Evaluation of protective effects of Chi-Zhi-Huang decoction on Phase I drug metabolism of liver injured rats by cocktail probe drugs

Journal of Ethnopharmacology

Volumn 117, Issue 3, 2008, Pages 420-426

  Tang, Hao ^a,b   Min, Guangtao ^c   Ge, Bin ^d   Li, Yumin ^c   Liu, Xia ^a   Jiang, Shengxiang ^a  

^a LANZHOU INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c LANZHOU UNIVERSITY   (China)

^d GANSU PROVINCIAL HOSPITAL   (China)

Author keywords

Chi Zhi Huang decoction; Cocktail probe drugs; High performance liquid chromatography; Phase I drug metabolism

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CAFFEINE; CHI ZHI HUANG; CHINESE DRUG; CHLORZOXAZONE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DAPSONE; GARDENIA JASMINOIDES EXTRACT; MICROSOMAL AMINOPEPTIDASE; PAEONIA LACTIFLORA EXTRACT; PHENYL ISOTHIOCYANATE; RHUBARB EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER FUNCTION; LIVER INJURY; MALE; NONHUMAN; RAT;

ALANINE TRANSAMINASE; ANIMALS; AREA UNDER CURVE; ASPARTATE AMINOTRANSFERASES; BILIRUBIN; CAFFEINE; CHLORZOXAZONE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DAPSONE; DRUGS, CHINESE HERBAL; HEPATITIS, TOXIC; LIVER; LIVER FUNCTION TESTS; MALE; PLANTS, MEDICINAL; PROTECTIVE AGENTS; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 42749091457     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.02.020     Document Type: Article

References (28)

1. Badyal D.K., and Dadhich A.P. Cytochrome P450 and drug interactions. Indian Journal of Pharmacology 33 (2001) 248-259
2. Cheng Y.Y., Chan Y.S., Choang Tai.K.F., and Chang H.M. Effect of geniposide on acute jaundice in rats caused by ANIT poisoning. Zhongguo Yao Li Xue Bao 7 (1986) 69-72
3. Fan H.R., He F., Li Q.S., Huang Y.R., Wei G.L., Xiao S.H., et al. Study on influence of ginsenoside Re on cytochrome P450 isoforms by cocktail approach using probe drugs, caffeine, chlorzoxazone, omeprazole, and dapsone in rats. Asian Journal of Drug Metabolic and Pharmacokinetics 4 (2004) 91-98
4. Guo M.Z., and Xu H.R. Progression of pharmacologic study of rhein. Foreign Medical Science 24 (2002) 139-143
5. Huang H.Z., Wu F.F., Fu J.F., Yi Z.W., Sun H.F., Liu Y., Li W., Wang A.N., Zhang T., You X., and Wang J.H. Clinical observations on deep icteric severe hepatitis treated mainly with mixture PGR. Journal of Ningxia Medical 1 (1989) 6-7
6. Kang J.J., Wang H.W., Liu T.Y., Chen Y.C., and Ueng T.H. Modulation of cytochrome P-450-dependent monooxygenases, glutathione and glutathione S-transferase in rat liver by geniposide from Gardenia jasminoides. Food and Chemical Toxicology 35 (1997) 957-965
7. Kimura M., Kimura I., Takahashi K., Muroi M., Yoshizaki M., and Kanaoka M. Blocking effects of blended paeoniflorin or its related compounds with glycyrrhizin on neuromuscular junctions in frog and mouse. Japanese Journal of Pharmacology 36 (1984) 275-282
8. Kuo W.H., Chou F.P., Young S.C., Chang Y.C., and Wang C.J. Geniposide activates GSH S-transferase by the induction of GST M1 and GST M2 subunits involving the transcription and phosphorylation of MEK-1 signaling in rat hepatocytes. Toxicology and Applied Pharmacology 208 (2005) 155-162
9. Liu Y., Zhang P., Huang H.Z., Li W., Gao L., and Dai S.Z. The effect of Chinese herbal medicine on blood SOD activity in patients with viral hepatitis. Journal of Ningxia Medical College 17 (1995) 204-206
10. Liu Y. 168 Patients of deep icteric chronic viral hepatitis treatment with mixture PGR. Shanxi Traditional Medical 20 (1999) 396
11. Medical Administration Department of Ministry of Public Health, P.R.C., 2006. National Guide to Clinical Laboratory Procedures, third edition. Publishing Company of Dongna University, Najing, pp. 456-457, 406-414.
12. Min G.T., Tang H., and Li Y.M. 32 Patients of cholestatic hepatitis treatment with combination of TCM with Western. Chinese Journal of Integrated Traditional and Western Medicine on Liver Disease 14 (2004) 49-50
13. Murray M. P450 enzymes: inhibition mechanisms, genetic regulation and effect of liver disease. Clinical Pharmacokinetics 23 (1992) 132-146
14. Paolini M., Pozzetti L., Sapone A., and Cantelli-Forti G. Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases. Life Sciences 62 (1998) 571-582
15. Raucy J.L., Lasker J.M., Lieber C.S., and Black M. Acetaminophen activation by human liver cytochrome P450IIE1 and P4501A2. Archives of Biochemistry and Biophysics 271 (1989) 270-283
16. Shah V.P., Midha K.K., Dighe S., McGilveray I.J., Skelly J.P., Yacobi A., et al. Analysis methods validation: bioavailability, bioequivalence and pharmacokinetics studies. Journal of Pharmaceutical Sciences 81 (1992) 309-312
17. Sharma A., Pilote S., Bélanger P.M., Arsenault M., and Hamelin B.A. A convenient five-drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study. British Journal of Clinical Pharmacology 58 (2004) 288-297
18. Shen X.S., Shu Z.J., Wang H.M., Wang F.R., Zhu W.P., and Huang H.Z. Morphological study on the action of PGR decoction in preventing the development of experimental liver cirrhosis. Journal of Ningxia Medical College 16 (1994) 9-14
19. Shimada T., Yamazaki H., Mimura M., Inui Y., and Guengerich F.P. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. The Journal of Pharmacology and Experimental Therapeutics 270 (1994) 414-423
20. Smith T.J., Guo Z., Guengerich F.P., and Yang C.S. Metabolism of 4-(methylnitrosamine)-1-)3-pyridil-1-butanone(NNK) by human cytochrome P450 and its inhibition by phenethyl isothiocynate. Carcinogenesis 17 (1996) 809-813
21. Takeda S., Isono T., Wakui Y., Matsuzaki Y., Sasaki H., Amagaya S., and Maruno M. Absorption and excretion of paeoniflorin in rats. The Journal of Pharmacy and Pharmacology 47 (1995) 1036-1040
22. Takeda S., Isono T., Wakui Y., Mizuhara Y., Amagaya S., Maruno M., and Hattori M. In-vivo assessment of extrahepatic metabolism of paeoniflorin in rats: relevance to intestinal floral metabolism. The Journal of Pharmacy and Pharmacology 49 (1997) 35-39
23. Tang J.C., Zhang J.N., Wu Y.T., and Li Z.X. Effect of the water extract and ethanol extract from traditional Chinese medicines Angelica sinensis (Oliv.) Diels, Ligusticum chuanxiong Hort. and Rheum palmatum L. on rat liver cytochrome P450 activity. Phytotherapy Research 20 (2006) 1046-1051
24. Watkins P.B., Wrighton S.A., Schuetz E.G., Molowa D.T., and Guzelian P.S. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. The Journal of Clinical Investigation 80 (1987) 1029-1036
25. Wu J.H., and Li B. The preventive effect of Shuganling on experiment liver injure mouse. Chinese Journal of Integrated Traditional and Western Medicine on Liver Disease 10 (2000) 27-28
26. Xiong X.J., Chen W.Y., Cui J.L., Yi S.B., Zhang Z.W., and Li K.Q. Effects of ursolic acid on liver-protection and bile secretion. Journal of Chinese Medicinal Materials 26 (2003) 578-581
27. Yamahara J., Yamada T., Kimura H., Sawada T., and Fujimura H. Biologically active principles of crude drug. II. Anti-allergic principles in BShoseir-yu-To" anti-inflammatory properties of paeoniflorin and its derivatives. Journal of Pharmacobio-Dynamics 5 (1982) 921-929
28. Zhang X.P. General situation in pharmacological studies on emodin. Chinese Pharmacological Bulletin 19 (2003) 851-854