TMPRSS4 correlates with colorectal cancer pathological stage and regulates cell proliferation and self-renewal ability

Cancer Biology and Therapy

Volumn 15, Issue 3, 2014, Pages 297-304

  Huang, Ao ^a,b,c   Zhou, Houmin ^d   Zhao, Hongchao ^a,b,c   Quan, Yingjun ^a,b,c   Feng, Bo ^a,b,c   Zheng, Minhua ^a,b,c  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Institute of Digestive Surgery   (China)

^c Shanghai Minimally Invasive Surgery Center   (China)

^d QINGDAO UNIVERSITY   (China)

Author keywords

Cancer stem cell; Colorectal cancer; Proliferation; Self renewal ability; TMPRSS4

Indexed keywords

AGAROSE; MESSENGER RNA; SERINE PROTEINASE; TRANSMEMBRANE PROTEASE SERINE 4; UNCLASSIFIED DRUG; CD133 ANTIGEN; CD44 PROTEIN, HUMAN; GLYCOPROTEIN; HERMES ANTIGEN; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN; PEPTIDE; TMPRSS4 PROTEIN, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CANCER STAGING; CANCER STEM CELL; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CELL RENEWAL; CLONOGENESIS; CLONOGENIC ASSAY; COLORECTAL CANCER; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WST-8 ASSAY; CELL MOTION; COLORECTAL TUMOR; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE; TUMOR INVASION;

ANTIGENS, CD; ANTIGENS, CD44; APOPTOSIS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; GLYCOPROTEINS; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PEPTIDES; SERINE ENDOPEPTIDASES;

EID: 84896529721     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.27308     Document Type: Article

References (37)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin 2013; 63:11-30; PMID:23335087; http://dx.doi.org/10.3322/caac.21166
2. Gao P, Song YX, Wang ZN, Xu YY, Tong LL, Sun JX, Yu M, Xu HM. Is the prediction of prognosis not improved by the seventh edition of the TNM classification for colorectal cancer? Analysis of the surveilla006Ece, epidemiology, and end results (SEER) database. BMC Cancer 2013; 13:123; PMID:23496812; http://dx.doi.org/10.1186/1471-2407-13-123
3. Sadahiro S, Suzuki T, Ishikawa K, Nakamura T, Tanaka Y, Masuda T, Mukoyama S, Yasuda S, Tajima T, Makuuchi H, et al. Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years. Hepatogastroenterology 2003; 50:1362-6; PMID:14571738 (Pubitemid 37186484)
4. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-8; PMID:19487818; http://dx.doi.org/10.1172/ JCI39104
5. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011; 147:275-92; PMID:22000009; http://dx.doi.org/10. 1016/j.cell.2011.09.024
6. Scheel C, Weinberg RA. Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol 2012; 22:396-403; PMID:22554795; http://dx.doi.org/10.1016/j. semcancer.2012.04.001
7. Netzel-Arnett S, Hooper JD, Szabo R, Madison EL, Quigley JP, Bugge TH, Antalis TM. Membrane anchored serine proteases: a rapidly expanding group of cell surface proteolytic enzymes with potential roles in cancer. Cancer Metastasis Rev 2003; 22:237-58; PMID:12784999; http://dx.doi.org/10.1023/A: 1023003616848 (Pubitemid 36561060)
8. Szabo R, Bugge TH. Type II transmembrane serine proteases in development and disease. Int J Biochem Cell Biol 2008; 40:1297-316; PMID:18191610; http://dx.doi.org/10.1016/j.biocel.2007.11.013
9. Yuan X, Zheng X, Lu D, Rubin DC, Pung CY, Sadler JE. Structure of murine enterokinase (enteropeptidase) and expression in small intestine during development. Am J Physiol 1998; 274:G342-9; PMID:9486188
10. Guipponi M, Tan J, Cannon PZ, Donley L, Crewther P, Clarke M, Wu Q, Shepherd RK, Scott HS. Mice deficient for the type II transmembrane serine protease, TMPRSS1/hepsin, exhibit profound hearing loss. Am J Pathol 2007; 171:608-16; PMID:17620368; http://dx.doi.org/10.2353/ajpath.2007.070068 (Pubitemid 47344693)
11. Scott HS, Kudoh J, Wattenhofer M, Shibuya K, Berry A, Chrast R, Guipponi M, Wang J, Kawasaki K, Asakawa S, et al. Insertion of beta-satellite repeats identifies a transmembrane protease causing both congenital and childhood onset autosomal recessive deafness. Nat Genet 2001; 27:59-63; PMID:11137999; http://dx.doi.org/10.1038/83768 (Pubitemid 32044519)
12. Ohler A, Becker-Pauly C. Morpholino knockdown of the ubiquitously expressed transmembrane serine protease TMPRSS4a in zebrafish embryos exhibits severe defects in organogenesis and cell adhesion. Biol Chem 2011; 392:653-64; PMID:21657981; http://dx.doi.org/10.1515/bc.2011.070
13. Choi SY, Bertram S, Glowacka I, Park YW, Pöhlmann S. Type II transmembrane serine proteases in cancer and viral infections. Trends Mol Med 2009; 15:303-12; PMID:19581128; http://dx.doi.org/10.1016/j. molmed.2009.05.003
14. Kim S, Kang HY, Nam EH, Choi MS, Zhao XF, Hong CS, Lee JW, Lee JH, Park YK. TMPRSS4 induces invasion and epithelial-mesenchymal transition through upregulation of integrin alpha5 and its signaling pathways. Carcinogenesis 2010; 31:597-606; PMID:20118200; http://dx.doi.org/10.1093/carcin/bgq024
15. Kang S, Min HJ, Kang MS, Jung MG, Kim S. Discovery of novel 2-hydroxydiarylamide derivatives as TMPRSS4 inhibitors. Bioorg Med Chem Lett 2013; 23:1748-51; PMID:23414802; http://dx.doi.org/10.1016/j.bmcl.2013.01.055
16. Liang B, Wu M, Bu Y, Zhao A, Xie F. Prognostic value of TMPRSS4 expression in patients with breast cancer. Med Oncol 2013; 30:497; PMID:23420063; http://dx.doi.org/10.1007/s12032-013-0497-8
17. Cheng D, Kong H, Li Y. TMPRSS4 as a poor prognostic factor for triple-negative breast cancer. Int J Mol Sci 2013; 14:14659-68; PMID:23857060; http://dx.doi.org/10.3390/ijms140714659
18. Jung H, Lee KP, Park SJ, Park JH, Jang YS, Choi SY, Jung JG, Jo K, Park DY, Yoon JH, et al. TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelialmesenchymal transition. Oncogene 2008; 27:2635-47; PMID:17968309; http://dx.doi.org/10.1038/sj.onc.1210914 (Pubitemid 351550879)
19. Chaipan C, Kobasa D, Bertram S, Glowacka I, Steffen I, Tsegaye TS, Takeda M, Bugge TH, Kim S, Park Y, et al. Proteolytic activation of the 1918 influenza virus hemagglutinin. J Virol 2009; 83:3200-11; PMID:19158246; http://dx.doi.org/10.1128/JVI.02205-08
20. Bahgat MM, Błazejewska P, Schughart K. Inhibition of lung serine proteases in mice: a potentially new approach to control influenza infection. Virol J 2011; 8:27; PMID:21251300; http://dx.doi.org/10.1186/1743-422X-8-27
21. Wallrapp C, Hähnel S, Müller-Pillasch F, Burghardt B, Iwamura T, Ruthenbürger M, Lerch MM, Adler G, Gress TM. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. Cancer Res 2000; 60:2602-6; PMID:10825129 (Pubitemid 30318232)
22. Kebebew E, Peng M, Reiff E, Duh QY, Clark OH, McMillan A. ECM1 and TMPRSS4 are diagnostic markers of malignant thyroid neoplasms and improve the accuracy of fine needle aspiration biopsy. Ann Surg 2005; 242:353-61, discussion 361-3; PMID:16135921
23. Nguyen TH, Weber W, Havari E, Connors T, Bagley RG, McLaren R, Nambiar PR, Madden SL, Teicher BA, Roberts B, et al. Expression of TMPRSS4 in nonsmall cell lung cancer and its modulation by hypoxia. Int J Oncol 2012; 41:829-38; PMID:22692880
24. Larzabal L, Nguewa PA, Pio R, Blanco D, Sanchez B, Rodríguez MJ, Pajares MJ, Catena R, Montuenga LM, Calvo A. Overexpression of TMPRSS4 in nonsmall cell lung cancer is associated with poor prognosis in patients with squamous histology. Br J Cancer 2011; 105:1608-14; PMID:22067904; http://dx.doi.org/10.1038/bjc.2011.432
25. Kebebew E, Peng M, Reiff E, McMillan A. Diagnostic and extent of disease multigene assay for malignant thyroid neoplasms. Cancer 2006; 106:2592-7; PMID:16688775; http://dx.doi.org/10.1002/cncr.21922
26. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 2002; 298:1911-2; PMID:12471242; http://dx.doi.org/10.1126/science.1072682 (Pubitemid 35425238)
27. Bacus SS, Gudkov AV, Lowe M, Lyass L, Yung Y, Komarov AP, Keyomarsi K, Yarden Y, Seger R. Taxolinduced apoptosis depends on MAP kinase pathways (ERK and p38) and is independent of p53. Oncogene 2001; 20:147-55; PMID:11313944; http://dx.doi.org/10.1038/sj.onc.1204062 (Pubitemid 32150260)
28. Suh Y, Yoon CH, Kim RK, Lim EJ, Oh YS, Hwang SG, An S, Yoon G, Gye MC, Yi JM, et al. Claudin-1 induces epithelial-mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells. Oncogene 2013; 32:4873-82; PMID:23160379; http://dx.doi.org/10.1038/onc.2012.505
29. Yoon CH, Kim MJ, Park MJ, Park IC, Hwang SG, An S, Choi YH, Yoon G, Lee SJ. Claudin-1 acts through c-Abl-protein kinase Cdelta (PKCdelta) signaling and has a causal role in the acquisition of invasive capacity in human liver cells. J Biol Chem 2010; 285:226-33; PMID:19897486; http://dx.doi.org/10.1074/jbc. M109.054189
30. Shiozaki A, Bai XH, Shen-Tu G, Moodley S, Takeshita H, Fung SY, Wang Y, Keshavjee S, Liu M. Claudin 1 mediates TNFα-induced gene expression and cell migration in human lung carcinoma cells. PLoS One 2012; 7:e38049; PMID:22675434; http://dx.doi.org/10.1371/journal.pone.0038049
31. Ikenouchi J, Matsuda M, Furuse M, Tsukita S. Regulation of tight junctions during the epitheliummesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 2003; 116:1959-67; PMID:12668723; http://dx.doi.org/10.1242/jcs.00389 (Pubitemid 36622294)
32. Bezdekova M, Brychtova S, Sedlakova E, Langova K, Brychta T, Belej K. Analysis of snail-1, e-cadherin and claudin-1 expression in colorectal adenomas and carcinomas. Int J Mol Sci 2012; 13:1632-43; PMID:22408413; http://dx.doi.org/10.3390/ijms13021632
33. Morel AP, Lièvre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008; 3:e2888; PMID:18682804; http://dx.doi.org/10.1371/ journal.pone.0002888
34. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008; 133:704-15; PMID:18485877; http://dx.doi.org/10.1016/j.cell.2008.03.027 (Pubitemid 351636299)
35. Sanders MA, Majumdar AP. Colon cancer stem cells: implications in carcinogenesis. Front Biosci (Landmark Ed) 2011; 16:1651-62; PMID:21196254; http://dx.doi.org/10.2741/3811
36. Mao Z, Sun J, Feng B, Ma J, Zang L, Dong F, Zhang D, Zheng M. The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. PLoS One 2013; 8:e68206; PMID:23874544; http://dx.doi.org/10.1371/journal.pone.0068206
37. Dong TT, Zhou HM, Wang LL, Feng B, Lv B, Zheng MH. Salinomycin selectively targets 'CD133+' cell subpopulations and decreases malignant traits in colorectal cancer lines. Ann Surg Oncol 2011; 18:1797-804; PMID:21267784; http://dx.doi.org/10.1245/s10434-011-1561-2