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Volumn 44, Issue 3, 2014, Pages 791-796

Epigallocatechin-3-gallate inhibits cell growth, induces apoptosis and causes S phase arrest in hepatocellular carcinoma by suppressing the AKT pathway

Author keywords

Apoptosis; Cell cycle; Epigallocatechin 3 gallate; Pathway; SMMC7721

Indexed keywords

ANTINEOPLASTIC AGENT; EPIGALLOCATECHIN GALLATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 84896733343     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2251     Document Type: Article
Times cited : (58)

References (33)
  • 2
    • 84892905097 scopus 로고    scopus 로고
    • Implications of the use of eukaryotic tanslation initiation factor 5A (eIF5A) for prognosis and treatment of hepatocellular carcinoma
    • 760928
    • Shek FH, Fatima S and Lee NP: Implications of the use of eukaryotic tanslation initiation factor 5A (eIF5A) for prognosis and treatment of hepatocellular carcinoma. Int J Hepatol 2012: 760928, 2012.
    • (2012) Int J Hepatol , pp. 2012
    • Shek, F.H.1    Fatima, S.2    Lee, N.P.3
  • 3
    • 84879668883 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells
    • Hagen RM, Chedea VS, Mintoff CP, Bowler E, Morse HR and Ladomery MR: Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells. Int J Oncol 43: 194-200, 2013.
    • (2013) Int J Oncol , vol.43 , pp. 194-200
    • Hagen, R.M.1    Chedea, V.S.2    Mintoff, C.P.3    Bowler, E.4    Morse, H.R.5    Ladomery, M.R.6
  • 4
    • 84869020640 scopus 로고    scopus 로고
    • Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo
    • Li JJ, Gu QH, Li M, Yang HP, Cao LM and Hu CP: Role of Ku70 and Bax in epigallocatechin-3-gallate-induced apoptosis of A549 cells in vivo. Oncol Lett 5: 101-106, 2013.
    • (2013) Oncol Lett , vol.5 , pp. 101-106
    • Li, J.J.1    Gu, Q.H.2    Li, M.3    Yang, H.P.4    Cao, L.M.5    Hu, C.P.6
  • 5
    • 84864433190 scopus 로고    scopus 로고
    • Pro-apoptotic effect of epigallo-catechin-3-gallate on B lymphocytes through regulating BAFF/PI3K/ Akt/mTOR signaling in rats with collagen-induced arthritis
    • Liu D, Li P, Song S, et al: Pro-apoptotic effect of epigallo-catechin-3- gallate on B lymphocytes through regulating BAFF/PI3K/ Akt/mTOR signaling in rats with collagen-induced arthritis. Eur J Pharmacol 690: 214-225, 2012.
    • (2012) Eur J Pharmacol , vol.690 , pp. 214-225
    • Liu, D.1    Li, P.2    Song, S.3
  • 6
    • 0034739715 scopus 로고    scopus 로고
    • Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity
    • Zhang G, Miura Y and Yagasaki K: Suppression of adhesion and invasion of hepatoma cells in culture by tea compounds through antioxidative activity. Cancer Lett 159: 169-173, 2000.
    • (2000) Cancer Lett , vol.159 , pp. 169-173
    • Zhang, G.1    Miura, Y.2    Yagasaki, K.3
  • 7
    • 36448962451 scopus 로고    scopus 로고
    • EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer
    • Shankar S, Ganapathy S, Hingorani SR and Srivastava RK: EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. Front Biosci 13: 440-452, 2008.
    • (2008) Front Biosci , vol.13 , pp. 440-452
    • Shankar, S.1    Ganapathy, S.2    Hingorani, S.R.3    Srivastava, R.K.4
  • 8
    • 84870476514 scopus 로고    scopus 로고
    • EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin
    • Shankar S, Marsh L and Srivastava RK: EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin. Mol Cell Biochem 372: 83-94, 2013.
    • (2013) Mol Cell Biochem , vol.372 , pp. 83-94
    • Shankar, S.1    Marsh, L.2    Srivastava, R.K.3
  • 9
    • 37849009071 scopus 로고    scopus 로고
    • Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (-)-epigallocatechin against HCT116 colorectal carcinoma cells
    • Inaba H, Nagaoka Y, Kushima Y, et al: Comparative examination of anti-proliferative activities of (-)-epigallocatechin gallate and (-)-epigallocatechin against HCT116 colorectal carcinoma cells. Biol Pharm Bull 31: 79-84, 2008.
    • (2008) Biol Pharm Bull , vol.31 , pp. 79-84
    • Inaba, H.1    Nagaoka, Y.2    Kushima, Y.3
  • 10
    • 0037810718 scopus 로고    scopus 로고
    • Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats
    • Li ZG, Shimada Y, Sato F, et al: Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats. Oncol Rep 10: 421-426, 2003.
    • (2003) Oncol Rep , vol.10 , pp. 421-426
    • Li, Z.G.1    Shimada, Y.2    Sato, F.3
  • 11
    • 66749093527 scopus 로고    scopus 로고
    • Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line
    • Kushima Y, Iida K, Nagaoka Y, et al: Inhibitory effect of (-)-epigallocatechin and (-)-epigallocatechin gallate against heregulin beta1-induced migration/invasion of the MCF-7 breast carcinoma cell line. Biol Pharm Bull 32: 899-904, 2009.
    • (2009) Biol Pharm Bull , vol.32 , pp. 899-904
    • Kushima, Y.1    Iida, K.2    Nagaoka, Y.3
  • 12
    • 70349649506 scopus 로고    scopus 로고
    • EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
    • Huang CH, Tsai SJ, Wang YJ, Pan MH, Kao JY and Way TD: EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. Mol Nutr Food Res 53: 1156-1165, 2009.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1156-1165
    • Huang, C.H.1    Tsai, S.J.2    Wang, Y.J.3    Pan, M.H.4    Kao, J.Y.5    Way, T.D.6
  • 13
    • 84859243058 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways
    • Kim H and Sakamoto K: (-)-Epigallocatechin gallate suppresses adipocyte differentiation through the MEK/ERK and PI3K/Akt pathways. Cell Biol Int 36: 147-153, 2012.
    • (2012) Cell Biol Int , vol.36 , pp. 147-153
    • Kim, H.1    Sakamoto, K.2
  • 14
    • 33846821868 scopus 로고    scopus 로고
    • A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
    • Qin J, Xie LP, Zheng XY, et al: A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins. Biochem Biophys Res Commun 354: 852-857, 2007.
    • (2007) Biochem Biophys Res Commun , vol.354 , pp. 852-857
    • Qin, J.1    Xie, L.P.2    Zheng, X.Y.3
  • 15
    • 70349585440 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis
    • Shirakami Y, Shimizu M, Adachi S, et al: (-)-Epigallocatechin gallate suppresses the growth of human hepatocellular carcinoma cells by inhibiting activation of the vascular endothelial growth factor-vascular endothelial growth factor receptor axis. Cancer Sci 100: 1957-1962, 2009.
    • (2009) Cancer Sci , vol.100 , pp. 1957-1962
    • Shirakami, Y.1    Shimizu, M.2    Adachi, S.3
  • 16
    • 73949133652 scopus 로고    scopus 로고
    • Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells
    • Tsang WP and Kwok TT: Epigallocatechin gallate up-regulation of miR-16 and induction of apoptosis in human cancer cells. J Nutr Biochem 21: 140-146, 2010.
    • (2010) J Nutr Biochem , vol.21 , pp. 140-146
    • Tsang, W.P.1    Kwok, T.T.2
  • 17
    • 0035840438 scopus 로고    scopus 로고
    • Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells
    • Uesato S, Kitagawa Y, Kamishimoto M, Kumagai A, Hori H and Nagasawa H: Inhibition of green tea catechins against the growth of cancerous human colon and hepatic epithelial cells. Cancer Lett 170: 41-44, 2001.
    • (2001) Cancer Lett , vol.170 , pp. 41-44
    • Uesato, S.1    Kitagawa, Y.2    Kamishimoto, M.3    Kumagai, A.4    Hori, H.5    Nagasawa, H.6
  • 19
    • 33646126051 scopus 로고    scopus 로고
    • A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins
    • Nishikawa T, Nakajima T, Moriguchi M, et al: A green tea polyphenol, epigalocatechin-3-gallate, induces apoptosis of human hepatocellular carcinoma, possibly through inhibition of Bcl-2 family proteins. J Hepatol 44: 1074-1082, 2006.
    • (2006) J Hepatol , vol.44 , pp. 1074-1082
    • Nishikawa, T.1    Nakajima, T.2    Moriguchi, M.3
  • 20
    • 38049112379 scopus 로고    scopus 로고
    • Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells
    • Bu X, Jia F, Wang W, Guo X, Wu M and Wei L: Coupled down-regulation of mTOR and telomerase activity during fluorouracil-induced apoptosis of hepatocarcinoma cells. BMC Cancer 7: 208, 2007.
    • (2007) BMC Cancer , vol.7 , pp. 208
    • Bu, X.1    Jia, F.2    Wang, W.3    Guo, X.4    Wu, M.5    Wei, L.6
  • 21
    • 63449089496 scopus 로고    scopus 로고
    • Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis
    • Tang C, Lu YH, Xie JH, et al: Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis. Anticancer Drugs 20: 249-258, 2009.
    • (2009) Anticancer Drugs , vol.20 , pp. 249-258
    • Tang, C.1    Lu, Y.H.2    Xie, J.H.3
  • 22
    • 33745058978 scopus 로고    scopus 로고
    • Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells
    • Zhang Q, Tang X, Lu Q, Zhang Z, Rao J and Le AD: Green tea extract and (-)-epigallocatechin-3-gallate inhibit hypoxia- and serum-induced HIF-1alpha protein accumulation and VEGF expression in human cervical carcinoma and hepatoma cells. Mol Cancer Ther 5: 1227-1238, 2006.
    • (2006) Mol Cancer Ther , vol.5 , pp. 1227-1238
    • Zhang, Q.1    Tang, X.2    Lu, Q.3    Zhang, Z.4    Rao, J.5    Le, A.D.6
  • 23
    • 84862942636 scopus 로고    scopus 로고
    • Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy
    • Zhang G, Wang Y, Zhang Y, et al: Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy. Curr Mol Med 12: 163-176, 2012.
    • (2012) Curr Mol Med , vol.12 , pp. 163-176
    • Zhang, G.1    Wang, Y.2    Zhang, Y.3
  • 24
    • 84866607823 scopus 로고    scopus 로고
    • Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation
    • Park SB, Bae JW, Kim JM, Lee SG and Han M: Antiproliferative and apoptotic effect of epigallocatechin-3-gallate on Ishikawa cells is accompanied by sex steroid receptor downregulation. Int J Mol Med 30: 1211-1218, 2012.
    • (2012) Int J Mol Med , vol.30 , pp. 1211-1218
    • Park, S.B.1    Bae, J.W.2    Kim, J.M.3    Lee, S.G.4    Han, M.5
  • 25
    • 84879520790 scopus 로고    scopus 로고
    • Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines
    • De Amicis F, Perri A, Vizza D, et al: Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines. J Cell Physiol 228: 2054-2062, 2013.
    • (2013) J Cell Physiol , vol.228 , pp. 2054-2062
    • De Amicis, F.1    Perri, A.2    Vizza, D.3
  • 26
    • 84859485240 scopus 로고    scopus 로고
    • Notch, apoptosis and cancer
    • Dang TP: Notch, apoptosis and cancer. Adv Exp Med Biol 727: 199-209, 2012.
    • (2012) Adv Exp Med Biol , vol.727 , pp. 199-209
    • Dang, T.P.1
  • 27
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A and Greenberg ME: Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927, 1999.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 28
    • 84876093576 scopus 로고    scopus 로고
    • DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis
    • Roos WP and Kaina B: DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett 332: 237-248, 2013.
    • (2013) Cancer Lett , vol.332 , pp. 237-248
    • Roos, W.P.1    Kaina, B.2
  • 29
    • 79960691382 scopus 로고    scopus 로고
    • EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells
    • Shimizu M, Shirakami Y, Sakai H, et al: EGCG inhibits activation of the insulin-like growth factor (IGF)/IGF-1 receptor axis in human hepatocellular carcinoma cells. Cancer Lett 262: 10-18, 2008.
    • (2008) Cancer Lett , vol.262 , pp. 10-18
    • Shimizu, M.1    Shirakami, Y.2    Sakai, H.3
  • 30
    • 67649363667 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation
    • Kaufmann R, Henklein P, Henklein P and Settmacher U: Green tea polyphenol epigallocatechin-3-gallate inhibits thrombin-induced hepatocellular carcinoma cell invasion and p42/p44-MAPKinase activation. Oncol Rep 21: 1261-1267, 2009.
    • (2009) Oncol Rep , vol.21 , pp. 1261-1267
    • Kaufmann, R.1    Henklein, P.2    Henklein, P.3    Settmacher, U.4
  • 31
    • 56849103869 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate induces apoptosis in human hepatocellular carcinoma cells
    • In Chinese
    • Chen XL, Wang Q, Cao LQ, et al: Epigallocatechin-3-gallate induces apoptosis in human hepatocellular carcinoma cells. Zhonghua Yi Xue Za Zhi 88: 2524-2528, 2008 (In Chinese).
    • (2008) Zhonghua Yi Xue Za Zhi , vol.88 , pp. 2524-2528
    • Chen, X.L.1    Wang, Q.2    Cao, L.Q.3
  • 32
    • 77956323508 scopus 로고    scopus 로고
    • Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines
    • Roomi MW, Monterrey JC, Kalinovsky T, Rath M and Niedzwiecki A: Comparative effects of EGCG, green tea and a nutrient mixture on the patterns of MMP-2 and MMP-9 expression in cancer cell lines. Oncol Rep 24: 747-757, 2010.
    • (2010) Oncol Rep , vol.24 , pp. 747-757
    • Roomi, M.W.1    Monterrey, J.C.2    Kalinovsky, T.3    Rath, M.4    Niedzwiecki, A.5
  • 33
    • 84883312102 scopus 로고    scopus 로고
    • Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells
    • Zhang Y, Owusu L, Duan W, et al: Anti-metastatic and differential effects on protein expression of epigallocatechin-3-gallate in HCCLM6 hepatocellular carcinoma cells. Int J Mol Med 32: 959-964, 2013.
    • (2013) Int J Mol Med , vol.32 , pp. 959-964
    • Zhang, Y.1    Owusu, L.2    Duan, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.