Innovative cationic fullerenes as broad-spectrum light-activated antimicrobials

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 6, Issue 3, 2010, Pages 442-452

  Huang, Liyi ^a,b,c   Terakawa, Mitsuhiro ^a,d   Zhiyentayev, Timur ^a,e   Huang, Ying Ying ^a,b,c   Sawayama, Yohei ^a,f   Jahnke, Ashlee ^g   Tegos, George P ^a,b   Wharton, Tim ^g   Hamblin, Michael R ^a,b,h  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c GUANGXI MEDICAL UNIVERSITY   (China)

^d KEIO UNIVERSITY   (Japan)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f UNIVERSITY OF TOKYO   (Japan)

^g LYNNTECH INC   (United States)

^h HARVARD MIT DIVISION OF HEALTH SCIENCES AND TECHNOLOGY   (United States)

Author keywords

Antimicrobial photoinactivation; Broad spectrum antimicrobials; Functionalized fullerenes; Photodynamic therapy; Quantitative structure function relationships

Indexed keywords

BROAD-SPECTRUM ANTIMICROBIALS; FUNCTIONALIZED; FUNCTIONALIZED FULLERENES; PHOTOINACTIVATION; QUANTITATIVE STRUCTURES;

BACTERIA; BACTERIOLOGY; COMPLEXATION; FULLERENES; FUNCTIONAL GROUPS; MOLECULES; OPTICAL MATERIALS; OXYGEN; PHOTOSENSITIZERS; PLASMONS; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL); TOXIC MATERIALS; YEAST;

PHOTODYNAMIC THERAPY;

ANTIINFECTIVE AGENT; CATIONIC FULLERENE DERIVATIVE; FULLERENE DERIVATIVE; PHOTOSENSITIZING AGENT; UNCLASSIFIED DRUG; CATION;

ANTIMICROBIAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; HYDROPHOBICITY; ILLUMINATION; LIPOPHILICITY; NONHUMAN; PHOTOACTIVATION; PHOTODYNAMICS; PSEUDOMONAS AERUGINOSA; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STAPHYLOCOCCUS AUREUS; BACTERIA; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; LIGHT; MICROBIAL SENSITIVITY TEST; MICROBIAL VIABILITY; RADIATION RESPONSE;

ANTI-INFECTIVE AGENTS; BACTERIA; CATIONS; FULLERENES; LIGHT; MICROBIAL SENSITIVITY TESTS; MICROBIAL VIABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

NEGIBACTERIA; POSIBACTERIA;

EID: 77952744202     PISSN: 15499634     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nano.2009.10.005     Document Type: Article

References (48)

1. Yoneyama H., and Katsumata R. Antibiotic resistance in bacteria and its future for novel antibiotic development. Biosci Biotechnol Biochem 70 (2006) 1060-1075
2. Dowell S.F. Antimicrobial resistance: is it really that bad?. Semin Pediatr Infect Dis 15 (2004) 99-104
3. Yoshikawa T.T. Antimicrobial resistance and aging: beginning of the end of the antibiotic era?. J Am Geriatr Soc 50 (2002) S226-S229
4. Hamblin M.R., and Mroz P. Advances in photodynamic therapy: basic, translational and clinical (2008), Norwood, MA, Artech House
5. Moan J., and Peng Q. An outline of the hundred-year history of PDT. Anticancer Res 23 (2003) 3591-3600
6. Dolmans D.E., Fukumura D., and Jain R.K. Photodynamic therapy for cancer. Nat Rev Cancer 3 (2003) 380-387
7. Wormald R., Evans J., Smeeth L., and Henshaw K. Photodynamic therapy for neovascular age-related macular degeneration. Cochrane Database Syst Rev (2007) CD002030
8. Hamblin MR, Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? 2004;3:436-50.
9. Jori G., and Brown S.B. Photosensitized inactivation of microorganisms. Photochem Photobiol Sci 3 (2004) 403-405
10. Maisch T. Anti-microbial photodynamic therapy: useful in the future?. Lasers Med Sci 22 (2007) 83-91
11. Lilly H.A., Lowbury E.J., and Wilkins M.D. Limits to progressive reduction of resident skin bacteria by disinfection. J Clin Pathol 32 (1979) 382-385
12. Soncin M., Fabris C., Busetti A., Dei D., Nistri D., Roncucci G., et al. Approaches to selectivity in the Zn(II)-phthalocyanine-photosensitized inactivation of wild-type and antibiotic-resistant Staphylococcus aureus. Photochem Photobiol Sci 1 (2002) 815-819
13. Tang H.M., Hamblin M.R., and Yow C.M. A comparative in vitro photoinactivation study of clinical isolates of multidrug-resistant pathogens. J Infect Chemother 13 (2007) 87-91
14. Lauro F.M., Pretto P., Covolo L., Jori G., and Bertoloni G. Photoinactivation of bacterial strains involved in periodontal diseases sensitized by porphycene-polylysine conjugates. Photochem Photobiol Sci 1 (2002) 468-470
15. Malik Z., Ladan H., and Nitzan Y. Photodynamic inactivation of Gram-negative bacteria: problems and possible solutions. J Photochem Photobiol B 14 (1992) 262-266
16. Merchat M., Bertolini G., Giacomini P., Villanueva A., and Jori G. Meso-substituted cationic porphyrins as efficient photosensitizers of gram-positive and gram-negative bacteria. J Photochem Photobiol B 32 (1996) 153-157
17. Nitzan Y., Gutterman M., Malik Z., and Ehrenberg B. Inactivation of gram-negative bacteria by photosensitized porphyrins. Photochem Photobiol 55 (1992) 89-96
18. Alves E., Costa L., Carvalho C.M., Tome J.P., Faustino M.A., Neves M.G., et al. Charge effect on the photoinactivation of Gram-negative and Gram-positive bacteria by cationic meso-substituted porphyrins. BMC Microbiol 9 (2009) 70
19. Mroz P., Tegos G.P., Gali H., Wharton T., Sarna T., and Hamblin M.R. Photodynamic therapy with fullerenes. Photochem Photobiol Sci 6 (2007) 1139-1149
20. Mroz P., Pawlak A., Satti M., Lee H., Wharton T., Gali H., et al. Functionalized fullerenes mediate photodynamic killing of cancer cells: type I versus type II photochemical mechanism. Free Radic Biol Med 43 (2007) 711-719
21. 2. J Am Chem Soc 125 (2003) 12803-12809
22. 24] fullerene phototoxicity towards HaCaT keratinocytes: type I vs type II mechanisms. Chem Res Toxicol 21 (2008) 1056-1063
23. Tegos G.P., Demidova T.N., Arcila-Lopez D., Lee H., Wharton T., Gali H., et al. Cationic fullerenes are effective and selective antimicrobial photosensitizers. Chem Biol 12 (2005) 1127-1135
24. Nobile C.J., and Mitchell A.P. Regulation of cell-surface genes and biofilm formation by the C. albicans transcription factor Bcr1p. Curr Biol 15 (2005) 1150-1155
25. Sherman F. Getting started with yeast. Methods Enzymol 194 (1991) 3-21
26. Demidova T.N., and Hamblin M.R. Effect of cell-photosensitizer binding and cell density on microbial photoinactivation. Antimicrob Agents Chemother 49 (2005) 2329-2335
27. Jett B.D., Hatter K.L., Huycke M.M., and Gilmore M.S. Simplified agar plate method for quantifying viable bacteria. Biotechniques 23 (1997) 648-650
28. Spesia M.B., Milanesio M.E., and Durantini E.N. Synthesis, properties and photodynamic inactivation of Escherichia coli by novel cationic fullerene C(60) derivatives. Eur J Med Chem 43 (2008) 853-861
29. Maggini M., Scorrano G., and Prato M. Addition of azomethine ylides to C-60-synthesis, characterization, and functionalization of fullerene pyrrolidines. J Am Chem Soc 115 (1993) 9798-9799
30. ow) and aqueous solubility. Environ Sci Technol 42 (2008) 5945-5950
31. Bakry R., Vallant R.M., Najam-ul-Haq M., Rainer M., Szabo Z., Huck C.W., et al. Medicinal applications of fullerenes. Int J Nanomed 2 (2007) 639-649
32. Demidova T.N., and Hamblin M.R. Photodynamic therapy targeted to pathogens. Int J Immunopathol Pharmacol 17 (2004) 245-254
33. Gottenbos B., van der Mei H.C., Klatter F., Grijpma D.W., Feijen J., Nieuwenhuis P., et al. Positively charged biomaterials exert antimicrobial effects on gram-negative bacilli in rats. Biomaterials 24 (2003) 2707-2710
34. Mitik-Dineva N., Wang J., Truong V.K., Stoddart P., Malherbe F., Crawford R.J., et al. Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus attachment patterns on glass surfaces with nanoscale roughness. Curr Microbiol 58 (2009) 268-273
35. Fass R.J., and Barnishan J. Effect of divalent cation concentrations on the antibiotic susceptibilities of nonfermenters other than Pseudomonas aeruginosa. Antimicrob Agents Chemother 16 (1979) 434-438
36. Vaara M. Agents that increase the permeability of the outer membrane. Microbiol Rev 56 (1992) 395-411
37. Hancock R.E. The Pseudomonas aeruginosa outer membrane permeability barrier and how to overcome it. Antibiot Chemother 36 (1985) 95-102
38. Yoshimura F., and Nikaido H. Permeability of Pseudomonas aeruginosa outer membrane to hydrophilic solutes. J Bacteriol 152 (1982) 636-642
39. Hancock R.E. Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria. Clin Infect Dis 27 Suppl 1 (1998) S93-S99
40. George S., Hamblin M.R., and Kishen A. Uptake pathways of anionic and cationic photosensitizers into bacteria. Photochem Photobiol Sci 8 (2009) 788-795
41. Merchat M., Spikes J.D., Bertoloni G., and Jori G. Studies on the mechanism of bacteria photosensitization by meso-substituted cationic porphyrins. J Photochem Photobiol B 35 (1996) 149-157
42. Bliss J.M., Bigelow C.E., Foster T.H., and Haidaris C.G. Susceptibility of Candida species to photodynamic effects of photofrin. Antimicrob Agents Chemother 48 (2004) 2000-2006
43. Munin E., Giroldo L.M., Alves L.P., and Costa M.S. Study of germ tube formation by Candida albicans after photodynamic antimicrobial chemotherapy (PACT). J Photochem Photobiol B 88 (2007) 16-20
44. Blanco M.T., Blanco J., Sanchez-Benito R., Perez-Giraldo C., Moran F.J., Hurtado C., et al. Incubation temperatures affect adherence to plastic of Candida albicans by changing the cellular surface hydrophobicity. Microbios 89 (1997) 23-28
45. Hazen K.C., Brawner D.L., Riesselman M.H., Jutila M.A., and Cutler J.E. Differential adherence of hydrophobic and hydrophilic Candida albicans yeast cells to mouse tissues. Infect Immun 59 (1991) 907-912
46. Soukos N.S., Ximenez-Fyvie L.A., Hamblin M.R., Socransky S.S., and Hasan T. Targeted antimicrobial photochemotherapy. Antimicrob Agents Chemother 42 (1998) 2595-2601
47. Soukos N.S., Wilson M., Burns T., and Speight P.M. Photodynamic effects of toluidine blue on human oral keratinocytes and fibroblasts and Streptococcus sanguis evaluated in vitro. Lasers Surg Med 18 (1996) 253-259
48. Zeina B., Greenman J., Corry D., and Purcell W.M. Cytotoxic effects of antimicrobial photodynamic therapy on keratinocytes in vitro. Br J Dermatol 146 (2002) 568-573