The simultaneous determination of hydrophobicity and dissociation constant by liquid chromatography-mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis

Volumn 94, Issue , 2014, Pages 180-187

  Wiczling, P ^a   Struck Lewicka, W ^a   Kubik, Ł ^a   Siluk, D ^a   Markuszewski, M J ^a   Kaliszan, R ^a  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

Author keywords

Acidity; Gradient RP HPLC; Hydrophobicity; PH organic modifier; Throughput analysis

Indexed keywords

AMINOPHENAZONE; AMITRIPTYLINE; AMMONIUM ACETATE; AMMONIUM FORMATE; BUFFER; CHLORPHENIRAMINE; CIMETIDINE; CLONIDINE; COCAINE; DICLOFENAC; DIPHENHYDRAMINE; IMIPRAMINE; LIDOCAINE; METOCLOPRAMIDE; METOPROLOL; METRONIDAZOLE; NICOTINE; NORTRIPTYLINE; PARACETAMOL; PHENOBARBITAL; PHENYLBUTAZONE; PINDOLOL; PROCAINAMIDE; PROCAINE; PROMETHAZINE; SALICYLIC ACID; TETRACAINE; THEOPHYLLINE; UNINDEXED DRUG; WARFARIN;

ACCURACY; ARTICLE; DISSOCIATION CONSTANT; ELECTROSPRAY MASS SPECTROMETRY; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; IONIC STRENGTH; LIPOPHILICITY; METHODOLOGY; PARTITION COEFFICIENT; PH; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TIME OF FLIGHT MASS SPECTROMETRY;

ACIDITY; GRADIENT RP HPLC; HYDROPHOBICITY; PH/ORGANIC MODIFIER; THROUGHPUT ANALYSIS;

BUFFERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; PROTON-MOTIVE FORCE;

EID: 84896807902     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.01.038     Document Type: Article

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