The multifaceted balance of TNF-α and type I/II interferon responses in SLE and RA: How monocytes manage the impact of cytokines

Journal of Molecular Medicine

Volumn 90, Issue 11, 2012, Pages 1295-1309

  Smiljanovic, Biljana ^a   Grün, Joachim R ^a   Biesen, Robert ^b   Schulte Wrede, Ursula ^a   Baumgrass, Ria ^a   Stuhlmüller, Bruno ^b   Maslinski, Wlodzimierz ^c   Hiepe, Falk ^b   Burmester, Gerd R ^b   Radbruch, Andreas ^a   Häupl, Thomas ^b   Grützkau, Andreas ^a  

^a DEUTSCHES RHEUMA FORSCHUNGSZENTRUM   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c INSTITUTE OF RHEUMATOLOGY   (Poland)

Author keywords

IFN ; Monocytes; RA; SLE; TNF ; Transcriptome

Indexed keywords

ALPHA INTERFERON A; ALPHA INTERFERON A2; AZATHIOPRINE; CYCLOPHOSPHAMIDE; GAMMA INTERFERON; LEFLUNOMIDE; METHOTREXATE; METHYLPREDNISOLONE; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; STAT1 PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MONOCYTE; RHEUMATOID ARTHRITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADULT; AGED; ARTHRITIS, RHEUMATOID; CYTOKINES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERFERON TYPE I; INTERFERON-ALPHA; INTERFERON-GAMMA; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; MONOCYTES; STAT1 TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84868145563     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0907-y     Document Type: Article

References (36)

1. Marrack P, Kappler J, Kotzin BL (2001) Autoimmune disease: why and where it occurs. Nat Med 7:899-905. doi: 10.1038/90935
2. Ronnblom L, Elkon KB (2010) Cytokines as therapeutic targets in SLE. Nat Rev Rheumatol 6:339-347. doi: 10.1038/nrrheum.2010.64
3. McInnes IB, Schett G (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat Rev Immunol 7:429-442
4. Aringer M, Smolen JS (2008) The role of tumor necrosis factor-alpha in systemic lupus erythematosus. Arthritis Res Ther 10:202. doi: 10.1186/ar2341
5. Burmester GR, Haupl T (2004) Strategies using functional genomics in rheumatic diseases. Autoimmun Rev 3:541-549
6. Batliwalla FM, Baechler EC, Xiao X, Li W, Balasubramanian S, Khalili H, Damle A, Ortmann WA, Perrone A, Kantor AB et al (2005) Peripheral blood gene expression profiling in rheumatoid arthritis. Genes Immunol 6:388-397
7. Baechler EC, Bauer JW, Slattery CA, Ortmann WA, Espe KJ, Novitzke J, Ytterberg SR, Gregersen PK, Behrens TW, Reed AM (2007) An interferon signature in the peripheral blood of dermatomyositis patients is associated with disease activity. Mol Med 13:59-68
8. Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V et al (2003) Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 100:2610-2615
9. van der Pouw Kraan TC, Wijbrandts CA, van Baarsen LG, Voskuyl AE, Rustenburg F, Baggen JM, Ibrahim SM, Fero M, Dijkmans BA, Tak PP et al (2007) Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann Rheum Dis 66:1008-1014. doi: 10.1136/ard.2006.063412
10. Palucka AK, Blanck JP, Bennett L, Pascual V, Banchereau J (2005) Cross-regulation of TNF and IFN-alpha in autoimmune diseases. Proc Natl Acad Sci U S A 102:3372-3377. doi: 10.1073/pnas.0408506102
11. Batliwalla FM, Li W, Ritchlin CT, Xiao X, Brenner M, Laragione T, Shao T, Durham R, Kemshetti S, Schwarz E et al (2005) Microarray analyses of peripheral blood cells identifies unique gene expression signature in psoriatic arthritis. Mol Med 11:21-29
12. Baechler EC, Gregersen PK, Behrens TW (2004) The emerging role of interferon in human systemic lupus erythematosus. Curr Opin Immunol 16:801-807
13. Reynier F, Pachot A, Paye M, Xu Q, Turrel-Davin F, Petit F, Hot A, Auffray C, Bendelac N, Nicolino M et al (2010) Specific gene expression signature associated with development of autoimmune type-I diabetes using whole-blood microarray analysis. Genes Immunol 11:269-278. doi: 10.1038/gene.2009.112
14. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, Oni T, Wilkinson KA, Banchereau R, Skinner J, Wilkinson RJ et al (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466:973-977. doi: 10.1038/nature09247
15. van Baarsen LG, Wijbrandts CA, Rustenburg F, Cantaert T, van der Pouw Kraan TC, Baeten DL, Dijkmans BA, Tak PP, Verweij CL (2010) Regulation of IFN response gene activity during infliximab treatment in rheumatoid arthritis is associated with clinical response to treatment. Arthritis Res Ther 12:R11. doi: 10.1186/ar2912
16. Lyons PA, McKinney EF, Rayner TF, Hatton A, Woffendin HB, Koukoulaki M, Freeman TC, Jayne DR, Chaudhry AN, Smith KG (2010) Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis. Ann Rheum Dis 69:1208-1213. doi: 10.1136/ard.2009.108043
17. Gruetzkau A, Radbruch A (2008) Separation of whole blood cells and its impact on gene expression. In: Bosio A, Gerstmeyer B (eds) Microarrays in Inflammation. Birkhaeuser Verlag, Basel, pp 31-40
18. Grutzkau A, Grun J, Haupl T, Burmester GR, Radbruch A (2007) Gene expression in inflammatory rheumatic diseases. Dtsch Med Wochenschr 132:1888-1891. doi: 10.1055/s-2007-984982
19. Gordon S, Taylor PR (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5:953-964
20. Kinne RW, Stuhlmuller B, Burmester GR (2007) Cells of the synovium in rheumatoid arthritis. Macrophages. Arthritis Res Ther 9:224. doi: 10.1186/ar2333
21. Jiang N, Reich CF 3rd, Pisetsky DS (2003) Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. Blood 102:2243-2250. doi: 10.1182/blood-2002-10-3312
22. Biesen R, Demir C, Barkhudarova F, Grun JR, Steinbrich-Zollner M, Backhaus M, Haupl T, Rudwaleit M, Riemekasten G, Radbruch A et al (2008) Sialic acid-binding Ig-like lectin 1 expression in inflammatory and resident monocytes is a potential biomarker for monitoring disease activity and success of therapy in systemic lupus erythematosus. Arthritis Rheum 58:1136-1145. doi: 10.1002/art.23404
23. Stuhlmuller B, Haupl T, Hernandez MM, Grutzkau A, Kuban RJ, Tandon N, Voss JW, Salfeld J, Kinne RW, Burmester GR (2010) CD11c as a transcriptional biomarker to predict response to anti-TNF monotherapy with adalimumab in patients with rheumatoid arthritis. Clin Pharmacol Ther 87:311-321. doi: 10.1038/clpt.2009.244
24. Smiljanovic B, Grun JR, Steinbrich-Zollner M, Stuhlmuller B, Haupl T, Burmester GR, Radbruch A, Grutzkau A, Baumgrass R (2010) Defining TNF-alpha- and LPS-induced gene signatures in monocytes to unravel the complexity of peripheral blood transcriptomes in health and disease. J Mol Med 88:1065-1079. doi: 10.1007/s00109-010-0648-8
25. Kim SK, Lund J, Kiraly M, Duke K, Jiang M, Stuart JM, Eizinger A, Wylie BN, Davidson GS (2001) A gene expression map for Caenorhabditis elegans. Science 293:2087-2092. doi: 10.1126/science.1061603
26. Der SD, Zhou A, Williams BR, Silverman RH (1998) Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A 95:15623-15628
27. van Boxel-Dezaire AH, Rani MR, Stark GR (2006) Complex modulation of cell type-specific signaling in response to type I interferons. Immunity 25:361-372. doi: 10.1016/j.immuni.2006.08.014
28. van Boxel-Dezaire AH, Stark GR (2007) Cell type-specific signaling in response to interferon-gamma. Curr Top Microbiol Immunol 316:119-154
29. Ramana CV, Gil MP, Han Y, Ransohoff RM, Schreiber RD, Stark GR (2001) Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A 98:6674-6679. doi: 10.1073/pnas.111164198
30. Gil MP, Bohn E, O'Guin AK, Ramana CV, Levine B, Stark GR, Virgin HW, Schreiber RD (2001) Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A 98:6680-6685. doi: 10.1073/pnas.111163898
31. Bauer JW, Baechler EC, Petri M, Batliwalla FM, Crawford D, Ortmann WA, Espe KJ, Li W, Patel DD, Gregersen PK et al (2006) Elevated serum levels of interferon-regulated chemokines are biomarkers for active human systemic lupus erythematosus. PLoS Med 3:e491
32. Ramana CV, Gil MP, Schreiber RD, Stark GR (2002) Stat1-dependent and -independent pathways in IFN-gamma-dependent signaling. Trends Immunol 23:96-101
33. Zhao LJ, Hua X, He SF, Ren H, Qi ZT (2011) Interferon alpha regulates MAPK and STAT1 pathways in human hepatoma cells. Virol J 8:157. doi: 10.1186/1743-422X-8-157
34. Taylor MW, Grosse WM, Schaley JE, Sanda C, Wu X, Chien SC, Smith F, Wu TG, Stephens M, Ferris MW et al (2004) Global effect of PEG-IFN-alpha and ribavirin on gene expression in PBMC in vitro. J Interferon Cytokine Res 24:107-118. doi: 10.1089/107999004322813354
35. Karonitsch T, Feierl E, Steiner CW, Dalwigk K, Korb A, Binder N, Rapp A, Steiner G, Scheinecker C, Smolen J et al (2009) Activation of the interferon-gamma signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells. Arthritis Rheum 60:1463-1471. doi: 10.1002/art.24449
36. Feldmann M (2002) Development of anti-TNF therapy for rheumatoid arthritis. Nat Rev Immunol 2:364-371. doi: 10.1038/nri802