-
1
-
-
0037219411
-
Beta-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
-
Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Beta-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes. Diabetes. 2003;52(1): 102-10.
-
(2003)
Diabetes
, vol.52
, Issue.1
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
2
-
-
12344323484
-
Type 2 diabetes-a matter of beta-cell life and death?
-
Rhodes CJ. Type 2 diabetes-a matter of beta-cell life and death? Science. 2005;307(5708): 380-4.
-
(2005)
Science
, vol.307
, Issue.5708
, pp. 380-384
-
-
Rhodes, C.J.1
-
3
-
-
10344228731
-
Dysfunctional fat cells, lipotoxicity and type 2 diabetes
-
DeFronzo RA. Dysfunctional fat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl. 2004;143: 9-21.
-
(2004)
Int J Clin Pract Suppl.
, vol.143
, pp. 9-21
-
-
DeFronzo, R.A.1
-
4
-
-
0035125917
-
Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
-
Unger RH, Zhou YT. Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes. 2001;50(Suppl 1): S118-21.
-
(2001)
Diabetes
, vol.50
, Issue.SUPPL. 1
-
-
Unger, R.H.1
Zhou, Y.T.2
-
5
-
-
0034991799
-
Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas
-
Leung PS, Carlsson PO. Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas. J Mol Endocrinol. 2001;26(3): 155-64.
-
(2001)
J Mol Endocrinol.
, vol.26
, Issue.3
, pp. 155-164
-
-
Leung, P.S.1
Carlsson, P.O.2
-
6
-
-
1542374750
-
Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets
-
Lau T, Carlsson PO, Leung PS. Evidence for a local angiotensin-generating system and dose-dependent inhibition of glucose-stimulated insulin release by angiotensin II in isolated pancreatic islets. Diabetologia. 2004;47(2): 240-8.
-
(2004)
Diabetologia
, vol.47
, Issue.2
, pp. 240-248
-
-
Lau, T.1
Carlsson, P.O.2
Leung, P.S.3
-
7
-
-
0031911742
-
Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats
-
Carlsson PO, Berne C, Jansson L. Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats. Diabetologia. 1998;41(2): 127-33.
-
(1998)
Diabetologia
, vol.41
, Issue.2
, pp. 127-133
-
-
Carlsson, P.O.1
Berne, C.2
Jansson, L.3
-
8
-
-
0033765672
-
High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
-
Inoguchi T, Li P, Umeda F, Yu HY, Kakimoto M, Imamura M, Aoki T, Etoh T, Hashimoto T, Naruse M, Sano H, Utsumi H, Nawata H. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells. Diabetes. 2000;49(11): 1939-45.
-
(2000)
Diabetes
, vol.49
, Issue.11
, pp. 1939-1945
-
-
Inoguchi, T.1
Li, P.2
Umeda, F.3
Yu, H.Y.4
Kakimoto, M.5
Imamura, M.6
Aoki, T.7
Etoh, T.8
Hashimoto, T.9
Naruse, M.10
Sano, H.11
Utsumi, H.12
Nawata, H.13
-
9
-
-
0037645789
-
Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase
-
Oliveira HR, Verlengia R, Carvalho CR, Britto LR, Curi R, Carpinelli AR. Pancreatic beta-cells express phagocyte-like NAD(P)H oxidase. Diabetes. 2003;52(6): 1457-63.
-
(2003)
Diabetes
, vol.52
, Issue.6
, pp. 1457-1463
-
-
Oliveira, H.R.1
Verlengia, R.2
Carvalho, C.R.3
Britto, L.R.4
Curi, R.5
Carpinelli, A.R.6
-
10
-
-
77951453096
-
Effect of valsartan on the incidence of diabetes and cardiovascular events
-
McMurray JJ, Holman RR, Haffner SM, Bethel MA, Holzhauer B, Hua TA, Belenkov Y, Boolell M, Buse JB, Buckley BM, Chacra AR, Chiang FT, Charbonnel B, Chow CC, Davies MJ, Deedwania P, Diem P, Einhorn D, Fonseca V, Fulcher GR, Gaciong Z, Gaztambide S, Giles T, Horton E, Ilkova H, Jenssen T, Kahn SE, Krum H, Laakso M, Leiter LA, Levitt NS, Mareev V, Martinez F, Masson C, Mazzone T, Meaney E, Nesto R, Pan C, Prager R, Raptis SA, Rutten GE, Sandstroem H, Schaper F, Scheen A, Schmitz O, Sinay I, Soska V, Stender S, Tamas G, Tognoni G, Tuomilehto J, Villamil AS, Vozar J, Califf RM. Effect of valsartan on the incidence of diabetes and cardiovascular events. N Engl J Med. 362(16): 1477-1490.
-
N Engl J Med.
, vol.362
, Issue.16
, pp. 1477-1490
-
-
McMurray, J.J.1
Holman, R.R.2
Haffner, S.M.3
Bethel, M.A.4
Holzhauer, B.5
Hua, T.A.6
Belenkov, Y.7
Boolell, M.8
Buse, J.B.9
Buckley, B.M.10
Chacra, A.R.11
Chiang, F.T.12
Charbonnel, B.13
Chow, C.C.14
Davies, M.J.15
Deedwania, P.16
Diem, P.17
Einhorn, D.18
Fonseca, V.19
Fulcher, G.R.20
Gaciong, Z.21
Gaztambide, S.22
Giles, T.23
Horton, E.24
Ilkova, H.25
Jenssen, T.26
Kahn, S.E.27
Krum, H.28
Laakso, M.29
Leiter, L.A.30
Levitt, N.S.31
Mareev, V.32
Martinez, F.33
Masson, C.34
Mazzone, T.35
Meaney, E.36
Nesto, R.37
Pan, C.38
Prager, R.39
Raptis, S.A.40
Rutten, G.E.41
Sandstroem, H.42
Schaper, F.43
Scheen, A.44
Schmitz, O.45
Sinay, I.46
Soska, V.47
Stender, S.48
Tamas, G.49
Tognoni, G.50
Tuomilehto, J.51
Villamil, A.S.52
Vozar, J.53
Califf, R.M.54
more..
-
11
-
-
24044536393
-
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials
-
Abuissa H, Jones PG, Marso SP, O'Keefe JH Jr. Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for prevention of type 2 diabetes: a meta-analysis of randomized clinical trials. J Am Coll Cardiol. 2005;46(5): 821-6.
-
(2005)
J Am Coll Cardiol.
, vol.46
, Issue.5
, pp. 821-826
-
-
Abuissa, H.1
Jones, P.G.2
Marso, S.P.3
O'Keefe Jr., J.H.4
-
12
-
-
33646200241
-
Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice
-
Shao J, Iwashita N, Ikeda F, Ogihara T, Uchida T, Shimizu T, Uchino H, Hirose T, Kawamori R, Watada H. Beneficial effects of candesartan, an angiotensin II type 1 receptor blocker, on beta-cell function and morphology in db/db mice. Biochem Biophys Res Commun. 2006;344(4): 1224-33.
-
(2006)
Biochem Biophys Res Commun.
, vol.344
, Issue.4
, pp. 1224-1233
-
-
Shao, J.1
Iwashita, N.2
Ikeda, F.3
Ogihara, T.4
Uchida, T.5
Shimizu, T.6
Uchino, H.7
Hirose, T.8
Kawamori, R.9
Watada, H.10
-
13
-
-
20444407654
-
Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
-
Nakayama M, Inoguchi T, Sonta T, Maeda Y, Sasaki S, Sawada F, Tsubouchi H, Sonoda N, Kobayashi K, Sumimoto H, Nawata H. Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist. Biochem Biophys Res Commun. 2005;332(4): 927-33.
-
(2005)
Biochem Biophys Res Commun.
, vol.332
, Issue.4
, pp. 927-933
-
-
Nakayama, M.1
Inoguchi, T.2
Sonta, T.3
Maeda, Y.4
Sasaki, S.5
Sawada, F.6
Tsubouchi, H.7
Sonoda, N.8
Kobayashi, K.9
Sumimoto, H.10
Nawata, H.11
-
14
-
-
1842475446
-
Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat
-
Tikellis C, Wookey PJ, Candido R, Andrikopoulos S, Thomas MC, Cooper ME. Improved islet morphology after blockade of the renin- angiotensin system in the ZDF rat. Diabetes. 2004;53(4): 989-97.
-
(2004)
Diabetes
, vol.53
, Issue.4
, pp. 989-997
-
-
Tikellis, C.1
Wookey, P.J.2
Candido, R.3
Andrikopoulos, S.4
Thomas, M.C.5
Cooper, M.E.6
-
15
-
-
33644781780
-
Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes
-
Chu KY, Lau T, Carlsson PO, Leung PS. Angiotensin II type 1 receptor blockade improves beta-cell function and glucose tolerance in a mouse model of type 2 diabetes. Diabetes. 2006;55(2): 367-74.
-
(2006)
Diabetes
, vol.55
, Issue.2
, pp. 367-374
-
-
Chu, K.Y.1
Lau, T.2
Carlsson, P.O.3
Leung, P.S.4
-
16
-
-
33745842894
-
Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor
-
Miura S, Fujino M, Hanzawa H, Kiya Y, Imaizumi S, Matsuo Y, Tomita S, Uehara Y, Karnik SS, Yanagisawa H, Koike H, Komuro I, Saku K. Molecular mechanism underlying inverse agonist of angiotensin II type 1 receptor. J Biol Chem. 2006;281(28): 19288-95.
-
(2006)
J Biol Chem.
, vol.281
, Issue.28
, pp. 19288-19295
-
-
Miura, S.1
Fujino, M.2
Hanzawa, H.3
Kiya, Y.4
Imaizumi, S.5
Matsuo, Y.6
Tomita, S.7
Uehara, Y.8
Karnik, S.S.9
Yanagisawa, H.10
Koike, H.11
Komuro, I.12
Saku, K.13
-
17
-
-
77950820320
-
Clinical and pharmacotherapeutic relevance of the double-chain domain of the angiotensin II type 1 receptor blocker olmesartan
-
Kiya Y, Miura S, Fujino M, Imaizumi S, Karnik SS, Saku K. Clinical and pharmacotherapeutic relevance of the double-chain domain of the angiotensin II type 1 receptor blocker olmesartan. Clin Exp Hypertens. 32(2): 129-136.
-
Clin Exp Hypertens
, vol.32
, Issue.2
, pp. 129-136
-
-
Kiya, Y.1
Miura, S.2
Fujino, M.3
Imaizumi, S.4
Karnik, S.S.5
Saku, K.6
-
18
-
-
1542547460
-
Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activity
-
Benson SC, Pershadsingh HA, Ho CI, Chittiboyina A, Desai P, Pravenec M, Qi N, Wang J, Avery MA, Kurtz TW. Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARγ-modulating activity. Hypertension. 2004;43(5): 993-1002.
-
(2004)
Hypertension
, vol.43
, Issue.5
, pp. 993-1002
-
-
Benson, S.C.1
Pershadsingh, H.A.2
Ho, C.I.3
Chittiboyina, A.4
Desai, P.5
Pravenec, M.6
Qi, N.7
Wang, J.8
Avery, M.A.9
Kurtz, T.W.10
-
19
-
-
70449521071
-
Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells
-
Saitoh Y, Hongwei W, Ueno H, Mizuta M, Nakazato M. Telmisartan attenuates fatty-acid-induced oxidative stress and NAD(P)H oxidase activity in pancreatic beta-cells. Diabetes Metab. 2009;35(5): 392-7.
-
(2009)
Diabetes Metab.
, vol.35
, Issue.5
, pp. 392-397
-
-
Saitoh, Y.1
Hongwei, W.2
Ueno, H.3
Mizuta, M.4
Nakazato, M.5
-
20
-
-
36249007030
-
Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan
-
Mogi M, Tsukuda K, Li JM, Iwanami J, Min LJ, Sakata A, Fujita T, Iwai M, Horiuchi M. Inhibition of cognitive decline in mice fed a high-salt and cholesterol diet by the angiotensin receptor blocker, olmesartan. Neuropharmacology. 2007;53(8): 899-905.
-
(2007)
Neuropharmacology
, vol.53
, Issue.8
, pp. 899-905
-
-
Mogi, M.1
Tsukuda, K.2
Li, J.M.3
Iwanami, J.4
Min, L.J.5
Sakata, A.6
Fujita, T.7
Iwai, M.8
Horiuchi, M.9
-
21
-
-
34047161460
-
Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice
-
Zhang GX, Ohmori K, Nagai Y, Fujisawa Y, Nishiyama A, Abe Y, Kimura S. Role of AT1 receptor in isoproterenol-induced cardiac hypertrophy and oxidative stress in mice. J Mol Cell Cardiol. 2007;42(4): 804-11.
-
(2007)
J Mol Cell Cardiol.
, vol.42
, Issue.4
, pp. 804-811
-
-
Zhang, G.X.1
Ohmori, K.2
Nagai, Y.3
Fujisawa, Y.4
Nishiyama, A.5
Abe, Y.6
Kimura, S.7
-
22
-
-
2442503516
-
Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation
-
Hilfiker-Kleiner D, Kaminski K, Kaminska A, Fuchs M, Klein G, Podewski E, Grote K, Kiian I, Wollert KC, Hilfiker A, Drexler H. Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation. Circulation. 2004;109(18): 2227-33.
-
(2004)
Circulation
, vol.109
, Issue.18
, pp. 2227-2233
-
-
Hilfiker-Kleiner, D.1
Kaminski, K.2
Kaminska, A.3
Fuchs, M.4
Klein, G.5
Podewski, E.6
Grote, K.7
Kiian, I.8
Wollert, K.C.9
Hilfiker, A.10
Drexler, H.11
-
23
-
-
23944473130
-
Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis
-
Grothusen C, Bley S, Selle T, Luchtefeld M, Grote K, Tietge UJ, Drexler H, Schieffer B. Combined effects of HMG-CoA-reductase inhibition and renin-angiotensin system blockade on experimental atherosclerosis. Atherosclerosis. 2005;182(1): 57-69.
-
(2005)
Atherosclerosis
, vol.182
, Issue.1
, pp. 57-69
-
-
Grothusen, C.1
Bley, S.2
Selle, T.3
Luchtefeld, M.4
Grote, K.5
Tietge, U.J.6
Drexler, H.7
Schieffer, B.8
-
24
-
-
34047261439
-
Protein kinase C-delta plays a non-redundant role in insulin secretion in pancreatic beta cells
-
Uchida T, Iwashita N, Ohara-Imaizumi M, Ogihara T, Nagai S, Choi JB, Tamura Y, Tada N, Kawamori R, Nakayama KI, Nagamatsu S, Watada H. Protein kinase C-delta plays a non-redundant role in insulin secretion in pancreatic beta cells. J Biol Chem. 2007;282(4): 2707-16.
-
(2007)
J Biol Chem.
, vol.282
, Issue.4
, pp. 2707-2716
-
-
Uchida, T.1
Iwashita, N.2
Ohara-Imaizumi, M.3
Ogihara, T.4
Nagai, S.5
Choi, J.B.6
Tamura, Y.7
Tada, N.8
Kawamori, R.9
Nakayama, K.I.10
Nagamatsu, S.11
Watada, H.12
-
25
-
-
10744233909
-
Little evidence of trans differentiation of bone marrow-derived cells into pancreatic beta cells
-
Choi JB, Uchino H, Azuma K, Iwashita N, Tanaka Y, Mochizuki H, Migita M, Shimada T, Kawamori R, Watada H. Little evidence of trans differentiation of bone marrow-derived cells into pancreatic beta cells. Diabetologia. 2003;46(10): 1366-74.
-
(2003)
Diabetologia
, vol.46
, Issue.10
, pp. 1366-1374
-
-
Choi, J.B.1
Uchino, H.2
Azuma, K.3
Iwashita, N.4
Tanaka, Y.5
Mochizuki, H.6
Migita, M.7
Shimada, T.8
Kawamori, R.9
Watada, H.10
-
26
-
-
52749093177
-
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
-
Ebato C, Uchida T, Arakawa M, Komatsu M, Ueno T, Komiya K, Azuma K, Hirose T, Tanaka K, Kominami E, Kawamori R, Fujitani Y, Watada H. Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008;8(4): 325-32.
-
(2008)
Cell Metab.
, vol.8
, Issue.4
, pp. 325-332
-
-
Ebato, C.1
Uchida, T.2
Arakawa, M.3
Komatsu, M.4
Ueno, T.5
Komiya, K.6
Azuma, K.7
Hirose, T.8
Tanaka, K.9
Kominami, E.10
Kawamori, R.11
Fujitani, Y.12
Watada, H.13
-
27
-
-
62249130886
-
Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima fatty rats
-
Kaihara M, Nakamura Y, Sugimoto T, Uchida HA, Norii H, Hanayama Y, Makino H. Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima fatty rats. Acta Med Okayama. 2009;63(1): 35-42.
-
(2009)
Acta Med Okayama.
, vol.63
, Issue.1
, pp. 35-42
-
-
Kaihara, M.1
Nakamura, Y.2
Sugimoto, T.3
Uchida, H.A.4
Norii, H.5
Hanayama, Y.6
Makino, H.7
-
28
-
-
9644280976
-
Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells
-
Tsubouchi H, Inoguchi T, Inuo M, Kakimoto M, Sonta T, Sonoda N, Sasaki S, Kobayashi K, Sumimoto H, Nawata H. Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells. Biochem Biophys Res Commun. 2005;326(1): 60-5.
-
(2005)
Biochem Biophys Res Commun.
, vol.326
, Issue.1
, pp. 60-65
-
-
Tsubouchi, H.1
Inoguchi, T.2
Inuo, M.3
Kakimoto, M.4
Sonta, T.5
Sonoda, N.6
Sasaki, S.7
Kobayashi, K.8
Sumimoto, H.9
Nawata, H.10
-
29
-
-
10744227975
-
Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase
-
Kawamori D, Kajimoto Y, Kaneto H, Umayahara Y, Fujitani Y, Miyatsuka T, Watada H, Leibiger IB, Yamasaki Y, Hori M. Oxidative stress induces nucleo-cytoplasmic translocation of pancreatic transcription factor PDX-1 through activation of c-Jun NH(2)-terminal kinase. Diabetes. 2003;52(12): 2896-904.
-
(2003)
Diabetes
, vol.52
, Issue.12
, pp. 2896-2904
-
-
Kawamori, D.1
Kajimoto, Y.2
Kaneto, H.3
Umayahara, Y.4
Fujitani, Y.5
Miyatsuka, T.6
Watada, H.7
Leibiger, I.B.8
Yamasaki, Y.9
Hori, M.10
-
30
-
-
84859393335
-
Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome
-
Rodriguez R, Viscarra JA, Minas JN, Nakano D, Nishiyama A, Ortiz RM. Angiotensin receptor blockade increases pancreatic insulin secretion and decreases glucose intolerance during glucose supplementation in a model of metabolic syndrome. Endocrinology. 153(4): 1684-1695.
-
Endocrinology
, vol.153
, Issue.4
, pp. 1684-1695
-
-
Rodriguez, R.1
Viscarra, J.A.2
Minas, J.N.3
Nakano, D.4
Nishiyama, A.5
Ortiz, R.M.6
|