-
2
-
-
77954320936
-
Primary colon cancer: ESMO Clinical Practice Guideline for diagnosis, adjuvant treatment and follow-up
-
Labianca R, Nordlinger B, Beretta GD. Primary colon cancer: ESMO Clinical Practice Guideline for diagnosis, adjuvant treatment and follow-up. Ann Oncol. 2010;21 suppl 5:v70-7.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 5
-
-
Labianca, R.1
Nordlinger, B.2
Beretta, G.D.3
-
3
-
-
84858166365
-
Molecular pathways: Microsatellite instability in colorectal cancer: Prognosis, predictive, and therapeutic implications
-
Sinicrope FA, Sargent DJ. Molecular pathways: microsatellite instability in colorectal cancer: prognosis, predictive, and therapeutic implications. Clin Cancer Res. 2012;18:1506-12.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 1506-1512
-
-
Sinicrope, F.A.1
Sargent, D.J.2
-
5
-
-
0031004175
-
Genetic instability in colorectal cancers
-
DOI 10.1038/386623a0
-
.• Lengauer C, Kinzler KW, Vogelstein B. Genetic instability in colorectal cancers. Nature. 1997;386:623-7. This seminal manuscript describes the relationship between genetic instability and colorectal cancer. (Pubitemid 27175430)
-
(1997)
Nature
, vol.386
, Issue.6625
, pp. 623-627
-
-
Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
-
6
-
-
53049087109
-
Genomic and epigenetic instability in colorectal cancer pathogenesis
-
Grady WM, Carethers JM. Genomic and epigenetic instability in colorectal cancer pathogenesis. Gastroenterology. 2008;135:1079- 99.
-
(2008)
Gastroenterology
, vol.135
, pp. 1079-1099
-
-
Grady, W.M.1
Carethers, J.M.2
-
7
-
-
0037805547
-
RAS oncogenes: The first 30 years
-
DOI 10.1038/nrc1097
-
Malumbres M, BarbacidM. RAS oncogenes: the first 30 years. Rev Cancer. 2003;3:459-65. (Pubitemid 37328850)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.6
, pp. 459-465
-
-
Malumbres, M.1
Barbacid, M.2
-
8
-
-
79960237399
-
Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/ Akt/m-TOR signaling pathways
-
McCubrey JA, Steelman LS, Kempf CR, et al. Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/ Akt/m-TOR signaling pathways. J Cell Physiol. 2011;226:2762-81.
-
(2011)
J Cell Physiol
, vol.226
, pp. 2762-2781
-
-
McCubrey, J.A.1
Steelman, L.S.2
Kempf, C.R.3
-
9
-
-
0037757793
-
Role of Smad4 (DPC4) inactivation in human cancer
-
Miyaki M, Kuroki T. Role of Smad4 (DPC4) inactivation in human cancer. Biochem Biophys Res Commun. 2003;306:799-80.
-
(2003)
Biochem Biophys Res Commun
, vol.306
, pp. 799-880
-
-
Miyaki, M.1
Kuroki, T.2
-
10
-
-
0025634118
-
p53 Gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorgenesis
-
Baker SJ, Preisinger AC, Jessup JM, et al. p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorgenesis. Cancer Res. 1990;50:7717-22.
-
(1990)
Cancer Res
, vol.50
, pp. 7717-7722
-
-
Baker, S.J.1
Preisinger, A.C.2
Jessup, J.M.3
-
11
-
-
46349086833
-
Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis
-
DOI 10.1136/gut.2007.135004
-
Whalter A, Houlston R, Tomlinsion I. Associations between chromosomal instability and prognosis in colorectal cancer: a metaanalysis. Gut. 2008;57:941-50. (Pubitemid 351919529)
-
(2008)
Gut
, vol.57
, Issue.7
, pp. 941-950
-
-
Walther, A.1
Houlston, R.2
Tomlinson, I.3
-
12
-
-
0025056930
-
Identification of a chromosome 18q gene that is altered in colorectal cancers
-
Fearon ER, Cho KR, Nigro JM, et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 1990;247:49-56.
-
(1990)
Science
, vol.247
, pp. 49-56
-
-
Fearon, E.R.1
Cho, K.R.2
Nigro, J.M.3
-
13
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
DOI 10.1038/363558a0
-
.• Ionov Y, Peinado MA, Malkhosyan S, et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature. 1993;363:558-61. This manuscript explains how MSI can be one of the causes that would lead to carcinogenesis in colorectal cancer. (Pubitemid 23186645)
-
(1993)
Nature
, vol.363
, Issue.6429
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
-
14
-
-
0028859671
-
Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
-
This manuscript describes how MSI is associated with mismatch repair gene defects
-
.• Liu B, Nicolaides NC, Markowitz S, et al. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nat Genet. 1995;9:48-55. This manuscript describes how MSI is associated with mismatch repair gene defects.
-
(1995)
Nat Genet
, vol.9
, pp. 48-55
-
-
Liu, B.1
Nicolaides, N.C.2
Markowitz, S.3
-
15
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
This is the first study describing CpG islandmethylation as an important event in colorectal cancer carcinogenesis
-
.• Toyota M, Ahuja, Ohe Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A. 1999;96: 8681-6. This is the first study describing CpG islandmethylation as an important event in colorectal cancer carcinogenesis.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 8681-8686
-
-
Toyota, M.1
Ahuja2
Ohe Toyota, M.3
-
16
-
-
58249089525
-
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
-
Ogino S, Nosho K, Kirkner GJ, et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut. 2009;58:90-6.
-
(2009)
Gut
, vol.58
, pp. 90-96
-
-
Ogino, S.1
Nosho, K.2
Kirkner, G.J.3
-
17
-
-
33745541234
-
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer
-
DOI 10.1038/ng1834, PII N1834
-
Weisenberger DJ, Siegmund KD, Campan M, et al. CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet. 2006;38:787-93. (Pubitemid 43980599)
-
(2006)
Nature Genetics
, vol.38
, Issue.7
, pp. 787-793
-
-
Weisenberger, D.J.1
Siegmund, K.D.2
Campan, M.3
Young, J.4
Long, T.I.5
Faasse, M.A.6
Kang, G.H.7
Widschwendter, M.8
Weener, D.9
Buchanan, D.10
Koh, H.11
Simms, L.12
Barker, M.13
Leggett, B.14
Levine, J.15
Kim, M.16
French, A.J.17
Thibodeau, S.N.18
Jass, J.19
Haile, R.20
Laird, P.W.21
more..
-
18
-
-
24144449572
-
Evaluation of a large population-based simple supports a CpG island methylator phenotype (CIMP) in colon cancer
-
Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large population-based simple supports a CpG island methylator phenotype (CIMP) in colon cancer. Gastroenterology. 2005;129:837 - 45.
-
(2005)
Gastroenterology
, vol.129
, pp. 837-845
-
-
Samowitz, W.S.1
Albertsen, H.2
Herrick, J.3
-
19
-
-
39649118620
-
Sporadic and Syndromic Hyperplastic Polyps and Serrated Adenomas of the Colon: Classification, Molecular Genetics, Natural History, and Clinical Management
-
DOI 10.1016/j.gtc.2007.12.014, PII S0889855307001380
-
East JE, Saunders BP, Jass JR. Sporadic and syndromic hyperplastic polyps and serrated adenomas of colon: classification, molecular genetics, natural history and clinical management. Gastroenterol Clin North Am. 2008;37:25-46. (Pubitemid 351289032)
-
(2008)
Gastroenterology Clinics of North America
, vol.37
, Issue.1
, pp. 25-46
-
-
East, J.E.1
Saunders, B.P.2
Jass, J.R.3
-
20
-
-
79958806016
-
Four Molecular subtypes of colorectal cancer and their precursor Lesions
-
Gyeon Hoon Kang. Four Molecular subtypes of colorectal cancer and their precursor Lesions. Arch Pathol Lab Med. 2011;135:698-703.
-
(2011)
Arch Pathol Lab Med
, vol.135
, pp. 698-703
-
-
Kang, G.H.1
-
21
-
-
84863922124
-
Comprehensive molecular characterization of human colon and rectal cancer
-
Cancer Genome Atlas Network. This is the most extensive genome analysis in colorectal cancer describing the genomic aberrations in this tumor
-
.• Cancer Genome Atlas Network. Comprehensive molecular characterization of human colon and rectal cancer. Nature. 2012;487:330-7. This is the most extensive genome analysis in colorectal cancer describing the genomic aberrations in this tumor.
-
(2012)
Nature
, vol.487
, pp. 330-337
-
-
-
22
-
-
84881247803
-
A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: Implications for prognosis
-
Simons JM, Hughes LAE, Smits KM, et al. A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis. Ann Oncol. 2013;24:2048-56.
-
(2013)
Ann Oncol
, vol.24
, pp. 2048-2056
-
-
Simons, J.M.1
Hughes, L.A.E.2
Smits, K.M.3
-
23
-
-
84872921463
-
Use of multivariate analysis to suggest a new molecular classification of colorectal cancer
-
Domingo E, Ramamoorthy R, Oukrif D, et al. Use of multivariate analysis to suggest a new molecular classification of colorectal cancer. Pathol. 2013;229:441-8.
-
(2013)
Pathol
, vol.229
, pp. 441-448
-
-
Domingo, E.1
Ramamoorthy, R.2
Oukrif, D.3
-
24
-
-
0034680102
-
Molecular portraits of human breast tumors
-
Genetic profile widely accepted as classifying breast cancer into four subtypes
-
.• Perou CM, Sørlie T, Eisen MB, et al. Molecular portraits of human breast tumors. Nature. 2000;406:747-52. Genetic profile widely accepted as classifying breast cancer into four subtypes.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sørlie, T.2
Eisen, M.B.3
-
25
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1
-
Verhaak RG, Hoadley KA, Purdom E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR and NF1. Cancer Cell. 2010;17:98-110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
26
-
-
78651529782
-
EMT is the dominant program in human colon cancer
-
This manuscript describes a genetic profile for colon cancer clearly associated with epithelial and mesenchymal phenotypes, later confirmed by many studies
-
.• Loboda A, Nebozhyn MV, Watters JW, et al. EMT is the dominant program in human colon cancer. BMC Med Genomics. 2011;4:9. This manuscript describes a genetic profile for colon cancer clearly associated with epithelial and mesenchymal phenotypes, later confirmed by many studies.
-
(2011)
BMC Med Genomics
, vol.4
, pp. 9
-
-
Loboda, A.1
Nebozhyn, M.V.2
Watters, J.W.3
-
27
-
-
84865012891
-
Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer
-
Oh SC, Park Y-Y, Park ES, et al. Prognostic gene expression signature associated with two molecularly distinct subtypes of colorectal cancer. Gut. 2012;61:1291-8.
-
(2012)
Gut
, vol.61
, pp. 1291-1298
-
-
Oh, S.C.1
Park, Y.-Y.2
Park, E.S.3
-
28
-
-
84871676568
-
Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines
-
Schlicker A, Beran G, Chresta CM, et al. Subtypes of primary colorectal tumors correlate with response to targeted treatment in colorectal cell lines. BMC Med Genomics. 2012;31(5):66.
-
(2012)
BMC Med Genomics
, vol.31
, Issue.5
, pp. 66
-
-
Schlicker, A.1
Beran, G.2
Chresta, C.M.3
-
29
-
-
84873704094
-
Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior
-
Perez-Villamil B, Romera-Lopez A, Hernandez-Prieto S, et al. Colon cancer molecular subtypes identified by expression profiling and associated to stroma, mucinous type and different clinical behavior. BMC Cancer. 2012;12:260.
-
(2012)
BMC Cancer
, vol.12
, pp. 260
-
-
Perez-Villamil, B.1
Romera-Lopez, A.2
Hernandez-Prieto, S.3
-
30
-
-
84877619075
-
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
-
One of the main colorectal subtypes classifications and very important because its implications for treatment in adjuvant and systemic setting and the use of cetuximab
-
.• Sadanandam A, Costas A, Lyssiotis, et al. A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Med. 2013;19(5):619-26. One of the main colorectal subtypes classifications and very important because its implications for treatment in adjuvant and systemic setting and the use of cetuximab.
-
(2013)
Nature Med
, vol.19
, Issue.5
, pp. 619-626
-
-
Sadanandam, A.1
Costas, A.2
Lyssiotis3
-
31
-
-
84885184379
-
Gene expression patterns unveil a new level ofmolecular heterogeneity in colorectal cancer
-
Budinska E, Popovici V, Tejpar S, et al. Gene expression patterns unveil a new level ofmolecular heterogeneity in colorectal cancer. J Pathol. 2013;231:63-76.
-
(2013)
J Pathol
, vol.231
, pp. 63-76
-
-
Budinska, E.1
Popovici, V.2
Tejpar, S.3
-
32
-
-
84877600884
-
Poor prognosis colon cancer is defined by molecularly distinct subtype and develops from serrated precursors
-
Important reference that shows that subtypes are associated with MSI or CIN status and that there is a worse prognosis subtype clearly defined
-
• De Sousa E, Melo F, Wang X, et al. Poor prognosis colon cancer is defined by molecularly distinct subtype and develops from serrated precursors. Nature Med. 2013;19:614-8. Important reference that shows that subtypes are associated with MSI or CIN status and that there is a worse prognosis subtype clearly defined.
-
(2013)
Nature Med
, vol.19
, pp. 614-618
-
-
De Sousa, E.1
Melo, F.2
Wang, X.3
-
33
-
-
85075544768
-
Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition
-
Jul 13. An important manuscript on the colorectal cancer subtypes that correlates these subtypes with proliferation, EMT, MSI, and response to treatment
-
• Roepman P, Schlicker A, Tabernero J, et al. Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition. Int J Cancer 2013 Jul 13. An important manuscript on the colorectal cancer subtypes that correlates these subtypes with proliferation, EMT, MSI, and response to treatment.
-
(2013)
Int J Cancer
-
-
Roepman, P.1
Schlicker, A.2
Tabernero, J.3
-
34
-
-
79951506562
-
Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer
-
One of the first genetic profiles to predict prognosis, and the basis for Ref. [33]
-
• Salazar R, Roepman P, Capella G, et al. Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol. 2011;29:17-24. One of the first genetic profiles to predict prognosis, and the basis for Ref. [33].
-
(2011)
J Clin Oncol
, vol.29
, pp. 17-24
-
-
Salazar, R.1
Roepman, P.2
Capella, G.3
-
35
-
-
14544300998
-
Systematic review of microsatellite instability and colorectal cancer prognosis
-
DOI 10.1200/JCO.2005.01.086
-
Popat A. S, Hueber R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol. 2005;23:609-18. (Pubitemid 46224239)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.3
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
36
-
-
77957197346
-
Microsatellite instability as a marker of prognosis and response to therapy: A meta-analysis of colorectal cancer survival date
-
Guastedisegni C, Colafranceschi M, Ottini L, et al. Microsatellite instability as a marker of prognosis and response to therapy: a meta-analysis of colorectal cancer survival date. Eur J Cancer. 2010;46: 2788-98.
-
(2010)
Eur J Cancer
, vol.46
, pp. 2788-2798
-
-
Guastedisegni, C.1
Colafranceschi, M.2
Ottini, L.3
-
37
-
-
43249121177
-
Stromal gene expression predicts clinical outcome in breast cancer
-
DOI 10.1038/nm1764, PII NM1764
-
Finak G, Bertos N, Pepin F, et al. Stroma gene expression predicts clinical outcome in breast cancer. Nature Med. 2008;14:518-27. (Pubitemid 351655218)
-
(2008)
Nature Medicine
, vol.14
, Issue.5
, pp. 518-527
-
-
Finak, G.1
Bertos, N.2
Pepin, F.3
Sadekova, S.4
Souleimanova, M.5
Zhao, H.6
Chen, H.7
Omeroglu, G.8
Meterissian, S.9
Omeroglu, A.10
Hallett, M.11
Park, M.12
-
38
-
-
67650248525
-
Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients
-
Mesker WE, Liefers GJ, Jungeburt JM, et al. Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients. Cell Oncol. 2009;31: 169-78.
-
(2009)
Cell Oncol
, vol.31
, pp. 169-178
-
-
Mesker, W.E.1
Liefers, G.J.2
Jungeburt, J.M.3
-
39
-
-
53749096264
-
Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC). A pooled molecular analysis of randomized chemotherapy trials
-
This abstract shows that tumors with the MSI phenotype do not benefit from chemotherapy in adjuvant setting
-
• Sargent D, Marsoni S, Thibodeau SN, et al. Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC). A pooled molecular analysis of randomized chemotherapy trials. Proc ASCO. 2008;26:A4008. This abstract shows that tumors with the MSI phenotype do not benefit from chemotherapy in adjuvant setting.
-
(2008)
Proc ASCO
, vol.26
-
-
Sargent, D.1
Marsoni, S.2
Thibodeau, S.N.3
-
40
-
-
33646228635
-
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
-
Lievre A, Bachet JB, Le Corre D, et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res. 2006;66:3992-5.
-
(2006)
Cancer Res
, vol.66
, pp. 3992-3995
-
-
Lievre, A.1
Bachet, J.B.2
Le Corre, D.3
|