Pattern of microbial translocation in patients living with HIV-1 from Vietnam, Ethiopia and Sweden

Journal of the International AIDS Society

Volumn 17, Issue , 2014, Pages

  Abdurahman, Samir ^a   Barqasho, Babilonia ^a   Nowak, Piotr ^a   Cuong, Do Duy ^b   Amogne, Wondwossen ^c   Larsson, Mattias ^d,e   Lindquist, Lars ^a   Marrone, Gaetano ^d   Sönnerborg, Anders ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b BACH MAI HOSPITAL   (Viet Nam)

^c ADDIS ABABA UNIVERSITY   (Ethiopia)

^d KAROLINSKA INSTITUTE   (Sweden)

^e OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

Author keywords

HIV in Ethiopia; HIV in Sweden; HIV in Vietnam; Immune activation; LPS; Microbial translocation; sCD14; Treatment na ve patients living with HIV

Indexed keywords

ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; FLAGELLIN; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDE; TUBERCULOSTATIC AGENT;

ADULT; ARTICLE; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; ETHIOPIA; FEMALE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; RACE DIFFERENCE; SWEDEN; VIET NAM;

HIV IN ETHIOPIA; HIV IN SWEDEN; HIV IN VIETNAM; IMMUNE ACTIVATION; LPS; MICROBIAL TRANSLOCATION; SCD14; TREATMENT-NAÏVE PATIENTS LIVING WITH HIV;

ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; ANTIGENS, CD14; BACTERIAL TRANSLOCATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ETHIOPIA; FEMALE; FLAGELLIN; HIV INFECTIONS; HIV-1; HUMANS; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; SWEDEN; VIETNAM; VIRAL LOAD;

EID: 84896819433     PISSN: None     EISSN: 17582652     Source Type: Journal    
DOI: 10.7448/IAS.17.1.18841     Document Type: Article

References (20)

1. Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365-71. (Pubitemid 44924494)
2. Ancuta P, Kamat A, Kunstman KJ, Kim EY, Autissier P, Wurcel A, et al. Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients. PLoS One. 2008;3:e2516.
3. Schoepfer AM, Schaffer T, Seibold-Schmid B, Muller S, Seibold F. Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients. Neurogastroenterol Motil. 2008;20:1110-8.
4. Targan SR, Landers CJ, Yang H, Lodes MJ, Cong Y, Papadakis KA, et al. Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn's disease. Gastroenterology. 2005;128:2020-8. (Pubitemid 40824710)
5. Lodes MJ, Cong Y, Elson CO, Mohamath R, Landers CJ, Targan SR, et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest. 2004;113:1296-306. (Pubitemid 39069929)
6. Troseid M, Nowak P, Nystrom J, Lindkvist A, Abdurahman S, Sonnerborg A. Elevated plasma levels of lipopolysaccharide and high mobility group box-1 protein are associated with high viral load in HIV-1 infection: reduction by 2-year antiretroviral therapy. AIDS. 2010;24:1733-7.
7. Nowak P, Abdurahman S, Lindkvist A, Troseid M, Sonnerborg A. Impact of HMGB1/TLR ligand complexes on HIV-1 replication: possible role for flagellin during HIV-1 infection. Int J Microbiol. 2012;2012:263836.
8. Vesterbacka J, Nowak P, Barqasho B, Abdurahman S, Nystrom J, Nilsson S, et al. Kinetics of microbial translocation markers in patients on efavirenz or lopinavir/r based antiretroviral therapy. PLoS One. 2013;8:e55038.
9. Redd AD, Dabitao D, Bream JH, Charvat B, Laeyendecker O, Kiwanuka N, et al. Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa. Proc Natl Acad Sci U S A. 2009;106:6718-23.
10. Lester RT, Yao XD, Ball TB, McKinnon LR, Omange WR, Kaul R, et al. HIV-1 RNA dysregulates the natural TLR response to subclinical endotoxemia in Kenyan female sex-workers. PLoS One. 2009;4:e5644.
11. Cassol E, Malfeld S, Mahasha P, van der Merwe S, Cassol S, Seebregts C, et al. Persistent microbial translocation and immune activation in HIV-1-infected South Africans receiving combination antiretroviral therapy. J Infect Dis. 2010;202:723-33.
12. Cuong do D, Thorson A, Sonnerborg A, Hoa NP, Chuc NT, Phuc HD, et al. Survival and causes of death among HIV-infected patients starting antiretroviral therapy in north-eastern Vietnam. Scand J Infect Dis. 2012;44:201-8.
13. El-Sadr WM, Tsiouris SJ. HIV-associated tuberculosis: diagnostic and treatment challenges. Semin Respir Crit Care Med. 2008;29:525-31.
14. Borkow G, Bentwich Z. Chronic immune activation associated with chronic helminthic and human immunodeficiency virus infections: role of hyporesponsiveness and anergy. Clin Microbiol Rev. 2004;17:1012-30. table of contents. (Pubitemid 39372528)
15. Toossi Z, Funderburg NT, Sirdeshmuk S, Whalen CC, Nanteza MW, Johnson DF, et al. Systemic immune activation and microbial translocation in dual HIV/tuberculosis-infected subjects. J Infect Dis. 2013;207:1841-9.
16. Baroncelli S, Galluzzo CM, Pirillo MF, Mancini MG, Weimer LE, Andreotti M, et al. Microbial translocation is associated with residual viral replication in HAART-treated HIV+ subjects with <50 copies/ml HIV-1 RNA. J Clin Virol. 2009;46:367-70.
17. Dye C, Williams BG. The population dynamics and control of tuberculosis. Science. 2010;328:856-61.
18. McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, Liu Z, et al. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoS Pathog. 2008;4:e20.
19. Kuller LH, Tracy R, Belloso W, Wit SD, Drummond F, Lane HC, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Med. 2008;5:e203.
20. Sandler NG, Wand H, Roque A, Law M, Nason MC, Nixon DE, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis. 2011;203:780-90.