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Volumn 14, Issue 2, 2014, Pages 143-148

Eosinophils in the pathogenesis of paediatric severe asthma

Author keywords

eosinophils; innate lymphoid cells; interleukin 5; remodelling; severe asthma

Indexed keywords

BENRALIZUMAB; INTERLEUKIN 13; INTERLEUKIN 25; INTERLEUKIN 33; INTERLEUKIN 5; MEPOLIZUMAB; SMAD3 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84896731495     PISSN: 15284050     EISSN: 14736322     Source Type: Journal    
DOI: 10.1097/ACI.0000000000000045     Document Type: Review
Times cited : (43)

References (33)
  • 1
    • 84863393701 scopus 로고    scopus 로고
    • Pediatric severe asthma is character-ized by eosinophilia and remodeling without T(H]2 cytokines
    • Bossley CJ, Fleming L, Gupta A, et al. Pediatric severe asthma is character-ized by eosinophilia and remodeling without T(H]2 cytokines. J Allergy Clin Immunol 2012; 129:974-982.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 974-982
    • Bossley, C.J.1    Fleming, L.2    Gupta, A.3
  • 2
    • 84873736081 scopus 로고    scopus 로고
    • Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma
    • Ullmann N, Bossley CJ, Fleming L, et al. Blood eosinophil counts rarely reflect airway eosinophilia in children with severe asthma. Allergy 2013; 68:402-406.
    • (2013) Allergy , vol.68 , pp. 402-406
    • Ullmann, N.1    Bossley, C.J.2    Fleming, L.3
  • 3
    • 84882896337 scopus 로고    scopus 로고
    • Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects
    • Hastie AT, Moore WC, Li H, et al. Biomarker surrogates do not accurately predict sputum eosinophil and neutrophil percentages in asthmatic subjects. J Allergy Clin Immunol 2013; 132:72-80.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 72-80
    • Hastie, A.T.1    Moore, W.C.2    Li, H.3
  • 4
    • 84857431715 scopus 로고    scopus 로고
    • Use of sputum eosinophil counts to guidemanagement inchildren with severe asthma
    • Fleming L, Wilson N, Regamey N, Bush A. Use of sputum eosinophil counts to guidemanagement inchildren with severe asthma. Thorax 2012;67:193-198.
    • (2012) Thorax , vol.67 , pp. 193-198
    • Fleming, L.1    Wilson, N.2    Regamey, N.3    Bush, A.4
  • 5
    • 84864022085 scopus 로고    scopus 로고
    • Sputum inflammatory phenotypes are not stable in children with asthma
    • Fleming L, Tsartsali L, Wilson N, et al. Sputum inflammatory phenotypes are not stable in children with asthma. Thorax 2012; 67:675-681.
    • (2012) Thorax , vol.67 , pp. 675-681
    • Fleming, L.1    Tsartsali, L.2    Wilson, N.3
  • 6
    • 85027938910 scopus 로고    scopus 로고
    • Lysis of primed eosinophils in severe asthma
    • Persson C. Lysis of primed eosinophils in severe asthma. J Allergy Clin Immunol 2013; 132:1459-1460.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 1459-1460
    • Persson, C.1
  • 7
    • 84881187383 scopus 로고    scopus 로고
    • Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: Role for reactive oxygen species-enhanced MEK/ERK activation
    • Kano G, Almanan M, Bochner BS, Zimmermann N. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. J Allergy Clin Immunol 2013; 132: 437-445.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 437-445
    • Kano, G.1    Almanan, M.2    Bochner, B.S.3    Zimmermann, N.4
  • 8
    • 84880290541 scopus 로고    scopus 로고
    • Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children
    • Muniz-Junqueira MI, Barbosa-Marques SM, Junqueira LF Jr. Morphological changes in eosinophils are reliable markers of the severity of an acute asthma exacerbation in children. Allergy 2013; 68:911-920.
    • (2013) Allergy , vol.68 , pp. 911-920
    • Muniz-Junqueira, M.I.1    Barbosa-Marques, S.M.2    Junqueira, Jr.L.F.3
  • 9
    • 84871397074 scopus 로고    scopus 로고
    • Clinical control of asthma associates with measures of airway inflammation
    • Volbeda F, Broekema M, Lodewijk ME, et al. Clinical control of asthma associates with measures of airway inflammation. Thorax 2013; 68:19-24.
    • (2013) Thorax , vol.68 , pp. 19-24
    • Volbeda, F.1    Broekema, M.2    Lodewijk, M.E.3
  • 10
    • 84884986382 scopus 로고    scopus 로고
    • Eosinophil peroxidase in sputum repre-& sents a unique biomarker of airway eosinophilia
    • A potential novel marker of eosinophil activity in induced sputum that may be useful in determining airway eosinophilia, and prevent the need for sputum cell counts
    • Nair P, Ochkur SI, Protheroe C, et al. Eosinophil peroxidase in sputum repre-& sents a unique biomarker of airway eosinophilia. Allergy 2013; 68:1177-1184. A potential novel marker of eosinophil activity in induced sputum that may be useful in determining airway eosinophilia, and prevent the need for sputum cell counts.
    • (2013) Allergy , vol.68 , pp. 1177-1184
    • Nair, P.1    Ochkur, S.I.2    Protheroe, C.3
  • 11
    • 84865145614 scopus 로고    scopus 로고
    • Mepolizumab for severe eosinophilic & asthma (DREAM): A multicentre, double-blind, placebo-controlled trial
    • Pavord ID, Korn S, Howarth P, et al. Mepolizumab for severe eosinophilic & asthma (DREAM): a multicentre, double-blind, placebo-controlled trial. Lancet 2012; 380:651-659.
    • (2012) Lancet , vol.380 , pp. 651-659
    • Pavord, I.D.1    Korn, S.2    Howarth, P.3
  • 12
    • 84865151725 scopus 로고    scopus 로고
    • Targeting IL-5 in severe asthma: A DREAM come true?
    • Hashimoto S, Bel EH. Targeting IL-5 in severe asthma: a DREAM come true? Lancet 2012; 380:626-627.
    • (2012) Lancet , vol.380 , pp. 626-627
    • Hashimoto, S.1    Bel, E.H.2
  • 13
    • 84887020563 scopus 로고    scopus 로고
    • Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia
    • Laviolette M, Gossage DL, Gauvreau G, et al. Effects of benralizumab on airway eosinophils in asthmatic patients with sputum eosinophilia. J Allergy Clin Immunol 2013; 132:1086-1096.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 1086-1096
    • Laviolette, M.1    Gossage, D.L.2    Gauvreau, G.3
  • 14
    • 84887019341 scopus 로고    scopus 로고
    • Eosinophilic asthma: Insights into the effects of reducing IL-5 receptor-positive cell levels
    • Assa'ad AH, Rothenberg ME. Eosinophilic asthma: insights into the effects of reducing IL-5 receptor-positive cell levels. J Allergy Clin Immunol 2013; 132: 1097-1098.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 1097-1098
    • Assa'Ad, A.H.1    Rothenberg, M.E.2
  • 15
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells: A proposal for uniform nomenclature
    • Spits H, Artis D, Colonna M, et al. Innate lymphoid cells: a proposal for uniform nomenclature. Nat Rev Immunol 2013; 13:145-149.
    • (2013) Nat Rev Immunol , vol.13 , pp. 145-149
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 16
    • 84455202426 scopus 로고    scopus 로고
    • Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreac-tivity
    • Barlow JL, Bellosi A, Hardman CS, et al. Innate IL-13-producing nuocytes arise during allergic lung inflammation and contribute to airways hyperreac-tivity. J Allergy Clin Immunol 2012; 129:191-198.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 191-198
    • Barlow, J.L.1    Bellosi, A.2    Hardman, C.S.3
  • 17
    • 84884905739 scopus 로고    scopus 로고
    • IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction
    • Barlow JL, Peel S, Fox J, et al. IL-33 is more potent than IL-25 in provoking IL-13-producing nuocytes (type 2 innate lymphoid cells) and airway contraction. J Allergy Clin Immunol 2013; 132:933-941.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 933-941
    • Barlow, J.L.1    Peel, S.2    Fox, J.3
  • 18
    • 84883218243 scopus 로고    scopus 로고
    • IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma
    • Saglani S, Lui S, Ullmann N, et al. IL-33 promotes airway remodeling in pediatric patients with severe steroid-resistant asthma. J Allergy Clin Immunol 2013; 132:676-685.
    • (2013) J Allergy Clin Immunol , vol.132 , pp. 676-685
    • Saglani, S.1    Lui, S.2    Ullmann, N.3
  • 19
    • 85027945857 scopus 로고    scopus 로고
    • Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
    • Bernink JH, Peters CP, Munneke M, et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol 2013; 14:221-229.
    • (2013) Nat Immunol , vol.14 , pp. 221-229
    • Bernink, J.H.1    Peters, C.P.2    Munneke, M.3
  • 20
    • 84867773093 scopus 로고    scopus 로고
    • The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells
    • Mjosberg J, Bernink J, Golebski K, et al. The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity 2012; 37:649-659.
    • (2012) Immunity , vol.37 , pp. 649-659
    • Mjosberg, J.1    Bernink, J.2    Golebski, K.3
  • 21
    • 80054889051 scopus 로고    scopus 로고
    • Human IL-25-and IL-33-responsive type2 innate lymphoid cells are defined by expression of CRTH2 and CD161
    • Mjosberg JM, Trifari S, Crellin NK, et al. Human IL-25-and IL-33-responsive type2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol 2011; 12:1055-1062.
    • (2011) Nat Immunol , vol.12 , pp. 1055-1062
    • Mjosberg, J.M.1    Trifari, S.2    Crellin, N.K.3
  • 22
    • 84876008998 scopus 로고    scopus 로고
    • Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    • Barnig C, Cernadas M, Dutile S, et al. Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 2013; 5:174ra26.
    • (2013) Sci Transl Med , vol.5
    • Barnig, C.1    Cernadas, M.2    Dutile, S.3
  • 23
    • 84885572626 scopus 로고    scopus 로고
    • Type 2 innate lymphoid cells control eosinophil homeostasis
    • Nussbaum JC, Van Dyken SJ, von MJ, et al. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature 2013; 502:245-248.
    • (2013) Nature , vol.502 , pp. 245-248
    • Nussbaum, J.C.1    Van Dyken, S.J.2    Von, M.3
  • 24
    • 84882239266 scopus 로고    scopus 로고
    • Eosinophils in the spotlight: Finding the link between obesity and asthma
    • Lloyd CM, Saglani S. Eosinophils in the spotlight: finding the link between obesity and asthma. Nat Med 2013; 19:976-977.
    • (2013) Nat Med , vol.19 , pp. 976-977
    • Lloyd, C.M.1    Saglani, S.2
  • 25
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky AB, Nussbaum JC, Liang HE, et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med 2013; 210:535-549.
    • (2013) J Exp Med , vol.210 , pp. 535-549
    • Molofsky, A.B.1    Nussbaum, J.C.2    Liang, H.E.3
  • 26
    • 84886304307 scopus 로고    scopus 로고
    • Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice
    • Calixto MC, Lintomen L, Andre DM, et al. Metformin attenuates the exacerbation of the allergic eosinophilic inflammation in high fat-diet-induced obesity in mice. PLoS One 2013; 8:e76786.
    • (2013) PLoS One , vol.8
    • Calixto, M.C.1    Lintomen, L.2    Andre, D.M.3
  • 27
    • 84884653018 scopus 로고    scopus 로고
    • Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma
    • Desai D, Newby C, Symon FA, et al. Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med 2013; 188:657-663.
    • (2013) Am J Respir Crit Care Med , vol.188 , pp. 657-663
    • Desai, D.1    Newby, C.2    Symon, F.A.3
  • 28
    • 84879521824 scopus 로고    scopus 로고
    • Airway and systemic inflammation in obese children with asthma
    • Jensen ME, Gibson PG, Collins CE, Wood LG. Airway and systemic inflammation in obese children with asthma. Eur Respir J 2013; 42: 1012-1019.
    • (2013) Eur Respir J , vol.42 , pp. 1012-1019
    • Jensen, M.E.1    Gibson, P.G.2    Collins, C.E.3    Wood, L.G.4
  • 29
    • 84879032476 scopus 로고    scopus 로고
    • Obesity increases eosinophil activity in asthmatic children and adolescents
    • Grotta MB, Squebola-Cola DM, Toro AA, et al. Obesity increases eosinophil activity in asthmatic children and adolescents. BMC Pulm Med 2013; 13:39.
    • (2013) BMC Pulm Med , vol.13 , pp. 39
    • Grotta, M.B.1    Squebola-Cola, D.M.2    Toro, A.A.3
  • 30
    • 78751691489 scopus 로고    scopus 로고
    • Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease
    • Fattouh R, Al-Garawi A, Fattouh M, et al. Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease. Am J Respir Crit Care Med 2011; 183:179-188.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. 179-188
    • Fattouh, R.1    Al-Garawi, A.2    Fattouh, M.3
  • 31
    • 84877961861 scopus 로고    scopus 로고
    • Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells
    • Yasukawa A, Hosoki K, Toda M, et al. Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells. PLoS One 2013; 8: e64281.
    • (2013) PLoS One , vol.8
    • Yasukawa, A.1    Hosoki, K.2    Toda, M.3
  • 32
    • 84873408118 scopus 로고    scopus 로고
    • Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma
    • Miyata J, Fukunaga K, Iwamoto R, et al. Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. J Allergy Clin Immunol 2013; 131:353-360.
    • (2013) J Allergy Clin Immunol , vol.131 , pp. 353-360
    • Miyata, J.1    Fukunaga, K.2    Iwamoto, R.3
  • 33
    • 84884928688 scopus 로고    scopus 로고
    • ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48
    • Ha SG, Ge XN, Bahaie NS, et al. ORMDL3 promotes eosinophil trafficking and activation via regulation of integrins and CD48. Nat Commun 2013; 4:2479.
    • (2013) Nat Commun , vol.4 , pp. 2479
    • Ha, S.G.1    Ge, X.N.2    Bahaie, N.S.3


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