Association between GRIN3A gene polymorphism in Kawasaki disease and coronary artery aneurysms in Taiwanese children

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Lin, Ying Ju ^a,b   Chang, Jeng Sheng ^a   Liu, Xiang ^a,c   Hung, Chien Hui ^d   Lin, Ting Hsu ^a   Huang, Shao Mei ^a   Jeang, Kuan Teh ^c   Chen, Chia Yen ^c   Liao, Chiu Chu ^a   Lin, Cheng Wen ^b   Lai, Chih Ho ^e   Tien, Ni ^b   Lan, Yu Ching ^b   Ho, Mao Wang ^a   Chien, Wen Kuei ^b,f   Chen, Jin Hua ^b,f   Huang, Yu Chuen ^a,b   Tsang, Hsinyi ^c   Wu, Jer Yuarn ^b,g   Chen, Chien Hsiun ^b,g   Chang, Li Ching ^g   Tsai, Fuu Jen ^a,b,h   more..

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d CHANG GUNG UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY   (Taiwan)

^f TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^g INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GUANINE; IMMUNOGLOBULIN; GRIN3A PROTEIN, HUMAN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; ASIAN; CHILD; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY ANEURYSM; DISEASE DURATION; FEMALE; FEVER; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GRIN3A GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PRESCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; TAIWANESE; ASIAN CONTINENTAL ANCESTRY GROUP; GENE LINKAGE DISEQUILIBRIUM; GENETIC PREDISPOSITION; GENETICS; INFANT; RISK; TAIWAN;

ASIAN CONTINENTAL ANCESTRY GROUP; CHILD, PRESCHOOL; CORONARY ANEURYSM; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INFANT; LINKAGE DISEQUILIBRIUM; MALE; MUCOCUTANEOUS LYMPH NODE SYNDROME; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, N-METHYL-D-ASPARTATE; TAIWAN;

EID: 84896694282     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081384     Document Type: Article

References (56)

1. Burns JC, Glodé MP (2004) Kawasaki syndrome. Lancet 364: 533-544. doi:10.1016/S0140-6736(04)16814-1. PubMed: 15302199. (Pubitemid 39070416)
2. Kawasaki T (2001) Kawasaki disease: a new disease? Acta Paediatr Taiwan 42: 8-10. PubMed: 11270190.
3. Chang LY, Chang IS, Lu CY, Chiang BL, Lee CY et al. (2004) Epidemiologic features of Kawasaki disease in Taiwan, 1996-2002. Pediatrics 114: e678-e682. doi:10.1542/peds.2004-0726. PubMed: 15574600.
4. Lin YJ, Wan L, Wu JY, Sheu JJ, Lin CW et al. (2009) HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms. Arthritis Rheum 60: 604-610. doi:10.1002/art.24261. PubMed: 19180512.
5. Kato H, Sugimura T, Akagi T, Sato N, Hashino K et al. (1996) Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation 94: 1379-1385. doi:10.1161/01.CIR.94.6.1379. PubMed: 8822996. (Pubitemid 26307269)
6. Akagi T, Rose V, Benson LN, Newman A, Freedom RM (1992) Outcome of coronary artery aneurysms after Kawasaki disease. J Pediatr 121: 689-694. doi:10.1016/S0022-3476(05)81894-3. PubMed: 1432415.
7. Leung DY, Geha RS, Newburger JW, Burns JC, Fiers W et al. (1986) Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med 164: 1958-1972. doi:10.1084/jem.164.6.1958. PubMed: 3491174. (Pubitemid 17217976)
8. Leung DY, Cotran RS, Kurt-Jones E, Burns JC, Newburger JW et al. (1989) Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease. Lancet 2: 1298-1302. PubMed: 2480498. (Pubitemid 20005671)
9. Lapointe JS, Nugent RA, Graeb DA, Robertson WD (1984) Cerebral infarction and regression of widespread aneurysms in Kawasaki's disease: case report. Pediatr Radiol 14: 1-5. doi:10.1007/BF02386720. PubMed: 6141546. (Pubitemid 14217655)
10. Gitiaux C, Kossorotoff M, Bergounioux J, Adjadj E, Lesage F et al. (2012) Cerebral vasculitis in severe Kawasaki disease: early detection by magnetic resonance imaging and good outcome after intensive treatment. Dev Med Child Neurol 54: 1160-1163. doi:10.1111/dmcn.12002. PubMed: 23163818.
11. Iannetti L, Zito R, Bruschi S, Papetti L, Ulgiati F, et al. (2012) Recent understanding on diagnosis and management of central nervous system vasculitis in children. Clin Dev Immunol 2012: 698327
12. Takanashi J, Shirai K, Sugawara Y, Okamoto Y, Obonai T et al. (2012) Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS). J Neurol Sci 315: 167-169. doi:10.1016/j.jns.2011.11.022. PubMed: 22129937.
13. Burgner D, Davila S, Breunis WB, Ng SB, Li Y et al. (2009) A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet 5: e1000319. PubMed: 19132087.
14. Kim JJ, Hong YM, Sohn S, Jang GY, Ha KS et al. (2011) A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease. Hum Genet 129: 487-495. doi:10.1007/s00439-010-0937-x. PubMed: 21221998.
15. Tsai FJ, Lee YC, Chang JS, Huang LM, Huang FY et al. (2011) Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study. PLOS ONE 6: e16853. doi:10.1371/journal.pone.0016853. PubMed: 21326860.
16. Lee YC, Kuo HC, Chang JS, Chang LY, Huang LM et al. (2012) Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis. Nat Genet 44: 522-525. doi:10.1038/ng.2227. PubMed: 22446961.
17. Khor CC, Davila S, Breunis WB, Lee YC, Shimizu C et al. (2011) Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease. Nat Genet 43: 1241-1246. doi:10.1038/ng.981. PubMed: 22081228.
18. Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M et al. (2012) A genome-wide association study identifies three new risk loci for Kawasaki disease. Nat Genet 44: 517-521. doi:10.1038/ng.2220. PubMed: 22446962.
19. Onouchi Y, Gunji T, Burns JC, Shimizu C, Newburger JW et al. (2008) ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 40: 35-42. doi:10.1038/ng.2007.59. PubMed: 18084290.
20. Hsieh YY, Chang CC, Hsu CM, Chen SY, Lin WH et al. (2011) Major histocompatibility complex class I chain-related gene polymorphisms: associated with susceptibility to Kawasaki disease and coronary artery aneurysms. Genet Test Mol Biomarkers 15: 755-763. doi:10.1089/gtmb.2011.0001. PubMed: 21815799.
21. Kuo HC, Yu HR, Juo SH, Yang KD, Wang YS et al. (2011) CASP3 gene single-nucleotide polymorphism (rs72689236) and Kawasaki disease in Taiwanese children. J Hum Genet 56: 161-165. doi:10.1038/jhg.2010.154. PubMed: 21160486.
22. Hsieh YY, Lin YJ, Chang CC, Chen DY, Hsu CM et al. (2010) Human lymphocyte antigen B-associated transcript 2, 3, and 5 polymorphisms and haplotypes are associated with susceptibility of Kawasaki disease and coronary artery aneurysm. J Clin Lab Anal 24: 262-268. doi:10.1002/jcla.20409. PubMed: 20626023.
23. Huang YC, Lin YJ, Chang JS, Chen SY, Wan L et al. (2010) Single nucleotide polymorphism rs2229634 in the ITPR3 gene is associated with the risk of developing coronary artery aneurysm in children with Kawasaki disease. Int J Immunogenet 37: 439-443. doi:10.1111/j.1744-313X.2010.00943.x. PubMed: 20618519.
24. Kim JJ, Hong SJ, Hong YM, Kim S, Kang MJ et al. (2008) Genetic variants in the HLA-G region are associated with Kawasaki disease. Hum Immunol 69: 867-871. doi:10.1016/j.humimm.2008.10.002. PubMed: 18976687.
25. Jin HS, Kim HB, Kim BS, Lee JK, Seo EJ et al. (2007) The IL-10 (-627 A/C) promoter polymorphism may be associated with coronary aneurysms and low serum albumin in Korean children with Kawasaki disease. Pediatr Res 61: 584-587. doi:10.1203/pdr.0b013e3180459fb5. PubMed: 17413867. (Pubitemid 46650011)
26. Takeuchi K, Yamamoto K, Kataoka S, Kakihara T, Tanaka A et al. (1997) High incidence of angiotensin I converting enzyme genotype II in Kawasaki disease patients with coronary aneurysm. Eur J Pediatr 156: 266-268. doi:10.1007/s004310050597. PubMed: 9128808. (Pubitemid 27142144)
27. Kuo HC, Chao MC, Hsu YW, Lin YC, Huang YH, et al. (2012) CD40 Gene polymorphisms associated with susceptibility and coronary artery lesions of Kawasaki disease in the Taiwanese population. ScientificWorldJournal 2012: 520865
28. Lin WY, Liu HP, Chang JS, Lin YJ (2013) Genetic variations within the PSORS1 region affect Kawasaki disease development and coronary artery aneurysm formation. Biomedicine 3: 73-81. doi:10.1016/j.biomed.2013.03.001.
29. Krizbai IA, Deli MA, Pestenácz A, Siklós L, Szabó CA et al. (1998) Expression of glutamate receptors on cultured cerebral endothelial cells. J Neurosci Res 54: 814-819. doi:10.1002/(SICI)1097- 4547(19981215)54:6. PubMed: 9856865. (Pubitemid 28544382)
30. Sharp CD, Fowler M, Jackson THt, Houghton J, Warren A et al. (2003) Human neuroepithelial cells express NMDA receptors. BMC Neurosci 4: 28. doi:10.1186/1471-2202-4-28. PubMed: 14614784. Available online at: doi:10.1186/1471-2202-4-28 Available online at: PubMed: 14614784
31. Sharp CD, Hines I, Houghton J, Warren A, Jackson T, et al. (2003) Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am J Physiol Heart Circ Physiol 285: H2592-H2598. PubMed: 12893641. Available online at: PubMed: 12893641 (Pubitemid 37443078)
32. Sharp CD, Houghton J, Elrod JW, Warren A, Jackson T, et al. (2005) N-methyl-D-aspartate receptor activation in human cerebral endothelium promotes intracellular oxidant stress. Am J Physiol Heart Circ Physiol 288: H1893-H1899. PubMed: 15576430. Available online at: PubMed: 15576430 (Pubitemid 40418018)
33. Yoshio T, Okamoto H, Hirohata S, Minota S (2013) IgG anti-NR2 glutamate receptor autoantibodies from patients with systemic lupus erythematosus activate endothelial cells. Arthritis Rheum 65: 457-463. doi:10.1002/art.37745. PubMed: 23055186.
34. Lin CY, Lin CC, Hwang B, Chiang B (1992) Serial changes of serum interleukin-6, interleukin-8, and tumor necrosis factor alpha among patients with Kawasaki disease. J Pediatr 121: 924-926. doi:10.1016/S0022-3476(05)80343- 9. PubMed: 1447658.
35. Matsubara T, Furukawa S, Yabuta K (1990) Serum levels of tumor necrosis factor, interleukin 2 receptor, and interferon-gamma in Kawasaki disease involved coronary-artery lesions. Clin Immunol Immunopathol 56: 29-36. doi:10.1016/0090-1229(90)90166-N. PubMed: 2113446. (Pubitemid 20220882)
36. Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY et al. (2004) Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Pediatrics 114: 1708-1733. doi:10.1542/peds.2004-2182. PubMed: 15574639. (Pubitemid 41754943)
37. Falcini F (2006) Kawasaki disease. Curr Opin Rheumatol 18: 33-38. doi:10.1097/01.bor.0000197998.50450.f6. PubMed: 16344617.
38. Kim S, Dedeoglu F (2005) Update on pediatric vasculitis. Curr Opin Pediatr 17: 695-702. doi:10.1097/01.mop.0000187190.97166.83. PubMed: 16282773. (Pubitemid 41689660)
39. Wu SF, Chang JS, Wan L, Tsai CH, Tsai FJ (2005) Association of IL-1Ra gene polymorphism, but no association of IL-1beta and IL-4 gene polymorphisms, with Kawasaki disease. J Clin Lab Anal 19: 99-102. doi:10.1002/jcla.20059. PubMed: 15900570. (Pubitemid 40746133)
40. Wu SF, Chang JS, Peng CT, Shi YR, Tsai FJ (2004) Polymorphism of angiotensin-1 converting enzyme gene and Kawasaki disease. Pediatr Cardiol 25: 529-533. doi:10.1007/s00246-003-0662-5. PubMed: 15164145.
41. Sherry ST, Ward MH, Kholodov M, Baker J, Phan L et al. (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29: 308-311. doi:10.1093/nar/29.1.308. PubMed: 11125122. (Pubitemid 32054478)
42. Sherry ST, Ward M, Sirotkin K (2000) Use of molecular variation in the NCBI dbSNP database. Hum Mutat 15: 68-75. doi:10.1002/(SICI)1098-1004(200001)15: 1. PubMed: 10612825. (Pubitemid 30036172)
43. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265. PubMed: 15297300. (Pubitemid 40202029)
44. Tindall EA, Petersen DC, Nikolaysen S, Miller W, Schuster SC et al. (2010) Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation. BMC Res Notes 3: 39. PubMed: 20175893.
45. Gabriel SB, Schaffner SF, Nguyen H, Moore JM, Roy J et al. (2002) The structure of haplotype blocks in the human genome. Science 296: 2225-2229. PubMed: 12029063. (Pubitemid 34680308)
46. Callinan LS, Tabnak F, Holman RC, Maddox RA, Kim JJ et al. (2012) Kawasaki syndrome and factors associated with coronary artery abnormalities in California. Pediatr Infect Dis J 31: 894-898. doi:10.1097/INF.0b013e31825c4d7c. PubMed: 22565293.
47. Mitani Y, Sawada H, Hayakawa H, Aoki K, Ohashi H et al. (2005) Elevated levels of high-sensitivity C-reactive protein and serum amyloid-A late after Kawasaki disease: association between inflammation and late coronary sequelae in Kawasaki disease. Circulation 111: 38-43. doi:10.1161/01.CIR.0000151311.38708. 29. PubMed: 15611368. (Pubitemid 40070841)
48. Cheung YF, Ho MH, Tam SC, Yung TC (2004) Increased high sensitivity C reactive protein concentrations and increased arterial stiffness in children with a history of Kawasaki disease. Heart 90: 1281-1285. doi:10.1136/hrt.2003. 018507. PubMed: 15486121. (Pubitemid 39433987)
49. Kim T, Choi W, Woo CW, Choi B, Lee J et al. (2007) Predictive risk factors for coronary artery abnormalities in Kawasaki disease. Eur J Pediatr 166: 421-425. doi:10.1007/s00431-006-0251-8. PubMed: 17033807. (Pubitemid 46450474)
50. von Ahsen N, Oellerich M (2004) The intronic prothrombin 19911A>G polymorphism influences splicing efficiency and modulates effects of the 20210G>A polymorphism on mRNA amount and expression in a stable reporter gene assay system. Blood 103: 586-593. doi:10.1182/blood-2003-02-0419. PubMed: 14504098.
51. McCullough AJ, Berget SM (1997) G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection. Mol Cell Biol 17: 4562-4571. PubMed: 9234714. (Pubitemid 27318133)
52. Buratti E, Baralle FE (2004) Influence of RNA secondary structure on the pre-mRNA splicing process. Mol Cell Biol 24: 10505-10514. doi:10.1128/MCB.24.24. 10505-10514.2004. PubMed: 15572659. (Pubitemid 39603113)
53. Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR et al. (1999) Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17. Proc Natl Acad Sci U S A 96: 8229-8234. doi:10.1073/pnas.96.14.8229. PubMed: 10393977. (Pubitemid 29328437)
54. Furukawa H, Singh SK, Mancusso R, Gouaux E (2005) Subunit arrangement and function in NMDA receptors. Nature 438: 185-192. doi:10.1038/nature04089. PubMed: 16281028. (Pubitemid 41599865)
55. Burns JC (2002) Commentary: translation of Dr. Tomisaku Kawasaki's original report of fifty patients in 1967. Pediatr Infect Dis J 21: 993-995. doi:10.1097/00006454-200211000-00002. PubMed: 12442017.
56. Fernández-Pisonero I, Dueñas AI, Barreiro O, Montero O, Sánchez-Madrid F et al. (2012) Lipopolysaccharide and sphingosine-1-phosphate cooperate to induce inflammatory molecules and leukocyte adhesion in endothelial cells. J Immunol 189: 5402-5410. doi:10.4049/jimmunol. 1201309. PubMed: 23089395.