Conduit artery structure and function in lowlanders and native highlanders: Relationships with oxidative stress and role of sympathoexcitation

Journal of Physiology

Volumn 592, Issue 5, 2014, Pages 1009-1024

  Lewis, Nia C S ^a   Bailey, Damian M ^b   DuManoir, Gregory R ^a   Messinger, Laura ^a   Lucas, Samuel J E ^c,d   Cotter, James D ^c   Donnelly, Joseph ^c   McEneny, Jane ^e   Young, Ian S ^e   Stembridge, Mike ^f   Burgess, Keith R ^g   Basnet, Aparna S ^h   Ainslie, Philip N ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF GLAMORGAN   (United Kingdom)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^f CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^g Peninsula Sleep Laboratory   (Australia)

^h Banner Good Samaritan Health Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ALPHA 1 ADRENERGIC RECEPTOR; ANTIOXIDANT; FREE RADICAL; GLYCERYL TRINITRATE; LIPID HYDROPEROXIDE; NITRITE; OXYGEN;

ACUTE DISEASE; ADRENERGIC STIMULATION; ADULT; ALLOMETRY; ALPHA ADRENERGIC RECEPTOR BLOCKING; ALTITUDE ACCLIMATIZATION; ALTITUDE DISEASE; ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ARTERY BLOOD FLOW; ARTERY DILATATION; ARTERY DISEASE; ARTERY ENDOTHELIUM; ARTICLE; BLOOD VESSEL FUNCTION; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CEPHALIC VEIN; COMMON CAROTID ARTERY; CONTROLLED STUDY; ECHOGRAPHY; FEMALE; FOLLOW UP; HUMAN; HYPOXIA; LIPID PEROXIDATION; LOW DRUG DOSE; MALE; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULSE WAVE; STRUCTURE ANALYSIS; TONOMETRY;

ACCLIMATIZATION; ADULT; ALTITUDE; ANOXIA; BLOOD PRESSURE; CAROTID ARTERIES; CAROTID INTIMA-MEDIA THICKNESS; FEMALE; HUMANS; MALE; MUSCLE, SMOOTH, VASCULAR; OXIDATION-REDUCTION; PLACEBO EFFECT; PRESSURE; REACTIVE OXYGEN SPECIES; SYMPATHETIC NERVOUS SYSTEM; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 84896735434     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2013.268615     Document Type: Article

References (72)

1. Ainslie PN & Ogoh S (2010). Regulation of cerebral blood flow in mammals during chronic hypoxia: a matter of balance. Exp Physiol 95, 251-262.
2. Atkinson G & Batterham AM (2013). Allometric scaling of diameter change in the original flow-mediated dilation protocol. Atherosclerosis 226, 425-427.
3. Atkinson G, Batterham AM, Black MA, Cable NT, Hopkins ND, Dawson EA, Thijssen DH, Jones H, Tinken TM & Green DJ (2009). Is the ratio of flow-mediated dilation and shear rate a statistically sound approach to normalization in cross-sectional studies on endothelial function? J Appl Physiol 107, 1893-1899.
4. Atkinson G, Batterham AM, Thijssen DH & Green DJ (2013). A new approach to improve the specificity of flow-mediated dilation for indicating endothelial function in cardiovascular research. J Hypertens 31, 287-291.
5. Avolio AP, Deng FQ, Li WQ, Luo YF, Huang ZD, Xing LF & O'Rourke MF (1985). Effects of aging on arterial distensibility in populations with high and low prevalence of hypertension: comparison between urban and rural communities in China. Circulation 71, 202-210.
6. Awan NA, Miller RR, Maxwell K & Mason DT (1977). Effects of prazosin on forearm resistance and capacitance vessels. Clin Pharmacol Ther 22, 79-84.
7. Bailey DM, Rimoldi SF, Rexhaj E, Pratali L, Salinas Salmon C, Villena M, McEneny J, Young IS, Nicod P, Allemann Y, Scherrer U & Sartori C (2013). Oxidative-nitrosative stress and systemic vascular function in highlanders with and without exaggerated hypoxemia. Chest 143, 444-451.
8. Basnyat B, Gertsch JH, Holck PS, Johnson EW, Luks AM, Donham BP, Fleischman RJ, Gowder DW, Hawksworth JS, Jensen BT, Kleiman RJ, Loveridge AH, Lundeen EB, Newman SL, Noboa JA, Miegs DP, O'Beirne KA, Philpot KB, Schultz MN, Valente MC, Wiebers MR & Swenson ER (2006). Acetazolamide 125 mg BD is not significantly different from 375 mg BD in the prevention of acute mountain sickness: the prophylactic acetazolamide dosage comparison for efficacy (PACE) trial. High Alt Med Biol 7, 17-27.
9. Beall CM (2007). Detecting natural selection in high-altitude human populations. Respir Physiol Neurobiol 158, 161-171.
10. Beall CM, Laskowski D & Erzurum SC (2012). Nitric oxide in adaptation to altitude. Free Radic Biol Med 52, 1123-1134.
11. Black MA, Cable NT, Thijssen DH & Green DJ (2008). Importance of measuring the time course of flow-mediated dilatation in humans. Hypertension 51, 203-210.
12. Bruno RM, Ghiadoni L, Seravalle G, Dell'oro R, Taddei S & Grassi G (2012). Sympathetic regulation of vascular function in health and disease. Front Physiol 3, 284.
13. Catignani GL & Bieri JG (1983). Simultaneous determination of retinol and alpha-tocopherol in serum or plasma by liquid chromatography. Clin Chem 29, 708-712.
14. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J & Vogel R (2002). Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39, 257-265.
15. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO, 3rd & Gladwin MT (2003). Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9, 1498-1505.
16. Doshi SN, Naka KK, Payne N, Jones CJ, Ashton M, Lewis MJ & Goodfellow J (2001). Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond) 101, 629-635.
17. Duplain H, Vollenweider L, Delabays A, Nicod P, Bartsch P & Scherrer U (1999). Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation 99, 1713-1718.
18. Dweik RA (2005). Nitric oxide, hypoxia, and superoxide: the good, the bad, and the ugly! Thorax 60, 265-267.
19. Dyson KS, Shoemaker JK & Hughson RL (2006). Effect of acute sympathetic nervous system activation on flow-mediated dilation of brachial artery. Am J Physiol Heart Circ Physiol 290, H1446-H1453.
20. Fok H, Jiang B, Clapp B & Chowienczyk P (2012). Regulation of vascular tone and pulse wave velocity in human muscular conduit arteries: selective effects of nitric oxide donors to dilate muscular arteries relative to resistance vessels. Hypertension 60, 1220-1225.
21. Frick M, Rinner A, Mair J, Alber HF, Mittermayr M, Pachinger O, Humpeler E, Schobersberger W & Weidinger F (2006). Transient impairment of flow-mediated vasodilation in patients with metabolic syndrome at moderate altitude (1, 700 m). Int J Cardiol 109, 82-87.
22. Green D (2005). Point: Flow-mediated dilation does reflect nitric oxide-mediated endothelial function. J Appl Physiol 99, 1233-1234; (discussion 1237-1238).
23. Green DJ, Bilsborough W, Naylor LH, Reed C, Wright J, O'Driscoll G & Walsh JH (2005). Comparison of forearm blood flow responses to incremental handgrip and cycle ergometer exercise: relative contribution of nitric oxide. J Physiol 562, 617-628.
24. Green DJ, Jones H, Thijssen D, Cable NT & Atkinson G (2012). Flow-mediated dilation and cardiovascular event prediction: does nitric oxide matter? Hypertension 57, 363-369.
25. Green DJ, Rowley N, Spence A, Carter H, Whyte G, George K, Naylor LH, Cable NT, Dawson EA & DH JT (2013). Why isn't flow-mediated dilation enhanced in athletes? Med Sci Sports Exerc 45, 75-82.
26. Green DJ, Spence A, Halliwill JR, Cable NT & Thijssen DH (2011). Exercise and vascular adaptation in asymptomatic humans. Exp Physiol 96, 57-70.
27. Hansen J & Sander M (2003). Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 546, 921-929.
28. Hernandez-Guerra M, de Ganzo ZA, Gonzalez-Mendez Y, Salido E, Abreu P, Moreno M, Felipe V, Abrante B & Quintero E (2013). Chronic intermittent hypoxia aggravates intrahepatic endothelial dysfunction in cirrhotic rats. Hepatology 57, 1564-1574.
29. Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ & Rabelink TJ (2002). Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol 39, 683-688.
30. Janocha AJ, Koch CD, Tiso M, Ponchia A, Doctor A, Gibbons L, Gaston B, Beall CM & Erzurum SC (2011). Nitric oxide during altitude acclimatization. N Engl J Med 365, 1942-1944.
31. Jauernig RA, Moulds RF & Shaw J (1978). The action of prazosin in human vascular preparations. Arch Int Pharmacodyn Ther 231, 81-89.
32. Jones H, Lewis NC, Green DJ, Ainslie PN, Lucas SJ, Tzeng YC, Grant EJ & Atkinson G (2011). alpha1-Adrenoreceptor activity does not explain lower morning endothelial-dependent, flow-mediated dilation in humans. Am J Physiol Regul Integr Comp Physiol 300, R1437-R1442.
33. Lantelme P, Mestre C, Lievre M, Gressard A & Milon H (2002). Heart rate: an important confounder of pulse wave velocity assessment. Hypertension 39, 1083-1087.
34. Laughlin MH, Newcomer SC & Bender SB (2008). Importance of hemodynamic forces as signals for exercise-induced changes in endothelial cell phenotype. J Appl Physiol 104, 588-600.
35. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I & Struijker-Boudier H (2006). Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27, 2588-2605.
36. 1-blockade on orthostatic tolerance. Chronobiol Int 29, 882-890.
37. Lewis NC, Ainslie PN, Atkinson G, Jones H, Grant EJ & Lucas SJ (2013). Initial orthostatic hypotension and cerebral blood flow regulation: effect of alpha1-adrenoreceptor activity. Am J Physiol Regul Integr Comp Physiol 304, R147-R154.
38. Lucas SJ, Burgess KR, Thomas KN, Donnelly J, Peebles KC, Lucas RA, Fan JL, Cotter JD, Basnyat R & Ainslie PN (2011). Alterations in cerebral blood flow and cerebrovascular reactivity during 14 days at 5050 m. J Physiol 589, 741-753.
39. Lurie A (2011). Endothelial dysfunction in adults with obstructive sleep apnea. Adv Cardiol 46, 139-170.
40. Maher AR, Milsom AB, Gunaruwan P, Abozguia K, Ahmed I, Weaver RA, Thomas P, Ashrafian H, Born GV, James PE & Frenneaux MP (2008). Hypoxic modulation of exogenous nitrite-induced vasodilation in humans. Circulation 117, 670-677.
41. Marshall JM (1994). Peripheral chemoreceptors and cardiovascular regulation. Physiol Rev 74, 543-594.
42. Maruhashi T, Soga J, Fujimura N, Idei N, Mikami S, Iwamoto Y, Kajikawa M, Matsumoto T, Hidaka T, Kihara Y, Chayama K, Noma K, Nakashima A, Goto C & Higashi Y (2013). Nitroglycerine-induced vasodilation for assessment of vascular function: a comparison with flow-mediated vasodilation. Arterioscler Thromb Vasc Biol 33, 1401-1408.
43. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE & MacAllister RJ (2001). Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: relevance to endothelial dysfunction in hypercholesterolemia. Circ Res 88, 145-151.
44. Munzel T, Feil R, Mulsch A, Lohmann SM, Hofmann F & Walter U (2003). Physiology and pathophysiology of vascular signaling controlled by guanosine 3', 5'-cyclic monophosphate-dependent protein kinase [corrected]. Circulation 108, 2172-2183.
45. Naghavi M (2009). Asymptomatic Atherosclerosis, 1st edn. Humana Press, New York.
46. Ogoh S, Brothers RM, Eubank WL & Raven PB (2008). Autonomic neural control of the cerebral vasculature: acute hypotension. Stroke 39, 1979-1987.
47. Otsuka K, Norboo T, Otsuka Y, Higuchi H, Hayajiri M, Narushima C, Sato Y, Tsugoshi T, Murakami S, Wada T, Ishine M, Okumiya K, Matsubayashi K, Yano S, Chogyal T, Angchuk D, Ichihara K, Cornelissen G & Halberg F (2005). Chronoecological health watch of arterial stiffness and neuro-cardio-pulmonary function in elderly community at high altitude (3524 m), compared with Japanese town. Biomed Pharmacother 59(Suppl. 1), S58-S67.
48. Parkhurst KL, Lin HF, Devan AE, Barnes JN, Tarumi T & Tanaka H (2012). Contribution of blood viscosity in the assessment of flow-mediated dilation and arterial stiffness. Vasc Med 17, 231-234.
49. Pelletier MM, Kleinbongard P, Ringwood L, Hito R, Hunter CJ, Schechter AN, Gladwin MT & Dejam A (2006). The measurement of blood and plasma nitrite by chemiluminescence: pitfalls and solutions. Free Radic Biol Med 41, 541-548.
50. Phillips CL, Butlin M, Wong KK & Avolio AP (2013). Is obstructive sleep apnoea causally related to arterial stiffness? A critical review of the experimental evidence. Sleep Med Rev 17, 7-18.
51. Pyke KE & Tschakovsky ME (2005). The relationship between shear stress and flow-mediated dilatation: implications for the assessment of endothelial function. J Physiol 568, 357-369.
52. Pyke KE & Tschakovsky ME (2007). Peak vs. total reactive hyperemia: which determines the magnitude of flow-mediated dilation? J Appl Physiol 102, 1510-1519.
53. Reboul C, Tanguy S, Gibault A, Dauzat M & Obert P (2005). Chronic hypoxia exposure depresses aortic endothelium-dependent vasorelaxation in both sedentary and trained rats: involvement of L-arginine. J Appl Physiol 99, 1029-1035.
54. Rhodes HL, Chesterman K, Chan CW, Collins P, Kewley E, Pattinson KT, Myers S, Imray CH & Wright AD (2011). Systemic blood pressure, arterial stiffness and pulse waveform analysis at altitude. J R Army Med Corps 157, 110-113.
55. Rimoldi SF, Rexhaj E, Pratali L, Bailey DM, Hutter D, Faita F, Salinas Salmon C, Villena M, Nicod P, Allemann Y, Scherrer U & Sartori C (2012). Systemic vascular dysfunction in patients with chronic mountain sickness. Chest 141, 139-146.
56. Ritschel WA, Paulos C, Arancibia A, Agrawal MA, Wetzelsberger KM & Lucker PW (1998). Urinary excretion of acetazolamide in healthy volunteers after short- and long-term exposure to high altitude. Methods Find Exp Clin Pharmacol 20, 133-137.
57. Rowley NJ, Dawson EA, Hopman MT, George K, Whyte GP, Thijssen DH & Green DJ (2012). Conduit diameter and wall remodelling in elite athletes and spinal cord injury. Med Sci Sports Exerc 44, 844-849.
58. Saito M, Mano T, Iwase S, Koga K, Abe H & Yamazaki Y (1988). Responses in muscle sympathetic activity to acute hypoxia in humans. J Appl Physiol 65, 1548-1552.
59. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, Najjar SS, Rembold CM & Post WS (2008). Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 21, 93-111; (quiz 189-190).
60. Stewart AD, Millasseau SC, Kearney MT, Ritter JM & Chowienczyk PJ (2003). Effects of inhibition of basal nitric oxide synthesis on carotid-femoral pulse wave velocity and augmentation index in humans. Hypertension 42, 915-918.
61. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA & Seals DR (2000). Aging, habitual exercise, and dynamic arterial compliance. Circulation 102, 1270-1275.
62. Thijssen DH, Black MA, Pyke KE, Padilla J, Atkinson G, Harris RA, Parker B, Widlansky ME, Tschakovsky ME & Green DJ (2011). Assessment of flow-mediated dilation in humans: a methodological and physiological guideline. Am J Physiol Heart Circ Physiol 300, H2-H12.
63. Thurnham DI, Smith E & Flora PS (1988). Concurrent liquid-chromatographic assay of retinol, alpha-tocopherol, beta-carotene, alpha-carotene, lycopene, and beta-cryptoxanthin in plasma, with tocopherol acetate as internal standard. Clin Chem 34, 377-381.
64. Tinken TM, Thijssen DH, Black MA, Cable NT & Green DJ (2008). Time course of change in vasodilator function and capacity in response to exercise training in humans. J Physiol 586, 5003-5012.
65. Tuttle JL, Nachreiner RD, Bhuller AS, Condict KW, Connors BA, Herring BP, Dalsing MC & Unthank JL (2001). Shear level influences resistance artery remodeling: wall dimensions, cell density, and eNOS expression. Am J Physiol Heart Circ Physiol 281, H1380-H1389.
66. Umbrello M, Dyson A, Feelisch M & Singer M (2013). The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. Antioxid Redox Signal 19, 1690-1710.
67. Vlachopoulos C, Aznaouridis K & Stefanadis C (2010). Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55, 1318-1327.
68. Weber T, Ammer M, Rammer M, Adji A, O'Rourke MF, Wassertheurer S, Rosenkranz S & Eber B (2009). Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement. J Hypertens 27, 1624-1630.
69. Wilkinson IB & McEniery CM (2004). Arterial stiffness, endothelial function and novel pharmacological approaches. Clin Exp Pharmacol Physiol 31, 795-799.
70. Wolff SP (1994). Ferrous ion oxidation in presence of ferric indicator xylenol orange for measurement of hydroperoxides. Methods in Enzymology 233, 183-189.
71. Woodman RJ, Playford DA, Watts GF, Cheetham C, Reed C, Taylor RR, Puddey IB, Beilin LJ, Burke V, Mori TA & Green D (2001). Improved analysis of brachial artery ultrasound using a novel edge-detection software system. J Appl Physiol 91, 929-937.
72. Xie A, Skatrud JB, Puleo DS & Morgan BJ (2001). Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 91, 1555-1562.