Improved computational fluid dynamic simulations of blood flow in membrane oxygenators from x-ray imaging

Annals of Biomedical Engineering

Volumn 41, Issue 10, 2013, Pages 2088-2098

  Jones, Cameron C ^a   McDonough, James M ^a   Capasso, Patrizio ^a   Wang, Dongfang ^a   Rosenstein, Kyle S ^a   Zwischenberger, Joseph B ^a  

^a NONE   (United States)

Author keywords

Artificial Lung; CFD; Ergun equation; Navier Stokes equations; Porous media

Indexed keywords

ARTIFICIAL LUNG; AVERAGE DIFFERENCE; COMMERCIAL MEMBRANES; DIGITAL SUBTRACTION ANGIOGRAPHY; ERGUN EQUATION; GAS TRANSPORT PROPERTIES; INERTIAL COEFFICIENTS; MEMBRANE OXYGENATORS;

ARTIFICIAL ORGANS; COMPUTATIONAL FLUID DYNAMICS; COMPUTER SIMULATION; FIBERS; NAVIER STOKES EQUATIONS; NUMERICAL METHODS; POROUS MATERIALS; TRANSPORT PROPERTIES; VELOCITY;

OXYGENATORS;

ARTICLE; ARTIFICIAL LUNG; BLOOD FLOW; COMPUTATIONAL FLUID DYNAMICS; DIGITAL SUBTRACTION ANGIOGRAPHY; MEMBRANE OXYGENATOR; MEMBRANE PERMEABILITY; POROSITY; RADIOGRAPHY; SIMULATION; ANIMAL; BIOLOGICAL MODEL; BLOOD FLOW VELOCITY; COMPUTER SIMULATION; HUMAN; TOMOGRAPHY;

ANIMALS; BLOOD FLOW VELOCITY; COMPUTER SIMULATION; HUMANS; MODELS, CARDIOVASCULAR; OXYGENATORS, MEMBRANE; TOMOGRAPHY, X-RAY;

EID: 84896696037     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-013-0824-4     Document Type: Article

References (36)

1. Ansys fluent 12.0 user's guide. ANSYS Inc.; 2009.
2. Asakawa, Y.; A. Funakubo, K. Fukunaga, I. Taga, T. Higami, T. Kawamura, et al. Development of an implantable oxygenator with cross-flow pump. ASAIO J. 52:291-295, 2006.
3. Baurmeister, U. Multilayer hollow fiber wound body. Pat. No. 5,143,312.
4. Bird, R.; W. Stewart, and E. Lightfoot, eds. Transport Phenomena. 2nd ed.: John Wiley & Sons, Inc.; 2007.
5. Burke, S.; and W. Plummer. Gas flow through packed columns. Ind. Eng. Chem. 20:1196-1200, 1928.
6. Carman, P. Fluid flow through granular beds. Trans. Inst. Chem. Eng. (London) 15:150-166, 1937.
7. Cattaneo, G.; H. Reul, T. Schmitz-Rode, and U. Steinseifer. Intravascular blood oxygenation using hollow fibers in a disk-shaped configuration: experimental evaluation of the relationship between porosity and performance. ASAIO J. 52:180-185, 2006.
8. Chhabra, R.; J. Comiti, and I. Machač. Flow of non-newtonian fluids in fixed and fluidised beds. Chem. Eng. Sci. 56:1-27, 2001.
9. Civan, F. Porous Media Transport Phenomena. John Wiley & Sons, 2011.
10. Dierickx, P.; D. de Wachter, F. de Somer, G. Van Nooten, and P. Verdonck. Mass transfer characteristics of artificial lungs. ASAIO J. 47:628-633, 2001.
11. Dierickx, P.; D. De Wachter, and P. Verdonck. Blood flow around hollow fibers. Int. J. Artif. Organs. 23:610-617, 2000.
12. Dybbs, A.; and R. Edwards, eds. A New Look at Porous Media Fluid Mechanics. Darcy to Turbulent: The Hague: Martinus Nijhoff, 1984.
13. Ergun, S. Fluid flow through packed columns. Chem. Eng. Prog. 48:89-94, 1952.
14. Fill, B.; M. Gartner, G. Johnson, M. Horner, and J. Ma. Computational fluid flow and mass transfer of a functionally integrated pediatric pump-oxygenator configuration. ASAIO J. 54:214-219, 2008.
15. Funakubo, A.; I. Taga, J. McGilucuddy, Y. Fukui, R. Hirschl, and R. Bartlett. Flow vectorial analysis in an artificial implantable lung. ASAIO J. 49:383-387, 2003.
16. Gage, K.; M. Gartner, G. Burgreen, and W. Wagner. Predicting membrane oxygenator pressure drop using computational fluid dynamics. Artif. Organs. 26:600-607, 2002.
17. Gartner, M.; C. Wilhelm, K. Gage, M. Fabrizio, and W. Wagner. Modeling flow effects on thrombotic deposition in a membrane oxygenator. Artif. Organs. 24:29-36, 2000.
18. Goodin, M.; E. Thor, and W. Haworth. Use of computational fluid dynamics in the design of the Avecor Affinity oxygenator. Perfusion 9:217-222, 1994.
19. Graefe, R.; R. Borchardt, J. Arens, P. Schlanstein, T. Schmitz-Rode, and U. Steinseifer. Improving oxygenator performance using computational simulation and flow field-based parameters. Artif. Organs. 34:930-936, 2010.
20. Jackson, G.; and J. Df. The permeability of fibrous porous media. Can. J. Chem. Eng. 64:364-374, 1986.
21. Jaganathan, S.; H. Tafreshi, and B. Pourdeyhimi. A realistic approach for modeling permeability of fibrous media: 3-d imaging coupled with CFD simulation. Chem. Eng. Sci. 63:244-252, 2008.
22. Jones, C.; P. Capasso, J. McDonough, D. Wang, K. Rosenstein, and J. Zwischenberger. Biplane angiography for experimental verification of CFD models of blood flow in artificial lungs. ASAIO J. (in press).
23. Jönsson, K.; and B. Jönsson. Fluid-flow in compressible porous media I: Steady-state conditions. AIChE J. 38:1340-1348, 1992.
24. Leva, M. Fluidization. New York: McGraw-Hill Book Co.; 1959.
25. Macdonald, T.; M. El-Sayed, K. Mow, and F. Dullien. Flow through porous media - the Ergun equation revisited. Ind. Eng. Chem. Fundam. 18:199-208, 1979.
26. Mazaheri, A.; and G. Ahmadi. Uniformity of the fluid flow velocities within hollow fiber membranes of blood oxygenation devices. Artif. Organs. 30:10-15, 2006.
27. McDonough, J. Lectures in basic computational numerical analysis. 2007.
28. McDonough, J. Lectures in computational fluid dynamics of incompressible flow: Mathematics, algorithms and implementations. 2007.
29. Niven, R. Physical insight into the Ergun and Wen & Yu equations for fluid flow in packed and fluidised beds. Chem. Eng. Sci. 57:527-534, 2002.
30. Pacella, H.; H. Eash, B. Frankowski, and W. Federspiel. Darcy permeability of hollow fiber bundles used in blood oxygenation devices. J. Membr. Sci. 382:238-242, 2011.
31. Roache, P. Quantification of uncertainty in computational fluid dynamics. Ann. Rev. Fluid. Mech. 29:123-160, 1997.
32. Sato, H.; I. Taga, T. Kinoshita, A. Funakubo, S. Ichiba, and N. Shimizu. In vitro evaluation of a newly developed implantable artificial lung. Acta Med. Okayama 60:113-119, 2006.
33. Verdonck, P. The role of computational fluid dynamics for artificial organ design. Artif. Organs. 26:569-570, 2002.
34. Wickramasinghe, S.; B. Han, J. Garcia, and R. Specht. Microporous membrane blood oxygenators. AIChE J. 51:656-670, 2005.
35. Zhang, J.; T. Nolan, T. Zhang, B. Griffith, and J. Zhongjun. Characterization of membrane blood oxygenation devices using computational fluid dynamics. J. Membr. Sci. 288:268-279, 2007.
36. Zobel, S.; B. Maze, H. Tafreshi, Q. Wang, and B. Pourdeyhimi. Simulating permeability of 3d calendered fibrous structures. Chem. Eng. Sci. 62:6285-6296, 2007.