Effects of ambient levels of traffic-derived air pollution on the ocular surface: Analysis of symptoms, conjunctival goblet cell count and mucin 5AC gene expression

Environmental Research

Volumn 131, Issue , 2014, Pages 59-63

  Torricelli, André Augusto Miranda ^a   Matsuda, Monique ^a   Novaes, Priscila ^a   Braga, Alfésio Luiz Ferreira ^a   Saldiva, Paulo Hilário Nascimento ^a   Alves, Milton Ruiz ^a   Monteiro, Mário Luiz Ribeiro ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Air pollution; Goblet cell; Mucin; Ocular surface

Indexed keywords

MESSENGER RNA; MUCIN 5AC;

AMBIENT AIR; ATMOSPHERIC POLLUTION; CYTOLOGY; DISEASE INCIDENCE; GENE EXPRESSION; HEALTH IMPACT; POLLUTION EFFECT; RNA; SYMPTOM; TRAFFIC EMISSION;

AIR POLLUTION; AMBIENT AIR; ARTICLE; CELL COUNT; CELL DENSITY; CLINICAL ASSESSMENT TOOL; CONJUNCTIVA; CONJUNCTIVAL GOBLET CELL COUNT; DRIVER; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION; GOBLET CELL; HUMAN; IMPRESSION CYTOLOGY; LONG TERM EXPOSURE; MALE; NORMAL HUMAN; OCULAR SURFACE DISEASE INDEX QUESTIONNAIRE; PARTICULATE MATTER; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRAFFIC;

AIR POLLUTION; GOBLET CELL; MUCIN; OCULAR SURFACE;

ADULT; AIR POLLUTION; CONJUNCTIVA; GOBLET CELLS; HEALTHY VOLUNTEERS; HUMANS; MALE; MIDDLE AGED; MUCIN 5AC; VEHICLE EMISSIONS;

EID: 84896517574     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2014.02.014     Document Type: Article

References (43)

1. Aragona P., et al. Impression cytology of the conjunctival epithelium in patients with vernal conjunctivitis. Eye (London) 1996, 10(Pt 1):82-85.
2. Argueso P., et al. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Investig. Ophthalmol. Vis. Sci. 2002, 43:1004-1011.
3. Basbaum C., et al. Control of mucin transcription by diverse injury-induced signaling pathways. Am. J. Respir. Crit. Care Med. 1999, 160:S44-S48.
4. Caffery B., et al. MUC1 expression in Sjogren[U+05F3]s syndrome, KCS, and control subjects. Mol. Vis. 2010, 16:1720-1727.
5. Camargo Pires-Neto R., et al. Effects of Sao Paulo air pollution on the upper airways of mice. Environ. Res. 2006, 101:356-361.
6. Conceicao G.M., et al. Air pollution and child mortality: a time-series study in Sao Paulo, Brazil. Environ. Health Perspect. 2001, 109(Suppl 3):S347-S350.
7. Corrales R.M., et al. Levels of mucin gene expression in normal human conjunctival epithelium in vivo. Curr. Eye Res. 2003, 27:323-328.
8. Corrales R.M., et al. Ocular mucin gene expression levels as biomarkers for the diagnosis of dry eye syndrome. Investig. Ophthalmol. Vis. Sci. 2011, 52:8363-8369.
9. de Paula Santos U., et al. Effects of air pollution on blood pressure and heart rate variability: a panel study of vehicular traffic controllers in the city of Sao Paulo, Brazil. Eur. Heart J. 2005, 26:193-200.
10. de Toledo G.I., Nardocci A.C. [Traffic related air pollution and population health: a review about Sao Paulo (SP), Brazil]. Rev. Brasileira Epidemiol. 2011, 14:445-454.
11. Dogru M., et al. Atopic ocular surface disease: implications on tear function and ocular surface mucins. Cornea 2005, 24:S18-S23.
12. Doughty M.J. Goblet cells of the normal human bulbar conjunctiva and their assessment by impression cytology sampling. Ocul Surf. 2012, 10:149-169.
13. Gipson I.K. Distribution of mucins at the ocular surface. Exp. Eye Res. 2004, 78:379-388.
14. Gipson I.K., et al. Comparison of mucin levels at the ocular surface of postmenopausal women with and without a history of dry eye. Cornea 2011, 30:1346-1352.
15. Grigg J. Traffic-derived air pollution and lung function growth. Am. J. Respir. Crit. Care Med. 2012, 186:1208-1209.
16. Gupta S.K., et al. Subclinically dry eyes in urban Delhi: an impact of air pollution?. Ophthalmologica 2002, 216:368-371.
17. Jerrett M., et al. A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environ. Health Perspect. 2009, 117:772-777.
18. Johnson H.G., et al. 15-Hydroxyeicosatetraenoic acid is a potent inflammatory mediator and agonist of canine tracheal mucus secretion. Am. Rev. Respir. Dis. 1985, 131:917-922.
19. Kardon R., et al. Bacterial conjunctivitis in Muc1 null mice. Investig Ophthalmol. Vis. Sci. 1999, 40:1328-1335.
20. Kelly F., et al. The impact of the congestion charging scheme on air quality in London. Part 1. Emissions modeling and analysis of air pollution measurements. Res. Rep. Health Eff. Inst. 2011, 5-71.
21. Kelly F.J., et al. Monitoring air pollution: use of early warning systems for public health. Respirology 2012, 17:7-19.
22. Kunzli N., et al. Assessment of deaths attributable to air pollution: should we use risk estimates based on time series or on cohort studies?. Am. J. Epidemiol. 2001, 153:1050-1055.
23. Mantelli F., Argueso P. Functions of ocular surface mucins in health and disease. Curr. Opin. Allergy Clin. Immunol. 2008, 8:477-483.
24. Marom Z., et al. Human airway monohydroxyeicosatetraenoic acid generation and mucus release. J. Clin. Investig. 1983, 72:122-127.
25. Martins L.C., et al. Air pollution and emergency room visits due to chronic lower respiratory diseases in the elderly: an ecological time-series study in Sao Paulo, Brazil. J. Occup. Environ. Med. 2002, 44:622-627.
26. Medina-Ramon M., et al. The effect of ozone and PM10 on hospital admissions for pneumonia and chronic obstructive pulmonary disease: a national multicity study. Am. J. Epidemiol. 2006, 163:579-588.
27. Novaes P., et al. Ambient levels of air pollution induce goblet-cell hyperplasia in human conjunctival epithelium. Environ. Health Perspect. 2007, 115:1753-1756.
28. Novaes P., et al. The effects of chronic exposure to traffic derived air pollution on the ocular surface. Environ. Res. 2011, 110:372-374.
29. Pereira L.A., et al. Association between air pollution and intrauterine mortality in Sao Paulo, Brazil. Environ. Health Perspect. 1998, 106:325-329.
30. Pisella P.J., et al. Flow cytometric analysis of conjunctival epithelium in ocular rosacea and keratoconjunctivitis sicca. Ophthalmology 2000, 107:1841-1849.
31. Prigol A.M., et al. [Translation and validation of ocular surface disease index to Portuguese]. Arq. Bras. Ofalmol. 2012, 75:24-28.
32. Saldiva P.H., et al. Air pollution and mortality in elderly people: a time-series study in Sao Paulo, Brazil. Arch. Environ. Health 1995, 50:159-163.
33. Samoli E., et al. Investigating the dose-response relation between air pollution and total mortality in the APHEA-2 multicity project. Occup. Environ. Med. 2003, 60:977-982.
34. Saxena R., et al. Impact of environmental pollution on the eye. Acta Ophthalmol. Scand. 2003, 81:491-494.
35. Schiffman R.M., et al. Reliability and validity of the Ocular Surface Disease Index. Arch. Ophthalmol. 2000, 118:615-621.
36. Singh R., et al. Impression cytology of the ocular surface. Br. J. Ophthalmol. 2005, 89:1655-1659.
37. Souza M.B., et al. Respiratory changes due to long-term exposure to urban levels of air pollution: a histopathologic study in humans. Chest 1998, 113:1312-1318.
38. Tei M., et al. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Investig. Ophthalmol. Vis. Sci. 2000, 41:82-88.
39. Torricelli A.A., et al. Ocular surface adverse effects of ambient levels of air pollution. Arq. Bras. Ofalmol. 2011, 74:377-381.
40. Torricelli A.A., et al. Correlation between signs and symptoms of ocular surface dysfunction and tear osmolarity with ambient levels of air pollution in a large metropolitan area. Cornea 2013, 32:e11-e15.
41. Versura P., et al. Eye discomfort and air pollution. Ophthalmologica 1999, 213:103-109.
42. Wolkoff P. Ocular discomfort by environmental and personal risk factors altering the precorneal tear film. Toxicol. Lett. 2010, 199:203-212.
43. Yanni J.M., et al. Effect of intravenously administered lipoxygenase metabolites on rat tracheal mucous gel layer thickness. Int. Arch. Allergy Appl. Immunol. 1989, 90:307-309.