Modulation of c-Fos and BDNF protein expression in pentylenetetrazole- kindled mice following the treatment with novel antiepileptic compound HHL-6

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Malhi, Saima Mahmood ^a   Jawed, Huma ^a   Hanif, Farina ^a   Ashraf, Nadeem ^a   Zubair, Farhat ^a   Siddiqui, Bina S ^a   Begum, Sabira ^a   Kabir, Nurul ^a   Simjee, Shabana Usman ^a  

^a UNIVERSITY OF KARACHI   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

(2 ACETYL 3 (2 HEXANOYLAMIDOETHYL) 7 METHOXYINDOLE); ANTICONVULSIVE AGENT; BRAIN DERIVED NEUROTROPHIC FACTOR; DIAZEPAM; PENTETRAZOLE; PROTEIN C FOS; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EPILEPTOGENESIS; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; KINDLING; MALE; MOUSE; NONHUMAN; ONCOGENE C FOS; PENTYLENETETRAZOLE-INDUCED SEIZURE; PROTEIN EXPRESSION; TONIC CLONIC SEIZURE; ANIMAL; BIOSYNTHESIS; BRAIN; DISEASE MODEL; EPILEPSY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; ONCOGENE; PATHOLOGY; SEIZURE;

ANIMALS; ANTICONVULSANTS; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; DISEASE MODELS, ANIMAL; EPILEPSY; GENE EXPRESSION REGULATION; GENES, FOS; MICE; PENTYLENETETRAZOLE; SEIZURES;

EID: 84896877161     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/876712     Document Type: Article

References (63)

1. Fisher R. S., Van Emde Boas W., Blume W., Elger C., Genton P., Lee P., Engel J. Jr., Epileptic seizures and epilepsy: definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE). Epilepsia 2005 46 4 470 472 2-s2.0-16344387731 10.1111/j.0013-9580.2005.66104.x
2. World Health Organization, Epilepsy: Epidemiology, Aetiology and Prognosis 2001 number 165 WHO Factsheet
3. Sato T., Yamada N., Morimoto K., Uemura S., Kuroda S., A behavioral and immunohistochemical study on the development of perirhinal cortical kindling: a comparison with other types of limbic kindling. Brain Research 1998 811 1-2 122 132 2-s2.0-0032539055 10.1016/S0006-8993(98)00895-6
4. Li J., Shen H., Naus C. C. G., Zhang L., Carlen P. L., Upregulation of gap junction connexin 32 with epileptiform activity in the isolated mouse hippocampus. Neuroscience 2001 105 3 589 598 2-s2.0-0035881359 10.1016/S0306-4522(01)00204-4
5. Gorji A., Madeja M., Straub H., Köhling R., Speckmann E.-J., Lowering of the potassium concentration induces epileptiform activity in guinea-pig hippocampal slices. Brain Research 2001 908 2 130 139 2-s2.0-0035958592 10.1016/S0006-8993(01)02622-1
6. Pitkänen A., Lukasiuk K., Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy and Behavior 2009 14 1 16 25 2-s2.0-55749104050 10.1016/j.yebeh.2008.09.023
7. Löscher W., Current status and future directions in the pharmacotherapy of epilepsy. Trends in Pharmacological Sciences 2002 23 3 113 118 2-s2.0-0036499726 10.1016/S0165-6147(00)01974-X
8. Pitkänen A., Kharatishvili I., Karhunen H., Lukasiuk K., Immonen R., Nairismägi J., Gröhn O., Nissinen J., Epileptogenesis in experimental models. Epilepsia 2007 48 2 13 20 2-s2.0-34249801746 10.1111/j.1528-1167.2007. 01063.x
9. Akula K. K., Dhir A., Bishnoi M., Kulkarni S. K., Effect of systemic administration of adenosine on brain adenosine levels in pentylenetetrazol- induced seizure threshold in mice. Neuroscience Letters 2007 425 1 39 42 2-s2.0-34548628705 10.1016/j.neulet.2007.08.006
10. Rattka M., Brandt C., Bankstahl M., Bröer S., Löscher W., Enhanced susceptibility to the GABA antagonist pentylenetetrazole during the latent period following a pilocarpine-induced status epilepticus in rats. Neuropharmacology 2011 60 2-3 505 512 2-s2.0-78650846816 10.1016/j.neuropharm. 2010.11.005
11. Sato M., Kindling: an experimental model of epilepsy. Psychiatry and Clinical Neurosciences 1982 36 4 440 441
12. Sato M., Racine R. J., McIntyre D. C., Kindling: basic mechanisms and clinical validity. Electroencephalography and Clinical Neurophysiology 1990 76 5 459 472 2-s2.0-0025053759
13. Yoshii A., Constantine-Paton M., Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease. Developmental Neurobiology 2010 70 5 304 322 2-s2.0-77949754231 10.1002/dneu.20765
14. Ballarin M., Ernfors P., Lindefors N., Persson H., Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain. Experimental Neurology 1991 114 1 35 43 2-s2.0-0025951696 10.1016/0014-4886(91)90082-N
15. Lähteinen S., Pitkänen A., Knuuttila J., Törönen P., Castrén E., Brain-derived neurotrophic factor signaling modifies hippocampal gene expression during epileptogenesis in transgenic mice. European Journal of Neuroscience 2004 19 12 3245 3254 2-s2.0-3042755066 10.1111/j.0953-816X.2004.03440.x
16. Larmet Y., Reibel S., Carnahan J., Nawa H., Marescaux C., Depaulis A., Protective effects of brain-derived neurotrophic factor on the development of hippocampal kindling in the rat. NeuroReport 1995 6 14 1937 1941 2-s2.0-0029086156
17. Simonato M., Molteni R., Bregola G., Muzzolini A., Piffanelli M., Beani L., Racagni G., Riva M., Different patterns of induction of FGF-2, FGF-1 and BDNF mRNAs during kindling epileptogenesis in the rat. European Journal of Neuroscience 1998 10 3 955 963 2-s2.0-0031903452 10.1046/j.1460-9568.1998.00105. x
18. Herrera D. G., Robertson H. A., Activation of c-fos in the brain. Progress in Neurobiology 1996 50 2-3 83 107 2-s2.0-0030272218 10.1016/S0301-0082(96)00021-4
19. Curran T., Morgan J. I., Fos: an immediate-early transcription factor in neurons. Journal of Neurobiology 1995 26 3 403 412 2-s2.0-0028860249 10.1002/neu.480260312
20. Kovács K. J., c-Fos as a transcription factor: a stressful (re)view from a functional map. Neurochemistry International 1998 33 4 287 297 2-s2.0-0032191915 10.1016/S0197-0186(98)00023-0
21. Sagar S. M., Sharp F. R., Curran T., Expression of c-fos protein in brain: metabolic mapping at the cellular level. Science 1988 240 4857 1328 1331 2-s2.0-0023891990
22. Dragunow M., Robertson H. A., Localization and induction of c-fos protein-like immunoreactive material in the nuclei of adult mammalian neurons. Brain Research 1988 440 2 252 260 2-s2.0-0023852641
23. Kiessling M., Gass P., Immediate early gene expression in experimental epilepsy. Brain Pathology 1993 3 4 381 393 2-s2.0-0027527125
24. Iryo Y., Matsuoka M., Igisu H., Suppression of pentylenetetrazol-induced seizures and c-fos expression in mouse brain by L-carnitine. Journal of Occupational Health 2000 42 3 119 123 2-s2.0-0033920301
25. Humpel C., Wetmore C., Olson L., Regulation of brain-derived neurotrophic factor messenger RNA and protein at the cellular level in pentylenetetrazol- induced epileptic seizures. Neuroscience 1993 53 4 909 918 2-s2.0-0027230699 10.1016/0306-4522(93)90476-V
26. Racine R. J., Modification of seizure activity by electrical stimulation: II. Motor seizure. Electroencephalography and Clinical Neurophysiology 1972 32 3 281 294 2-s2.0-0015309163
27. Racine R., Tuff L., Zaide J., Kindling, unit discharge patterns and neural plasticity. Canadian Journal of Neurological Sciences 1975 2 4 395 405 2-s2.0-0016701776
28. Faingold C. L., Jobes P. C., Laird H. E., Seizures induced by convulsant drugs. Neurotransmitters and Epilepsy 1987 Humana Press 215 276
29. Mandhane S. N., Aavula K., Rajamannar T., Timed pentylenetetrazol infusion test: a comparative analysis with s.c.PTZ and MES models of anticonvulsant screening in mice. Seizure 2007 16 7 636 644 2-s2.0-34548165281 10.1016/j.seizure.2007.05.005
30. Oliveira F. A., De Almeida R. N., Sousa M. D. F. V., Barbosa-Filho J. M., Diniz S. A., De Medeiros I. A., Anticonvulsant properties of N -salicyloyltryptamine in mice. Pharmacology Biochemistry and Behavior 2001 68 2 199 202 2-s2.0-0035084577 10.1016/S0091-3057(00)00484-6
31. Oliveira F. D. A., E Silva D. A., Quintans L. J. Jr., Chavez Gutierrez S. J., De Almeida R. N., Barbosa-Filho J. M., Vanderlei De Souza M. D. F., Synthesis and structural characterization of N -benzoyltryptamine and its new analogue N -salicyloyltryptamine, a potential anticonvulsant agent. Journal of the Chilean Chemical Society 2006 51 2 919 922 2-s2.0-33745812748
32. Altintaş H., Ateş Ö., Uydeş-Doan B. S., Alp F. I., Kaleli D., Özdemir O., Birteksöz S., Ötük G., Şatana D., Uzun M., Synthesis and evaluation of antimicrobial and anticonvulsant activities of some new 3-[2-(5-aryl-1,3,4-oxadiazol-2-yl/4- carbethoxymethylthiazol-2-yl)imino-4-thiazolidinon-5-ylidene]-5-substituted/ nonsubstituted 1H-indole-2-ones and investigation of their structure-activity relationships. Arzneimittel-Forschung 2006 56 3 239 248 2-s2.0-33645470717
33. Gale K., Role of GABA in the genesis of chemoconvulsant seizures. Toxicology Letters 1992 64-65 417 428 2-s2.0-0026620868 10.1016/0378-4274(92) 90215-6
34. De Sarro G., Palma E., Costa N., Rosario Marra R. M., Gratteri S., De Sarro A., Rotiroti D., Effects of compounds acting on GABA(B) receptors in the pentylenetetrazole kindling model of epilepsy in mice. Neuropharmacology 2000 39 11 2147 2161 2-s2.0-0033838084 10.1016/S0028-3908(00)00050-2
35. Morgan J. I., Cohen D. R., Hempstead J. L., Curran T., Mapping patterns of c-fos expression in the central nervous system after seizure. Science 1987 237 4811 192 196 2-s2.0-0023193514
36. Burazin T. C. D., Gundlach A. L., Rapid and transient increases in cellular immediate early gene and neuropeptide mRNAs in cortical and limbic areas after amygdaloid kindling seizures in the rat. Epilepsy Research 1996 26 1 281 293 2-s2.0-0030557808 10.1016/S0920-1211(96)00060-5
37. Mhyre T. R., Applegate C. D., Persistent regional increases in brain-derived neurotrophic factor in the flurothyl model of epileptogenesis are dependent upon the kindling status of the animal. Neuroscience 2003 121 4 1031 1045 2-s2.0-0142247451 10.1016/S0306-4522(03)00475-5
38. Clark M., Post R. M., Weiss S. R. B., Cain C. J., Nakajima T., Regional expression of c-fos mRNA in rat brain during the evolution of amygdala kindled seizures. Molecular Brain Research 1991 11 1 55 64 2-s2.0-0025837503 10.1016/0169-328X(91)90021-O
39. Labiner D. M., Butler L. S., Cao Z., Hosford D. A., Shin C., McNamara J. O., Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. Journal of Neuroscience 1993 13 2 744 751 2-s2.0-0027399134
40. Erdtmann-Vourliotis M., Riechert U., Mayer P., Grecksch G., Höllt V., Pentylenetetrazole (PTZ)-induced c-fos expression in the hippocampus of kindled rats is suppressed by concomitant treatment with naloxone. Brain Research 1998 792 2 299 308 2-s2.0-0032507753 10.1016/S0006-8993(98)00159-0
41. Giulia D., Francesca V., Sandra S., Alessandra S., Gualtiero G., Luciana G., Laura C., A molecular study of hippocampus in dogs with convulsion during canine distemper virus encephalitis. Brain Research 2006 1098 1 186 195 2-s2.0-33747789376 10.1016/j.brainres.2006.04.051
42. Szyndler J., Maciejak P., Turzyńska D., Sobolewska A., Taracha E., Skórzewska A., Lehner M., Bidziński A., Hamed A., Wisłowska-Stanek A., Krzaścik P., Płaźnik A., Mapping of c-Fos expression in the rat brain during the evolution of pentylenetetrazol-kindled seizures. Epilepsy and Behavior 2009 16 2 216 224 2-s2.0-70349832530 10.1016/j.yebeh.2009.07.030
43. Kasof G. M., Mandelzys A., Maika S. D., Hammer R. E., Curran T., Morgan J. I., Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats. Journal of Neuroscience 1995 15 6 4238 4249 2-s2.0-0029025008
44. Chiasson B. J., Hong M. G. L., Robertson H. A., Putative roles for the inducible transcription factor c-fos in the central nervous system: studies with antisense oligonucleotides. Neurochemistry International 1997 31 3 459 475 2-s2.0-0030857278 10.1016/S0197-0186(96)00115-5
45. Nawa H., Carnahan J., Call C., BDNF protein measured by a novel enzyme immunoassay in normal brain and after seizure: partial disagreement with mRNA levels. European Journal of Neuroscience 1995 7 7 1527 1535 2-s2.0-0029031207 10.1111/j.1460-9568.1995.tb01148.x
46. Numakawa T., Suzuki S., Kumamaru E., Adachi N., Richards M., Kunugi H., BDNF function and intracellular signaling in neurons. Histology and Histopathology 2010 25 2 237 258 2-s2.0-74449091832
47. Binder D. K., Croll S. D., Gall C. M., Scharfman H. E., BDNF and epilepsy: too much of a good thing? Trends in Neurosciences 2001 24 1 47 53 2-s2.0-0035054951 10.1016/S0166-2236(00)01682-9
48. Wang Y., Qi J.-S., Kong S., Sun Y., Fan J., Jiang M., Chen G., BDNF-TrkB signaling pathway mediates the induction of epileptiform activity induced by a convulsant drug cyclothiazide. Neuropharmacology 2009 57 1 49 59 2-s2.0-67349111087 10.1016/j.neuropharm.2009.04.007
49. Lindholm D., Castren E., Berzaghi M., Blochl A., Thoenen H., Activity-dependent and hormonal regulation of neurotrophin mRNA levels in the brain-implications for neuronal plasticity. Journal of Neurobiology 1994 25 11 1362 1372 2-s2.0-0027970123 10.1002/neu.480251105
50. Elmer E., Kokaia M., Kokaia Z., Ferencz I., Lindvall O., Delayed kindling development after rapidly recurring seizures: relation to messy fiber sprouting and neurotrophin, GAP-43 and dynorphin gene expression. Brain Research 1996 712 1 19 34 2-s2.0-0029982074 10.1016/0006-8993(95)01424-1
51. Isackson P. J., Huntsman M. M., Murray K. D., Gall C. M., BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: temporal patterns of induction distinct from NGF. Neuron 1991 6 6 937 948 2-s2.0-0025883295 10.1016/0896-6273(91)90234-Q
52. Croll S. D., Suri C., Compton D. L., Simmons M. V., Yancopoulos G. D., Lindsay R. M., Wiegand S. J., Rudge J. S., Scharfman H. E., Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience 1999 93 4 1491 1506 2-s2.0-0032765275 10.1016/S0306-4522(99)00296-1
53. Wetmore C., Olson L., Bean A. J., Regulation of brain-derived neurotrophic factor (BDNF) expression and release from hippocampal neurons is mediated by non-NMDA type glutamate receptors. Journal of Neuroscience 1994 14 3 1688 1700 2-s2.0-0028346535
54. Gottschalk W., Pozzo-Miller L. D., Figurov A., Lu B., Presynaptic modulation of synaptic transmission and plasticity by brain- derived neurotrophic factor in the developing hippocampus. Journal of Neuroscience 1998 18 17 6830 6839 2-s2.0-17344369060
55. He X.-P., Minichiello L., Klein R., McNamara J. O., Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. Journal of Neuroscience 2002 22 17 7502 7508 2-s2.0-0036759632
56. Gass P., Kiessling M., Bading H., Regionally selective stimulation of mitogen activated protein (MAP) kinase tyrosine phosphorylation after generalized seizures in the rat brain. Neuroscience Letters 1993 162 1-2 39 42 2-s2.0-0027440120 10.1016/0304-3940(93)90554-X
57. Herdegen T., Blume A., Buschmann T., Georgakopoulos E., Winter C., Schmid W., Hsieh T. F., Zimmermann M., Gass P., Expression of activating transcription factor-2, serum response factor and camp/ca response element binding protein in the adult rat brain following generalized seizures, nerve fibre lesion and ultraviolet irradiation. Neuroscience 1997 81 1 199 212 2-s2.0-0030868260 10.1016/S0306-4522(97)00170-X
58. Heinrich C., Lähteinen S., Suzuki F., Anne-Marie L., Huber S., Häussler U., Haas C., Larmet Y., Castren E., Depaulis A., Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiology of Disease 2011 42 1 35 47 2-s2.0-79751532232 10.1016/j.nbd.2011.01.001
59. Kokaia M., Ernfors P., Kokaia Z., Elmer E., Jaenisch R., Lindvall O., Suppressed epileptogenesis in BDNF mutant mice. Experimental Neurology 1995 133 2 215 224 2-s2.0-0029160413 10.1006/exnr.1995.1024
60. Lähteinen S., Pitkänen A., Saarelainen T., Nissinen J., Koponen E., Castrén E., Decreased BDNF signalling in transgenic mice reduces epileptogenesis. European Journal of Neuroscience 2002 15 4 721 734 2-s2.0-18744409324 10.1046/j.1460-9568.2002.01897.x
61. Frank L., Ventimiglia R., Anderson K., Lindsay R. M., Rudge J. S., BDNF down-regulates neurotrophin responsiveness, TrkB protein and TrkB mRNA levels in cultured rat hippocampal neurons. European Journal of Neuroscience 1996 8 6 1220 1230 2-s2.0-0029946148 10.1111/j.1460-9568.1996.tb01290.x
62. Sommerfeld M. T., Schweigreiter R., Barde Y.-A., Hoppe E., Down-regulation of the neurotrophin receptor TrkB following ligand binding: evidence for an involvement of the proteasome and differential regulation of TrkA and TrkB. Journal of Biological Chemistry 2000 275 12 8982 8990 2-s2.0-0034708738 10.1074/jbc.275.12.8982
63. He X.-P., Kotloski R., Nef S., Luikart B. W., Parada L. F., McNamara J. O., Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. Neuron 2004 43 1 31 42 2-s2.0-3242704193 10.1016/j.neuron.2004. 06.019