De novo membrano-proliferative nephritis following interferon therapy for chronic hepatitis c (case study and literature review)

Digestive Diseases and Sciences

Volumn 59, Issue 3, 2014, Pages 691-695

  Fabrizi, Fabrizio ^a   Aghemo, Alessio ^a   Moroni, Gabriella ^a   Passerini, Patrizia ^a   D'Ambrosio, Roberta ^a   Martin, Paul ^b   Messa, Piergiorgio ^a  

^a FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Hepatitis C; Interferon; Membrano proliferative glomerulonephritis; Ribavirin

Indexed keywords

ALPHA2B INTERFERON; ANGIOTENSIN RECEPTOR ANTAGONIST; COMPLEMENT COMPONENT C1Q; CREATININE; CYCLOPHOSPHAMIDE; DOXAZOSIN; IMMUNOGLOBULIN M; INSULIN; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NIFEDIPINE; PREDNISONE; PROTEIN; RANITIDINE; REPAGLINIDE; RIBAVIRIN; SPIRONOLACTONE; VIRUS ANTIBODY; VIRUS RNA;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CASE REPORT; CAUCASIAN; CHRONIC ACTIVE HEPATITIS; CREATININE BLOOD LEVEL; CRYOGLOBULINEMIA; DRUG PULSE THERAPY; DRUG WITHDRAWAL; FATTY LIVER; FIBRIN DEPOSITION; FOLLOW UP; GLOMERULUS; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYPERGLYCEMIA; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; LIVER BIOPSY; MALE; MIDDLE AGED; PHASE CONTRAST MICROSCOPY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PROTEINURIA; REPEAT PROCEDURE; SCLEROSIS; STEROID THERAPY; TREATMENT RESPONSE; URINALYSIS; URINARY EXCRETION; URINE SEDIMENT; VIRUS LOAD;

ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; GLOMERULONEPHRITIS, MEMBRANOPROLIFERATIVE; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RIBAVIRIN;

EID: 84896728698     PISSN: 01632116     EISSN: 15732568     Source Type: Journal    
DOI: 10.1007/s10620-013-2959-4     Document Type: Article

References (26)

1. Ogawa E, Furusyo N, Kajiwara E, et al. Evaluation of the adverse effect of premature discontinuation of pegylated interferon a-2b and ribavirin treatment for chronic hepatitis C virus infection: Results from the Kyushu University Liver Disease Study [KULDS] Group. J Gastroenterol Hepatol. 2012;27:1233-1240.
2. Johnson R, Gretch D, Couser W, et al. Hepatitis C virus-associated glomerulonephritis. Effects of a-interferon therapy. Kidney Int. 1994;46:1700-1704.
3. Kidney Disease: Improving Global Outcomes. KDIGO clinical practice guidelines for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease. Kidney Int. 2008; 73: S1-S99.
4. Cattran D. Interferon therapy: A double-edged sword? Am J Kidney Dis. 1999;33:1174-1176.
5. Dusheiko G. Side effects of alpha interferon in chronic hepatitis C. Hepatology. 1997;26:S112-S121.
6. Ohta S, Yokoyama H, Wada T, et al. Exacerbation of glomerulonephritis in subjects with chronic hepatitis C virus infection after interferon therapy. Am J Kidney Dis. 1999;33:1040-1048.
7. Roithinger F, Allinger S, Kirchgatterer A, et al. A lethal course of chronic hepatitis C, glomerulonephritis, and pulmonary vasculitis unresponsive to interferon treatment. Am J Gastroenterol. 1995;90:1006-1009.
8. Coroneos E, Petrusevska G, Varghese F, Truong L. Focal segmental glomerulosclerosis with acute renal failure associated with a-interferon therapy. Am J Kidney Dis. 1996;28:888-892.
9. Horino T, Kuriyama S, Tomonari H, et al. Renal damage in a chronic active hepatitis C patient receiving interferon-alpha therapy. Nihon Jinzo Gakkai Shi. 1998;40:48-53.
10. Endo M, Ohi H, Fujita T, Ohsawa I, Kanmatsuse K, Yamaguchi Y. Appearance of nephrotic syndrome following interferon-a therapy in a patients with hepatitis B virus and hepatitis C virus coinfection. Am J Nephrol. 1998;18:439-443.
11. Stein D, Ahmed A, Sunkhara V, Khalbuss W. Collapsing focal segmental glomerulosclerosis with recovery of renal function: An uncommon complication of interferon therapy for hepatitis C. Dig Dis Sci. 2001;46:530-535.
12. Nishimura S, Miura H, Yamada H, Shinoda T, Kitamura S, Miura Y. Acute onset of nephrotic syndrome during interferon-a treatment for chronic active hepatitis C. J Gastroenterol. 2002;37: 854-858.
13. Willson R. Nephrotoxicity of interferon alpha-ribavirin therapy for chronic hepatitis C. J Clin Gastroenterol. 2002;35:89-92.
14. Dizer U, Beker C, Yavuz I, Ortatatli M, Ozguven V, Pahsa A. Minimal change disease in a patient receiving IFN-a therapy for chronic hepatitis C virus infection. J Interferon Cytokine Res. 2003;23:51-54.
15. Suresh R, Suryati Y, Merican I. Interferon induced glomerular disease in a patient with chronic hepatitis C. Med J Malays. 2003;58:594-596.
16. Fisher M, Rossini M, Simmons E, Harris R, Moeckel G, Zent R. A woman with chronic hepatitis C infection and nephrotic syndrome who developed multiple renal lesions after interferon alpha therapy. Am J Kidney Dis. 2004;44:567-573.
17. Gordon A, Menahem S, Mitchell J, Jenkins P, Dowlings J, Roberts S. Combination pegylated interferon and ribavirin therapy precipitating acute renal failure and exacerbating IgA nephropathy. Nephrol Dial Transpl. 2004;19:2155-2159.
18. Couto A, Faria L, Ribeiro D, de Paula F, de Melo Couto O, de Abreu Ferrari T. Life-threatening thrombocytopenia and nephrotic syndrome due to focal segmental glomerulosclerosis associated with pegylated interferon alpha-2b and ribavirin treatment for hepatitis C. Liver Int. 2006;26:1294-1297.
19. Tovar J, Buti M, Segarra A, Majo J, Esteban R. De novo nephrotic syndrome following pegylated interferon alfa 2b/ribavirin therapy for chronic hepatitis C infection. Int Urol Nephrol. 2008;40:539-541.
20. Kanungo S, Tamirisa S, Gopalakrishnan R, Salinas-Madrigal L, Bastani B. Collapsing glomerulopathy as a complication of interferon therapy for hepatitis C infection. Int Urol Nephrol. 2010;42:219-222.
21. Markowitz G, Nasr S, Stokes M, D'Agati V. Treatment with IFNa,-b or-c is associated with collapsing focal segmental glomerulosclerosis. Clin J Am Soc Nephrol. 2010;5:607-615.
22. Tsai M, Chen J, Fang Y, Yang A, Chang C. Membranous nephropathy induced by pegylated interferon a-2a therapy for chronic viral hepatitis B. Clin Nephrol. 2012;77:496-500.
23. Lai K, Wei C, Tan L, et al. Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol. 2007;18:1476-1485.
24. Gresser I. Interferon: An unfolding tale. J Interferon Cytokine Res. 2007;27:447-452.
25. Kimmel P, Abraham A, Phillips T. Membranoproliferative glomerulonephritis in a patient treated with interferon-a for human immunodeficiency virus infection. Am J Kidney Dis. 1994;24: 858-863.
26. Yokoyama H, Takaeda M, Wada T, et al. Intraglomerular expression of MHC-class II and Ki-67 antigens and serum cinterferon levels in IgA nephropathy. Nephron. 1992;62:169-175.