Endostar combined with radiotherapy increases radiation sensitivity by decreasing the expression of TGF-β1, HIF-1α and bFGF

Experimental and Therapeutic Medicine

Volumn 7, Issue 4, 2014, Pages 911-916

  Wu, Yaogui ^a   Zheng, Yongfa ^a   Shen, Zhixiang ^a   Ge, Wei ^a   Xie, Yishan ^a   Li, Changhu ^a  

^a RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

Author keywords

Endostar; Radiation sensitivity; Radiotherapy; Tumor angiogenesis

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; HYPOXIA INDUCIBLE FACTOR 1; RECOMBINANT ENDOSTATIN; TRANSFORMING GROWTH FACTOR BETA1;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL GROWTH; CELL INVASION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IRRADIATION; LUNG ADENOCARCINOMA; METASTASIS; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; RADIOSENSITIVITY;

EID: 84896716103     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.1526     Document Type: Article

References (20)

1. McCloskey P, Balduyck B, Van Schil PE, et al: Radical treatment of non-small cell lung cancer during the last 5 years. Eur J Cancer 49: 1555-1564, 2013.
2. Chi A, Liao Z, Nguyen NP, et al: Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications. Radiother Oncol 94: 1-11, 2010.
3. Salama JK and Vokes EE: New radiotherapy and chemoradiotherapy approaches for non-small-cell lung cancer. J Clin Oncol 31: 1029-1038, 2013.
4. Folkman J: Tumor angiogenesis: therapeutic implications. N Engl J Med 285: 1182-1186, 1971.
5. Hanahan D and Weinberg RA: Hallmarks of cancer: the next generation. Cell 144: 646-674, 2011.
6. Zhang L, Ge W, Hu K, et al: Endostar down-regulates HIF-1 and VEGF expression and enhances the radioresponse to human lung adenocarcinoma cancer cells. Mol Biol Rep 39: 89-95, 2012.
7. Ge W, Cao DD, Wang HM, et al: Endostar combined with chemotherapy versus chemotherapy alone for advanced NSCLCs: a meta-analysis. Asian Pac J Cancer Prev 12: 2901-2907, 2011.
8. Agani F and Jiang BH: Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer. Curr Cancer Drug Targets 13: 245-251, 2013.
9. Tang CM and Yu J: Hypoxia-inducible factor-1 as a therapeutic target in cancer. J Gastroenterol Hepatol 28: 401-405, 2013.
10. Monti SM, Supuran CT and De Simone G: Anticancer carbonic anhydrase inhibitors: a patent review (2008-2013). Expert Opin Ther Pat 23: 737-749, 2013.
11. Sedlakova O, Svastova E, Takacova M, et al: Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors. Front Physiol 4: 400, 2014.
12. Montesano R, Vassalli JD, Baird A, et al: Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci USA 83: 7297-7301, 1986.
13. Stylianopoulos T and Jain RK: Combining two strategies to improve perfusion and drug delivery in solid tumors. Proc Natl Acad Sci USA 110: 18632-18637, 2013.
14. Goel S, Duda DG, Xu L, et al: Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev 91: 1071-1121, 2011.
15. Favaro E, Nardo G, Persano L, et al: Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. Am J Pathol 173: 1186-1201, 2008.
16. Koul HK, Pal M and Koul S: Role of p38 MAP Kinase Signal Transduction in Solid Tumors. Genes Cancer 4: 342-359, 2013.
17. Driessen A, Landuyt W, Pastorekova S, et al: Expression of carbonic anhydrase IX (CA IX), a hypoxia-related protein, rather than vascular-endothelial growth factor (VEGF), a pro-angiogenic factor, correlates with an extremely poor prognosis in esophageal and gastric adenocarcinomas. Ann Surg 243: 334-340, 2006.
18. Akhurst RJ: TGF-beta antagonists: why suppress a tumor suppressor? J Clin Invest 109: 1533-1536, 2002.
19. Liang Q, Li L, Zhang J, et al: CDK5 is essential for TGF-β1-induced epithelial-mesenchymal transition and breast cancer progression. Sci Rep 3: 2932, 2013.
20. Chen KC, Chen CY, Lin CJ, et al: Luteolin attenuates TGF-β1-induced epithelial-mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt-NF-κB-Snail pathway. Life Sci 93:924-933, 2013.