A polymeric device for controlled transscleral multi-drug delivery to the posterior segment of the eye

Acta Biomaterialia

Volumn 10, Issue 2, 2014, Pages 680-687

  Nagai, Nobuhiro ^a   Kaji, Hirokazu ^b   Onami, Hideyuki ^a   Ishikawa, Yumi ^a   Nishizawa, Matsuhiko ^b   Osumi, Noriko ^a   Nakazawa, Toru ^a   Abe, Toshiaki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

Author keywords

Multi drug delivery; Poly(ethyleneglycol) dimethacrylate; Retina; Transscleral delivery

Indexed keywords

CONTROLLED DRUG DELIVERY; DISEASES; FLUORESCENCE; FUNCTIONAL POLYMERS; TARGETED DRUG DELIVERY;

CONTROLLED RELEASE; DIMETHACRYLATES; MULTI-DRUG DELIVERY; POLY(ETHYLENE GLYCOL); POLY(ETHYLENEGLYCOL) DIMETHACRYLATE; POLYMERIC DEVICES; POSTERIOR SEGMENT; RELEASE RATE; RETINA; TRANSSCLERAL DELIVERY;

POLYOLS;

POLY(ETHYLENEGLYCOL)DIMETHACRYLATE; POLYMETHACRYLIC ACID DERIVATIVE; TRIETHYLENE GLYCOL DIMETHACRYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DIFFUSION; DRUG DELIVERY DEVICE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FLUORESCENCE; MALE; MICROTECHNOLOGY; NONHUMAN; POLYMERIZATION; POSTERIOR EYE SEGMENT; PRIORITY JOURNAL; RAT; SCLERA; SUSTAINED RELEASE FORMULATION;

RATTUS;

MULTI-DRUG DELIVERY; POLY(ETHYLENEGLYCOL) DIMETHACRYLATE; RETINA; TRANSSCLERAL DELIVERY;

ANIMALS; DIFFUSION; DRUG DELIVERY SYSTEMS; FLUORESCEIN; INDOLES; METHACRYLATES; PERMEABILITY; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; POSTERIOR EYE SEGMENT; PROSTHESIS IMPLANTATION; RATS; RETINA; RHODAMINES; SCLERA;

EID: 84896545712     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.11.004     Document Type: Article

References (41)

1. S. Resnikoff, D. Pascolini, D. Etya'ale, I. Kocur, R. Pararajasegaram, and G.P. Pokharel et al. Global data on visual impairment in the year 2002 Bull World Health Organ 82 2004 844 851
2. E.S. Gragoudas, A.P. Adamis, E.T. Cunningham Jr., M. Feinsod, and D.R. Guyer Pegaptanib for neovascular age-related macular degeneration N Engl J Med 351 2004 2805 2816
3. M. Kim, and B.J. Yoon Adaptive reference update (ARU) algorithm. A stochastic search algorithm for efficient optimization of multi-drug cocktails BMC Genomics 13 Suppl 6 2012 S12
4. D.J. Calkins Critical pathogenic events underlying progression of neurodegeneration in glaucoma Prog Retin Eye Res 31 2012 702 719
5. Q.L. Fu, X. Li, H.K. Yip, Z. Shao, W. Wu, and S. Mi et al. Combined effect of brain-derived neurotrophic factor and LINGO-1 fusion protein on long-term survival of retinal ganglion cells in chronic glaucoma Neuroscience 162 2009 375 382
6. D.H. Shin, R.M. Feldman, and W.P. Sheu Efficacy and safety of the fixed combinations latanoprost/timolol versus dorzolamide/timolol in patients with elevated intraocular pressure Ophthalmology 111 2004 276 282
7. R.F. Spaide Rationale for combination therapy in age-related macular degeneration Retina 29 2009 S5 S7
8. S. He, T. Xia, H. Wang, L. Wei, X. Luo, and X. Li Multiple release of polyplexes of plasmids VEGF and bFGF from electrospun fibrous scaffolds towards regeneration of mature blood vessels Acta Biomater 8 2012 2659 2669
9. P.A. Campochiaro Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders Gene Ther 13 2006 559 562
10. M. Frasson, S. Picaud, T. Leveillard, M. Simonutti, S. Mohand-Said, and H. Dreyfus et al. Glial cell line-derived neurotrophic factor induces histologic and functional protection of rod photoreceptors in the rd/rd mouse Invest Ophthalmol Vis Sci 40 1999 2724 2734
11. P.J. Rosenfeld, D.M. Brown, J.S. Heier, D.S. Boyer, P.K. Kaiser, and C.Y. Chung et al. Ranibizumab for neovascular age-related macular degeneration N Engl J Med 355 2006 1419 1431
12. P.M. Hughes, O. Olejnik, J.E. Chang-Lin, and C.G. Wilson Topical and systemic drug delivery to the posterior segments Adv Drug Deliv Rev 57 2005 2010 2032
13. E.M. Del Amo, and A. Urtti Current and future ophthalmic drug delivery systems. A shift to the posterior segment Drug Discov Today 13 2008 135 143
14. D.H. Geroski, and H.F. Edelhauser Transscleral drug delivery for posterior segment disease Adv Drug Deliv Rev 52 2001 37 48
15. V.P. Ranta, and A. Urtti Transscleral drug delivery to the posterior eye: prospects of pharmacokinetic modeling Adv Drug Deliv Rev 58 2006 1164 1181
16. J. Ambati, and A.P. Adamis Transscleral drug delivery to the retina and choroid Prog Retin Eye Res 21 2002 145 151
17. T.W. Olsen, H.F. Edelhauser, J.I. Lim, and D.H. Geroski Human scleral permeability. Effects of age, cryotherapy, transscleral diode laser, and surgical thinning Invest Ophthalmol Vis Sci 36 1995 1893 1903
18. X. Li, Z. Zhang, J. Li, S. Sun, Y. Weng, and H. Chen Diclofenac/ biodegradable polymer micelles for ocular applications Nanoscale 4 2012 4667 4673
19. S.R. Patel, D.E. Berezovsky, B.E. McCarey, V. Zarnitsyn, H.F. Edelhauser, and M.R. Prausnitz Targeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye Invest Ophthalmol Vis Sci 53 2012 4433 4441
20. P. Aksungur, M. Demirbilek, E.B. Denkbas, J. Vandervoort, A. Ludwig, and N. Unlu Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: cellular toxicity, uptake, and kinetic studies J Control Release 151 2011 286 294
21. J. Chhablani, A. Nieto, H. Hou, E.C. Wu, W.R. Freeman, and M.J. Sailor et al. Oxidized porous silicon particles covalently grafted with daunorubicin as a sustained intraocular drug delivery system Invest Ophthalmol Vis Sci 54 2013 1268 1279
22. C.W. Chen, D.W. Lu, M.K. Yeh, C.Y. Shiau, and C.H. Chiang Novel RGD-lipid conjugate-modified liposomes for enhancing siRNA delivery in human retinal pigment epithelial cells Int J Nanomedicine 6 2011 2567 2580
23. J.M. Kaiser, H. Imai, J.K. Haakenson, R.M. Brucklacher, T.E. Fox, and S.S. Shanmugavelandy et al. Nanoliposomal minocycline for ocular drug delivery Nanomedicine 9 2013 130 140
24. X. Li, Z. Zhang, and H. Chen Development and evaluation of fast forming nano-composite hydrogel for ocular delivery of diclofenac Int J Pharm 448 2013 96 100
25. C.H. Wang, Y.S. Hwang, P.R. Chiang, C.R. Shen, W.H. Hong, and G.H. Hsiue Extended release of bevacizumab by thermosensitive biodegradable and biocompatible hydrogel Biomacromolecules 13 2012 40 48
26. N. Kunou, Y. Ogura, T. Yasukawa, H. Kimura, H. Miyamoto, and Y. Honda et al. Long-term sustained release of ganciclovir from biodegradable scleral implant for the treatment of cytomegalovirus retinitis J Control Release 68 2000 263 271
27. H. Zhang, C. Zhao, H. Cao, G. Wang, L. Song, and G. Niu et al. Hyperbranched poly(amine-ester) based hydrogels for controlled multi-drug release in combination chemotherapy Biomaterials 31 2010 5445 5454
28. H.C. Shin, A.W. Alani, D.A. Rao, N.C. Rockich, and G.S. Kwon Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs J Control Release 140 2009 294 300
29. T.P. Richardson, M.C. Peters, A.B. Ennett, and D.J. Mooney Polymeric system for dual growth factor delivery Nat Biotechnol 19 2001 1029 1034
30. T. Lammers, V. Subr, K. Ulbrich, P. Peschke, P.E. Huber, and W.E. Hennink et al. Simultaneous delivery of doxorubicin and gemcitabine to tumors in vivo using prototypic polymeric drug carriers Biomaterials 30 2009 3466 3475
31. R. Elia, P.W. Fuegy, A. VanDelden, M.A. Firpo, G.D. Prestwich, and R.A. Peattie Stimulation of in vivo angiogenesis by in situ crosslinked, dual growth factor-loaded, glycosaminoglycan hydrogels Biomaterials 31 2010 4630 4638
32. Y. Wang, B. Wang, W. Qiao, and T. Yin A novel controlled release drug delivery system for multiple drugs based on electrospun nanofibers containing nanoparticles J Pharm Sci 99 2010 4805 4811
33. S.H. Dickens, G.M. Flaim, and C.J. Floyd Effects of adhesive, base and diluent monomers on water sorption and conversion of experimental resins Dent Mater 26 2010 675 681
34. D.S. Benoit, A.R. Durney, and K.S. Anseth Manipulations in hydrogel degradation behavior enhance osteoblast function and mineralized tissue formation Tissue Eng 12 2006 1663 1673
35. S. Kalachandra Influence of fillers on the water sorption of composites Dent Mater 5 1989 283 288
36. T. Kawashima, N. Nagai, H. Kaji, N. Kumasaka, H. Onami, and Y. Ishikawa et al. A scalable controlled-release device for transscleral drug delivery to the retina Biomaterials 32 2011 1950 1956
37. L. Pitkanen, V.P. Ranta, H. Moilanen, and A. Urtti Permeability of retinal pigment epithelium: effects of permeant molecular weight and lipophilicity Invest Ophthalmol Vis Sci 46 2005 641 646
38. E. Mannermaa, K.S. Vellonen, and A. Urtti Drug transport in corneal epithelium and blood-retina barrier: emerging role of transporters in ocular pharmacokinetics Adv Drug Deliv Rev 58 2006 1136 1163
39. S. Imai, Y. Inokuchi, S. Nakamura, K. Tsuruma, M. Shimazawa, and H. Hara Systemic administration of a free radical scavenger, edaravone, protects against light-induced photoreceptor degeneration in the mouse retina Eur J Pharmacol 642 2010 77 85
40. M. Tanito, Y.W. Kwon, N. Kondo, J. Bai, H. Masutani, and H. Nakamura et al. Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage J Neurosci 25 2005 2396 2404
41. K. Tsuruma, Y. Tanaka, M. Shimazawa, Y. Mashima, and H. Hara Unoprostone reduces oxidative stress- and light-induced retinal cell death, and phagocytotic dysfunction, by activating BK channels Mol Vis 17 2011 3556 3565 Technology