Rapamycin treatment of healthy pigs subjected to acute myocardial ischemia-reperfusion injury attenuates cardiac functions and increases myocardial necrosis

Annals of Thoracic Surgery

Volumn 97, Issue 3, 2014, Pages 901-907

  Lassaletta, Antonio D ^a   Elmadhun, Nassrene Y ^a   Zanetti, Arthus V D ^a,c   Feng, Jun ^a   Anduaga, Javier ^a   Gohh, Reginald Y ^b   Sellke, Frank W ^a   Bianchi, Cesario ^a  

^a RHODE ISLAND HOSPITAL   (United States)

^b BROWN UNIVERSITY   (United States)

^c FACULDADE DE CIÊNCIAS MÉDICAS DA SANTA CASA DE SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; TRIPHENYLTETRAZOLIUM; TROPONIN I;

ACUTE MYOCARDIAL ISCHEMIA REPERFUSION INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CARDIOVERSION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HEART FUNCTION; HEART INFARCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE METABOLISM; HEART MUSCLE NECROSIS; HEART PROTECTION; HYPOTHESIS; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; STERNOTOMY; TREATMENT OUTCOME; VASODILATATION; WESTERN BLOTTING; YORKSHIRE PIG;

ACUTE DISEASE; ANIMALS; IMMUNOSUPPRESSIVE AGENTS; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NECROSIS; SIROLIMUS; SWINE;

EID: 84896726592     PISSN: 00034975     EISSN: 15526259     Source Type: Journal    
DOI: 10.1016/j.athoracsur.2013.09.059     Document Type: Article

References (30)

1. E. Dazert, and M.N. Hall mTOR signaling in disease Curr Opin Cell Biol 23 2011 744 755
2. M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
3. D. Benjamin, M. Colombi, C. Moroni, and M.N. Hall Rapamycin passes the torch: A new generation of mTOR inhibitors Nat Rev Drug Discov 10 2011 868 880
4. T. Aoyagi, and T. Matsui Phosphoinositide-3 kinase signaling in cardiac hypertrophy and heart failure Curr Pharm Des 17 2011 1818 1824
5. S. Balasubramanian, R.K. Johnston, P.C. Moschella, S.K. Mani, W.J. Tuxworth Jr., and D. Kuppuswamy mTOR in growth and protection of hypertrophying myocardium Cardiovasc Hematol Agents Med Chem 7 2009 52 63
6. S.K. Hwang, and H.H. Kim The functions of mTOR in ischemic diseases BMB Rep 44 2011 506 511
7. Z.Z. Chong, Y.C. Shang, and K. Maiese Cardiovascular disease and motor signaling Trends Cardiovasc Med 21 2011 151 155
8. Committee. Guide for the care and use of laboratory animals 2011 The National Academies Press Washington (DC)
9. C. Bianchi, H. Wakiyama, and R. Faro et al. A novel peroxynitrite decomposer catalyst (fp-15) reduces myocardial infarct size in an in vivo peroxynitrite decomposer and acute ischemia-reperfusion in pigs Ann Thorac Surg 74 2002 1201 1207
10. R.M. Osipov, C. Bianchi, and R.T. Clements et al. Thrombin fragment (tp508) decreases myocardial infarction and apoptosis after ischemia reperfusion injury Ann Thorac Surg 87 2009 786 793
11. J. Feng, L.M. Chu, and M.P. Robich et al. Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation Circulation 122 2010 S150 S155
12. H.P. Glazer, R.M. Osipov, R.T. Clements, F.W. Sellke, and C. Bianchi Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling Cell Cycle 8 2009 1738 1746
13. M. Clinic Sirolimus level Mayo Medical Laboratories December 2011
14. D. Zhang, R. Contu, and M.V. Latronico et al. mTORC1 regulates cardiac function and myocyte survival through 4e-bp1 inhibition in mice J Clin Invest 120 2010 2805 2816
15. J.A. Hill Autophagy in cardiac plasticity and disease Pediatr Cardiol 32 2011 282 289
16. S. Sciarretta, N. Hariharan, Y. Monden, D. Zablocki, and J. Sadoshima Is autophagy in response to ischemia and reperfusion protective or detrimental for the heart? Pediatr Cardiol 32 2011 275 281
17. D.J. Hausenloy, and D.M. Yellon Reperfusion injury salvage kinase signalling: Taking a risk for cardioprotection Heart Fail Rev 12 2007 217 234
18. T. Weichhart Mammalian target of rapamycin: A signaling kinase for every aspect of cellular life Methods Mol Biol 821 2012 1 14
19. S. Zissimopoulos, S. Seifan, C. Maxwell, A.J. Williams, and F.A. Lai Disparities in the association of the ryanodine receptor and the fk506-binding proteins in mammalian heart J Cell Sci 125 2012 1759 1769
20. E. Calderon-Sanchez, M. Rodriguez-Moyano, and T. Smani Immunophilins and cardiovascular complications Curr Med Chem 18 2011 5408 5413
21. R.P. Katra, T. Oya, G.S. Hoeker, and K.R. Laurita Ryanodine receptor dysfunction and triggered activity in the heart Am J Physiol Heart Circ Physiol 292 2007 H2144 H2151
22. E. Watorek, M. Szymczak, M. Boratynska, D. Patrzalek, and M. Klinger Cardiovascular risk in kidney transplant recipients receiving mammalian target of rapamycin inhibitors Transplant Proc 43 2011 2967 2969
23. X. Xu, J. Li, M. Simons, R.J. Laham, and F.W. Sellke Expression of vascular endothelial growth factor and its receptors is increased, but microvascular relaxation is impaired in patients after acute myocardial ischemia J Thorac Cardiovasc Surg 121 2001 735 742
24. D.M. Dudzinski, J. Igarashi, D. Greif, and T. Michel The regulation and pharmacology of endothelial nitric oxide synthase Annu Rev Pharmacol Toxicol 46 2006 235 276
25. A. Jabs, S. Gobel, and P. Wenzel et al. Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation J Am Coll Cardiol 51 2008 2130 2138
26. Y. Huo, V. Iadevaia, and Z. Yao et al. Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis Biochem J 444 2012 141 151
27. C.C. Thoreen, L. Chantranupong, H.R. Keys, T. Wang, N.S. Gray, and D.M. Sabatini A unifying model for mTORC1-mediated regulation of mRNA translation Nature 485 2012 109 113
28. E. Iwai-Kanai, H. Yuan, and C. Huang et al. A method to measure cardiac autophagic flux in vivo Autophagy 4 2008 322 329
29. J.A. Rodriguez-Navarro, and A.M. Cuervo Dietary lipids and aging compromise chaperone-mediated autophagy by similar mechanisms Autophagy 8 2012 1152 1154
30. X. Ma, H. Liu, and S.R. Foyil et al. Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury Circulation 125 2012 3170 3181