Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats

Journal of the American Society of Nephrology

Volumn 18, Issue 5, 2007, Pages 1476-1485

  Lai, Kin Wai ^a   Wei, Chang Li ^a   Tan, Li Kiang ^a   Tan, Puay Hoon ^b   Chiang, Gilbert S C ^b   Lee, Caroline G L ^a   Jordan, Stanley C ^d   Yap, Hui Kim ^a,c  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b SINGAPORE GENERAL HOSPITAL   (Singapore)

^c NATIONAL UNIVERSITY HOSPITAL   (Singapore)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALBUMIN; B7 ANTIGEN; BETA ACTIN; CHOLESTEROL; CREATININE; DYSTROGLYCAN; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 4 RECEPTOR ALPHA; NEPHRIN; PODOCIN;

ALBUMIN BLOOD LEVEL; ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MARKER; DOWN REGULATION; ELECTRON MICROSCOPY; ELECTROPORATION; EXPRESSION VECTOR; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HISTOLOGY; HYBRIDIZATION; HYPERCHOLESTEROLEMIA; HYPOALBUMINEMIA; IMMUNOFLUORESCENCE TEST; IN VIVO STUDY; JUXTAGLOMERULAR CELL; KIDNEY DISEASE; MAMMAL; MEASUREMENT; MOLECULAR CLONING; NEPHROTIC SYNDROME; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEINURIA; QUADRICEPS FEMORIS MUSCLE; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WISTAR RAT;

EID: 34248158679     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1681/ASN.2006070710     Document Type: Article

References (45)

1. Eddy AA, Symons JM: Nephrotic syndrome in childhood. Lancet 362: 629-639, 2003
2. Pavenstadt H, Kriz W, Kretzler M: Cell biology of the glomerular podocyte. Physiol Rev 83: 253-307, 2002
3. Asanuma K, Mundel P: The role of podocytes in glomerular pathobiology. Clin Exp Nephrol 7: 255-259, 2003
4. Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR: Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 56: 1481-1491, 1999
5. Schwarz K, Simons M, Reiser J, Saleem MA, Faul C, Kriz W, Shaw AS, Holzman LB, Mundel P: Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. J Clin Invest 108: 1621-1629, 2001
6. Simons M, Schwarz K, Kriz W, Miettinen A, Reiser J, Mundel P, Holthofer H: Involvement of lipid rafts in nephrin phosphorylation and organization of the glomerular slit diaphragm. Am J Pathol 159: 1069-1077, 2001
7. Khoshnoodi J, Sigmundsson K, Ofverstedt LG, Skoglund U, Obrink B, Wartiovaara J, Tryggvason K: Nephrin promotes cell-cell adhesion through homophilic interactions. Am J Pathol 163: 2337-2346, 2003
8. Ibraghimov-Beskrovnaya O, Ervasti JM, Leveille CJ, Slaughter CA, Sernett SW, Campbell KP: Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Nature 355: 696-702, 1992
9. Raats CJ, van den Born J, Bakker MA, Oppers-Walgreen B, Pisa BJ, Dijkman HB, Assmann KJ, Berden JH: Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. Am J Pathol 156: 1749-1765, 2000
10. Gesemann M, Brancaccio A, Schumacher B, Ruegg MA: Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue. J Biol Chem 273: 600-605, 1998
11. Schnaper HW: The immune system in minimal change nephrotic syndrome. Pediatr Nephrol 3: 101-110, 1989
12. Yap HK, Cheung W, Murugasu B, Sim SK, Seah CC, Jordan SC: Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: Evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol 10: 529-537, 1999
13. Cheung W, Wei CL, Seah CC, Jordan SC, Yap HK: Atopy, serum IgE, and interleukin-13 in steroid-responsive nephrotic syndrome. Pediatr Nephrol 19: 627-632, 2004
14. Chen SP, Cheung W, Heng CK, Jordan SC, Yap HK: Childhood nephrotic syndrome in relapse is associated with down-regulation of monocyte CD14 expression and lipopolysaccharide-induced tumour necrosis factor-alpha production. Clin Exp Immunol 134: 111-119, 2003
15. Kimata H, Fujimoto M, Furusho K: Involvement of interleukin (IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome. Eur J Immunol 25: 1497-1501, 1995
16. Wei CL, Cheung W, Heng CK, Arty N, Chong SS, Lee BW, Puah KL, Yap HK: Interleukin-13 genetic polymorphisms in Singapore Chinese children correlate with long-term outcome of minimal-change disease. Nephrol Dial Transplant 20: 728-734, 2005
17. van den Berg JG, Aten J, Anwar Chand M, Claessen N, Dijkink L, Wijdenes J, Lakkis FG, Weening JJ: Interleukin-4 and interleukin-13 act on glomerular visceral epithelial cells. J Am Soc Nephrol 11: 413-422, 2000
18. Henry J, Miller MM, Pontarotti P: Structure and evolution of the extended B7 family. Immunol Today 20: 285-288, 1999
19. Chambers CA, Allison JP: Costimulatory regulation of T cell function. Curr Opin Cell Biol 11: 203-210, 1999
20. Abbas AK, Sharpe AH: T-cell stimulation: An abundance of B7s. Nat Med 5: 1345-1346, 1999
21. Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P: Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113: 1390-1397, 2004
22. Reiser J, Mundel P: Danger signaling by glomerular podocytes defines a novel function of inducible B7-1 in the pathogenesis of nephrotic syndrome. J Am Soc Nephrol 15: 2246-2248, 2004
23. Mathieson PW: Immune dysregulation in minimal change nephropathy. Nephrol Dial Transplant 18[Suppl 6]: vi26-vi29, 2003
24. Grimbert P, Valanciute A, Audard V, Pawlak A, Le gouvelo S, Lang P, Niaudet P, Bensman A, Guellaen G, Sahali D: Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization. J Exp Med 198: 797-807, 2003
25. Skinnider BF, Kapp U, Mak TW: Interleukin 13: A growth factor in Hodgkin lymphoma. Int Arch Allergy Immunol 126: 267-276, 2001
26. Skinnider BF, Elia AJ, Gascoyne RD, Trumper LH, von Bonin F, Kapp U, Patterson B, Snow BE, Mak TW: Interleukin 13 and interleukin 13 receptor are frequently expressed by Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma. Blood 98: 2877-2878, 2001
27. Kapp U, Yeh WC, Patterson B, Elia AJ, Kagi D, Ho A, Hessel A, Tipsword M, Williams A, Mirtsos C, Itie A, Moyle M, Mak TW: Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells. J Exp Med 189: 1939-1946, 1999
28. Tomanin R, Friso A, Alba S, Piller Puicher E, Mennuni C, La Monica N, Hortelano G, Zacchello F, Scarpa M: Nonviral transfer approaches for the gene therapy of mucopolysaccharidosis type II (Hunter syndrome). Acta Paediatr Suppl 91: 100-104, 2002
29. Aurisicchio L, Ceccacci A, La Monica N, Palombo F, Traboni C: Tamarin alpha-interferon is active in mouse liver upon intramuscular gene delivery. J Gene Med 3: 394-402, 2001
30. Kaysen GA: Hyperlipidemia of the nephrotic syndrome. Kidney Int 39[Suppl 31]:S8-S15, 1991
31. Vaziri ND, Liang K: Up-regulation of acyl-coenzyme A: cholesterol acyltransferase (ACAT) in nephrotic syndrome. Kidney Int 61: 1769-1775, 2002
32. Liang K, Vaziri ND: HMG-CoA reductase, cholesterol 7alpha-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia. Kidney Int 64: 192-198, 2003
33. Luimula P, Ahola H, Wang SX, Solin ML, Aaltonen P, Tikkanen I, Kerjaschki D, Holthofer H: Nephrin in experimental glomerular disease. Kidney Int 58: 1461-1468, 2000
34. Kawachi H, Koike H, Kurihara H, Yaoita E, Orikasa M, Shia MA, Sakai T, Yamamoto T, Salant DJ, Shimizu F: Cloning of rat nephrin: Expression in developing glomeruli and in proteinuric states. Kidney Int 57: 1949-1961, 2000
35. Doublier S, Ruotsalainen V, Salvidio G, Lupia E, Biancone L, Conaldi PG, Reponen P, Tryggvason K, Camussi G: Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 158: 1723-1731, 2001
36. Kim BK, Hong HK, Kim JH, Lee HS: Differential expression of nephrin in acquired human proteinuric diseases. Am J Kidney Dis 40: 964-973, 2002
37. Huh W, Kim DJ, Kim MK, Kim YG, Oh HY, Ruotsalainen V, Tryggvason K: Expression of nephrin in acquired human glomerular disease. Nephrol Dial Transplant 17: 478-484, 2002
38. Luimula P, Sandstrom N, Novikov D, Holthofer H: Podocyte-associated molecules in puromycin aminonucleoside nephrosis of the rat. Lab Invest 82: 713-718, 2002
39. Guan N, Ding J, Zhang J, Yang J: Expression of nephrin, podocin, alpha-actinin, and WT1 in children with nephrotic syndrome. Pediatr Nephrol 18: 1122-1127, 2003
40. Guan N, Ding J, Deng J, Zhang J, Yang J: Key molecular events in puromycin aminonucleoside nephrosis rats. Pathol Int 54: 703-711, 2004
41. Hosoyamada M, Yan K, Nishibori Y, Takiue Y, Kudo A, Kawakami H, Shibasaki T, Endou H: Nephrin and podocin expression around the onset of puromycin aminonucleoside. J Pharm Sci 97: 234-241, 2005
42. Kojima K, Davidovits A, Poczewski H, Langer B, Uchida S, Nagy-Bojarski K, Hovorka A, Sedivy R, Kerjaschki D: Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction. J Am Soc Nephrol 15: 2079-2089, 2004
43. Regele HM, Fillipovic E, Langer B, Poczewki H, Kraxberger I, Bittner RE, Kerjaschki D: Glomerular expression of dystroglycans is reduced in minimal change nephrosis but not in focal segmental glomerulosclerosis. J Am Soc Nephrol 11: 403-412, 2000
44. Greenwald RJ, Freeman GJ, Sharpe AH: The B7 family revisited. Annu Rev Immunol 23: 515-548, 2005
45. Niemann-Masanek U, Mueller A, Yard BA, Waldherr R, van der Woude FJ: B7-1 (CD80) and B7-2 (CD86) expression in human tubular epithelial cells in vivo and in vitro. Nephron 92: 542-556, 2002