Structure-function relationships of Nile blue (EtNBS) derivatives as antimicrobial photosensitizers

European Journal of Medicinal Chemistry

Volumn 75, Issue , 2014, Pages 479-491

  Vecchio, Daniela ^a,b   Bhayana, Brijesh ^a   Huang, Liyi ^a,b,c   Carrasco, Elisa ^a,d   Evans, Conor L ^a,b   Hamblin, Michael R ^a,b,e  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GUANGXI MEDICAL UNIVERSITY   (China)

^d UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^e HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Benzophenothiazinium dye; Electron withdrawing donating substituents; Gram negative bacteria; Gram positive bacteria; Nile blue derivatives antimicrobial photodynamic inactivation; Structure activity relationships

Indexed keywords

2 [[AMINO(IMINIO)METHYL]AMINO] N [9 (DIETHYLAMINO) 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE]ETHANAMINIUM; ANTIBIOTIC AGENT; ARGININE DERIVATIVE; BENZENE DERIVATIVE; BENZOPHENOTHIAZINIUM DYE; GUANIDINE; N [1 ACETAMIDO 9 (DIETHYLAMINO) 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE] ETHANAMINIUM; N [1 AMINO 9 (DIETHYLAMINO) 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE]ETHANAMINIUM; N [9 (DIETHYLAMINO) 1 (N ETHYLPROPYLSULFONAMIDO) 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE]ETHANAMINIUM; N [9 (DIETHYLAMINO) 1 NITRO 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE]ETHANAMINIUM; N [9 (DIETHYLAMINO) 4 (N ETHYLPROPYLSULFONAMIDO) 5H BENZO[A]PHENOTHIAZIN 5 YLIDENE]ETHANAMINIUM; N ETHYLPROPYLSULFONAMIDO; PHOTOSENSITIZING AGENT; REACTIVE OXYGEN METABOLITE; SULFONAMIDE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ARTICLE; BACTERIAL CELL; BACTERIAL STRAIN; BACTERIUM CULTURE; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; ISOMER; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

BENZOPHENOTHIAZINIUM DYE; ELECTRON WITHDRAWING/DONATING SUBSTITUENTS; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; NILE BLUE DERIVATIVES, ANTIMICROBIAL PHOTODYNAMIC INACTIVATION; STRUCTURE-ACTIVITY RELATIONSHIPS;

ANTI-BACTERIAL AGENTS; GRAM-NEGATIVE BACTERIA; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIA; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; LIGHT; MICROBIAL SENSITIVITY TESTS; OXAZINES; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 84896709063     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.01.064     Document Type: Article

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