In vitro modulation of P-glycoprotein, MRP-1 and BCRP expression by mangiferin in doxorubicin-treated MCF-7 cells

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 4, 2014, Pages 1639-1642

  Louisa, Melva ^a   Soediro, Tjahjani Mirawati ^a   Suyatna, Frans Dhyanagiri ^a  

^a UNIVERSITY OF INDONESIA   (Indonesia)

Author keywords

BCRP; Doxorubicin; Mangiferin; MRP1; P glycoprotein

Indexed keywords

ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC ANTIBIOTIC; DOXORUBICIN; MANGIFERIN; MESSENGER RNA; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; PLANT MEDICINAL PRODUCT; TUMOR PROTEIN; XANTHONE DERIVATIVE;

ARTICLE; BIOSYNTHESIS; BREAST TUMOR; CELL SURVIVAL; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENETICS; HUMAN; MANGIFERA; MCF 7 CELL LINE; METABOLISM; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; HUMANS; MANGIFERA; MCF-7 CELLS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; PLANT PREPARATIONS; RNA, MESSENGER; XANTHONES;

EID: 84896915719     PISSN: 15137368     EISSN: 2476762X     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.4.1639     Document Type: Article

References (23)

1. Andreopoulou E, Sparano JA (2013). Chemotherapy in Patients with Anthracycline-and Taxane-Pretreated Metastatic Breast Cancer: An Overview. Curr Breast Cancer Rep, 5, 42-50.
2. Bruning A, Friese K, Burges A, Mylonas I (2010). Tamoxifen enhances the cytotoxic effects of nelfinavir in breast cancer cells. Breast Cancer Res, 12, 45.
3. Calcagno AM, Fostel JM, To KKW, et al (2008). Single-step doxorubicin-selected cancer cells overexpress the ABCG2 drug transporter through epigenetic changes. Br J Cancer, 98, 151-24.
4. Chieli E, Romiti N, Rodeiro I, Garrido G (2009). The in vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity. Food Chem Toxicol, 47, 2703-10.
5. Chieli E, Romiti N, Rodeiro I, Garrido G (2010). In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica. Chem Biol Interact, 186, 287-94.
6. Chien AJ, Moasser MM (2008). Cellular mechanisms of resistance to anthracyclines and taxanes in cancer: intrinsic and acquired. Semin Oncol, 35, 1-14.
7. Choi CH (2005). ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal. Cancer Cell Int, 5, 30.
8. Donmez Y, Akhmetova L, Iseri OD, Kars MD, Gunduz U (2011). Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells. Cancer Chemother Pharmacol, 67, 823-8.
9. Du Plessis-Stoman D, du Preez J, van de Venter M (2011). Combination treatment with oxaliplatin and mangiferin causes increased apoptosis and downregulation of NF?B in cancer cell lines. Afr J Tradit Complement Altern Med, 8, 177-84.
10. Farabegoli F, Papi A, Bartolini G, Ostan R, Orlandi M. (2010). (-)-Epigallocatechin-3-gallate downregulates Pg-P and BCRP in a tamoxifen resistant MCF-7 cell line. Phytomedicine, 17, 356-62.
11. Ghebeh H, Lehe C, Barhoush E, et al (2010). Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule. Breast Cancer Res. 12, 48.
12. Kars MD, Iseri OD, Gunduz U, et al (2006). Development of rational in vitro models for drug resistance in breast cancer and modulation of MDR by selected compounds. Anticancer Res, 26, 4559-68.
13. Li H, Huang J, Yang B, et al (2013). Mangiferin exerts antitumor activity in breast cancer cells by regulating matrix metalloproteinases, epithelial to mesenchymal transition, and β-catenin signaling pathway. Toxicol Appl Pharmacol, 272, 180-90
14. Livak KJ, Schmittgen TD, (2001). Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Method Methods. 25, 402-8.
15. Matkowski A, Kuss P, Goralska E, Wozniak D (2013). Mangiferin-a bioactive xanthonoid, not only from mango and not just antioxidant. Mini Rev Med Chem, 13, 439-55.
16. Nabekura T (2010). Overcoming multidrug resistance in human cancer cells by natural compounds. Toxins, 2, 1207-24.
17. Shah KA, Patel MB, Patel RJ, Parmar PK (2010). Mangifera indica (mango). Pharmacogn Rev, 4, 42-8.
18. Smith L, Watson MB, O'Kane SL, et al (2006). The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther, 5, 2115-20.
19. Sparano JA, Makhson AN, Semiglazov VF, et al (2009). Pegylated liposomal doxorubicin plus docetaxel significantly improves time to progression without additive cardiotoxicity compared with docetaxel monotherapy in patients with advanced breast cancer previously treated with neoadjuvant-adjuvant anthracycline therapy: results from a randomized phase III study. J Clin Oncol, 27, 4522-9.
20. Wind NS, Holen I (2011). Multidrug resistance in breast cancer: from in vitro models to clinical studies. Int J Breast Cancer, 2011, 967419.
21. Wong ILK, Chan KF, Tsang KH, et al (2009). Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives. J Med Chem, 52, 5311-22.
22. Zhang B, Fang J, Chen Y (2013). Antioxidant effect of mangiferin and its potential to be a cancer chemoprevention agent. Letters Drug Design Discovery, 10, 239-44.
23. Zhang L, Yang Y, Wei XY, et al (2007). Reversing adriamycin resistance of human breast cancer cells by hyperthermia combined with Interferon alpha and Verapamil. J Exp Clin Cancer Res, 26, 201-7.