Improvements of venous tone with pycnogenol in chronic venous insufficiency: An ex vivo study on venous segments

International Journal of Angiology

Volumn 23, Issue 1, 2014, Pages 47-52

  Belcaro, Gianni ^a   Dugall, Mark ^a   Luzzi, Roberta ^a   Hosoi, M ^a   Corsi, Marcello ^a  

^a CH PE University   (Italy)

Author keywords

chronic venous insufficiency; Pycnogenol; varicose veins; venous tone

Indexed keywords

PYCNOGENOL;

ADULT; ARTICLE; CHRONIC VEIN INSUFFICIENCY; CLINICAL ARTICLE; CONTROLLED STUDY; ELASTICITY; EX VIVO STUDY; FEMALE; HUMAN; MALE; MEASUREMENT; PRIORITY JOURNAL; SAPHENOUS VEIN; STRETCHING; SUPPLEMENTATION; VARICOSIS; VEIN DIAMETER; VEIN DILATATION; VEIN TONE;

EID: 84896719056     PISSN: 10611711     EISSN: 16155939     Source Type: Journal    
DOI: 10.1055/s-0033-1363785     Document Type: Article

References (43)

1. Caro C. G., Pedley T. J., Schroter R. C., Seed W. A. The Mechanics of the Circulation. Cambridge Cambridge University press: 2011
2. Szendro G., Veller M., Fisher C., et al. The effect of elastic compression on the venous tone in patients with varicose veins. Vasa: 1992; 21 2 198 202
3. Belcaro G., Cesarone M. R., de Sanctis M. T., et al. Laser Doppler and transcutaneous oximetry: modern investigations to assess drug efficacy in chronic venous insufficiency. Int J Microcirc Clin Exp: 1995; 15 01 45 49
4. Petruzzellis V., Troccoli T., Candiani C., et al. Oxerutins (Venoruton): efficacy in chronic venous insufficiency-A double-blind, randomized, controlled study. Angiology: 2002; 53 3 257 263
5. Bertrand-Thiebault C., Ferrari L., Boutherin-Falson O., et al. Cytochromes P450 are differently expressed in normal and varicose human saphenous veins: linkage with varicosis. Clin Exp Pharmacol Physiol: 2004; 31 5-6 295 301
6. Svedman C., Cherry G. W., Ryan T. J. The veno-arteriolar reflex in venous leg ulcer patients studied by laser Doppler imaging. Acta Derm Venereol: 1998; 78 4 258 261
7. Belcaro G., Nicolaides A. N., Stansby G. The Venous Clinic. London Imperial College Press: 2001
8. Belcaro G., Veller M., Nicolaides A. N. Venous Disorders. A Manual of diagnosis and Treatment. London Saunders: 1999
9. Belcaro G., Nicolaides A. N. Non invasive investigations in vascular disease. London Imperial College Press: 2001
10. Belcaro G., Hofman U., Bollinger A., Nicolaides A. N. Laser Doppler. London MedOrion: 1996
11. Belcaro G., Taccoen A. Venous wall perfusion. In: Intern Union Phlebologie. London International Union of Angiology; 1197. Abstract 122
12. Belcaro G., Laurora G., Cesarone M. R., et al. Vasa vasorum visualised by power-Doppler in normal and arteriosclerotic carotid arteries. Vasa: 1996; 25 3 226 232
13. Taccoen A., Belcaro G., Lebard C., Zuccarelli F. Etiologies et mécanismes des varices: réalités et perspectives. Sang Thrombose Vaisseau.: 1997; 9 354 363
14. Belcaro G., Hu S., Hosoi M. Circulation Sciences. Pycnogenol into the venous wall. Physiology and chromatography. Circulation Sciences Journal: 2010; 13 18
15. Belcaro G., Cesarone M. R., Errichi B. M., et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology: 2005; 56 6 699 705
16. Errichi B. M., Belcaro G., Hosoi M., et al. Prevention of post thrombotic syndrome with Pycnogenol® in a twelve month study. Panminerva Med: 2011; 53 3 01 21 27
17. Nuzum D. S., Gebru T. T., Kouzi S. A. Pycnogenol for chronic venous insufficiency. Am J Health Syst Pharm: 2011; 68 17 1589 1590, 1599-1601
18. Cesarone M. R., Belcaro G., Rohdewald P., et al. Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study. Phytomedicine: 2010; 17 11 835 839
19. Cesarone M. R., Belcaro G., Rohdewald P., et al. Rapid relief of signs/symptoms in chronic venous microangiopathy with pycnogenol: a prospective, controlled study. Angiology: 2006; 57 5 569 576
20. Belcaro G., Cesarone M. R., Ricci A., et al. Control of edema in hypertensive subjects treated with calcium antagonist (nifedipine) or angiotensin-converting enzyme inhibitors with Pycnogenol. Clin Appl Thromb Hemost: 2006; 12 4 440 444
21. Belcaro G., Cesarone M. R., Rohdewald P., et al. Prevention of venous thrombosis and thrombophlebitis in long-haul flights with pycnogenol. Clin Appl Thromb Hemost: 2004; 10 4 373 377
22. Cesarone M. R., Belcaro G., Nicolaides A. N., et al. Prevention of venous thrombosis in long-haul flights with Flite Tabs: the LONFLIT-FLITE randomized, controlled trial. Angiology: 2003; 54 5 531 539
23. Boisseau M. R. Pharmacological targets of drugs employed in chronic venous and lymphatic insufficiency. Int Angiol: 2002; 21 2 01 33 39
24. Cesarone M. R., Belcaro G., Rohdewald P., et al. Comparison of Pycnogenol and Daflon in treating chronic venous insufficiency: a prospective, controlled study. Clin Appl Thromb Hemost: 2006; 12 2 205 212
25. Belcaro G., Cesarone M. R., Errichi B. M., et al. Venous ulcers: microcirculatory improvement and faster healing with local use of Pycnogenol. Angiology: 2005; 56 6 699 705
26. Vinciguerra G., Belcaro G., Cesarone M. R., et al. Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology: 2006; 57 3 331 339
27. Doherty G. M. Current Surgical Diagnosis and Treatment, 12th ed. New York, NY McGraw Hill: 2003
28. Nicolaides A. N.; Cardiovascular Disease Educational and Research Trust; European Society of Vascular Surgery; The International Angiology Scientific Activity Congress Organization; International Union of Angiology; Union Internationale de Phlebologie at the Abbaye des Vaux de Cernay. Investigation of chronic venous insufficiency: A consensus statement (France, March 5-9, 1997). Circulation: 2000; 102 20 E126 E163
29. Kasperczak J., Ropacka-Lesiak M., Breborowicz H. G. Definition, classification and diagnosis of chronic venous insufficiency - part II [in Polish]. Ginekol Pol: 2013; 84 1 51 55
30. Ropacka-Lesiak M., Kasperczak J., Breborowicz G. H. Risk factors for the development of venous insufficiency of the lower limbs during pregnancy-part 1 [in Polish]. Ginekol Pol: 2012; 83 12 939 942
31. Somers P., Knaapen M. The histopathology of varicose vein disease. Angiology: 2006; 57 5 546 555
32. Thulesius O. Physiology of veins and their relationship with venous disorders. In: Belcaro G., Veller M., Nicolaides A. N., eds. Venous Disorders. A Manual of diagnosis and Treatment. London Saunders: 1999
33. Clarke G. H. Venous Elasticity [dissertation]. London University College: 1989
34. Beckwith T., Clarke G. H., Richardson G. A. Correlation between blood flow volume and ultrasonic Doppler wave forms in the study of valve efficiency. In: Intern Union Phlebologie. International Union of Angiology (London): 1991; Abstract 23
35. Clarke H., Smith S. RG, Vasdekis S. N., Hobbs J. T., Nicolaides A. N. Role of venous elasticity in the development of varicose veins. Br J Surg: 1989; 76 6 577 580
36. Clarke G. H., Vasdekis S. N., Hobbs J. T., Nicolaides A. N. Venous wall function in the pathogenesis of varicose veins. Surgery: 1992; 111 4 402 408
37. Hosoi Y., Zukowski A., Kakkos S. K., Nicolaides A. N. Ambulatory venous pressure measurements: new parameters derived from a mathematic hemodynamic model. J Vasc Surg: 2002; 36 1 137 142
38. Zukowski A. J., Nicolaides A. N., Szendro G., et al. Haemodynamic significance of incompetent calf perforating veins. Br J Surg: 1991; 78 5 625 629
39. Nicolaides A. N., Zukowski A. J. The value of dynamic venous pressure measurements. World J Surg: 1986; 10 6 919 924
40. Grimm T., Schäfer A., Högger P. Antioxidant activity and inhibition of matrix metalloproteinases by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med: 2004; 36 6 811 822
41. Grimm T., Chovanová Z., Muchová J., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol). J Inflamm (Lond): 2006; 3 1
42. Fitzpatrick D. F., Bing B., Rohdewald P. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol: 1998; 32 4 509 515
43. Ivanov V., Ivanova S., Roomi M. W., Kalinovsky T., Niedzwiecki A., Rath M. Extracellular matrix-mediated control of aortic smooth muscle cell growth and migration by a combination of ascorbic acid, lysine, proline, and catechins. J Cardiovasc Pharmacol: 2007; 50 5 541 547