Nestin expression is associated with aggressive cutaneous melanoma of the nodular type

Modern Pathology

Volumn 27, Issue 3, 2014, Pages 396-401

  Ladstein, Rita G ^a   Bachmann, Ingeborg M ^a,b   Straume, Oddbjørn ^a,b   Akslen, Lars A ^a,b  

^a UNIVERSITY OF BERGEN   (Norway)

^b HAUKELAND UNIVERSITY HOSPITAL   (Norway)

Author keywords

Melanoma; Nestin; Prognosis; Survival

Indexed keywords

NESTIN;

ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER PROGNOSIS; CANCER STAGING; CANCER SURVIVAL; CAUSE OF DEATH; CONTROLLED STUDY; CUTANEOUS MELANOMA; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MELANOCYTIC NEVUS; PATHOLOGY; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; TUMOR CELL; TUMOR INVASION; TUMOR LOCALIZATION; TUMOR NECROSIS;

AGED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MELANOMA; NESTIN; PROGNOSIS; SKIN NEOPLASMS; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 84896703821     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.151     Document Type: Article

References (32)

1. Garbe C, Eigentler TK, Keilholz U, et al. Systematic review of medical treatment in melanoma: current status and future prospects. Oncologist 2011;16: 5-24.
2. Garbe C, Leiter U. Melanoma epidemiology and trends. Clin Dermatol 2009;27: 3-9.
3. Lendahl U, Zimmerman LB, McKay RD. CNS stem cells express a new class of intermediate filament protein. Cell 1990;60: 585-595.
4. Wiese C, Rolletschek A, Kania G, et al. Nestin expression-a property of multi-lineage progenitor cells? Cell Mol Life Sci 2004;61: 2510-2522.
5. Ishiwata T, Matsuda Y, Naito Z. Nestin in gastrointestinal and other cancers: effects on cells and tumor angiogenesis. World J Gastroenterol 2011;17: 409-418.
6. Milde T, Hielscher T, Witt H, et al. Nestin expression identifies ependymoma patients with poor outcome. Brain Pathol 2012;22: 848-860.
7. Zhang M, Song T, Yang L, et al. Nestin and CD133: valuable stem cell-specific markers for determining clinical outcome of glioma patients. J Exp Clin Cancer Res 2008;27:85.
8. Ryuge S, Sato Y, Wang GQ, et al. Prognostic significance of nestin expression in resected non-small cell lung cancer. Chest 2011;139: 862-869.
9. Liu C, Chen B, Zhu J, et al. Clinical implications for nestin protein expression in breast cancer. Cancer Sci 2010;101: 815-819.
10. Yang XH, Wu QL, Yu XB, et al. Nestin expression in different tumours and its relevance to malignant grade. J Clin Pathol 2008;61: 467-473.
11. Gravdal K, Halvorsen OJ, Haukaas SA, et al. Proliferation of immature tumor vessels is a novel marker of clinical progression in prostate cancer. Cancer Res 2009;69: 4708-4715.
12. Kruger K, Stefansson IM, Collett K, et al. Microvessel proliferation by co-expression of endothelial nestin and Ki-67 is associated with a basal-like phenotype and aggressive features in breast cancer. Breast 2012;22: 282-288.
13. Teranishi N, Naito Z, Ishiwata T, et al. Identification of neovasculature using nestin in colorectal cancer. Int J Oncol 2007;30: 593-603.
14. Klein WM, Wu BP, Zhao S, et al. Increased expression of stem cell markers in malignant melanoma. Mod Pathol 2007;20: 102-107.
15. Florenes VA, Holm R, Myklebost O, et al. Expression of the neuroectodermal intermediate filament nestin in human melanomas. Cancer Res 1994;54: 354-356.
16. Piras F, Perra MT, Murtas D, et al. The stem cell marker nestin predicts poor prognosis in human melanoma. Oncol Rep 2010;23: 17-24.
17. Tanabe K, Amoh Y, Kanoh M, et al. Prognostic significance of the hair follicle stem cell marker nestin in patients with malignant melanoma. Eur J Dermatol 2010;20: 283-288.
18. Straume O, Sviland L, Akslen LA. Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma. Clin Cancer Res 2000;6: 1845-1853.
19. Ladstein RG, Bachmann IM, Straume O, et al. Prognostic importance of the mitotic marker phosphohistone h3 in cutaneous nodular melanoma. J Invest Dermatol 2012;132: 1247-1252.
20. Ladstein RG, Bachmann IM, Straume O, et al. Tumor necrosis is a prognostic factor in thick cutaneous melanoma. Am J Surg Pathol 2012;36: 1477-1482.
21. Breslow A. Thickness, cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 1970;172: 902-908.
22. Clark WH Jr, From L, Bernardino EA, et al. The histogenesis and biologic behavior of primary human malignant melanomas of the skin. Cancer Res 1969;29: 705-727.
23. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med 1998;4: 844-847.
24. Nocito A, Bubendorf L, Tinner EM, et al. Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade. J Pathol 2001;194: 349-357.
25. Straume O, Akslen LA. Importance of vascular phenotype by basic fibroblast growth factor, and influence of the angiogenic factors basic fibroblast growth factor/fibroblast growth factor receptor-1 and ephrin-A1/EphA2 on melanoma progression. Am J Pathol 2002;160: 1009-1019.
26. Aas T, Borresen AL, Geisler S, et al. Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat Med 1996; 2: 811-814.
27. Straume O, Akslen LA. Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma. Int J Cancer 1997;74: 535-539.
28. Fusi A, Reichelt U, Busse A, et al. Expression of the stem cell markers nestin and CD133 on circulating melanoma cells. J Invest Dermatol 2011;131: 487-494.
29. Setia N, Abbas O, Sousa Y, et al. Profiling of ABC transporters ABCB5, ABCF2 and nestin-positive stem cells in nevi, in situ and invasive melanoma. Mod Pathol 2012;25: 1169-1175.
30. Chen PL, Chen WS, Li J, et al. Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas. Mod Pathol 2012;26: 44-53.
31. Brychtova S, Fiuraskova M, Hlobilkova A, et al. Nestin expression in cutaneous melanomas and melanocytic nevi. J Cutan Pathol 2007;34: 370-375.
32. Ehrmann J, Kolar Z, Mokry J. Nestin as a diagnostic and prognostic marker: immunohistochemical analysis of its expression in different tumours. J Clin Pathol 2005;58: 222-223.