Chronic low dose-rate radiation down-regulates transcription related to mitosis and chromosomal movement similar to acute high dose in prostate cells

International Journal of Radiation Biology

Volumn 90, Issue 3, 2014, Pages 231-240

  McDonald, J Tyson ^a   Briggs, Christine ^a   Szelag, Heather ^a   Peluso, Michael ^a   Schneider, Douglas ^b   Perepletchikov, Aleksandr ^b   Klement, Giannoula Lakka ^a   Tuerk, Ingolf ^b   Hlatky, Lynn ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST ELIZABETH'S MEDICAL CENTER   (United States)

Author keywords

Gene expression; Ionizing radiation; Low dose rate; Low dose effects; Prostate; Risk assessment

Indexed keywords

CESIUM 137; COBALT 57; CYCLIN DEPENDENT KINASE INHIBITOR 2A; HEME OXYGENASE 1; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR RB1; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE M PHASE; CELL DEATH; CELL MOTION; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOME; COMPARATIVE STUDY; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOWN REGULATION; FIBROBLAST CULTURE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MITOSIS; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION DOSE DISTRIBUTION; RADIATION EXPOSURE; RADIOSENSITIVITY;

ALGORITHMS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHROMOSOMES; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; DOWN-REGULATION; FIBROBLASTS; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MITOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROSTATE; RADIATION, IONIZING; RECOMBINATION, GENETIC;

EID: 84896769398     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553002.2014.877175     Document Type: Article

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