Amino acid prodrug of quinidine: An approach to circumvent P-glycoprotein mediated cellular efflux

International Journal of Pharmaceutics

Volumn 464, Issue 1-2, 2014, Pages 196-204

  Patel, Mitesh ^a   Mandava, Nanda K ^a   Pal, Dhananjay ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Ile quinidine; LAT1 transporter; P gp circumvention; Prodrugs; Transport; Uptake

Indexed keywords

AMINO ACID; AMINO ACID TRANSPORTER; CARBON 14; CYCLOSPORIN; CYCLOSPORIN A; ELACRIDAR; ERYTHROMYCIN; LEVO ISOLEUCINE ESTER; MULTIDRUG RESISTANCE PROTEIN; PRODRUG; QUINIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHEMICAL MODIFICATION; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG PENETRATION; HYDROLYSIS; INTRACELLULAR TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MODIFICATION;

ILE-QUINIDINE; LAT1 TRANSPORTER; P-GP CIRCUMVENTION; PRODRUGS; TRANSPORT; UPTAKE;

ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE PERMEABILITY; DOGS; ISOLEUCINE; MADIN DARBY CANINE KIDNEY CELLS; P-GLYCOPROTEIN; PRODRUGS; QUINIDINE;

EID: 84896698562     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2014.01.006     Document Type: Article

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