IBD genetics: Focus on (dys) regulation in immune cells and the epithelium

Gastroenterology

Volumn 146, Issue 4, 2014, Pages 896-899

  Kaser, Arthur ^a   Pasaniuc, Bogdan ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

CHROMATIN; DNA HELIX; DNA SEQUENCE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOPRECIPITATION; IMMUNOREGULATION; INFLAMMATORY BOWEL DISEASE; INTESTINE EPITHELIUM; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW;

ANIMALS; GENETIC LOCI; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATORY BOWEL DISEASES; INTESTINAL MUCOSA; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 84896480856     PISSN: 00165085     EISSN: 15280012     Source Type: Journal    
DOI: 10.1053/j.gastro.2014.02.023     Document Type: Editorial

References (21)

1. L. Jostins, S. Ripke, and R.K. Weersma et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease Nature 491 2012 119 124
2. J.P. Hugot, M. Chamaillard, and H. Zouali et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease Nature 411 2001 599 603
3. J. Hampe, A. Franke, and P. Rosenstiel et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1 Nat Genet 39 2007 207 211
4. M. Mokry, S. Middendorp, and C.L. Wiegerinck et al. Many inflammatory bowel disease risk loci include regions that regulate gene expression in immune cells and the intestinal epithelium Gastroenterology 146 2014 1040 1047
5. C.A. Dendrou, V. Plagnol, and E. Fung et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource Nat Genet 41 2009 1011 1015
6. B.P. Fairfax, S. Makino, and J. Radhakrishnan et al. Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles Nat Genet 44 2012 502 510
7. S. Raychaudhuri, R.M. Plenge, and E.J. Rossin et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions PLoS Genet 5 2009 e1000534
8. B.E. Bernstein, E. Birney, and I. Dunham et al. An integrated encyclopedia of DNA elements in the human genome Nature 489 2012 57 74
9. B. Li, M. Carey, and J.L. Workman The role of chromatin during transcription Cell 128 2007 707 719
10. M.A. Schaub, A.P. Boyle, and A. Kundaje et al. Linking disease associations with regulatory information in the human genome Genome Res 22 2012 1748 1759
11. M.T. Maurano, R. Humbert, and E. Rynes et al. Systematic localization of common disease-associated variation in regulatory DNA Science 337 2012 1190 1195
12. G. Trynka, C. Sandor, and B. Han et al. Chromatin marks identify critical cell types for fine mapping complex trait variants Nat Genet 45 2013 124 130
13. T.H. Pham, C. Benner, and M. Lichtinger et al. Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states Blood 119 2012 e161 e171
14. B.E. Bernstein, J.A. Stamatoyannopoulos, and J.F. Costello et al. The NIH Roadmap Epigenomics Mapping Consortium Nat Biotechnol 28 2010 1045 1048
15. E. Zigmond, and S. Jung Intestinal macrophages: well educated exceptions from the rule Trends Immunol 34 2013 162 168
16. L.S. Cauley, and L. Lefrancois Guarding the perimeter: protection of the mucosa by tissue-resident memory T cells Mucosal Immunol 6 2013 14 23
17. S. Buonocore, P.P. Ahern, and H.H. Uhlig et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology Nature 464 2010 1371 1375
18. K.J. Maloy, and F. Powrie Intestinal homeostasis and its breakdown in inflammatory bowel disease Nature 474 2011 298 306
19. K.L. Vandussen, T.C. Liu, and D. Li et al. Genetic variants synthesize to produce Paneth cell phenotypes that define subtypes of Crohn's disease Gastroenterology 146 2014 200 209
20. T.E. Adolph, M.F. Tomczak, and L. Niederreiter et al. Paneth cells as a site of origin for intestinal inflammation Nature 503 2013 272 276
21. J. Halfvarson, L. Bodin, and C. Tysk et al. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics Gastroenterology 124 2003 1767 1773