Cytotoxic and protein kinase inhibiting nakijiquinones and nakijiquinols from the sponge Dactylospongia metachromia

Journal of Natural Products

Volumn 77, Issue 2, 2014, Pages 218-226

  Daletos, Georgios ^a   De Voogd, Nicole J ^b   Müller, Werner E G ^c   Wray, Victor ^d   Lin, Wenhan ^e   Feger, Daniel ^f   Kubbutat, Michael ^f   Aly, Amal H ^a   Proksch, Peter ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b NATURALIS BIODIVERSITY CENTER   (Netherlands)

^c UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^d HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^e PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^f PROQINASE GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

18 HYDROXY 5 EPI HYRTIOPHENOL; 5 EPI NAKIJINOL C; 5 EPI NAKIJINOL D; 5 EPI NAKIJIQUINONE N; 5 EPI NAKIJIQUINONE Q; 5 EPI NAKIJIQUINONE S; 5 EPI NAKIJIQUINONE T; 5 EPI NAKIJIQUINONE U; ANAPLASTIC LYMPHOMA KINASE; AURORA B KINASE; FOCAL ADHESION KINASE; GLYCEROLIPID; KAHALALIDE F; NEK6 KINASE; PROTEIN KINASE; SCATTER FACTOR RECEPTOR; SESQUITERPENE AMINOQUINONE DERIVATIVE; SESQUITERPENE BENZOXAZOLE DERIVATIVE; SESQUITERPENE DERIVATIVE; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROLIFERATION ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DACTYLOSPONGIA METACHROMIA; DRUG ISOLATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; IC 50; LYMPHOMA CELL LINE; METASTASIS; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SPONGE (PORIFERA); TUMOR GROWTH;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOXAZOLES; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; MARINE BIOLOGY; MICE; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PORIFERA; PROTEIN KINASE INHIBITORS; QUINONES; SESQUITERPENES;

EID: 84896890656     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400633m     Document Type: Article

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