-
1
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
DOI 10.1056/NEJMoa066838
-
Hudes G, Carducci M, Tomczak P, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356: 2271-2281 (Pubitemid 46849157)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.22
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
Staroslawska, E.7
Sosman, J.8
McDermott, D.9
Bodrogi, I.10
Kovacevic, Z.11
Lesovoy, V.12
Schmidt-Wolf, I.G.H.13
Barbarash, O.14
Gokmen, E.15
O'Toole, T.16
Lustgarten, S.17
Moore, L.18
Motzer, R.J.19
-
2
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372: 449-456
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
3
-
-
84896709700
-
NCCN Clinical Practice Guidelines in Oncology
-
National Comprehensive Cancer Network Accessed May 2013
-
National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology. Kidney Cancer. V1.2013. Available at: http://www.nccn.org/ professionals/physician-gls/pdf/kidney.pdf. Accessed May 2013
-
Kidney Cancer. V1.2013
-
-
-
4
-
-
36148979189
-
-
European Association of Urology Accessed May 2013
-
European Association of Urology. EAU Guidelines on Renal Cell Carcinoma. 2013. Available at: http://www.uroweb.org/gls/pdf/10-Renal-Cell-Carcinoma-LRV2. pdf. Accessed May 2013
-
(2013)
EAU Guidelines on Renal Cell Carcinoma
-
-
-
5
-
-
79960613394
-
Common toxicities of mammalian target of rapamycin inhibitors
-
Soefje SA, Karnad A, Brenner AJ,. Common toxicities of mammalian target of rapamycin inhibitors. Target Oncol 2011; 6: 125-129
-
(2011)
Target Oncol
, vol.6
, pp. 125-129
-
-
Soefje, S.A.1
Karnad, A.2
Brenner, A.J.3
-
6
-
-
48749128305
-
Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features
-
Bellmunt J, Szczylik C, Feingold J, Strahs A, Berkenblit A,. Temsirolimus safety profile and management of toxic effects in patients with advanced renal cell carcinoma and poor prognostic features. Ann Oncol 2008; 19: 1387-1392
-
(2008)
Ann Oncol
, vol.19
, pp. 1387-1392
-
-
Bellmunt, J.1
Szczylik, C.2
Feingold, J.3
Strahs, A.4
Berkenblit, A.5
-
7
-
-
79952806004
-
Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus
-
Maroto JP, Hudes G, Dutcher JP, et al. Drug-related pneumonitis in patients with advanced renal cell carcinoma treated with temsirolimus. J Clin Oncol 2011; 29: 1750-1756
-
(2011)
J Clin Oncol
, vol.29
, pp. 1750-1756
-
-
Maroto, J.P.1
Hudes, G.2
Dutcher, J.P.3
-
8
-
-
33746617583
-
Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus
-
DOI 10.1016/j.ejca.2006.03.015, PII S0959804906003546
-
Duran I, Siu LL, Oza AM, et al. Characterisation of the lung toxicity of the cell cycle inhibitor temsirolimus. Eur J Cancer 2006; 42: 1875-1880 (Pubitemid 44149096)
-
(2006)
European Journal of Cancer
, vol.42
, Issue.12
, pp. 1875-1880
-
-
Duran, I.1
Siu, L.L.2
Oza, A.M.3
Chung, T.-B.4
Sturgeon, J.5
Townsley, C.A.6
Pond, G.R.7
Seymour, L.8
Niroumand, M.9
-
9
-
-
77956227464
-
Phase 3 trial of everolimus for metastatic renal cell carcinoma: Final results and analysis of prognostic factors
-
Motzer RJ, Escudier B, Oudard S, et al. Phase 3 trial of everolimus for metastatic renal cell carcinoma: final results and analysis of prognostic factors. Cancer 2010; 116: 4256-4265
-
(2010)
Cancer
, vol.116
, pp. 4256-4265
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
-
10
-
-
77956626151
-
Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma
-
White DA, Camus P, Endo M, et al. Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma. Am J Respir Crit Care Med 2010; 182: 396-403
-
(2010)
Am J Respir Crit Care Med
, vol.182
, pp. 396-403
-
-
White, D.A.1
Camus, P.2
Endo, M.3
-
11
-
-
84862002981
-
Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: Incidence, radiographic findings and correlation with clinical outcome
-
Dabydeen DA, Jagannathan JP, Ramaiya N, et al. Pneumonitis associated with mTOR inhibitors therapy in patients with metastatic renal cell carcinoma: incidence, radiographic findings and correlation with clinical outcome. Eur J Cancer 2012; 48: 1519-1524
-
(2012)
Eur J Cancer
, vol.48
, pp. 1519-1524
-
-
Dabydeen, D.A.1
Jagannathan, J.P.2
Ramaiya, N.3
-
12
-
-
12744281454
-
-
National Cancer Institute Accessed May 1, 2013
-
National Cancer Institute. Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0. Available at: http://evs.nci.nih.gov/ftp1/CTCAE/CTCAE-4. 03-2010-06-14-QuickReference-5x7.pdf. Accessed May 1, 2013
-
Common Terminology Criteria for Adverse Events (CTCAE). Version 4.0
-
-
-
13
-
-
77950516104
-
MTOR signaling and drug development in cancer
-
Dancey J,. mTOR signaling and drug development in cancer. Nat Rev Clin Oncol 2010; 7: 209-219
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 209-219
-
-
Dancey, J.1
-
14
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, et al. Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 2012; 366: 520-529
-
(2012)
N Engl J Med
, vol.366
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
-
15
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
Yao JC, Shah MH, Ito T, et al. Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 2011; 364: 514-523
-
(2011)
N Engl J Med
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
-
16
-
-
84864954263
-
Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma
-
Albiges L, Chamming's F, Duclos B, et al. Incidence and management of mTOR inhibitor-associated pneumonitis in patients with metastatic renal cell carcinoma. Ann Oncol 2012; 23: 1943-1953
-
(2012)
Ann Oncol
, vol.23
, pp. 1943-1953
-
-
Albiges, L.1
Chamming'S, F.2
Duclos, B.3
-
17
-
-
0035884304
-
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients
-
Morelon E, Stern M, Israel-Biet D, et al. Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patients. Transplantation 2001; 72: 787-790 (Pubitemid 32879846)
-
(2001)
Transplantation
, vol.72
, Issue.5
, pp. 787-790
-
-
Morelon, E.1
Stern, M.2
Israel-Biet, D.3
Correas, J.-M.4
Danel, C.5
Mamzer-Bruneel, M.-F.6
Peraldi, M.-N.7
Kreis, H.8
-
18
-
-
2342630498
-
Sirolimus-associated pulmonary toxicity
-
Pham PT, Pham PC, Danovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation 2004; 77: 1215-1220 (Pubitemid 38580300)
-
(2004)
Transplantation
, vol.77
, Issue.8
, pp. 1215-1220
-
-
Pham, P.-T.T.1
Pham, P.-C.T.2
Danovitch, G.M.3
Ross, D.J.4
Gritsch, H.A.5
Kendrick, E.A.6
Singer, J.7
Shah, T.8
Wilkinson, A.H.9
-
19
-
-
77949667760
-
Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents
-
Dancey JE, Dobbin KK, Groshen S, et al. Guidelines for the development and incorporation of biomarker studies in early clinical trials of novel agents. Clin Cancer Res 2010; 16: 1745-1755
-
(2010)
Clin Cancer Res
, vol.16
, pp. 1745-1755
-
-
Dancey, J.E.1
Dobbin, K.K.2
Groshen, S.3
-
20
-
-
84855186144
-
Toxicity as a biomarker of efficacy of molecular targeted therapies: Focus on EGFR and VEGF inhibiting anticancer drugs
-
Dienstmann R, Brana I, Rodon J, Tabernero J,. Toxicity as a biomarker of efficacy of molecular targeted therapies: focus on EGFR and VEGF inhibiting anticancer drugs. Oncologist 2011; 16: 1729-1740
-
(2011)
Oncologist
, vol.16
, pp. 1729-1740
-
-
Dienstmann, R.1
Brana, I.2
Rodon, J.3
Tabernero, J.4
-
21
-
-
44249105418
-
Validation of treatment induced specific adverse effect as a predictor of treatment benefit: A case study of NCIC CTG BR21
-
Ding K, Pater J, Whitehead M, Seymour L, Shepherd FA,. Validation of treatment induced specific adverse effect as a predictor of treatment benefit: a case study of NCIC CTG BR21. Contemp Clin Trials 2008; 29: 527-536
-
(2008)
Contemp Clin Trials
, vol.29
, pp. 527-536
-
-
Ding, K.1
Pater, J.2
Whitehead, M.3
Seymour, L.4
Shepherd, F.A.5
-
22
-
-
78650694719
-
First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: A subgroup analysis of data from the FLEX phase 3 study
-
Gatzemeier U, von Pawel J, Vynnychenko I, et al. First-cycle rash and survival in patients with advanced non-small-cell lung cancer receiving cetuximab in combination with first-line chemotherapy: a subgroup analysis of data from the FLEX phase 3 study. Lancet Oncol 2011; 12: 30-37
-
(2011)
Lancet Oncol
, vol.12
, pp. 30-37
-
-
Gatzemeier, U.1
Von Pawel, J.2
Vynnychenko, I.3
-
23
-
-
73249143536
-
Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival
-
Bonner JA, Harari PM, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010; 11: 21-28
-
(2010)
Lancet Oncol
, vol.11
, pp. 21-28
-
-
Bonner, J.A.1
Harari, P.M.2
Giralt, J.3
-
24
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer
-
DOI 10.1056/NEJMoa033025
-
Cunningham D, Humblet Y, Siena S, et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 2004; 351: 337-345 (Pubitemid 38944402)
-
(2004)
New England Journal of Medicine
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
25
-
-
34147103678
-
Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy- refractory metastatic colorectal cancer
-
DOI 10.1200/JCO.2006.08.1620
-
Van Cutsem E, Peeters M, Siena S, et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 2007; 25: 1658-1664 (Pubitemid 46797944)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.13
, pp. 1658-1664
-
-
Van Cutsem, E.1
Peeters, M.2
Siena, S.3
Humblet, Y.4
Hendlisz, A.5
Neyns, B.6
Canon, J.-L.7
Van Laethem, J.-L.8
Maurel, J.9
Richardson, G.10
Wolf, M.11
Amado, R.G.12
-
26
-
-
63449142391
-
Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy
-
Peeters M, Siena S, Van Cutsem E, et al. Association of progression-free survival, overall survival, and patient-reported outcomes by skin toxicity and KRAS status in patients receiving panitumumab monotherapy. Cancer 2009; 115: 1544-1554
-
(2009)
Cancer
, vol.115
, pp. 1544-1554
-
-
Peeters, M.1
Siena, S.2
Van Cutsem, E.3
-
27
-
-
77952318310
-
Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: Final results of CALGB 90206
-
Rini BI, Halabi S, Rosenberg JE, et al. Phase III trial of bevacizumab plus interferon alfa versus interferon alfa monotherapy in patients with metastatic renal cell carcinoma: final results of CALGB 90206. J Clin Oncol 2010; 28: 2137-2143
-
(2010)
J Clin Oncol
, vol.28
, pp. 2137-2143
-
-
Rini, B.I.1
Halabi, S.2
Rosenberg, J.E.3
-
28
-
-
34447343347
-
Hypertension as a predictive factor of Sunitinib activity [1]
-
DOI 10.1093/annonc/mdm184
-
Rixe O, Billemont B, Izzedine H,. Hypertension as a predictive factor of Sunitinib activity. Ann Oncol 2007; 18: 1117 (Pubitemid 47050505)
-
(2007)
Annals of Oncology
, vol.18
, Issue.6
, pp. 1117
-
-
Rixe, O.1
Billemont, B.2
Izzedine, H.3
-
29
-
-
79955767772
-
Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib
-
Rini BI, Cohen DP, Lu DR, et al. Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2011; 103: 763-773
-
(2011)
J Natl Cancer Inst
, vol.103
, pp. 763-773
-
-
Rini, B.I.1
Cohen, D.P.2
Lu, D.R.3
-
30
-
-
84888769386
-
Clinic and home blood pressure measurements are reliable for guiding therapy in patients with metastatic renal cell carcinoma receiving Axitinib as first-line therapy
-
Grunwald V, Fishman MN, Carducci M, et al. Clinic and home blood pressure measurements are reliable for guiding therapy in patients with metastatic renal cell carcinoma receiving Axitinib as first-line therapy. Ann Oncol 2012; 23: (Suppl. 9) 268
-
(2012)
Ann Oncol
, vol.23
, Issue.SUPPL. 9
, pp. 268
-
-
Grunwald, V.1
Fishman, M.N.2
Carducci, M.3
-
31
-
-
65549088617
-
Association of diastolic blood pressure (dBP) >= 90 mmHg with overall survival (OS) in patients treated with axitinib (AG-013736)
-
Rini BI, Schiller JH, Fruehauf JP, et al. Association of diastolic blood pressure (dBP) >= 90 mmHg with overall survival (OS) in patients treated with axitinib (AG-013736). J Clin Oncol 2008; 26 (Suppl. 15): 3543
-
(2008)
J Clin Oncol
, vol.26
, Issue.SUPPL. 15
, pp. 3543
-
-
Rini, B.I.1
Schiller, J.H.2
Fruehauf, J.P.3
-
32
-
-
48349122489
-
The clinical implications of sunitinib-induced hypothyroidism: A prospective evaluation
-
Wolter P, Stefan C, Decallonne B, et al. The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation. Br J Cancer 2008; 99: 448-454
-
(2008)
Br J Cancer
, vol.99
, pp. 448-454
-
-
Wolter, P.1
Stefan, C.2
Decallonne, B.3
-
33
-
-
84866746182
-
The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: A prospective single-center study
-
Baldazzi V, Tassi R, Lapini A, Santomaggio C, Carini M, Mazzanti R,. The impact of sunitinib-induced hypothyroidism on progression-free survival of metastatic renal cancer patients: a prospective single-center study. Urol Oncol 2012; 30: 704-710
-
(2012)
Urol Oncol
, vol.30
, pp. 704-710
-
-
Baldazzi, V.1
Tassi, R.2
Lapini, A.3
Santomaggio, C.4
Carini, M.5
Mazzanti, R.6
-
34
-
-
78651361788
-
Hypothyroidism in patients with renal cell carcinoma: Blessing or curse?
-
Schmidinger M, Vogl UM, Bojic M, et al. Hypothyroidism in patients with renal cell carcinoma: blessing or curse? Cancer 2011; 117: 534-544
-
(2011)
Cancer
, vol.117
, pp. 534-544
-
-
Schmidinger, M.1
Vogl, U.M.2
Bojic, M.3
-
35
-
-
69849108427
-
Clinical trial designs for predictive biomarker validation: Theoretical considerations and practical challenges
-
Mandrekar SJ, Sargent DJ,. Clinical trial designs for predictive biomarker validation: theoretical considerations and practical challenges. J Clin Oncol 2009; 27: 4027-4034
-
(2009)
J Clin Oncol
, vol.27
, pp. 4027-4034
-
-
Mandrekar, S.J.1
Sargent, D.J.2
|