Small synthetic hyaluronan disaccharides afford neuroprotection in brain ischemia-related models

Neuroscience

Volumn 265, Issue , 2014, Pages 313-322

  Egea, J ^a,c   Parada, E ^a   Gomez Rangel V ^a   Buendia, I ^a   Negredo, P ^e   Montell, E ^d   Ruhi R ^d   Verges J ^d   Roda, J M ^b   Garcia A G ^a,c   Lopez M G ^a,c  

^a INSTITUTO TEÓFILO HERNANDO   (Spain)

^b HOSPITAL UNIVERSITARIO LA PAZ IDIPAZ   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d BIOIBERICA SA   (Spain)

^e UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Hyaluronan disaccharides; Ischemia; Neuroprotection; Oxidative stress

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; DISODIUM SALT; GLUTATHIONE; HYALURONIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; METHYL 2 ACETAMIDO 2 DEOXY 3 O (BETA GLUCOPYRANOSYLURONIC ACID) 4,6 DI O SULFO A GLUCOPYRANOSIDE; METHYL 2 ACETAMIDO 2 DEOXY 3 O (BETA GLUCOPYRANOSYLURONIC ACID) 6 DI O SULFO A GLUCOPYRANOSIDE; METHYL 2 ACETAMIDO 2 DEOXY 3 O (BETA GLUCOPYRANOSYLURONIC ACID) O SULFO A GLUCOPYRANOSIDE; NEUROPROTECTIVE AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTECTIVE AGENT; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SODIUM; SODIUM CHLORIDE; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; DISACCHARIDE; METHYL 2-ACETAMIDO-2-DEOXY-3-O-(GLUCOPYRANOSYLURONIC ACID)-4,6-DI-O-SULFOGLUCOPYRANOSIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN SLICE; CELL DEATH; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR ACTIVITY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SULFATION; ANIMAL; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MOUSE; SPRAGUE DAWLEY RAT;

ANIMALS; BRAIN ISCHEMIA; CELL SURVIVAL; DISACCHARIDES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYALURONIC ACID; MALE; MICE; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES;

EID: 84896818550     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.01.032     Document Type: Article

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