Effects of growth hormone administration for 6months on bone turnover and bone marrow fat in obese premenopausal women

Bone

Volumn 62, Issue , 2014, Pages 29-35

  Bredella, Miriam A ^a   Gerweck, Anu V ^b   Barber, Lauren A ^a   Breggia, Anne ^c   Rosen, Clifford J ^c   Torriani, Martin ^a   Miller, Karen K ^b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c Maine Medical Center Research Institute   (United States)

Author keywords

Bone; Bone marrow fat; Bone turnover; Growth hormone; MR spectroscopy; Obesity

Indexed keywords

APOLIPOPROTEIN B; C REACTIVE PROTEIN; GROWTH HORMONE; OSTEOCALCIN; PLACEBO; SOMATOMEDIN C; BIOLOGICAL MARKER; PEPTIDE FRAGMENT; PROCOLLAGEN; PROCOLLAGEN TYPE I N-TERMINAL PEPTIDE;

ABDOMINAL OBESITY; ADULT; ARTICLE; BODY COMPOSITION; BONE DENSITY; BONE MARROW; BONE TURNOVER; CELL DIFFERENTIATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; HORMONE RELEASE; HUMAN; INFLAMMATION; LEAN BODY WEIGHT; MAJOR CLINICAL STUDY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OSSIFICATION; PREMENOPAUSE; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; BONE; BONE DEVELOPMENT; BONE REMODELING; DRUG EFFECTS; METABOLISM; OBESITY; PATHOLOGY; PATHOPHYSIOLOGY; REGRESSION ANALYSIS; TIME FACTOR;

ADIPOSITY; ADULT; APOLIPOPROTEINS B; BIOMARKERS; BODY COMPOSITION; BONE AND BONES; BONE MARROW; BONE REMODELING; FEMALE; GROWTH HORMONE; HUMANS; INFLAMMATION; OBESITY; OSTEOCALCIN; OSTEOGENESIS; PEPTIDE FRAGMENTS; PLACEBOS; PREMENOPAUSE; PROCOLLAGEN; PROTON MAGNETIC RESONANCE SPECTROSCOPY; REGRESSION ANALYSIS; TIME FACTORS;

EID: 84896739131     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.01.022     Document Type: Article

References (42)

1. Cohen A., Dempster D.W., Recker R.R., Lappe J.M., Zhou H., Zwahlen A., et al. Abdominal fat is associated with lower bone formation and inferior bone quality in healthy premenopausal women: a transiliac bone biopsy study. J Clin Endocrinol Metab 2013 Jun, 98(6):2562-2572.
2. Compston J.E., Watts N.B., Chapurlat R., Cooper C., Boonen S., Greenspan S., et al. Obesity is not protective against fracture in postmenopausal women: GLOW. Am J Med 2011 Nov, 124(11):1043-1050.
3. Bredella M.A., Torriani M., Ghomi R.H., Thomas B.J., Brick D.J., Gerweck A.V., et al. Determinants of bone mineral density in obese premenopausal women. Bone 2011 Apr 1, 48(4):748-754.
4. Bredella M.A., Torriani M., Ghomi R.H., Thomas B.J., Brick D.J., Gerweck A.V., et al. Vertebral bone marrow fat is positively associated with visceral fat and inversely associated with IGF-1 in obese women. Obesity (Silver Spring) 2011 Jan, 19(1):49-53.
5. Gilsanz V., Chalfant J., Mo A.O., Lee D.C., Dorey F.J., Mittelman S.D. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab 2009 Sep, 94(9):3387-3393.
6. Giustina A., Mazziotti G., Canalis E. Growth hormone, insulin-like growth factors, and the skeleton. Endocr Rev 2008 Aug, 29(5):535-559.
7. Gevers E.F., Loveridge N., Robinson I.C. Bone marrow adipocytes: a neglected target tissue for growth hormone. Endocrinology 2002 Oct, 143(10):4065-4073.
8. Takada I., Suzawa M., Matsumoto K., Kato S. Suppression of PPAR transactivation switches cell fate of bone marrow stem cells from adipocytes into osteoblasts. Ann N Y Acad Sci 2007 Nov, 1116:182-195.
9. Baum H.B., Biller B.M., Finkelstein J.S., Cannistraro K.B., Oppenhein D.S., Schoenfeld D.A., et al. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med 1996 Dec 1, 125(11):883-890.
10. Appiagyei-Dankah Y., Tapiador C.D., Evans J.F., Castro-Magana M., Aloia J.F., Yeh J.K. Influence of growth hormone on bone marrow adipogenesis in hypophysectomized rats. Am J Physiol Endocrinol Metab 2003 Mar, 284(3):E566-E573.
11. Rosen C.J., Ackert-Bicknell C., Rodriguez J.P., Pino A.M. Marrow fat and the bone microenvironment: developmental, functional, and pathological implications. Crit Rev Eukaryot Gene Expr 2009, 19(2):109-124.
12. Koh J.M., Khang Y.H., Jung C.H., Bae S., Kim D.J., Chung Y.E., et al. Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre- and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 2005 Oct, 16(10):1263-1271.
13. Parhami F., Jackson S.M., Tintut Y., Le V., Balucan J.P., Territo M., et al. Atherogenic diet and minimally oxidized low density lipoprotein inhibit osteogenic and promote adipogenic differentiation of marrow stromal cells. J Bone Miner Res 1999 Dec, 14(12):2067-2078.
14. Bredella M.A., Lin E., Brick D.J., Gerweck A.V., Harrington L.M., Torriani M., et al. Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial. Eur J Endocrinol 2012 Apr, 166(4):601-611.
15. Lean M.E., Han T.S., Morrison C.E. Waist circumference as a measure for indicating need for weight management. BMJ 1995 Jul 15, 311(6998):158-161.
16. Bredella M.A., Ghomi R.H., Thomas B.J., Miller K.K., Torriani M. Comparison of 3.0T proton magnetic resonance spectroscopy short and long echo-time measures of intramyocellular lipids in obese and normal-weight women. J Magn Reson Imaging 2010 Aug, 32(2):388-393.
17. Bredella M.A., Ghomi R.H., Thomas B.J., Ouellette H.A., Sahani D.V., Miller K.K., et al. Breath-hold 1H-magnetic resonance spectroscopy for intrahepatic lipid quantification at 3 Tesla. J Comput Assist Tomogr 2010 May-Jun, 34(3):372-376.
18. Bredella M.A., Ghomi R.H., Thomas B.J., Torriani M., Brick D.J., Gerweck A.V., et al. Comparison of DXA and CT in the assessment of body composition in premenopausal women with obesity and anorexia nervosa. Obesity (Silver Spring) 2010 Nov, 18(11):2227-2233.
19. Bredella M.A., Torriani M., Ghomi R.H., Thomas B.J., Brick D.J., Gerweck A.V., et al. Adiponectin is inversely associated with intramyocellular and intrahepatic lipids in obese premenopausal women. Obesity (Silver Spring) 2011 May, 19(5):911-916.
20. Bredella M.A., Torriani M., Thomas B.J., Ghomi R.H., Brick D.J., Gerweck A.V., et al. Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity. J Clin Endocrinol Metab 2009 Oct, 94(10):3995-4002.
21. Bredella M.A., Utz A.L., Torriani M., Thomas B., Schoenfeld D.A., Miller K.K. Anthropometry, CT, and DXA as predictors of GH deficiency in premenopausal women: ROC curve analysis. J Appl Physiol 2009 Feb, 106(2):418-422.
22. Bredella M.A., Fazeli P.K., Miller K.K., Misra M., Torriani M., Thomas B.J., et al. Increased bone marrow fat in anorexia nervosa. J Clin Endocrinol Metab 2009 Jun, 94(6):2129-2136.
23. Cauley J.A., Danielson M.E., Boudreau R.M., Forrest K.Y., Zmuda J.M., Pahor M., et al. Inflammatory markers and incident fracture risk in older men and women: the Health Aging and Body Composition Study. J Bone Miner Res 2007 Jul, 22(7):1088-1095.
24. Parhami F., Morrow A.D., Balucan J., Leitinger N., Watson A.D., Tintut Y., et al. Lipid oxidation products have opposite effects on calcifying vascular cell and bone cell differentiation. A possible explanation for the paradox of arterial calcification in osteoporotic patients. Arterioscler Thromb Vasc Biol 1997 Apr, 17(4):680-687.
25. Edwards C.J., Hart D.J., Spector T.D. Oral statins and increased bone-mineral density in postmenopausal women. Lancet 2000 Jun 24, 355(9222):2218-2219.
26. Hernandez J.L., Olmos J.M., Romana G., Martinez J., Castillo J., Yezerska I., et al. Bone mineral density in statin users: a population-based analysis from a Spanish cohort. J Bone Miner Metab 2013 Jun 20, PMID: 23784551 [Electronic publication ahead of print].
27. Adami S., Braga V., Guidi G., Gatti D., Gerardi D., Fracassi E. Chronic intravenous aminobisphosphonate therapy increases high-density lipoprotein cholesterol and decreases low-density lipoprotein cholesterol. J Bone Miner Res 2000 Mar, 15(3):599-604.
28. Snijder M.B., van Dam R.M., Visser M., Deeg D.J., Dekker J.M., Bouter L.M., et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 2005 Jul, 90(7):4119-4123.
29. Pijl H., Langendonk J.G., Burggraaf J., Frolich M., Cohen A.F., Veldhuis J.D., et al. Altered neuroregulation of GH secretion in viscerally obese premenopausal women. J Clin Endocrinol Metab 2001 Nov, 86(11):5509-5515.
30. Hansen T.B., Brixen K., Vahl N., Jorgensen J.O., Christiansen J.S., Mosekilde L., et al. Effects of 12months of growth hormone (GH) treatment on calciotropic hormones, calcium homeostasis, and bone metabolism in adults with acquired GH deficiency: a double blind, randomized, placebo-controlled study. J Clin Endocrinol Metab 1996 Sep, 81(9):3352-3359.
31. Hubina E., Lakatos P., Kovacs L., Szabolcs I., Racz K., Toth M., et al. Effects of 24months of growth hormone (GH) treatment on serum carboxylated and undercarboxylated osteocalcin levels in GH-deficient adults. Calcif Tissue Int 2004 Jan, 74(1):55-59.
32. Ferron M., Wei J., Yoshizawa T., Del Fattore A., DePinho R.A., Teti A., et al. Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 2010 Jul 23, 142(2):296-308.
33. Fulzele K., Riddle R.C., DiGirolamo D.J., Cao X., Wan C., Chen D., et al. Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 2010 Jul 23, 142(2):309-319.
34. Lee N.K., Sowa H., Hinoi E., Ferron M., Ahn J.D., Confavreux C., et al. Endocrine regulation of energy metabolism by the skeleton. Cell 2007 Aug 10, 130(3):456-469.
35. Menagh P.J., Turner R.T., Jump D.B., Wong C.P., Lowry M.B., Yakar S., et al. Growth hormone regulates the balance between bone formation and bone marrow adiposity. J Bone Miner Res 2010 Apr, 25(4):757-768.
36. Andersen M., Jensen C.H., Stoving R.K., Larsen J.B., Schroder H.D., Teisner B., et al. Fetal antigen 1 in healthy adults and patients with pituitary disease: relation to physiological, pathological, and pharmacological GH levels. J Clin Endocrinol Metab 2001 Nov, 86(11):5465-5470.
37. Abdallah B.M., Ding M., Jensen C.H., Ditzel N., Flyvbjerg A., Jensen T.G., et al. Dlk1/FA1 is a novel endocrine regulator of bone and fat mass and its serum level is modulated by growth hormone. Endocrinology 2007 Jul, 148(7):3111-3121.
38. Jorgensen J.O., Vahl N., Hansen T.B., Skjaerbaek C., Fisker S., Orskov H., et al. Determinants of serum insulin-like growth factor I in growth hormone deficient adults as compared to healthy subjects. Clin Endocrinol (Oxf) 1998 Apr, 48(4):479-486.
39. Bollerslev J., Ueland T., Jorgensen A.P., Fougner K.J., Wergeland R., Schreiner T., et al. Positive effects of a physiological dose of GH on markers of atherogenesis: a placebo-controlled study in patients with adult-onset GH deficiency. Eur J Endocrinol 2006 Apr, 154(4):537-543.
40. Wei S., Tanaka H., Kubo T., Ono T., Kanzaki S., Seino Y. Growth hormone increases serum 1,25-dihydroxyvitamin D levels and decreases 24,25-dihydroxyvitamin D levels in children with growth hormone deficiency. Eur J Endocrinol 1997 Jan, 136(1):45-51.
41. Fidler M.C., Sanchez M., Raether B., Weissman N.J., Smith S.R., Shanahan W.R., et al. A one-year randomized trial of lorcaserin for weight loss in obese and overweight adults: the BLOSSOM trial. J Clin Endocrinol Metab 2011 Oct, 96(10):3067-3077.
42. James W.P., Caterson I.D., Coutinho W., Finer N., Van Gaal L.F., Maggioni A.P., et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. N Engl J Med 2010 Sep 2, 363(10):905-917.