; 33:326-30
208. 2+ channel in human myocardium. ANESTHESIOLOGY 1993; 79:332-9
209. Lynch C: Differential depression of myocardial contractility by halothane and isoflurane in vitro. ANESTHESIOLOGY 1986; 64:620-31
210. 2+ transients and papillary muscle tension in guinea pigs. ANESTHESIOLOGY 1992; 76:123-31
211. Komai H, Rusy BF: Negative inotropic effects of isoflurane and halothane in rabbit papillary muscles. ANESTHESIOLOGY 1987; 66:29-33
212. Lynch C: Differential depression of myocardial contractility by volatile anesthetics in vitro: Comparison with uncouplers of excitation-contraction coupling. J Cardiovasc Pharmacol 1990; 15:655-65
213. Krane EJ, Su JY: Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit. I. Effects on contractile proteins. ANESTHESIOLOGY 1989; 70:76-81
214. Krane EJ, Su JY: Comparison of the effects of halothane on newborn and adult rabbit myocardium. Anesth Analg 1987; 66:1240-4
215. Rao CC, Boyer MS, Krishna G, Paradise RR: Increased sensitivity of the isometric contraction of the neonatal isolated rat atria to halothane, isoflurane, and enflurane. ANESTHESIOLOGY 1986; 64:13-8
216. Krane EJ, Su JY: Comparison of the effects of halothane on skinned myocardial fibers from newborn and adult rabbit: II. Effects on sarcoplasmic reticulum. ANESTHESIOLOGY 1989; 71:103-9
217. Murat I, Hoerter J, Ventura-Clapier R: Developmental changes in effects of halothane and isoflurane on contractile properties of rabbit cardiac skinned fibers. ANESTHESIOLOGY 1990; 73:137-45
218. Holzman RS, van der Velde ME, Kaus SJ, Body SC, Colan SD, Sullivan LJ, Soriano SG: Sevoflurane depresses myocardial contractility less than halothane during induction of anesthesia in children. ANESTHESIOLOGY 1996; 85:1260-7
219. Bers DM, Bridge JHB: Relaxation of rabbit ventricular muscle by Na-Ca exchange and sarcoplasmic reticulum calcium pump. Cardiovasc Res 1989; 65:334-42
220. Fisher DJ, Tate CA, Phillips S: Developmental regulation of the sarcoplasmic reticulum calcium pump in the rabbit heart. Pediatr Res 1992; 31:474-9
221. Thoresen M, Cowan F, Walloe L: Cardiovascular responses to tilting in healthy newborn babies. Early Human Dev 1991; 26:213-22
222. Buckner P, Maidens JM, Finer N: Characterization of the neonatal heart rate baroreflex during and after ECMO. Early Human Dev 1993; 32:49-61
223. Palmisano BW, Clifford PS, Coon RL, Seagard JL, Hoffmann RG, Kampine JP: Development of baroreflex control of heart rate in swine. Pediatr Res 1990; 27:148-52
224. Gootman PM: Development of central autonomic regulation of cardiovascular function, developmental neurobiology of the nervous system. Clifton. Humana Press, 1986, pp 279-326
225. Patton D, Hanna B: Postnatal maturation of baroreflex heart rate control in neonatal swine. Can J Cardiol 1994; 10:233-8
226. Segar J, Hajduczok G, Smith B, Merrill D, Robillard J: Ontogeny of baroreflex control of renal sympathetic nerve activity and heart rate. Am J Physiol 1992; 263:H1819-26
227. Duke PC, Fownes D, Wage JG: Halothane depresses baroreflex control of heart rate in man. ANESTHESIOLOGY 1977; 46:184-7
228. Seagard JL, Hopp FA, Donegan JH, Kalbfleisch JH, Kampine JP: Halothane and the carotid sinus reflex: Evidence for multiple sites of action. ANESTHESIOLOGY 1982; 57:191-202
229. Biscoe TJ, Millar RA: The effects of cyclopropane, halothane and ether on central baroreceptor pathways. J Physiol (Lond) 1966; 184:535-9
230. Palmisano BW, Clifford PS, Hoffman RG, Seagard JL, Coon RL, Kampine JP: Depression of baroreflex control of heart rate by halothane in growing piglets. ANESTHESIOLOGY 1991; 75:512-9
231. Wear R, Robinson S, Gregory G: The effect of halothane on the baroresponse of adult and baby rabbits. ANESTHESIOLOGY 1982; 56:188-91
232. Gregory GA: The baroresponses of preterm infants during halothane anesthesia. Can Anaesth Soc J 1982; 29:105-7
233. Seagard JL, Elegbe EO, Hoop FA, Bosnjak ZJ, vonColditz JH, Kalbleisch JH, Kampine JP: Effects of isoflurane on the baroreceptor reflex. ANESTHESIOLOGY 1983; 59:511-20
234. Kotrly KJ, Ebert TJ, Vucins E, Igler FO, Barney JA, Kampine JP: Baroreceptor reflex control of heart rate during isoflurane anesthesia in humans. ANESTHESIOLOGY 1984; 60:173-9
235. Murat I, Lapeyre G, Saint-Maurice C: Isoflurane attenuates baroreflex control of heart rate in human neonates. ANESTHESIOLOGY 1989; 70:395-400
236. Murat I, Levron J, Berg A, Saint-Maurice C: Effects of fentanyl on baroreceptor reflex control of heart rate in newborn infants. ANESTHESIOLOGY 1988; 68:717-22
237. Duncan PG, Gregory GA, Wade JG: The effect of nitrous oxide on baroreceptor function in newborn and adult rabbits. Can Anaesth Soc J 1981; 28:339-41