Diagnostic utility of neural stem and progenitor cell markers nestin and SOX2 in distinguishing nodal melanocytic nevi from metastatic melanomas

Modern Pathology

Volumn 26, Issue 1, 2013, Pages 44-53

  Chen, Pei Ling ^a   Chen, Wei Shen ^a   Li, Jianping ^a   Lind, Anne C ^a   Lu, Dongsi ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ST LUKE S HOSPITAL   (United States)

Author keywords

Metastatic melanomas; nestin; nodal melanocytic nevi; SOX2

Indexed keywords

MELAN A; NESTIN; TRANSCRIPTION FACTOR SOX2;

ADULT; AGED; ARTICLE; CANCER CYTODIAGNOSIS; CANCER STAGING; CELL INFILTRATION; CLINICAL ARTICLE; DESMOPLASTIC MELANOMA; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE; MALE; MELANOCYTIC NEVUS; METASTATIC MELANOMA; NEURAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEM CELL; TUMOR CELL;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MELANOMA; MIDDLE AGED; NEOPLASM STAGING; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEVUS, PIGMENTED; SENTINEL LYMPH NODE BIOPSY; SKIN NEOPLASMS; SOXB1 TRANSCRIPTION FACTORS; STEM CELLS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84871924911     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2012.132     Document Type: Article

References (29)

1. Gershenwald JE, Ross MI. Sentinel-lymph-node biopsyfor cutaneous melanoma. N Engl J Med 2011;364:1738-1745
2. Morton DL, Thompson JF, Cochran AJ, et al. Sentinelnodebiopsy or nodal observation in melanoma. N EnglJ Med 2006;355:1307-1317
3. Gershenwald JE, Andtbacka RH, Prieto VG, et al.Microscopic tumor burden in sentinel lymph nodespredicts synchronous nonsentinel lymph node involvementin patients with melanoma. J Clin Oncol 2008;26:4296-4303
4. Stebbins WG, Garibyan L, Sober AJ. Sentinel lymphnode biopsy and melanoma: 2010 update Part II. J AmAcad Dermatol 2010;62:737-748; quiz 749-750
5. Balch CM, Gershenwald JE, Atkins MB, et al. Melanomaof the skin. In: Edge SB, Byrd DR, Compton CC,et al. (eds), AJCC Cancer Staging Manual, 7th edn.Springer: New York; 2009, pp 325-344
6. Scheri RP, Essner R, Turner RR, et al. Isolated tumorcells in the sentinel node affect long-term prognosis ofpatients with melanoma. Ann Surg Oncol 2007;14:2861-2866 (Pubitemid 47460638)
7. Biddle DA, Evans HL, Kemp BL, et al. Intraparenchymalnevus cell aggregates in lymph nodes: a possiblediagnostic pitfall with malignant melanoma andcarcinoma. Am J Surg Pathol 2003;27:673-681 (Pubitemid 36514478)
8. Carson KF, Wen DR, Li PX, et al. Nodal nevi andcutaneous melanomas. Am J Surg Pathol 1996;20:834-840
9. Murray CA, Leong WL, McCready DR, et al. Histopathologicalpatterns of melanoma metastases insentinel lymph nodes. J Clin Pathol 2004;57:64-67 (Pubitemid 38091313)
10. Howell BG, Lipa JE, Ghazarian DM. Intracapsularmelanoma: a new pitfall for sentinel lymph nodebiopsy. J Clin Pathol 2006;59:891-892 (Pubitemid 44211764)
11. Shidham VB, Qi DY, Acker S, et al. Evaluation ofmicrometastases in sentinel lymph nodes of cutaneousmelanoma: higher diagnostic accuracy with Melan-Aand MART-1 compared with S-100 protein and HMB-45. Am J Surg Pathol 2001;25:1039-1046 (Pubitemid 32685901)
12. Ohsie SJ, Sarantopoulos GP, Cochran AJ, et al. Immunohistochemicalcharacteristics of melanoma.J Cutan Pathol 2008;35:433-444
13. Nonaka D, Chiriboga L, Rubin BP. Sox10: a panschwannianand melanocytic marker. Am J Surg Pathol2008;32:1291-1298
14. Lohmann CM, Iversen K, Jungbluth AA, et al. Expressionof melanocyte differentiation antigens and ki-67in nodal nevi and comparison of ki-67 expressionwith metastatic melanoma. Am J Surg Pathol 2002;26:1351-1357
15. Mahmood MN, Lee MW, Linden MD, et al. Diagnosticvalue of HMB-45 and anti-melan A staining of sentinellymph nodes with isolated positive cells. Mod Pathol2002;15:1288-1293 (Pubitemid 35462996)
16. Blochin E, Nonaka D. Diagnostic value of Sox10immunohistochemical staining for the detection ofmetastatic melanoma in sentinel lymph nodes. Histopathology2009;55:626-628
17. Boiko AD, Razorenova OV, van de Rijn M, et al. Humanmelanoma-initiating cells express neural crestnerve growth factor receptor CD271. Nature 2010;466:133-137
18. Lendahl U, Zimmerman LB, McKay RD. CNS stemcells express a new class of intermediate filamentprotein. Cell 1990;60:585-595
19. Florenes VA, Holm R, Myklebost O, et al. Expressionof the neuroectodermal intermediate filamentnestin in human melanomas. Cancer Res 1994;54:354-356 (Pubitemid 24053166)
20. Brychtova S, Fiuraskova M, Hlobilkova A, et al. Nestinexpression in cutaneous melanomas and melanocyticnevi. J Cutan Pathol 2007;34:370-375
21. Klein WM, Wu BP, Zhao S, et al. Increased expressionof stem cell markers in malignant melanoma. ModPathol 2007;20:102-107 (Pubitemid 44967955)
22. Bakos RM, Maier T, Besch R, et al. Nestin and SOX9and SOX10 transcription factors are coexpressed inmelanoma. Exp Dermatol 2010;19:e89-e94
23. Laga AC, Zhan Q, Weishaupt C, et al. SOX2 and nestinexpression in human melanoma: an immunohistochemicaland experimental study. Exp Dermatol2011;20:339- 345
24. Piras F, Perra MT, Murtas D, et al. The stem cell markernestin predicts poor prognosis in human melanoma.Oncol Rep 2010;23:17-24
25. Fusi A, Reichelt U, Busse A, et al. Expression of thestem cell markers nestin and CD133 on circulatingmelanoma cells. J Invest Dermatol 2011;131:487-494
26. Tanaka S, Kamachi Y, Tanouchi A, et al. Interplay ofSOX and POU factors in regulation of the Nestin genein neural primordial cells. Mol Cell Biol 2004;24:8834-8846 (Pubitemid 39313890)
27. Takahashi K, Yamanaka S. Induction of pluripotentstem cells from mouse embryonic and adult fibroblastcultures by defined factors. Cell 2006;126:663-676 (Pubitemid 44233629)
28. Stewart FW, Copeland MM. Neurogenic sarcoma. Am JCancer 1931;15:1235
29. Patterson JW. Nevus cell aggregates in lymph nodes.Am J Clin Pathol 2004;121:13-15 (Pubitemid 38090148)