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Selected examples: (a) Konkel, M. J.; Lagu, B.; Boteju, L. W.; Jimenez, H.; Noble, S.; Walker, M. W.; Chandrasena, G.; Blackburn, T. P.; Nikam, S. S.; Wright, J. L.; Kornberg, B. E.; Gregory, T.; Pugsley, T. A.; Akunne, H.; Zoski, K.; Wise, L. D. J. Med. Chem. 2006, 49, 3757.
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We have already separated and characterized the byproduct 2a-7 by 1H NMR, 13C NMR, and HRMS spectra (see SI for more detail)
-
We have already separated and characterized the byproduct 2a-7 by 1H NMR, 13C NMR, and HRMS spectra (see SI for more detail).
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35
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84896757405
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2a-6 is not stable. We tried to purify this key intermediate; unfortunately, this compound is easily oxidized to 3a even using preparative HPLC
-
2a-6 is not stable. We tried to purify this key intermediate; unfortunately, this compound is easily oxidized to 3a even using preparative HPLC.
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