Rapid reaction of superoxide with insulin-tyrosyl radicals to generate a hydroperoxide with subsequent glutathione addition

Free Radical Biology and Medicine

Volumn 70, Issue , 2014, Pages 86-95

  Das, Andrew B ^a   Nauser, Thomas ^b   Koppenol, Willem H ^b   Kettle, Anthony J ^a   Winterbourn, Christine C ^a   Nagy, Péter ^a,c  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b ETH ZURICH   (Switzerland)

^c NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

Author keywords

Free radicals; Glutathionylation; Insulin oxidation; Protein hydroperoxide; Pulse radiolysis; Superoxide radical; Tyrosyl radical

Indexed keywords

AMIDE; DIMER; GLUTATHIONE; HYDROPEROXIDE; INSULIN; INSULIN TYROSYL RADICAL; RADICAL; SUPEROXIDE; TYROSINE DERIVATIVE; UNCLASSIFIED DRUG; HYDROGEN PEROXIDE; TYROSINE; TYROSYL RADICAL YZ;

ALPHA CHAIN; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; DIMERIZATION; GLUTATHIONE METABOLISM; KINETICS; MASS SPECTROMETRY; MICHAEL ADDITION; OXIDATIVE STRESS; PH; PRIORITY JOURNAL; PULSE RADIOLYSIS; SIMULATION; ANALOGS AND DERIVATIVES; METABOLISM; OXIDATION REDUCTION REACTION;

GLUTATHIONE; HYDROGEN PEROXIDE; INSULIN; KINETICS; MASS SPECTROMETRY; OXIDATION-REDUCTION; PULSE RADIOLYSIS; SUPEROXIDES; TYROSINE;

EID: 84896541014     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.02.006     Document Type: Article

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