Enhanced thrombin generation after cardiopulmonary bypass surgery

Anesthesia and Analgesia

Volumn 112, Issue 1, 2011, Pages 37-45

  Lison, Susanne ^a   Dietrich, Wulf ^a   Braun, Siegmund ^b   Boehm, Johannes ^b   Schuster, Tibor ^c   Englhard, Anna ^a   Perchuc, Anna ^d   Spannagl, Michael ^a   Busley, Raimund ^e  

^a UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d Pentapharm Ltd   (Switzerland)

^e Behandlungszentrum Vogtareuth ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

D DIMER; PROTHROMBIN; TROPONIN T; WARFARIN;

AGED; ANTICOAGULATION; AORTA VALVE REPLACEMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; FEMALE; HEART SURGERY; HUMAN; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PRIORITY JOURNAL; THROMBIN TIME;

EID: 78650948270     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/ANE.0b013e3181fc6df0     Document Type: Article

References (57)

1. Mann KG, Butenas S, Brummel K. The dynamics of thrombin formation. Arterioscler Thromb Vasc Biol 2003;23:17-25
2. Butenas S, van't Veer C, Mann KG. 'Normal' thrombin generation. Blood 1999;94:2169-78
3. Edmunds LH Jr, Colman RW. Thrombin during cardiopulmonary bypass. Ann Thorac Surg 2006;82:2315-22
4. Boisclair MD, Lane DA, Philippou H, Esnouf MP, Sheikh S, Hunt B, Smith KJ. Mechanisms of thrombin generation during surgery and cardiopulmonary bypass. Blood 1993;82:3350-7
5. Esmon CT. Inflammation and thrombosis. J Thromb Haemost 2003;1:1343-8
6. Levy JH, Tanaka KA. Inflammatory response to cardiopulmonary bypass. Ann Thorac Surg 2003;75:S715-20
7. Choi G, Schultz MJ, Levi M, van der Poll T. The relationship between inflammation and the coagulation system. Swiss Med Wkly 2006;136:139-44
8. Cicala C, Cirino G. Linkage between inflammation and coagulation: an update on the molecular basis of the crosstalk. Life Sci 1998;62:1817-24
9. Slaughter TF, LeBleu TH, Douglas JM Jr, Leslie JB, Parker JK, Greenberg CS. Characterization of prothrombin activation during cardiac surgery by hemostatic molecular markers. Anesthesiology 1994;80:520-6
10. Chandler WL, Velan T. Estimating the rate of thrombin and fibrin generation in vivo during cardiopulmonary bypass. Blood 2003;101:4355-62
11. Eisses MJ, Seidel K, Aldea GS, Chandler WL. Reducing hemostatic activation during cardiopulmonary bypass: a combined approach. Anesth Analg 2004;98:1208-16
12. Kuitunen A, Hiippala S, Vahtera E, Rasi V, Salmenpera M. The effects of aprotinin and tranexamic acid on thrombin generation and fibrinolytic response after cardiac surgery. Acta Anaesthesiol Scand 2005;49:1272-9
13. Koster A, Huebler S, Merkle F, Hentschel T, Grundel M, Krabatsch T, Tambeur L, Praus M, Habazettl H, Kuebler WM, Kuppe H. Heparin-level-based anticoagulation management during cardiopulmonary bypass: a pilot investigation on the effects of a half-dose aprotinin protocol on postoperative blood loss and hemostatic activation and inflammatory response. Anesth Analg 2004;98:285-90
14. Casati V, Gerli C, Franco A, Della Valle P, Benussi S, Alfieri O, Torri G, D'Angelo A. Activation of coagulation and fibrinolysis during coronary surgery: on-pump versus off-pump techniques. Anesthesiology 2001;95:1103-9
15. Mariani MA, Gu YJ, Boonstra PW, Grandjean JG, van Oeveren W, Ebels T. Procoagulant activity after off-pump coronary operation: is the current anticoagulation adequate? Ann Thorac Surg 1999;67:1370-5
16. Lo B, Fijnheer R, Castigliego D, Borst C, Kalkman CJ, Nierich AP. Activation of hemostasis after coronary artery bypass grafting with or without cardiopulmonary bypass. Anesth Analg 2004;99:634-40
17. Hunt BJ, Parratt RN, Segal HC, Sheikh S, Kallis P, Yacoub M. Activation of coagulation and fibrinolysis during cardiothoracic operations. Ann Thorac Surg 1998;65:712-8
18. Parolari A, Mussoni L, Frigerio M, Naliato M, Alamanni F, Galanti A, Fiore G, Veglia F, Tremoli E, Biglioli P, Camera M. Increased prothrombotic state lasting as long as one month after on-pump and off-pump coronary surgery. J Thorac Cardiovasc Surg 2005;130:303-8
19. Bevan DH. Cardiac bypass haemostasis: putting blood through the mill. Br J Haematol 1999;104:208-19
20. Despotis GJ, Avidan MS, Hogue CW Jr. Mechanisms and attenuation of hemostatic activation during extracorporeal circulation. Ann Thorac Surg 2001;72:S1821-31
21. Lu H, Du Buit C, Soria J, Touchot B, Chollet B, Commin PL, Conseiller C, Echter E, Soria C. Postoperative hemostasis and fibrinolysis in patients undergoing cardiopulmonary bypass with or without aprotinin therapy. Thromb Haemost 1994;72:438-43
22. Harker LA, Malpass TW, Branson HE, Hessel EA II, Slichter SJ. Mechanism of abnormal bleeding in patients undergoing cardiopulmonary bypass: acquired transient platelet dysfunction associated with selective alpha-granule release. Blood 1980;56:824-34
23. Ardissino D, Merlini PA, Bauer KA, Galvani M, Ottani F, Franchi F, Bertocchi F, Rosenberg RD, Mannucci PM. Coagulation activation and long-term outcome in acute coronary syndromes. Blood 2003;102:2731-5
24. Granger CB, Becker R, Tracy RP, Califf RM, Topol EJ, Pieper KS, Ross AM, Roth S, Lambrew C, Bovill EG. Thrombin generation, inhibition and clinical outcomes in patients with acute myocardial infarction treated with thrombolytic therapy and heparin: results from the GUSTO-I Trial. GUSTO-I Hemostasis Substudy Group. Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries. J Am Coll Cardiol 1998;31:497-505
25. Ulrich-Mockel NV, Riehle M, Vollert J, Heller G Jr, Stork T, Riess H, Muller C, Frei U, Mockel M. Thrombin activity throughout the acute phase of acute ST-elevation myocardial infarction and the relation to outcome. Biomarkers 2009;14:311-6
26. Fontes ML, Aronson S, Mathew JP, Miao Y, Drenger B, Barash PG, Mangano DT. Pulse pressure and risk of adverse outcome in coronary bypass surgery. Anesth Analg 2008;107:1122-9
27. Serruys PW, Morice MC, Kappetein AP, Colombo A, Holmes DR, Mack MJ, Stahle E, Feldman TE, van den Brand M, Bass EJ, Van Dyck N, Leadley K, Dawkins KD, Mohr FW. Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 2009;360:961-72
28. Reis SE, Polak JF, Hirsch DR, Cohn LH, Creager MA, Donovan BC, Goldhaber SZ. Frequency of deep venous thrombosis in asymptomatic patients with coronary artery bypass grafts. Am Heart J 1991;122:478-82
29. Hemker HC, Al Dieri R, De Smedt E, Beguin S. Thrombin generation, a function test of the haemostatic-thrombotic system. Thromb Haemost 2006;96:553-61
30. Tanaka KA, Szlam F, Levy JH. The effect of aprotinin on activated protein C-mediated downregulation of endogenous thrombin generation. Br J Haematol 2006;134:77-82
31. Tanaka KA, Szlam F, Sun HY, Taketomi T, Levy JH. Thrombin generation assay and viscoelastic coagulation monitors demonstrate differences in the mode of thrombin inhibition between unfractionated heparin and bivalirudin. Anesth Analg 2007;105:933-9
32. Sniecinski R, Szlam F, Chen EP, Bader SO, Levy JH, Tanaka KA. Antithrombin deficiency increases thrombin activity after prolonged cardiopulmonary bypass. Anesth Analg 2008;106:713-8
33. Sumann G, Fries D, Griesmacher A, Falkensammer G, Klingler A, Koller A, Streif W, Greie S, Schobersberger B, Schobersberger W. Blood coagulation activation and fibrinolysis during a downhill marathon run. Blood Coagul Fibrinolysis 2007;18:435-40
34. Calatzis A, Reininger A, Spannagl M, Schramm W. Rapid and automated quantification of the kinetics of thrombin formation using the Thrombin Dynamics Test (TDT). J Thromb Haemost 2003;1:1589-9
35. Dietrich W, Spannagl M, Boehm J, Hauner K, Braun S, Schuster T, Busley R. Tranexamic acid and aprotinin in primary cardiac operations: an analysis of 220 cardiac surgical patients treated with tranexamic acid or aprotinin. Anesth Analg 2008;107: 1469-78
36. Prasa D, Svendsen L, Sturzebecher J. The ability of thrombin inhibitors to reduce the thrombin activity generated in plasma on extrinsic and intrinsic activation. Thromb Haemost 1997;77:498-503
37. Rijkers DT, Wielders SJ, Beguin S, Hemker HC. Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density. Thromb Res 1998;89:161-9
38. Januzzi JL, Lewandrowski K, MacGillivray TE, Newell JB, Kathiresan S, Servoss SJ, Lee-Lewandrowski E. A comparison of cardiac troponin T and creatine kinase-MB for patient evaluation after cardiac surgery. J Am Coll Cardiol 2002;39:1518-23
39. Sheldon MR, Fillyaw MJ, Thompson WD. The use and interpretation of the Friedman test in the analysis of ordinal-scale data in repeated measures designs. Physiother Res Int 1996;1:221-8
40. Tanaka KA, Key NS, Levy JH. Blood coagulation: hemostasis and thrombin regulation. Anesth Analg 2009;108:1433-46
41. Mannucci L, Gerometta PS, Mussoni L, Antona C, Parolari A, Salvi L, Biglioli P, Tremoli E. One month follow-up of haemostatic variables in patients undergoing aortocoronary bypass surgery: effect of aprotinin. Thromb Haemost 1995;73:356-61
42. Koster A, Fischer T, Praus M, Haberzettl H, Kuebler WM, Hetzer R, Kuppe H. Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management. Anesthesiology 2002;97:837-41
43. Dixon B, Santamaria J, Campbell D. Coagulation activation and organ dysfunction following cardiac surgery. Chest 2005;128: 229-36
44. Hemker HC, Beguin S. Thrombin generation in plasma: its assessment via the endogenous thrombin potential. Thromb Haemost 1995;74:134-8
45. Hemker HC, Giesen P, Al Dieri R, Regnault V, de Smedt E, Wagenvoord R, Lecompte T, Beguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003;33:4-15
46. Salvagno GL, Astermark J, Lippi G, Ekman M, Franchini M, Guidi GC, Berntorp E. Thrombin generation assay: a useful routine check-up tool in the management of patients with haemophilia? Haemophilia 2009;15:290-6
47. van Veen JJ, Gatt A, Bowyer AE, Cooper PC, Kitchen S, Makris M. Calibrated automated thrombin generation and modified thromboelastometry in haemophilia A. Thromb Res 2008;123: 895-901
48. Eichinger S, Hron G, Kollars M, Kyrle PA. Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer. Clin Chem 2008;54:2042-8
49. Orbe J, Zudaire M, Serrano R, Coma-Canella I, Martinez de Sizarrondo S, Rodriguez JA, Paramo JA. Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test. Thromb Haemost 2008;99:382-7
50. Brodin E, Seljeflot I, Arnesen H, Hurlen M, Appelbom H, Hansen JB. Endogenous thrombin potential (ETP) in plasma from patients with AMI during antithrombotic treatment. Thromb Res 2009;123:573-9
51. Calatzis A, Spannagl M, Schramm W. Influence of FV Leiden on the kinetics of thrombin formation as determined by the thrombin dynamics test (TDT). J Thromb Haemost 2007;5:465
52. Duff E, Billing V, McPherson D, Coakley M, Collins P, Hall JE. Thrombin generation during cardiac bypass surgery. Anaesthesia 2008;63:1271-3
53. Paparella D, Semeraro F, Scrascia G, Galeone A, Ammollo CT, Kounakis G, de Luca Tupputi Schinosa L, Semeraro N, Colucci M. Coagulation-fibrinolysis changes during off-pump bypass: effect of two heparin doses. Ann Thorac Surg 2010;89:421-7
54. Koestenberger M, Cvirn G, Nagel B, Rosenkranz A, Leschnik B, Gamillscheg A, Beitzke A, Muntean W. Thrombin generation determined by calibrated automated thrombography (CAT) in pediatric patients with congenital heart disease. Thromb Res 2008;122:13-9
55. Gatt A, van Veen JJ, Bowyer A, Woolley AM, Cooper P, Kitchen S, Makris M. Wide variation in thrombin generation in patients with atrial fibrillation and therapeutic international normalized ratio is not due to inflammation. Br J Haematol 2008;142:946-52
56. Brummel KE, Paradis SG, Branda RF, Mann KG. Oral anticoagulation thresholds. Circulation 2001;104:2311-7
57. Poullis M, Manning R, Laffan M, Haskard DO, Taylor KM, Landis RC. The antithrombotic effect of aprotinin: actions mediated via the protease activated receptor 1. J Thorac Cardiovasc Surg 2000;120:370-8