Life-threatening thrombocytopenia and nephrotic syndrome due to focal segmental glomerulosclerosis associated with pegylated interferon α-2b and ribavirin treatment for hepatitis C

Liver International

Volumn 26, Issue 10, 2006, Pages 1294-1297

  Alves Couto, Cláudia ^a   Costa Faria, Luciana ^a   Dias Ribeiro, Daniel ^a   de Paula Farah, Kátia ^a   de Melo Couto, Osvaldo Flávio ^a   de Abreu Ferrari, Teresa Cristina ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Focal segmental glomerulosclerosis; HepatitisC; Nephrotic syndrome; Pegylated interferon; Thrombocytopenia

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTINUCLEAR ANTIBODY; ASPARTATE AMINOTRANSFERASE; CYCLOSPORIN A; GAMMA GLUTAMYLTRANSFERASE; HEMOGLOBIN; PEGINTERFERON ALPHA2B; PREDNISONE; PROTHROMBIN; RIBAVIRIN; SIMVASTATIN; SMOOTH MUSCLE ANTIBODY; THROMBOPLASTIN; THYROID ANTIBODY; VIRUS RNA;

ADULT; ALCOHOL CONSUMPTION; ANAMNESIS; ARTICLE; CASE REPORT; CLINICAL EXAMINATION; CONVALESCENCE; DISEASE ASSOCIATION; DISEASE SEVERITY; DRUG WITHDRAWAL; ENZYME LINKED IMMUNOSORBENT ASSAY; FOCAL GLOMERULOSCLEROSIS; HEMATOCRIT; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; INTRAVENOUS DRUG ABUSE; LIVER BIOPSY; MALE; MEAN CORPUSCULAR VOLUME; NEPHROTIC SYNDROME; PARTIAL THROMBOPLASTIN TIME; POLYMERASE CHAIN REACTION; PROTHROMBIN TIME; THROMBOCYTOPENIA; TREATMENT DURATION; URINALYSIS;

ADULT; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HEPATITIS C, CHRONIC; HUMANS; INTERFERON ALFA-2B; MALE; NEPHROTIC SYNDROME; RIBAVIRIN; THROMBOCYTOPENIA;

EID: 33751005560     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01361.x     Document Type: Article

References (37)

1. Fried M W. Side effects of therapy of hepatitis C and their management. Hepatology 2002; 36: S237-44.
2. Pellicano R, Smedile A, Peyre S, et al. Autoimmune manifestations during interferon therapy in patients with chronic hepatitis C: The hepatologist's view. Minerva Gastroenterol Dietol 2005; 51: 55-61.
3. Peck-Radosavljevic M, Zacherl J, Meng Y G, et al. Is inadequate thrombopoietin production a major cause of thrombocytopenia in cirrhosis of the liver? J Hepatol 1997; 27: 127-31.
4. Durand J M, Lefevre P, Telle H, Kaplanski G, Quiles N, Soubeyrand J. Thrombocytopenic purpura and hepatitis C virus infection. Haematologica 1993; 78: 135.
5. Renault P F, Hoofnagle J H. Side effects of alpha-interferon. Semin Liver Dis 1989; 9: 273-7.
6. Hoofnagle J H. Thrombocytopenia during interferon alpha therapy. JAMA 1991; 266: 849.
7. Shrestha R, McKinley C, Bilir B M, Everson G T. Possible idiopathic thrombocytopenic purpura associated with natural alpha-interferon therapy for chronic hepatitis C infection. Am J Gastroenterol 1995; 90: 1146-7.
8. Dourakis S P, Deutsch M, Hadziyannis S J. Immune thrombocytopenia and alpha-interferon therapy. J Hepatol 1996; 25: 972-5.
9. Lopez Morante A J, Saez-Royuela F, Casanova Valero F, Yuguero del Moral L, Martin Lorente J L, Ojeda Gimenez C. Immune thrombocytopenia after alpha-interferon therapy in a patient with chronic hepatitis C. Am J Gastroenterol 1992; 87: 809-10.
10. Sagir A, Wettstein M, Heintges T, Haussiger D. Autoimmune thrombocytopenia induced by PEG-IFN-alpha 2b plus ribavirin in hepatitis C. Dig Dis Sci 2002; 47: 562-3.
11. Sevastianos V A, Deutsch M, Dourakis S P, Manesis E K. Pegylated interferon-2b associated autoimmune thrombocytopenia in a patient with chronic hepatitis C. Am J Gastroenterol 2003; 98: 706-7.
12. Medeiros B C, Seligman P A, Everson G T, Forman L M. Possible autoimmune thrombocytopenia associated with pegylated interferon-alpha 2a plus ribavirin treatment for hepatitis C. J Clin Gastroenterol 2004; 38: 84-5.
13. Visentin G P, Wolfmeyer K, Newman P J, Aster R H. Detection of drug-dependent, platelet-reactive antibodies by antigen-capture ELISA and flow cytometry. Transfusion 1990; 30: 694-700.
14. Jones G J, Itri L M. Safety and tolerance of recombinant interferon apha-2a (Roferon-A) in cancer patients. Cancer 1986; 57: 1709-15.
15. Quesada J R, Talpaz M, Rios A, Kurzrock R, Gutterman L U. Clinical toxicity of interferons in cancer patients: A review. J Clin Oncol 1986; 4: 234-43.
16. Selby P, Kohn J, Raymond J, Judson I, McElwain T. Nephrotic syndrome during treatment with interferon. Br Med J 1985; 290: 1180.
17. Ault B H, Stapleton F B, Gaber L, Martin A, Roy S III, Murphy S B. Acute renal failure during therapy with recombinant human gamma-interferon. N Engl J Med 1988; 319: 1397-400.
18. Nair S, Ernstoff M S, Bahson R R, Arthur S, Johnston J, Downs M A. Interferon-induced reversible acute renal failure with nephrotic syndrome. Urology 1992; 29: 169-72.
19. Dimitrov Y, Heibel F, Marcellin L, Chantrel F, Moulin B, Hannedouche T. Acute renal failure and nephrotic syndrome with alpha-interferon therapy. Nephrol Dial Transplant 1997; 12: 200-3.
20. Noel C, Vrtovsnik F, Facon T, et al. Acute and definitive renal failure in progressive multiple myeloma treated with recombinant interferon alpha-2a: Report on two patients. Am J Hematol 1992; 41: 298-9.
21. Sawamura M, Matsushima T, Tamura J, Murakami H, Tsuchiya J. Renal toxicity in long-term alpha interferon treatment in a patient with myeloma (letter). Am J Hematol 1992; 41: 146.
22. Lederer E, Truong L. Unusual glomerular lesion in a patient receiving long-term interferon alpha. Am J Kidney Dis 1992; 20: 516-8.
23. Miranda-Guardiola F, Fernandez-Llama P, Badia J R, et al. Acute renal failure associated with alpha-interferon therapy for chronic hepatitis B. Nephrol Dial Transplant 1995; 10: 1441-3.
24. Traynor A, Kuzel T, Samuelson E, Kanwar Y. Minimal-change glomerulopathy and glomerular visceral epithelial hyperplasia associated with alpha-interferon therapy for cutaneous T-cell lymphoma. Nephron 1994; 67: 94-100.
25. Averbuch S D, Austin H A III, Sherwin S A, Antonovych T, Bunn P A Jr, Longo D L. Acute interstitial nephritis with the nephrotic syndrome following recombinant leukocyte and interferon therapy for mycosis fungoides. N Engl J Med 1984; 310: 32-5.
26. Shah M, Jenis E H, Mookerjee B K, et al. Interferon-alpha-associated focal segmental glomerulosclerosis with massive proteinuria in patients with chronic myeloid leukemia following high dose chemotherapy. Cancer 1998; 83: 1938-46.
27. Bremer C T, Lastrapes A, Alper A B, Mudad R. Interferon-alpha-induced focal segmental glomerulosclerosis in chronic myelogenous leukemia: A case report and review of the literature. Am J Clin Oncol 2003; 26: 262-4.
28. Altraif I H, Abdulla A S, Al Sebayel M I, Said R A, Al Suhaibani M O, Jones A A. Hepatitis C associated glomerulonephritis. Am J Nephrol 1995; 15: 407-10.
29. Johnson R J, Gretch D R, Yamabe H, et al. Membranoproliferative glomerulonephritis associated with hepatitis C virus infection. N Engl J Med 1993; 328: 465-70.
30. Gopalani A, Ahuja T S. Prevalence of glomerulopathies in autopsies of patients infected with the hepatitis C virus. Am J Med Sci 2001; 322: 57-60.
31. Stehman-Breen C, Alpers C E, Fleet W P, Johnson R J. Focal segmental glomeular sclerosis among patients infected with hepatitis C virus. Nephron 1999; 81: 37-40.
32. Motta M, Malaguarnera M, Restuccia N, Romano M, Vinci E, Pistone G. Focal segmental glomerulosclerosis and hepatitis C virus: A case report. Panminerva Med 2001; 43: 49-52.
33. Ezaki Y, Tanaka U, Minoshima S, et al. Focal segmental glomerulosclerosis associated with type C virus hepatitis and decrement of proteinuria by interferon-alpha therapy. Nippon Jinzo Gakkai Shi 1999; 41: 83-8.
34. Coroneos E, Petrusevska G, Varghese F, Truong L D. Focal segmental glomerulosclerosis with acute renal failure associated with alpha-interferon therapy. Am J Kid Dis 1996; 28: 888-92.
35. Bellaïche G, Guettier C, Duboust A, Ley G, Slama J L. Nephrotic syndrome with acute renal failure due to focal segmental glomerulosclerosis in a patient treated with alpha-interferon for chronic hepatitis C. Gastroenterol Clin Biol 2000; 24: 465-6.
36. Stein D F, Ahmed A, Sunkhara V, Khalbuss W. Collapsing focal segmental glomerulosclerosis with recovery of renal function. An uncommon complication of interferon therapy for hepatitis C. Dig Dis Sci 2001; 46: 530-5.
37. Willson R A. Nephrotoxicity of interferon-alpha ribavirin therapy for chronic hepatitis C. J Clin Gastroenterol 2002; 35: 89-92.