Binding specificity of retinal analogs to photoactivated visual pigments suggest mechanism for fine-tuning GPCR-ligand interactions

Chemistry and Biology

Volumn 21, Issue 3, 2014, Pages 369-378

  Srinivasan, Sundaramoorthy ^a   Ramon, Eva ^a   Cordomí, Arnau ^b   Garriga, Pere ^a  

^a UNIVERSITAT POLITÈCNICA DE CATALUNYA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

11 CIS RETINAL; AMINO ACID; CONE OPSIN; G PROTEIN COUPLED RECEPTOR; OPSIN; RHODOPSIN; VISUAL PIGMENT; LIGAND; PROTEIN BINDING; RETINAL; TRANSDUCIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; BLEACHING; CONFORMATION; HUMAN; HUMAN CELL; NONHUMAN; OLIGOMERIZATION; PHOTOACTIVATION; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN INTERACTION; ANALOGS AND DERIVATIVES; ANIMAL; BOVINAE; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; GENETICS; ISOMERISM; KINETICS; LIGHT; METABOLISM; MOLECULAR DYNAMICS; PROTEIN TERTIARY STRUCTURE; REGENERATION;

ANIMALS; BINDING SITES; CATTLE; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; ISOMERISM; KINETICS; LIGANDS; LIGHT; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; REGENERATION; RETINAL PIGMENTS; RETINALDEHYDE; RHODOPSIN; TRANSDUCIN;

EID: 84896670860     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.01.006     Document Type: Article

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