Vorapaxar in acute coronary syndrome patients undergoing coronary artery bypass graft surgery: Subgroup analysis from the TRACER trial (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome)

Journal of the American College of Cardiology

Volumn 63, Issue 11, 2014, Pages 1048-1057

  Whellan, David J ^a   Tricoci, Pierluigi ^b   Chen, Edmond ^c   Huang, Zhen ^b   Leibowitz, David ^d   Vranckx, Pascal ^e   Marhefka, Gregary D ^a   Held, Claes ^f   Nicolau, Jose C ^g   Storey, Robert F ^h   Ruzyllo, Witold ⁱ   Huber, Kurt ^j   Sinnaeve, Peter ^k   Weiss, A Teddy ^d   Dery, Jean Pierre ^l   Moliterno, David J ^m   Van De Werf, Frans ^k   Aylward, Philip E ⁿ   White, Harvey D ^o   Armstrong, Paul W ^p   Wallentin, Lars ^f   Strony, John ^c   Harrington, Robert A ^q   Mahaffey, Kenneth W ^q   more..

^a THOMAS JEFFERSON UNIVERSITY HOSPITAL   (United States)

^b DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^e ERASMUS MEDICAL CENTER   (Netherlands)

^f UPPSALA CLINICAL RESEARCH CENTER   (Sweden)

^g UNIVERSITY OF SÃO PAULO   (Brazil)

^h UNIVERSITY OF SHEFFIELD   (United Kingdom)

ⁱ INSTITUTE OF CARDIOLOGY   (Poland)

^j WILHELMINEN HOSPITAL   (Austria)

^k UNIVERSITY OF LEUVEN   (Belgium)

^l LAVAL UNIVERSITY   (Canada)

^m UNIVERSITY OF KENTUCKY   (United States)

ⁿ FLINDERS UNIVERSITY   (Australia)

^o AUCKLAND CITY HOSPITAL   (New Zealand)

^p UNIVERSITY OF ALBERTA   (Canada)

^q STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

more..

Author keywords

bypass; coronary disease; myocardial infarction; platelets; thrombin

Indexed keywords

ANTICOAGULANT AGENT; CLOPIDOGREL; PLACEBO; VORAPAXAR;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLEEDING; BRAIN HEMORRHAGE; CEREBROVASCULAR ACCIDENT; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; DISEASE ASSOCIATION; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OUTCOME ASSESSMENT; PATIENT ASSESSMENT; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; RECURRENT DISEASE; REOPERATION; CORONARY ARTERY BYPASS GRAFT; DEATH; HOSPITAL READMISSION; HOSPITALIZATION; LOADING DRUG DOSE; RANDOMIZED CONTROLLED TRIAL (TOPIC);

BYPASS; CORONARY DISEASE; MYOCARDIAL INFARCTION; PLATELETS; THROMBIN;

ACUTE CORONARY SYNDROME; AGED; CONFIDENCE INTERVALS; CORONARY ARTERY BYPASS; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW-UP STUDIES; HOSPITAL MORTALITY; HUMANS; KAPLAN-MEIER ESTIMATE; LACTONES; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POSTOPERATIVE COMPLICATIONS; POSTOPERATIVE HEMORRHAGE; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; PYRIDINES; RECEPTORS, THROMBIN; REFERENCE VALUES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; STROKE; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84896532727     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2013.10.048     Document Type: Article

References (37)

1. H.M. Nathoe, D. van Dijk, and E.W. Jansen et al. A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients N Engl J Med 348 2003 394 402
2. P.W. Serruys, M.C. Morice, and A.P. Kappetein et al. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease N Engl J Med 360 2009 961 972
3. A.M. Fabricius, W. Gerber, M. Hanke, J. Garbade, R. Autschbach, and F.W. Mohr Early angiographic control of perioperative ischemia after coronary artery bypass grafting Eur J Cardiothorac Surg 19 2001 853 858
4. E.M. Boyle Jr., S.T. Lille, E. Allaire, A.W. Clowes, and E.D. Verrier Endothelial cell injury in cardiovascular surgery: atherosclerosis Ann Thorac Surg 63 1997 885 894
5. C.F. Reilly, and R.C. McFall Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells J Biol Chem 266 1991 9419 9427
6. E.D. Verrier, and E.M. Boyle Jr. Endothelial cell injury in cardiovascular surgery Ann Thorac Surg 62 1996 915 922
7. R.L. Nachman, and R. Silverstein Hypercoagulable states Ann Intern Med 119 1993 819 827
8. S. Ishiwata, T. Tukada, S. Nakanishi, S. Nishiyama, and A. Seki Postangioplasty restenosis: platelet activation and the coagulation-fibrinolysis system as possible factors in the pathogenesis of restenosis Am Heart J 133 1997 387 392
9. S. Goldman, J. Copeland, and T. Moritz et al. Long-term graft patency (3 years) after coronary artery surgery. Effects of aspirin: results of a VA cooperative study Circulation 89 1994 1138 1143
10. T.P. Gavaghan, V. Gebski, and D.W. Baron Immediate postoperative aspirin improves vein graft patency early and late after coronary artery bypass graft surgery. A placebo-controlled, randomized study Circulation 83 1991 1526 1533
11. N. Zimmermann, A. Wenk, and U. Kim et al. Functional and biochemical evaluation of platelet aspirin resistance after coronary artery bypass surgery Circulation 108 2003 542 547
12. D.T. Mangano Multicenter Study of Perioperative Ischemia Research Group. Aspirin and mortality from coronary bypass surgery N Engl J Med 347 2002 1309 1317
13. S. Yusuf, F. Zhao, S.R. Mehta, S. Chrolavicius, G. Tognoni, and K.K. Fox Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation N Engl J Med 345 2001 494 502
14. K.A. Fox, S.R. Mehta, and R. Peters et al. Benefits and risks of the combination of clopidogrel and aspirin in patients undergoing surgical revascularization for non-ST-elevation acute coronary syndrome: the Clopidogrel in Unstable angina to prevent Recurrent ischemic Events (CURE) trial Circulation 110 2004 1202 1208
15. C. Held, N. Asenblad, and J.P. Bassand et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes undergoing coronary artery bypass surgery: results from the PLATO (Platelet Inhibition and Patient Outcomes) trial J Am Coll Cardiol 57 2011 672 684
16. C. Varenhorst, U. Alström, and B.M. Scirica et al. Factors contributing to the lower mortality with ticagrelor compared with clopidogrel in patients undergoing coronary artery bypass surgery J Am Coll Cardiol 60 2012 1623 1630
17. P. Tricoci, M.T. Roe, and J. Mulgund et al. Clopidogrel to treat patients with non-ST-segment elevation acute coronary syndromes after hospital discharge Arch Intern Med 166 2006 806 811
18. F. Biancari, K.E. Airaksinen, and G.Y. Lip Benefits and risks of using clopidogrel before coronary artery bypass surgery: systematic review and meta-analysis of randomized trials and observational studies J Thorac Cardiovasc Surg 143 2012 665 675
19. P. Raivio, A. Kuitunen, R. Suojaranta-Ylinen, R. Lassila, and J. Petäjä Thrombin generation during reperfusion after coronary artery bypass surgery associates with postoperative myocardial damage J Thromb Haemost 4 2006 1523 1529
20. S. Lison, W. Dietrich, and S. Braun et al. Enhanced thrombin generation after cardiopulmonary bypass surgery Anesth Analg 112 2011 37 45
21. S. Leonardi, P. Tricoci, and K.W. Mahaffey Promises of PAR-1 inhibition in acute coronary syndrome Curr Cardiol Rep 14 2012 32 39
22. M. Chintala, S. Vemulapalli, and S. Kurowski et al. SCH 530348, a novel oral antiplatelet agent, demonstrated no bleeding risk alone or in combination with aspirin and clopidogrel in cynomolgus monkeys (abstr) Arterioscler Thromb Vasc Biol 28 2008 e138 e139
23. P. Tricoci, Z. Huang, and C. Held et al. Thrombin-receptor antagonist vorapaxar in acute coronary syndromes N Engl J Med 366 2012 20 33
24. D.A. Morrow, E. Braunwald, and M.P. Bonaca et al. Vorapaxar in the secondary prevention of atherothrombotic events N Engl J Med 366 2012 1404 1413
25. TRA*CER Executive and Steering Committees The Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome (TRA*CER) trial: study design and rationale Am Heart J 158 2009 327 334
26. M.D. Boisclair, D.A. Lane, H. Philippou, S. Sheikh, and B. Hunt Thrombin production, inactivation and expression during open heart surgery measured by assays for activation fragments including a new ELISA for prothrombin fragment F1 + 2 Thromb Haemost 70 1993 253 258
27. J. Petäjä, E. Pesonen, J.A. Fernández, A.E. Vento, O.J. Rämö, and J.H. Griffin Cardiopulmonary bypass and activation of antithrombotic plasma protein C J Thorac Cardiovasc Surg 118 1999 422 429 discussion 429-31
28. A. Kulik, M.R. Le May, and P. Voisine et al. Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the Clopidogrel After Surgery for Coronary Artery Disease (CASCADE) trial Circulation 122 2010 2680 2687
29. N. de Leon, and C.A. Jackevicius Use of aspirin and clopidogrel after coronary artery bypass graft surgery Ann Pharmacother 46 2012 678 687
30. G. Gao, Z. Zheng, Y. Pi, B. Lu, J. Lu, and S. Hu Aspirin plus clopidogrel therapy increases early venous graft patency after coronary artery bypass surgery: a single-center, randomized, controlled trial J Am Coll Cardiol 56 2010 1639 1643
31. L.D. Hillis, P.K. Smith, and J.L. Anderson et al. 2011 ACCF/AHA guideline for coronary artery bypass graft surgery: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines J Am Coll Cardiol 58 2011 e123 e210
32. P.K. Smith, L.T. Goodnough, and J.H. Levy et al. Mortality benefit with prasugrel in the TRITON-TIMI 38 coronary artery bypass grafting cohort: risk-adjusted retrospective data analysis J Am Coll Cardiol 60 2012 388 396
33. R.C. Becker, D.J. Moliterno, and L.K. Jennings et al. Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: a randomised, double-blind, placebo-controlled phase II study Lancet 373 2009 919 928
34. Judge HM, Jennings LK, Moliterno DJ, et al. PAR-1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact. Paper presented at: XXIV Congress of the International Society on Thrombosis and Haemostasis; June 29 to July 4, 2013; Amsterdam, the Netherlands. Available at: http://www.eventure-online.com/eventure/publicAbstractView.do?id= 215172&congressId=6839. Accessed May 1, 2013.
35. I. Cornelissen, D. Palmer, and T. David et al. Roles and interactions among protease-activated receptors and P2ry12 in hemostasis and thrombosis Proc Natl Acad Sci U S A 107 2010 18605 18610
36. R.D. Lopes, G.E. Hafley, and K.B. Allen et al. Endoscopic versus open vein-graft harvesting in coronary-artery bypass surgery N Engl J Med 361 2009 235 244
37. A.L. Shroyer, F.L. Grover, and B. Hattler et al. On-pump versus off-pump coronary-artery bypass surgery N Engl J Med 361 2009 1827 1837