Juglans mandshurica Maxim extracts exhibit antitumor activity on HeLa cells in vitro

Molecular Medicine Reports

Volumn 9, Issue 4, 2014, Pages 1313-1318

  Xin, Nian ^a   Hasan, Murtaza ^a   Li, Wei ^b   Li, Yan ^a  

^a BEIJING INSTITUTE OF TECHNOLOGY   (China)

^b THE FIRST HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Anti tumor; Apoptosis; HeLa cells; Juglans mandshurica Maxim extracts; S phase arrest

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTINEOPLASTIC AGENT; CISPLATIN; JUGLANS MANDSHURICA EXTRACT; PLANT EXTRACT; TELOMERASE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL DEATH; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; DNA FRAGMENTATION; DNA FRAGMENTATION ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HELA CELL; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; JUGLANS MANDSHURICA; MTT ASSAY; S PHASE CELL CYCLE CHECKPOINT; WALNUT;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL CYCLE; CELL PROLIFERATION; DNA, NEOPLASM; ELECTROPHORESIS, AGAR GEL; FLUORESCENCE; HELA CELLS; HUMANS; JUGLANS; NAPHTHOQUINONES; NECROSIS; PLANT EXTRACTS; SILVER STAINING; STAINING AND LABELING; TELOMERASE;

EID: 84896514117     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.1979     Document Type: Article

References (22)

1. Chen HC, Schiffman M, Lin CY, Pan MH, You SL, Chuang LC, Hsieh CY, Liaw KL, Hsing AW and Chen CJ; CBCSP-HPV Study group: Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. J Natl Cancer Inst 103: 1387-1396, 2011.
2. Parkin DM: The global health burden of infection-associated cancers in the year 2002. Int J Cancer 118: 3030-3044, 2006.
3. Kaefer CM and Milner JA: The role of herbs and spices in cancer prevention. J Nutr Biochem 19: 347-361, 2008. (Pubitemid 351689086)
4. Sun ML, Wang YM, Song ZQ and Fang GZ: Insecticidal activities and active components of the alcohol extract from green peel of Juglans mandshurica. J Forestry Res 18: 62-64, 2007.
5. Zhou YY and Wang D: Advances in study on the compounds of Juglans mandshurica Maxim. J Chin Mod Tradit Chin Med 3: 8-10, 2007 (In Chinese).
6. Li Y, Xin N, Li YJ and Zhang JY: Investigation into anti-tumor and immunomodulatory effects of Juglans mandshurica maxim extracts (HT). Transactions Beijing Inst Technol 31: 618-621, 2011 (In Chinese).
7. Li SZ, Wang YC, Jiang DF and Wang Y: Screening effective part of qinglongyi and Walnut sticks on anti-tumor by Brine Shrimp Lethelity Bioassay. Northwest Pharm J 15: 114, 2006 (In Chinese).
8. Guo JH, Cui LM, Li SH, Liu L, He RH and Liu B: Inhibitory effects and immunoregulation of Juglans mandshurica maxim extract on S180 mouse sarcoma. J Jilin Univ (Med Ed) 33: 286-289, 2007 (In Chinese). (Pubitemid 46638242)
9. Kim SH, Lee KS, Son JK, Je GH, Lee JS, Lee CH and Cheong CJ: Cytotoxic compounds from the roots of Juglans mandshurica. J Nat Prod 61: 643-645, 1998. (Pubitemid 28262034)
10. Murray AW: Recycling the cell cycle: cyclins revisited. Cell 116: 221-234, 2004.
11. Lu YJ, Yang SH, Chien CM, Lin YH, Hu XW, Wu ZZ, Wu MJ and Lin SR: Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. Toxicol in Vitro 21: 90-98, 2007.
12. Gamet-Payrastre L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J and Tercé F: Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and apoptosis in HT29 human colon cancer cells. Cancer Res 60: 1426-1433, 2000. (Pubitemid 30152017)
13. Fujimoto K, Hosotani R, Doi R, Wada M, Lee JU, Koshiba T, Miyamoto Y, Tsuji S, Nakajima Y and Imamura M: Induction of cell-cycle arrest and apoptosis by a novel retinobenzoic-acid derivative, TAC-101, in human pancreatic-cancer cells. Int J Cancer 81: 637-644, 1999. (Pubitemid 29203064)
14. Taylor WR and Stark GR: Regulation of the G2/M transition by p53. Oncogene 20: 1803-1815, 2001. (Pubitemid 32458690)
15. Luk SC, Siu SW, Lai CK, Wu YJ and Pang SF: Cell cycle arrest by a natural product via G2/M checkpoint. Int J Med Sci 2: 64-69, 2005. (Pubitemid 40944955)
16. Xu HL, Yu XF, Qu SC, Zhang R, Qu XR, Chen YP, Ma XY and Sui DY: Anti-proliferative effect of Juglone from Juglans mandshurica Maxim on human leukemia cell HL-60 by inducing apoptosis through the mitochondria-dependent pathway. Eur J Pharmacol 645: 14-22, 2010.
17. Blasco MA: Telomerase beyond telomeres. Nat Rev Cancer 2: 627-633, 2002.
18. Shi H and Ding ZS: Study progress of the chemical composition and pharmacological effects of the pecan species. Chin Tradit Patent Med 31: 924-928, 2009.
19. Chen FH and Tang WM: Studies on the Constituents and Biological Activity of the Bark of Juglans regia. Natural Product Research and Development 20: 16-18, 2008.
20. Zhang YL, Zhan M, Pan YF, Fan W, Li HZ and Huang QS: Study on the contribution to the cytokines of the carya bark decoction to the BALb/c tumor-bearing mice. Strait Pharm J 21: 40-43, 2009.
21. Han LK, Li W, Narimatsu S, Liu LJ, Fu HW, Okuda H and Koike K: Inhibitory effects of compounds isolated from fruit of Juglans mandshurica on pancreatic lipase. J Nat Med 61: 184-186, 2007.
22. Shi YY, Li H and Yang SJ: Induction of apoptosis by panax quinquefolium effective parts (PQEP) on K562 cells. Chin Pharmacol Bull 21: 1494-1497, 2005. (Pubitemid 43219192)