Antiretroviral adherence interventions in Southern Africa: Implications for using HIV treatments for prevention

Current HIV/AIDS Reports

Volumn 11, Issue 1, 2014, Pages 63-71

  Dewing, Sarah ^a   Mathews, Cathy ^a,d   Fatti, Geoffrey ^b   Grimwood, Ashraf ^b   Boulle, Andrew ^c  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b Kheth'Impilo   (South Africa)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

Author keywords

Antiretroviral adherence; ART care; HIV; HIV AIDS; Prevention; Retention in care; Science of prevention; South Africa; Southern Africa; TASP; Treatment as prevention (TasP)

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT;

ARTICLE; HEALTH EDUCATION; HEALTH PROGRAM; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION PREVENTION; INFORMATION RETRIEVAL; INTERVENTION STUDY; MEDICATION COMPLIANCE; PATIENT COMPLIANCE; SOUTH AFRICA;

ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; HIV INFECTIONS; HUMANS; MEDICATION ADHERENCE; SOUTH AFRICA;

EID: 84896708778     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-013-0193-5     Document Type: Article

References (63)

1. Williams B, Wood R, Dukay V, et al. Treatment as prevention: preparing the way. J Int AIDS Soc. 2011;14 Suppl 1:S6.
2. Goga A, Dinh T-H, Dlamini N, et al. Impact of the national prevention of mother to child transmission (PMTCT) program on mother-to-child transmission of HIV (MTCT), South Africa, 2010. In: 6th IAS Conference on Pathogenesis, Treatment and Prevention. Rome, Italy; 2011.
3. Kim MH, Ahmed S, Preidis GA, et al. Low Rates of Mother-to-Child HIV Transmission in a Routine Programmatic Setting in Lilongwe, Malawi. PLoS One. 2013;8:e64979.
4. Mofenson LM. Technical report: perinatal human immunodeficiency virus testing and prevention of transmission. Committee on Pediatric Aids. Pediatrics. 2000;106:E88.
5. Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365:493-505.
6. Eaton JW, Johnson LF, Salomon JA, et al. HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa. PLoS Med. 2012;9:e1001245.
7. Tanser F, Barnighausen T, Grapsa E, Zaidi J, Newell ML. High coverage of ART associated with decline in risk of HIV acquisition in rural KwaZulu-Natal, South Africa. Science. 2013;339:966-71.
8. Granich R, Gupta S, Suthar AB, Smyth C, Hoos D, Vitoria M, et al. Antiretroviral therapy in prevention of HIV and TB: update on current research efforts. Curr HIV Res. 2011;9:446-69.
9. McNairy ML, Howard AA, El-Sadr WM. Antiretroviral Therapy for Prevention of HIV and Tuberculosis: a Promising Intervention but Not a Panacea. J Acquir Immune Defic Syndr. 2013;63 Suppl 2: S200-7.
10. World Health Organization. Antiretroviral treatment as prevention (TasP)of HIV and TB: 2012 Update. Geneva: World Health Organization; 2012.
11. Bangsberg DR, Hecht FM, Charlebois ED, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS. 2000;14:357-66. (Pubitemid 30182431)
12. Nachega JB, Hislop M, Dowdy DW, et al. Adherence to nonnucleoside reverse transcriptase inhibitor-based HIV therapy and virologic outcomes. Ann Intern Med. 2007;146:564-73. (Pubitemid 351650537)
13. Bangsberg DR, Perry S, Charlebois ED, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS. 2001;15:1181-3. (Pubitemid 32549871)
14. Oyugi JH, Byakika-Tusiime J, Ragland K, et al. Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala, Uganda. AIDS. 2007;21:965-71. (Pubitemid 46684328)
15. Barnighausen T, Tanser F, Dabis F, Newell ML. Interventions to improve the performance of HIV health systems for treatment-as-prevention in sub-Saharan Africa: the experimental evidence. Curr Opin HIV AIDS. 2012;7:140-50.
16. Wandeler G, Keiser O, Pfeiffer K, et al. Outcomes of antiretroviral treatment programs in rural Southern Africa. J Acquir Immune Defic Syndr. 2012;59:e9-e16.
17. Cornell M, Grimsrud A, Fairall L, et al. Temporal changes in programme outcomes among adult patients initiating antiretroviral therapy across South Africa, 2002-2007. AIDS Behav. 2010;24:2263-70.
18. Mills EJ, Nachega JB, Buchan I, et al. Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis. JAMA. 2006;296:679-90. (Pubitemid 44200639)
19. Elul B, Basinga P, Nuwagaba-Biribonwoha H, et al. High levels of adherence and viral suppression in a nationally representative sample of HIV-infected adults on antiretroviral therapy for 6, 12 and 18 months in Rwanda. PLoS One. 2013;8:e53586.
20. Murphy RA, Sunpath H, Castilla C, et al. Second-line antiretroviral therapy: long-term outcomes in South Africa. J Acquir Immune Defic Syndr. 2012;61:158-63.
21. Nachega JB, Stein DM, Lehman DA, et al. Adherence to antiretroviral therapy in HIV-infected adults in Soweto, South Africa. AIDS Res Hum Retroviruses. 2004;20:1053-6. (Pubitemid 39392009)
22. Orrell C, Bangsberg DR, Badri M, Wood R. Adherence is not a barrier to successful antiretroviral therapy in South Africa. AIDS. 2003;17:1369-75. (Pubitemid 36819851)
23. Thirumurthy H, Siripong N, Vreeman RC, et al. Differences between self-reported and electronically monitored adherence among patients receiving antiretroviral therapy in a resource-limited setting. AIDS. 2012;26:2399-403.
24. Gupta RK, Jordan MR, Sultan BJ, et al. Global trends in antiretroviral resistance in treatment-naive individuals with HIV after rollout of antiretroviral treatment in resource-limited settings: a global collaborative study and meta-regression analysis. Lancet. 2012;380:1250-8.
25. Hamers RL, Sigaloff KC, Kityo C, Mugyenyi P, de Wit TF. Emerging HIV-1 drug resistance after roll-out of antiretroviral therapy in sub-Saharan Africa. Curr Opin HIV AIDS. 2013;8:19-26.
26. Nichols BE, Sigaloff KC, Kityo C, et al. Averted HIV infections due to expanded antiretroviral treatment eligibility offsets risk of transmitted drug resistance: a modeling study. AIDS. 2013. doi:10.1097/01.aids.0000433239.01611. 52.
27. Peltzer K, Ramlagan S, Jones D, et al. Efficacy of a lay health worker led group antiretroviral medication adherence training among non-adherent HIV-positive patients in KwaZulu-Natal, South Africa: results from a randomized trial. SAHARA J. 2012;9:218-26. This randomised trial suggests that lay health workers are as effective as professional clinic staff for providing ARV adherence support. Another significant finding is that an increase in adherence-related information on its own was not enough to impact ARV adherence behaviour..
28. Amico KR. Standard of care for antiretroviral therapy adherence and retention in care from the perspective of care providers attending the 5th International Conference on HIV Treatment Adherence. J Int Assoc Physicians AIDS Care (Chic). 2011;10:291-6.
29. Schneider H, Hlophe H, van Rensburg D. Community health workers and the response to HIV/AIDS in South Africa: tensions and prospects. Health Policy Plan. 2008;23:179-87.
30. Dewing S, Mathews C, Schaay N, et al. "It's Important to Take Your Medication Everyday Okay?" An Evaluation of Counselling by Lay Counsellors for ARV Adherence Support in the Western Cape. South Africa: AIDS and Behavior; 2012.
31. Myer L, Zulliger R, Pienaar D. Diversity of patient preparation activities before initiation of antiretroviral therapy in Cape Town, South Africa. Trop Med Int Health. 2012;17:972-7.
32. Torpey KE, Kabaso ME, Mutale LN, et al. Adherence support workers: a way to address human resource constraints in antiretroviral treatment programs in the public health setting in Zambia. PLoS One. 2008;3:e2204.
33. Ritzenthaler R. Delivering antiretroviral therapy in resource-constrained settings: Lessons from Ghana, Kenya and Rwanda. Arlington: Family Health International; 2005.
34. Feldacker C, Johnson D, Hosseinipour M, Phiri S, Tweya H. Who starts? Factors associated with starting antiretroviral therapy among eligible patients in two, public HIV clinics in Lilongwe, Malawi. PLoS One. 2012;7:e50871.
35. Remien RH, Mellins CA, Robbins RN, et al. Masivukeni: development of a multimedia based antiretroviral therapy adherence intervention for counselors and patients in South Africa. AIDS Behav. 2013;17:1979-91.
36. Dean AL, Makin JD, Kydd AS, Biriotti M, Forsyth BW. A pilot study using interactive SMS support groups to prevent mother-to-child HIV transmission in South Africa. J Telemed Telecare. 2012;18:399-403.
37. Tirivayi N, Koethe JR, Groot W. Clinic-based food assistance is associated with increased medication adherence among HIV-infected adults on long-term antiretroviral therapy in Zambia. J AIDS Clin Res. 2012;3:171.
38. Ford N, Mills EJ. Simplified ART delivery models are needed for the next phase of scale up. PLoS Med. 2011;8:e1001060.
39. • Luque-Fernandez MA, Van Cutsem G, Goemaere E, et al. Effectiveness of patient adherence groups as a model of care for stable patients on antiretroviral therapy in Khayelitsha, Cape Town, South Africa. PLoS One. 2013;8:e56088. This study provides evidence for the effectiveness of a simplified model of care in which the management of ARV treatment is moved out of primary healthcare facilities and in to the community. This model can facilitate the expansion of ART programmes in SSA.
40. Medicines Sans Frontiers: ART Adherence Club Report and Toolkit. In: Medicines Sans Frontiers; 2012.
41. • Fatti G, Meintjes G, Shea J, Eley B, Grimwood A. Improved survival and antiretroviral treatment outcomes in adults receiving community-based adherence support: 5-year results from a multicentre cohort study in South Africa. J Acquir Immune Defic Syndr. 2012;61:e50-8. This study shows that the large-scale implementation of a lay health worker delivered adherence support programme in South Africa has been effective in improving adherence outcomes. Strengths of this study include a 5 year follow-up and large sample size from 4 provinces..
42. Boyles TH, Wilkinson LS, Leisegang R, Maartens G. Factors influencing retention in care after starting antiretroviral therapy in a rural South African programme. PLoS One. 2011;6:e19201.
43. Kranzer K, Lewis JJ, Ford N, et al. Treatment interruption in a primary care antiretroviral therapy program in South Africa: cohort analysis of trends and risk factors. J Acquir Immune Defic Syndr. 2010;55:e17-23.
44. Lyimo RA, de Bruin M, van den Boogaard J, et al. Determinants of antiretroviral therapy adherence in northern Tanzania: a comprehensive picture from the patient perspective. BMC Public Health. 2012;12:716.
45. Weiser S, Wolfe W, Bangsberg D, et al. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. 2003;34:281-8. (Pubitemid 37377361)
46. Eholie SP, Tanon A, Polneau S, et al. Field adherence to highly active antiretroviral therapy in HIV-infected adults in Abidjan, Cote d'Ivoire. J Acquir Immune Defic Syndr. 2007;45:355-8. (Pubitemid 47012385)
47. Uzochukwu BS, Onwujekwe OE, Onoka AC, et al. Determinants of non-adherence to subsidized anti-retroviral treatment in southeast Nigeria. Health Policy Plan. 2009;24:189-96.
48. Talam NC, Gatongi P, Rotich J, Kimaiyo S. Factors affecting antiretroviral drug adherence among HIV/AIDS adult patients attending HIV/AIDS clinic at Moi Teaching and Referral Hospital, Eldoret, Kenya. East Afr J Public Health. 2008;5:74-8.
49. Byakika-Tusiime J, Crane J, et al. Longitudinal antiretroviral adherence in HIV+ Ugandan parents and their children initiating HAART in the MTCT-Plus family treatment model: role of depression in declining adherence over time. AIDS Behav. 2009;13 Suppl 1:82-91.
50. Musumari PM, Feldman MD, Techasrivichien T, et al. "If I have nothing to eat, I get angry and push the pills bottle away fromme": a qualitative study of patient determinants of adherence to antiretroviral therapy in the Democratic Republic of Congo. AIDS Care. 2013. doi:10.1080/09540121. 2013.764391.
51. Senkomago V, Guwatudde D, Breda M, Khoshnood K. Barriers to antiretroviral adherence in HIV-positive patients receiving free medication in Kayunga, Uganda. AIDS Care. 2011;23:1246-53.
52. Weiser SD, Tuller DM, Frongillo EA, et al. Food insecurity as a barrier to sustained antiretroviral therapy adherence in Uganda. PLoS One. 2010;5:e10340.
53. Siedner MJ, Lankowski A, Tsai AC, et al. GPS-measured distance to clinic, but not self-reported transportation factors, are associated with missed HIV clinic visits in rural Uganda. AIDS. 2013. doi:10.1097/QAD.0b013e32835fd873.
54. Dahab M, Charalambous S, Hamilton R, et al. "That is why I stopped the ART": patients' & providers' perspectives on barriers to and enablers of HIV treatment adherence in a South African workplace programme. BMC Public Health. 2008;8:63.
55. Miller MM, Ketlhapile M, Rybasack-Smith H, Rosen S. Why are antiretroviral treatment patients lost to follow-up? A qualitative study from South Africa. Trop Med Int Health. 2010;15:48-54.
56. Heffron R, Ngure K, Mugo N, et al. Willingness of Kenyan HIV-1 serodiscordant couples to use antiretroviral-based HIV-1 prevention strategies. J Acquir Immune Defic Syndr. 2012;61:116-9.
57. Haire B, Kaldor JM. Ethics of ARV based prevention: treatment-as- prevention and PrEP. Dev World Bioeth. 2013;13:63-9.
58. Decroo T, Mondlane V, Dos Santos N, et al. Community ART groups support ART access and retention among HIV-positive dependent children in rural Tete, Mozambique (WEPE720). In: International AIDS Conference. Washington DC; 2012.
59. Dewing S, Mathews C, Cloete A, et al. From research to practice: lay adherence counsellors' fidelity to an evidence-based intervention for promoting adherence to antiretroviral treatment in the Western Cape, South Africa. AIDS Behav. 2013;17:2935-45.
60. Mills EJ, Lester R, Ford N. Promoting long term adherence to antiretroviral treatment. BMJ. 2012;344:e4173. doi:10.1136/bmj.e4173.
61. Rodrigues R, Shet A, Antony J, et al. Supporting adherence to antiretroviral therapy with mobile phone reminders: results from a cohort in South India. PLoS One. 2012;7:e40723.
62. Nash D, Korves C, Saito S, et al. Characteristics of Facilities and Programs Delivering HIV Care and Treatment Services Are Associated with Loss to Follow-up Rates in Programs from 7 Sub-Saharan African Countries. In: 15th Conference on Retroviruses and Opportunistic Infections. Montreal, Canada; 2008.
63. Cantrell RA, Sinkala M, Megazinni K, et al. A pilot study of food supplementation to improve adherence to antiretroviral therapy among food-insecure adults in Lusaka, Zambia. J Acquir Immune Defic Syndr. 2008;49:190-5.