Pharmacokinetics, bioavailability and tissue distribution of geniposide following intravenous and peroral administration to rats

Biopharmaceutics and Drug Disposition

Volumn 35, Issue 2, 2014, Pages 97-103

  Wang, Fugang ^a   Cao, Juan ^a   Hao, Jifu ^a   Liu, Ke ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

Author keywords

bioavailability; Gardenia jasminoides; geniposide; pharmacokinetics; tissue distribution

Indexed keywords

GENIPOSIDE; HERBACEOUS AGENT; IRIDOID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG LIVER LEVEL; DRUG TISSUE LEVEL; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; LUNG; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; RAT; SPLEEN; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; BLOOD; BRAIN; HEART MUSCLE; INTRAVENOUS DRUG ADMINISTRATION; LIVER; METABOLISM; ORAL DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ADMINISTRATION, INTRAVENOUS; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BRAIN; DRUGS, CHINESE HERBAL; IRIDOIDS; KIDNEY; LIVER; LUNG; MALE; MYOCARDIUM; RATS, SPRAGUE-DAWLEY; SPLEEN; TISSUE DISTRIBUTION;

EID: 84896900637     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.1869     Document Type: Article

References (27)

1. Chang HM, But PP,. Pharmacology and Applications of Chinese Materia Medica, Vol. 2. World Scientific Publishing: Singapore, 1987; 1029-1033.
2. Hsu HY, Yang JJ, Lin SY, et al,. Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. Cancer Lett 1997; 113: 31-37.
3. Koo HJ, Lee S, Shin KH, et al,. Geniposide, an anti-Angiogenic compound from the fruits of Gardenia jasminoides. Planta Med 2004; 70: 467-469. (Pubitemid 38716483)
4. Koo HJ, Lim KH, Jung HJ, et al,. Anti-inflammatory evaluation of gardenia extract, geniposide and genipin. J Ethnopharmacol 2006; 103: 496-500.
5. Liaw J, Chao YC,. Effect of in vitro and in vivo aerosolized treatment with geniposide on tracheal permeability in ovalbumin-induced guinea pigs. Eur J Pharmacol 2001; 433: 115-121. (Pubitemid 34038088)
6. Suzuki Y, Kondo K, Ikeda Y, et al,. Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med 2001; 67: 807-810. (Pubitemid 34015542)
7. Chang WL, Wang HY, Shi LS, et al,. Immunosuppressive iridoids from the fruits of Gardenia jasminoides. J Nat Prod 2005; 68: 1683-1685.
8. Liu JH, Yin F, Guo LX, et al,. Neuroprotection of geniposide against hydrogen peroxide induced PC12 cells injury: involvement of PI3 kinase signal pathway. Acta Pharmacol Sin 2009; 30: 159-165.
9. Lee P, Lee J, Choi SY, et al,. Geniposide from Gardenia jasminoides attenuates neuronal cell death in oxygen and glucose deprivation-exposed rat hippocampal slice culture. Biol Pharm Bull 2006; 29: 174-176. (Pubitemid 43036718)
10. Wu SY, Wang GF, Liu ZQ, et al,. Effect of geniposide, a hypoglycemic glucoside, on hepatic regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Acta Pharmacol Sin 2009; 30: 202-208.
11. Kojima K, Shimada T, Nagareda Y, et al,. Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells. Biol Pharm Bull 2011; 34: 1613-1618.
12. Hou YC, Tsai SY, Lai PY, et al,. Metabolism and pharmacokinetics of genipin and geniposide in rats. Food Chem Toxicol 2008; 46: 2764-2769.
13. Sun Y, Feng F, Yu X,. Pharmacokinetics of geniposide in Zhi-Zi-Hou-Pu decoction and in different combinations of its constituent herbs. Phytother Res 2012; 26: 67-72.
14. Tseng TY, Tsai TH,. Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence on acupuncture. Anal Chim Acta 2004; 517: 47-52.
15. Ueno K, Takeda Y, Iwasaki Y, et al,. Simultaneous estimation of geniposide and genipin in mouse plasma using high-performance liquid chromatography. Anal Sci 2001; 17: 1237-1239. (Pubitemid 33042995)
16. Tian X, Li P, Wang H, et al,. Pharmacokinetics and bioavailabilities of geniposide in Beagle dogs after oral administration Xingnaojing. Zhongguo Zhong Yao Za Zhi 2012; 37: 2461-2464.
17. Tang H, Min G, Ge B, et al,. Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs. J Ethnopharmacol 2008; 117: 420-426.
18. Akao T, Kobashi K, Aburada M,. Enzymic studies on the animal and intestinal bacterial metabolism of geniposide. Biol Pharm Bull 1994; 17: 1573-1576.
19. Lin SP, Tsai SY, Lee Chao PD, et al,. Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats. Planta Med 2011; 77: 1800-1805.
20. O'Leary KA, Day AJ, Needs PW, et al,. Flavonoid glucuronides are substrates for human liver beta-glucuronidase. FEBS Lett 2001; 503: 103-106. (Pubitemid 32769964)
21. Reed MJ, Purohit A, Woo LW, et al,. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev 2005; 26: 171-202.
22. Tseng T-Y, Tsai T-H,. Measurement of unbound geniposide in blood, liver, brain and bile of anesthetized rats: an application of pharmacokinetic study and its influence on acupuncture. Anal Chim Acta 2004; 517: 47-52. (Pubitemid 38798306)
23. Wang CH, Wang ZT, Bligh SW, et al,. Pharmacokinetics and tissue distribution of gentiopicroside following oral and intravenous administration in mice. Eur J Drug Metab Pharmacokinet 2004; 29: 199-203. (Pubitemid 39447019)
24. Li X, Wang Q, Zhang L, et al,. HPLC study of tissue distribution of loganin in rats. Biomed Chromatogr 2006; 20: 1087-1092. (Pubitemid 44697048)
25. Yamazaki M, Chiba K, Mohri T,. Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases. Biol Pharm Bull 1996; 19: 791.
26. Lu Y, Du S, Bai J, et al,. Bioavailability and brain-targeting of geniposide in gardenia-borneol co-compound by different administration routes in mice. Int J Mol Sci 2012; 13: 14127-14135.
27. Yamazaki M, Chiba K,. Genipin exhibits neurotrophic effects through a common signaling pathway in nitric oxide synthase-expressing cells. Eur J Pharmacol 2008; 581: 255-261