15-deoxy-Δ12, 14-prostaglandin J2 ameliorates endotoxin-induced acute lung injury in rats

Chinese Medical Journal

Volumn 127, Issue 5, 2014, Pages 815-820

  Liu, Dong ^a   Geng, Zhi Long ^a   Zhu, Wan Kun ^a   Wang, Hui Wen ^a   Chen, Ye ^a   Liang, Juan ^a  

^a LANZHOU GENERAL HOSPITAL   (China)

Author keywords

15 deoxy 12, 14 prostaglandin J2; Acute lung injury; Endotoxin; Nuclear factor kappa B

Indexed keywords

15 DEOXY DELTA12, 14 PROSTAGLANDIN J2; CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; MYELOPEROXIDASE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; 15-DEOXYPROSTAGLANDIN J2; CXCL1 CHEMOKINE; CXCL1 PROTEIN, RAT; I KAPPA B; NF-KAPPAB INHIBITOR ALPHA; PROSTAGLANDIN D2;

ACUTE LUNG INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER WEIGHT; LUNG CIRCULATION; LUNG EDEMA; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; THORACOTOMY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; IMMUNOLOGY; METABOLISM; TOXICITY; WISTAR RAT;

ACUTE LUNG INJURY; ANIMALS; CHEMOKINE CXCL1; I-KAPPA B PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MALE; NF-KAPPA B; PROSTAGLANDIN D2; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84896846041     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.20131079     Document Type: Article

References (24)

1. Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342:1334-1349.
2. Balibrea JL, Arias-Dĺaz J. Acute respiratory distress syndrome in the septic surgical patient. World J Surg 2003; 27:1275-1284.
3. Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, Luo X, et al. Characterization of a murine model of endotoxin-induced acute lung injury. Shock 2002; 17: 300-303.
4. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol 2004; 202:145-156.
5. Shang Y, Jiang YX, Xu SP, Wu Y, Wu ZY, Yuan SY, et al. Reduction of pulmonary inflammatory response by erythropoietin in a rat model of endotoxaemia. Chin Med J 2009; 122: 834-838.
6. Fan J, Ye RD, Malik AB. Transcriptional mechanisms of acute lung injury. Am J Physiol Lung Cell Mol Physiol 2001; 281: L1037-L1050.
7. Surh YJ, Na HK, Park JM, Lee HN, Kim W, Yoon IS, et al. 15-deoxy-Δ12, 14-prostaglandin J2, an electrophilic lipid mediator of anti-inflammatory and pro-resolving signaling. Biochem Pharmacol 2011; 82: 1335-1351.
8. Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK. The peroxisome proliferator activated receptor-γ is a negative regulator of macrophage activation. Nature 1998; 391: 79-82.
9. Guyton K, Zingarelli B, Ashton S, Teti G, Tempel G, Reilly C, et al. Peroxisome proliferator-activated receptor-γ agonists modulate macrophage activation by gram-negative and gram-positive bacterial stimuli. Shock 2003; 20: 56-62.
10. Straus DS, Pascual G, Li M, Welch JS, Ricote M, Hsiang CH, et al. 15-deoxy-Δ12, 14-prostaglandin J2 inhibits multiple steps in the NF-kappa B signaling pathway. Proc Natl Acad Sci USA 2000; 97:4844-4849.
11. Castrillo A, Diaz-Guerra MJ, Hortelano S, Martin-Sanz P, Bosca L. Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Δ12, 14-prostaglandin J2 in activated murine macrophages. Mol Cell Biol 2000; 20: 1692-1698.
12. Zingarelli B, Sheehan M, Hake PW, O'Connor M, Denenberg A, Cook JA. Peroxisome proliferator activator receptor-γ ligands, 15-deoxy-Δ12, 14-prostaglandin J2 and ciglitazone, reduce systemic inflammation in polymicrobial sepsis by modulation of signal transduction pathyways. J Immunol 2003; 171: 6827-6837.
13. Hashimoto K, Ethridge RT, Saito H, Rajaraman S, Evers BM. The PPARγ ligand, 15d-PGJ2, attenuates the severity of cerulein-induced acute pancreatitis. Pancreas 2003; 27: 58-66.
14. Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Patel NS, Di Paola R, et al. Rosiglitazone and 15-deoxy-Δ12, 14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-γ (PPAR-γ), reduce ischaemia/reperfusion injury of the gut. Br J Pharmacol 2003; 140: 366-376.
15. Genovese T, Cuzzocrea S, Di Paola R, Mazzon E, Mastruzzo C, Catalano P, et al. Effect of rosiglitazone and 15-deoxy-Δ12, 14-prostaglandin J2 on bleomycin-induced lung injury. Eur Respir J 2005; 25: 225-234.
16. Abdelrahman M, Collin M, Thiemermann C. The peroxisome proliferator activator receptor-γ ligand 15-deoxy-Δ12, 14-prostaglandin J2 reduces the organ injury in hemorrhagic shock. Shock 2004; 22: 555-561.
17. Liu D, Zeng BX, Zhang SH, Wang YL, Zeng L, Geng ZL, et al. Rosiglitazone, a peroxisome proliferator-activated receptor-γ agonist, reduces acute lung injury in endotoxemic rats. Crit Care Med 2005; 33: 2309-2316.
18. Liu D, Zeng BX, Zhang SH, Yao SL. Rosiglitazone, an agonist of peroxisome proliferator-activated receptor γ, reduces pulmonary inflammatory response in a rat model of endotoxemia. Inflamm Res 2005; 54: 464-470.
19. Lee WL, Downey GP. Neutrophil activation and acute lung injury. Curr Opin Crit Care 2001; 7: 1-7.
20. Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, et al. Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. Proc Natl Acad Sci USA 2013; 110: 5205-5210.
21. Rajakariar R, Hilliard M, Lawrence T, Trivedi S, Colville-Nash P, Bellingan G, et al. Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxy-Δ12, 14-prostaglandin J2. Proc Natl Acad Sci USA 2007; 104: 20979-20984.
22. Kamochi M, Kamochi F, Kim YB, Sawh S, Sanders JM, Sarembock I, et al. P-selectin and ICAM-1 mediate endotoxin-induced neutrophil recruitment and injury to the lung and liver. Am J Physiol 1999; 277: L310-L319.
23. Ali S, Mann DA. Signal transduction via the NF-κB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct 2004; 22: 67-79.
24. Kaplan JM, Cook JA, Hake PW, O'Connor M, Burroughs TJ, Zingarelli B. 15-deoxy-Δ12, 14-prostaglandin J2, a peroxisome proliferator activated receptor γ ligand, reduces tissue leukosequestration and mortality in endotoxic shock. Shock 2005; 24: 59-65.