A genetic polymorphism (rs17251221) in the calcium-sensing receptor is associated with breast cancer susceptibility and prognosis

Cellular Physiology and Biochemistry

Volumn 33, Issue 1, 2014, Pages 165-172

  Li, Xiaoyan ^a   Kong, Xiangnan ^a   Jiang, Liyu ^a   Ma, Tingting ^a   Yan, Shi ^b   Yuan, Cunzhong ^b   Yang, Qifeng ^a,b  

^a SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Breast cancer; Calcium sensing receptor; Prognosis; Susceptibility

Indexed keywords

CALCIUM SENSING RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MESSENGER RNA; PROGESTERONE RECEPTOR; PROTEIN; TUMOR MARKER;

ADULT; AGE; ALLELE; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER PROGNOSIS; CANCER RISK; CANCER SIZE; CANCER SURVIVAL; CANCER SUSCEPTIBILITY; CANCER TISSUE; CASE CONTROL STUDY; CLINICAL FEATURE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MIDDLE AGED; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; CORRELATION ANALYSIS; QUANTITATIVE ANALYSIS; RECURRENCE FREE SURVIVAL; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; TUMOR VOLUME; BREAST TUMOR; GENETIC ASSOCIATION STUDY; GENETIC PREDISPOSITION; GENETICS; KAPLAN MEIER METHOD; PATHOLOGY; PROGNOSIS;

BREAST NEOPLASMS; CASE-CONTROL STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KAPLAN-MEIER ESTIMATE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; RECEPTORS, CALCIUM-SENSING;

EID: 84896733239     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356659     Document Type: Article

References (29)

1. Siegel R, Naishadham D, Jemal A: Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
2. Mavaddat N, Antoniou AC, Easton DF, Garcia-Closas M: Genetic susceptibility to breast cancer. Mol Oncol 2010;4:174-191.
3. Yu JC, Ding SL, Chang CH, Kuo SH, Chen ST, Hsu GC, Hsu HM, Hou MF, Jung LY, Cheng CW, Wu PE, Shen CY: Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell cycle and ubiquitin ligase genes. Carcinogenesis 2009;30:1562-1570.
4. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, et al.: A strong candidate for the breast and ovarian cancer susceptibility gene brca1. Science 1994;266:66-71.
5. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G: Identification of the breast cancer susceptibility gene brca2. Nature 1995;378:789-792.
6. Brown EM, Gamba G, Riccardi D, Lombardi M, Butters R, Kifor O, Sun A, Hediger MA, Lytton J, Hebert SC: Cloning and characterization of an extracellular Ca2+-sensing receptor from bovine parathyroid. Nature 1993;366:575-580.
7. Pollak MR, Brown EM, Chou YH, Hebert SC, Marx SJ, Steinmann B, Levi T, Seidman CE, Seidman JG: Mutations in the human Ca2+-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell 1993;75:1297-1303.
8. Brown EM, MacLeod RJ: Extracellular calcium sensing and extracellular calcium signaling. Physiol Rev 2001;81:239-297.
9. Magno AL, Ward BK, Ratajczak T: The calcium-sensing receptor: A molecular perspective. Endocr Rev 2011;32:3-30.
10. Pidasheva S, Grant M, Canaff L, Ercan O, Kumar U, Hendy GN: Calcium-sensing receptor dimerizes in the endoplasmic reticulum: Biochemical and biophysical characterization of casr mutants retained intracellularly. Hum Mol Genet 2006;15:2200-2209.
11. Kapur K, Johnson T, Beckmann ND, Sehmi J, Tanaka T, Kutalik Z, Styrkarsdottir U, Zhang W, Marek D, Gudbjartsson DF, Milaneschi Y, Holm H, Diiorio A, Waterworth D, Li Y, Singleton AB, Bjornsdottir US, Sigurdsson G, Hernandez DG, Desilva R, Elliott P, Eyjolfsson GI, Guralnik JM, Scott J, Thorsteinsdottir U, Bandinelli S, Chambers J, Stefansson K, Waeber G, Ferrucci L, Kooner JS, Mooser V, Vollenweider P, Beckmann JS, Bochud M, Bergmann S: Genome-wide meta-analysis for serum calcium identifies significantly associated snps near the calcium-sensing receptor (casr) gene. PLoS Genet 2010;6:e1001035.
12. Reh CM, Hendy GN, Cole DE, Jeandron DD: Neonatal hyperparathyroidism with a heterozygous calcium-sensing receptor (casr) r185q mutation: Clinical benefit from cinacalcet. J Clin Endocrinol Metab 2011;96:E707-712.
13. Chou YH, Woon PY, Chen WC, Hsu YW, Chang JM, Hwang DY, Chiu YC, Kuo HC, Chang WP, Hou MF, Liu ME, Chang JG, Chang WC: A genetic polymorphism (rs17251221) in the calcium-sensing receptor gene (casr) is associated with stone multiplicity in calcium nephrolithiasis. PLoS One 2011;6:e25227.
14. Jorde R, Schirmer H, Njolstad I, Lochen ML, Bogeberg Mathiesen E, Kamycheva E, Figenschau Y, Grimnes G: Serum calcium and the calcium-sensing receptor polymorphism rs17251221 in relation to coronary heart disease, type 2 diabetes, cancer and mortality: The tromso study. Eur J Epidemiol 2013;28:569-578.
15. Zhang N, Li X, Tao K, Jiang L, Ma T, Yan S, Yuan C, Moran MS, Liang F, Haffty BG, Yang Q: Bcl-2 (-938c a) polymorphism is associated with breast cancer susceptibility. BMC Med Genet 2011;12:48.
16. Li X, Kong X, Chen X, Zhang N, Jiang L, Ma T, Yang Q: Laptm4b allele *2 is associated with breast cancer susceptibility and prognosis. PLoS One 2012;7:e44916.
17. Rodriguez S, Gaunt TR, Day IN: Hardy-weinberg equilibrium testing of biological ascertainment for mendelian randomization studies. Am J Epidemiol 2009;169:505-514.
18. Wang DG, Fan JB, Siao CJ, Berno A, Young P, Sapolsky R, Ghandour G, Perkins N, Winchester E, Spencer J, Kruglyak L, Stein L, Hsie L, Topaloglou T, Hubbell E, Robinson E, Mittmann M, Morris MS, Shen N, Kilburn D, Rioux J, Nusbaum C, Rozen S, Hudson TJ, Lipshutz R, Chee M, Lander ES: Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 1998;280:1077-1082.
19. Ahmed S, Thomas G, Ghoussaini M, Healey CS, Humphreys MK, Platte R, Morrison J, Maranian M, Pooley KA, Luben R, Eccles D, Evans DG, Fletcher O, Johnson N, dos Santos Silva I, Peto J, Stratton MR, Rahman N, Jacobs K, Prentice R, Anderson GL, Rajkovic A, Curb JD, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver WR, Bojesen S, Nordestgaard BG, Flyger H, Dork T, Schurmann P, Hillemanns P, Karstens JH, Bogdanova NV, Antonenkova NN, Zalutsky IV, Bermisheva M, Fedorova S, Khusnutdinova E, Kang D, Yoo KY, Noh DY, Ahn SH, Devilee P, van Asperen CJ, Tollenaar RA, Seynaeve C, Garcia-Closas M, Lissowska J, Brinton L, Peplonska B, Nevanlinna H, Heikkinen T, Aittomaki K, Blomqvist C, Hopper JL, Southey MC, Smith L, Spurdle AB, Schmidt MK, Broeks A, van Hien RR, Cornelissen S, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Schmutzler RK, Burwinkel B, Bartram CR, Meindl A, Brauch H, Justenhoven C, Hamann U, Chang-Claude J, Hein R, Wang-Gohrke S, Lindblom A, Margolin S, Mannermaa A, Kosma VM, Kataja V, Olson JE, Wang X, Fredericksen Z, Giles GG, Severi G, Baglietto L, English DR, Hankinson SE, Cox DG, Kraft P, Vatten LJ, Hveem K, Kumle M, Sigurdson A, Doody M, Bhatti P, Alexander BH, Hooning MJ, van den Ouweland AM, Oldenburg RA, Schutte M, Hall P, Czene K, Liu J, Li Y, Cox A, Elliott G, Brock I, Reed MW, Shen CY, Yu JC, Hsu GC, Chen ST, Anton-Culver H, Ziogas A, Andrulis IL, Knight JA, Beesley J, Goode EL, Couch F, Chenevix-Trench G, Hoover RN, Ponder BA, Hunter DJ, Pharoah PD, Dunning AM, Chanock SJ, Easton DF: Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2, Nat Genet 2009 41 585-590.
20. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, Wang J, Yu K, Chatterjee N, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover RN, Thomas G, Chanock SJ: A genome-wide association study identifies alleles in fgfr2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 2007;39:870-874.
21. Zheng W, Long J, Gao YT, Li C, Zheng Y, Xiang YB, Wen W, Levy S, Deming SL, Haines JL, Gu K, Fair AM, Cai Q, Lu W, Shu XO: Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat Genet 2009;41:324-328.
22. Peto J, Collins N, Barfoot R, Seal S, Warren W, Rahman N, Easton DF, Evans C, Deacon J, Stratton MR: Prevalence of brca1 and brca2 gene mutations in patients with early-onset breast cancer. J Natl Cancer Inst 1999;91:943-949.
23. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K: Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from sweden, denmark, and finland. N Engl J Med 2000;343:78-85.
24. Cheng I, Klingensmith ME, Chattopadhyay N, Kifor O, Butters RR, Soybel DI, Brown EM: Identification and localization of the extracellular calcium-sensing receptor in human breast. J Clin Endocrinol Metab 1998;83:703-707.
25. Liu G, Hu X, Chakrabarty S: Calcium sensing receptor down-regulates malignant cell behavior and promotes chemosensitivity in human breast cancer cells. Cell Calcium 2009;45:216-225.
26. Chakrabarty S, Radjendirane V, Appelman H, Varani J: Extracellular calcium and calcium sensing receptor function in human colon carcinomas: Promotion of e-cadherin expression and suppression of beta-catenin/tcf activation. Cancer Res 2003;63:67-71.
27. Promkan M, Liu G, Patmasiriwat P, Chakrabarty S: Brca1 suppresses the expression of survivin and promotes sensitivity to paclitaxel through the calcium sensing receptor (casr) in human breast cancer cells. Cell Calcium 2011;49:79-88.
28. Promkan M, Liu G, Patmasiriwat P, Chakrabarty S: Brca1 modulates malignant cell behavior, the expression of survivin and chemosensitivity in human breast cancer cells. Int J Cancer 2009;125:2820-2828.
29. Singh N, Promkan M, Liu G, Varani J, Chakrabarty S: Role of calcium sensing receptor (casr) in tumorigenesis. Best Pract Res Clin Endocrinol Metab 2013;27:455-463.