Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma

PLoS ONE

Volumn 9, Issue 1, 2014, Pages

  Little, Frédéric F ^a   Delgado, Diana M ^a   Wexler, Philip J ^a   Oppenheim, Frank G ^b   Mitchell, Patricia ^c   Feldman, James A ^c   Walt, David R ^d   Peng, Roger D ^e   Matsui, Elizabeth C ^f  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON UNIVERSITY   (United States)

^c BOSTON MEDICAL CENTER   (United States)

^d TUFTS UNIVERSITY   (United States)

^e JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTACOID; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; LEUKOTRIENE MODIFIER; LEUKOTRIENE RECEPTOR AFFECTING AGENT; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; ARTICLE; ASTHMA; ASTHMA CONTROL QUESTIONNAIRE; BONE MARROW CELL; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE CONTROL; DISEASE EXACERBATION; DISEASE MARKER; DISEASE SEVERITY; EOSINOPHIL; FEMALE; HUMAN; INNATE IMMUNITY; MAJOR CLINICAL STUDY; MALE; PROTEIN ANALYSIS; QUESTIONNAIRE; SALIVA ANALYSIS; SALIVA LEVEL;

ADOLESCENT; ADULT; AGE FACTORS; ASTHMA; BIOLOGICAL MARKERS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFLAMMATION MEDIATORS; MALE; MIDDLE AGED; NASAL LAVAGE FLUID; PATIENT OUTCOME ASSESSMENT; PRINCIPAL COMPONENT ANALYSIS; SALIVA;

EID: 84896927131     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0084449     Document Type: Article

References (37)

1. Vital signs: asthma prevalence, disease characteristics, and self-management education: United States, 2001-2009. MMWR Morb Mortal Wkly Rep 60: 547-552.
2. Mvula M, Larzelere M, Kraus M, Moisiewicz K, Morgan C, et al (2005) Prevalence of asthma and asthma-like symptoms in inner-city schoolchildren. J Asthma 42: 9-16. (Pubitemid 40365723)
3. Mannino DM, Homa DM, Akinbami LJ, Moorman JE, Gwynn C, et al. (2002) Surveillance for asthma-United States, 1980-1999. MMWR Surveill Summ 51: 1-13.
4. Jackson DJ, Virnig CM, Gangnon RE, Evans MD, Roberg KA, et al (2009) Fractional exhaled nitric oxide measurements are most closely associated with allergic sensitization in school-age children. J Allergy Clin Immunol 124: 949-953.
5. Szefler SJ, Mitchell H, Sorkness CA, Gergen PJ, O'Connor GT, et al (2008) Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet 372: 1065-1072.
6. Rathnayake N, Akerman S, Klinge B, Lundegren N, Jansson H, et al (2013) Salivary biomarkers for detection of systemic diseases. PLoS One 8: e61356. 10.1371/journal.pone.0061356 [doi];PONE-D-12-37078 [pii].
7. Verrills NM, Irwin JA, He XY, Wood LG, Powell H, et al (2011) Identification of novel diagnostic biomarkers for asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 183: 1633-1643.
8. Saude EJ, Skappak CD, Regush S, Cook K, Ben-Zvi A, et al (2011) Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy. J Allergy Clin Immunol 127: 757-764.
9. Blicharz TM, Siqueira WL, Helmerhorst EJ, Oppenheim FG, Little FF, et al (2009) Fiber-optic microsphere-based antibody array for the analysis of inflammatory cytokines in saliva. Anal Chem 81: 2106-2114.
10. Dweik RA, Boggs PB, Erzurum SC, Irvin CG, Leigh MW, et al (2011) An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184: 602-615.
11. Beydon N, Davis SD, Lombardi E, Allen JL, Arets HG, et al (2007) An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 175: 1304-1345. (Pubitemid 46905757)
12. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, et al (2004) Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 113: 59-65. (Pubitemid 38096162)
13. Juniper EF, O'Byrne PM, Guyatt GH, Ferrie PJ, King DR (1999) Development and validation of a questionnaire to measure asthma control. Eur Respir J 14: 902-907. (Pubitemid 29519356)
14. Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, Yagi S, Boushey HA (1999) Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med 160: 100-108. (Pubitemid 29326074)
15. Yeh CK, Christodoulides NJ, Floriano PN, Miller CS, Ebersole JL, et al (2010) Current development of saliva/oral fluid-based diagnostics. Tex Dent J 127: 651-661.
16. Ono E, Taniguchi M, Higashi N, Mita H, Yamaguchi H, et al (2010) Increase in Salivary Cysteinyl-Leukotriene Concentration in Patients with Aspirin-Intolerant Asthma. Allergol Int 60: 37-43.
17. Schmekel B, Ahlner J, Malmstrom M, Venge P (2001) Eosinophil cationic protein (ECP) in saliva: a new marker of disease activity in bronchial asthma. Respir Med 95: 670-675. (Pubitemid 32785524)
18. Beirne P, Pantelidis P, Charles P, Wells AU, Abraham DJ, et al (2009) Multiplex immune serum biomarker profiling in sarcoidosis and systemic sclerosis. Eur Respir J 34: 1376-1382.
19. Lee CG, Link H, Baluk P, Homer RJ, Chapoval S, et al (2004) Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med 10: 1095-1103. 10.1038/nm1105 [doi];nm1105 [pii].
20. Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, et al (2006) Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A 103: 11021-11026. 0601057103 [pii];10.1073/pnas.0601057103 [doi].
21. Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, et al (2009) Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clin Immunol 132: 371-384. S1521-6616(09)00688-3 [pii];10.1016/j.clim.2009.05.016 [doi].
22. Kamat A, Misra V, Cassol E, Ancuta P, Yan Z, et al (2012) A plasma biomarker signature of immune activation in HIV patients on antiretroviral therapy. PLoS One 7: e30881.
23. Chen YC, Chin CH, Liu SF, Wu CC, Tsen CC, et al (2011) Prognostic values of serum IP-10 and IL-17 in patients with pulmonary tuberculosis. Dis Markers 31: 101-110.
24. Cannas A, Calvo L, Chiacchio T, Cuzzi G, Vanini V, et al D (2010) IP-10 detection in urine is associated with lung diseases. BMC Infect Dis 10:333.
25. Costa C, Rufino R, Traves SL, Lapa E, Silva JR, et al (2008) CXCR3 and CCR5 chemokines in induced sputum from patients with COPD. Chest 133: 26-33.
26. Nagata K, Maruyama K, Uno K, Shinomiya K, Yoneda K, et al (2012) Simultaneous analysis of multiple cytokines in the vitreous of patients with sarcoid uveitis. Invest Ophthalmol Vis Sci 53: 3827-3833.
27. Rathnayake N, Akerman S, Klinge B, Lundegren N, Jansson H, et al (2013) Salivary biomarkers of oral health: a cross-sectional study. J Clin Periodontol 40: 140-147. 10.1111/jcpe.12038 [doi].
28. Kaushik R, Yeltiwar RK, Pushpanshu K (2011) Salivary interleukin-1beta levels in patients with chronic periodontitis before and after periodontal phase I therapy and healthy controls: a case-control study. J Periodontol 82: 1353-1359. 10.1902/jop.2011.100472 [doi].
29. Kinney JS, Morelli T, Braun T, Ramseier CA, Herr AE, et al (2011) Saliva/ pathogen biomarker signatures and periodontal disease progression. J Dent Res 90: 752-758. 0022034511399908 [pii];10.1177/0022034511399908 [doi].
30. Lee A, Ghaname CB, Braun TM, Sugai JV, Teles RP, et al (2012) Bacterial and salivary biomarkers predict the gingival inflammatory profile. J Periodontol 83: 79-89. 10.1902/jop.2011.110060 [doi].
31. Wojnarowski C, Roithner B, Koller DY, Halmerbauer G, Gartner C, et al (1999) Lack of relationship between eosinophil cationic protein and eosinophil protein X in nasal lavage and urine and the severity of childhood asthma in a 6-month follow-up study. Clin Exp Allergy 29: 926-932. (Pubitemid 29317803)
32. Lonnkvist K, Anderson M, Hedlin G, Svartengren M (2004) Exhaled NO and eosinophil markers in blood, nasal lavage and sputum in children with asthma after withdrawal of budesonide. Pediatr Allergy Immunol 15: 351-358. (Pubitemid 39106835)
33. Pammer J, Weninger W, Mildner M, Burian M, Wojta J, Tschachler E (1998) Vascular endothelial growth factor is constitutively expressed in normal human salivary glands and is secreted in the saliva of healthy individuals. J Pathol 186: 186-191. (Pubitemid 28467829)
34. Fonseca FJ, Junior MM, Lourenco EJ, de Moraes TD, Figueredo CM (2012) Cytokines expression in saliva and peri-implant crevicular fluid of patients with peri-implant disease. Clin Oral Implants Res 10-epub ahead of print.
35. Yao C, Li X, Murdiastuti K, Kosugi-Tanaka C, Akamatsu T, et al (2005) Lipopolysaccharide-induced elevation and secretion of interleukin-1beta in the submandibular gland of male mice. Immunology 116: 213-222. (Pubitemid 41368663)
36. Yeh CK, Christodoulides NJ, Floriano PN, Miller CS, Ebersole JL, et al (2010) Current development of saliva/oral fluid-based diagnostics. Tex Dent J 127: 651-661.
37. Cox AJ, Pyne DB, Gleson M, Callister R (2008) Resting plasma and salivary IL-6 concentrations are not correlated in distance runners. Eur J Appl Physiol 103: 477-479.