A novel oxiranylchromenone derivative, MHY336, inducesapoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells

International Journal of Oncology

Volumn 44, Issue 3, 2014, Pages 943-949

  Lee, Sun Hwa ^a   Kang, Yong Jung ^a   Kim, Dong Hwan ^a   Sung, Bokyung ^a   Kang, Jin Ah ^a   Chun, Pusoon ^b   Yoon, Jeong Hyun ^a   Moon, Hyung Ryong ^a   Kim, Hyung Sik ^c   Chung, Hae Young ^a   Kim, Nam Deuk ^a  

^a Pusan National University   (South Korea)

^b Inje University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Apoptosis; Cell cycle; Colon cancer cells; Oxiranylchromenone derivative; p21; p53

Indexed keywords

ANTINEOPLASTIC AGENT; GYRASE INHIBITOR; MHY 336; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P21; PROTEIN P53; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CHEMOPROPHYLAXIS; COLORECTAL CARCINOMA; CYTOTOXICITY; DNA FRAGMENTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION;

APOPTOSIS; CELL CYCLE CHECKPOINTS; CELL DIVISION; COLONIC NEOPLASMS; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FLAVONOIDS; GENE KNOCKDOWN TECHNIQUES; HCT116 CELLS; HUMANS; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84896727936     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2013.2226     Document Type: Article

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